Molecular biology - Noise in gene expression: Origins, consequences, and control

Science

Volumn 309, Issue 5743, 2005, Pages 2010-2013

  Raser, Jonathan M ^a   O'Shea, Erin K ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACOUSTIC NOISE; BIOCHEMISTRY; CELLS; ENVIRONMENTAL IMPACT; GENETIC ENGINEERING;

BIOCHEMICAL REACTIONS; ENVIRONMENTAL EXPOSURE; GENE EXPRESSION; PHENOTYPE;

MOLECULAR BIOLOGY;

MESSENGER RNA; PROTEIN;

GENE EXPRESSION;

ENVIRONMENTAL EXPOSURE; FLOW CYTOMETRY; GENE CONTROL; GENE EXPRESSION; GENE MUTATION; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; HUMAN; MEASUREMENT; NOISE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REACTION ANALYSIS; REVIEW; STOCHASTIC MODEL; ALLELE; ANIMAL; BIOLOGICAL MODEL; BIOLOGICAL PHENOMENA AND FUNCTIONS CONCERNING THE ENTIRE ORGANISM; EVOLUTION; FEEDBACK SYSTEM; GENE DOSAGE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PROTEIN SYNTHESIS; STATISTICS;

ALLELES; ANIMALS; EVOLUTION; FEEDBACK, BIOCHEMICAL; GENE DOSAGE; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMANS; MODELS, BIOLOGICAL; PHENOTYPE; PHYSIOLOGICAL PROCESSES; PROTEIN BIOSYNTHESIS; PROTEINS; STOCHASTIC PROCESSES; TRANSCRIPTION, GENETIC;

EID: 25444468618     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1105891     Document Type: Review

References (39)

1. N. G. van Kampen, Stochastic Processes in Physics and Chemistry (North-Holland, Amsterdam, 1992).
2. P. S. Swain, M. B. Elowitz, E. D. Siggia, Proc. Natl. Acad. Sc.i U.S.A. 99, 12795 (2002).
3. J. M. Raser, E. K. O'Shea, Science 304, 1811 (2004).
4. J. M. Pedraza, A. van Oudenaarden, Science 307, 1965 (2005).
5. M. B. Elowitz, A. J. Levine, E. D. Siggia, P. S. Swain, Science 297, 1183 (2002).
6. E. M. Ozbudak, M. Thattai, I. Kurtser, A. D. Grossman, A. van Oudenaarden, Nat. Genet. 31, 69 (2002).
7. H. H. McAdams, A. Arkin, Proc. Natl. Acad. Sci. U.S.A. 94, 814 (1997).
8. A. M. Kierzek, J. Zaim, P. Zielenkiewicz, J. Biol. Chem. 276, 8165 (2001).
9. T. B. Kepler, T. C. Elston, Biophys. J. 81, 3116 (2001).
10. M. Thattai, A. van Oudenaarden, Proc Natl. Acad. Sci. USA 98, 8614 (2001).
11. W. J. Blake, M. Kaern, C. R. Cantor, J. J. Collins, Nature 422, 633 (2003).
12. N. Rosenfeld, J. W. Young, U. Alon, P. S. Swain, M. B. Elowitz, Science 307, 1962 (2005).
13. K. Ahmad, S. Henikoff, Cell 104, 839 (2001).
14. M. Six, R. M. Locksley, Science 281, 1352 (1998).
15. I. Riviere, M. J. Sunshine, D. R. Littman, Immunity 9, 217 (1998).
16. T. Pastinen et al., Physiol. Genomics 16, 184 (2004).
17. R. Kemkemer, S. Schrank, W. Vogel, H. Gruler, D. Kaufmann, Proc. Natl. Acad. Sci. U.S.A. 99, 13783 (2002).
18. J. A. Magee, S. A. Abdulkadir, J. Milbrandt, Cancer Cell 3, 273 (2003).
19. A. Chess, I. Simon, H. Cedar, R. Axel, Cell 78, 823 (1994).
20. S. Serizawa, K. Miyamichi, H. Sakano, Trends Genet 20, 648 (2004).
21. A. Arkin, J. Ross, H. H. McAdams, Genetics 149, 1633 (1998).
22. F. J. Isaacs, J. Hasty, C. R. Cantor, J. J. Collins, Proc. Natl. Acad. Sci. U.S.A. 100, 7714 (2003).
23. E. M. Ozbudak, M. Thattai, H. N. Lim, B. I. Shraiman, A. van Oudenaarden, Nature 427, 737 (2004).
24. J. Hasty, J. Pradines, M. Dolnik, J. J. Collins, Proc. Natl. Acad. Sci. U.S.A. 97, 2075 (2000).
25. S. Hooshangi, S. Thiberge, R. Weiss, Proc. Natl. Acad. Sci. U.S.A. 102, 3581 (2005).
26. M. S. Ko, J. Theor. Biol. 153, 181 (1991).
27. H. B. Fraser, A. E. Hirsh, G. Giaever, J. Kumm, M. B. Eisen, PLoS Biol. 2, e137 (2004).
28. M. Kellis, B. W. Birren, E. S. Lander, Nature 428, 617 (2004).
29. A. Becskei, L. Serrano, Nature 405, 590 (2000).
30. H. H. Ng, F. Robert, R. A. Young, K. Struhl, Mol. Cell 11, 709 (2003).
31. M. B. Elowitz, S. Leibler, Nature 403, 335 (2000).
32. I. Mihalcescu, W. Hsing, S. Leibler, Nature 430, 81 (2004).
33. J. Tomita, M. Nakajima, T. Kondo, H. Iwasaki, Science 307, 251 (2005).
34. C. Queitsch, T. A. Sangster, S. Lindquist, Nature 417, 618 (2002).
35. C. H. Waddington, Nature 183, 1654 (1959).
36. M. Pigliucci, C. J. Murren, Evolution Int. J. Org. Evolution 57, 1455 (2003).
37. A. K. Jain et al., Pattern Recognition 35, 2653 (2002).
38. T. Shin et al., Nature 415, 859 (2002).
39. We regret not acknowledging numerous contributors to this topic We thank A. Arkin, M. Elowitz, and A. van Oudenaarden for critical commentary. Supported by the Howard Hughes Medical Institute, NIH grant GM51377, the David and Lucile Packard Foundation (E.K.O.), the Burroughs Wellcome/UCSF Interfaces of Science Fellowship program, and the UCSF Medical Scientist Training Program (J.M.R.). E.K.O. is a member of the science board and occasional consultant for Chiron Corporation.