Molecular MRI detects low levels of cardiomyocyte apoptosis in a transgenic model of chronic heart failure

Circulation: Cardiovascular Imaging

Volumn 2, Issue 6, 2009, Pages 468-475

  Sosnovik, David E ^a,b,c   Nahrendorf, Matthias ^a,b   Panizzi, Peter ^a   Matsui, Takashi ^d   Aikawa, Elena ^a   Dai, Guangping ^c   Li, Ling ^d   Reynolds, Fred ^a   Dorn II, Gerald W ^e   Weissleder, Ralph ^a   Josephson, Lee ^a   Rosenzweig, Anthony ^d  

^a Center for Molecular Imaging Research (DES MN PP EA FR RW LJ)   (United States)

^b Cardiology Division   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Cardiomyocyte; Heart failure; Molecular imaging; MRI

Indexed keywords

CASPASE 3; NANOPARTICLE; CARBOCYANINE; CONTRAST MEDIUM; CY5.5 CYANINE DYE; LIPOCORTIN 5; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; POLY(ADP RIBOSE)POLYMERASE 1, MOUSE; POLY(ADP-RIBOSE)POLYMERASE-1, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BLOOD VESSEL PERMEABILITY; CARDIOMYOPATHY; CONTROLLED STUDY; FEMALE; GENE OVEREXPRESSION; HEART FAILURE; HEART MUSCLE CELL; HEART MUSCLE NECROSIS; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOGENESIS; PRIORITY JOURNAL; TRANSGENE; ANIMAL; ENZYMOLOGY; HUMAN; METABOLISM; METHODOLOGY; NICK END LABELING; NONPARAMETRIC TEST; PATHOLOGY; TRANSGENIC MOUSE; WESTERN BLOTTING;

ANIMALS; ANNEXIN A5; APOPTOSIS; BLOTTING, WESTERN; CARBOCYANINES; CASPASE 3; CONTRAST MEDIA; FEMALE; HEART FAILURE; HUMANS; IN SITU NICK-END LABELING; MAGNETIC RESONANCE IMAGING; MICE; MICE, TRANSGENIC; MYOCYTES, CARDIAC; POLY(ADP-RIBOSE) POLYMERASES; STATISTICS, NONPARAMETRIC;

EID: 73449116808     PISSN: 19419651     EISSN: 19420080     Source Type: Journal    
DOI: 10.1161/CIRCIMAGING.109.863779     Document Type: Article

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