Catecholaminergic polymorphic ventricular tachycardia is caused by mutation-linked defective conformational regulation of the ryanodine receptor

Circulation Research

Volumn 106, Issue 8, 2010, Pages 1413-1424

  Uchinoumi, Hitoshi ^a   Yano, Masafumi ^a   Suetomi, Takeshi ^a   Ono, Makoto ^a   Xu, Xiaojuan ^a   Tateishi, Hiroki ^a   Oda, Tetsuro ^a   Okuda, Shinichi ^a   Doi, Masahiro ^a   Kobayashi, Shigeki ^a   Yamamoto, Takeshi ^a   Ikeda, Yasuhiro ^a   Ohkusa, Tomoko ^a   Ikemoto, Noriaki ^b,c   Matsuzaki, Masunori ^a  

^a GRADUATE SCHOOL OF MEDICINE   (Japan)

^b BOSTON BIOMEDICAL RESEARCH INSTITUTE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Calcium; Ryanodine receptor; Sarcoplasmic reticulum; Ventricular tachycardia

Indexed keywords

CALCIUM; CYCLIC AMP DEPENDENT PROTEIN KINASE; ISOPRENALINE; RYANODINE RECEPTOR 2; ADRENALIN; CAFFEINE; PEPTIDE FRAGMENT; RYANODINE RECEPTOR; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL (2460 2495), SER(2474); RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL (2460-2495), SER(2474)-;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM TRANSPORT; CARBOXY TERMINAL SEQUENCE; CATECHOLAMINERGIC POLYMORPHIC VENTRICULAR TACHYCARDIA; CLINICAL ASSESSMENT; DISEASE ASSOCIATION; GENE MUTATION; HEART MUSCLE CELL; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; POINT MUTATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SARCOPLASMIC RETICULUM; TREADMILL EXERCISE; ANIMAL; C57BL MOUSE; CALCIUM SIGNALING; CELL CULTURE; CELL MEMBRANE POTENTIAL; CHEMICALLY INDUCED DISORDER; CHEMISTRY; DISEASE MODEL; EXCITATION CONTRACTION COUPLING; EXERCISE; GENETICS; GENOTYPE; HEART CONTRACTION; HEART VENTRICLE TACHYCARDIA; METABOLISM; PHENOTYPE; PHOSPHORYLATION; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION; TIME; TRANSGENIC MOUSE;

ANIMALS; CAFFEINE; CALCIUM SIGNALING; CELLS, CULTURED; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DISEASE MODELS, ANIMAL; EPINEPHRINE; EXCITATION CONTRACTION COUPLING; GENOTYPE; ISOPROTERENOL; MEMBRANE POTENTIALS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; PEPTIDE FRAGMENTS; PHENOTYPE; PHOSPHORYLATION; PHYSICAL EXERTION; POINT MUTATION; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SARCOPLASMIC RETICULUM; STRUCTURE-ACTIVITY RELATIONSHIP; TACHYCARDIA, VENTRICULAR; TIME FACTORS;

EID: 77952491660     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.109.209312     Document Type: Article

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