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Volumn 590, Issue 11, 2012, Pages 2555-2567

Exploiting mathematical models to illuminate electrophysiological variability between individuals

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; ION CHANNEL;

EID: 84861658382     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2011.223313     Document Type: Review
Times cited : (122)

References (74)
  • 1
    • 33746614853 scopus 로고    scopus 로고
    • Complex parameter landscape for a complex neuron model
    • Achard P & DeSchutter E (2006). Complex parameter landscape for a complex neuron model. PLoS Comput Biol 2, e94.
    • (2006) PLoS Comput Biol , vol.2
    • Achard, P.1    DeSchutter, E.2
  • 3
    • 79551587546 scopus 로고    scopus 로고
    • Sequential dissection of multiple ionic currents in single cardiac myocytes under action potential-clamp
    • Banyasz T, Horvath B, Jian Z, Izu LT & Chen-Izu Y (2011). Sequential dissection of multiple ionic currents in single cardiac myocytes under action potential-clamp. J Mol Cell Cardiol 50, 578-581.
    • (2011) J Mol Cell Cardiol , vol.50 , pp. 578-581
    • Banyasz, T.1    Horvath, B.2    Jian, Z.3    Izu, L.T.4    Chen-Izu, Y.5
  • 5
    • 46849088993 scopus 로고    scopus 로고
    • Minimal model for human ventricular action potentials in tissue
    • Bueno-Orovio A, Cherry EM & Fenton FH (2008). Minimal model for human ventricular action potentials in tissue. J Theor Biol 253, 544-560.
    • (2008) J Theor Biol , vol.253 , pp. 544-560
    • Bueno-Orovio, A.1    Cherry, E.M.2    Fenton, F.H.3
  • 6
    • 80955172247 scopus 로고    scopus 로고
    • A human ventricular cell model for investigation of cardiac arrhythmias under hyperkalaemic conditions
    • Carro J, Rodriguez JF, Laguna P & Pueyo E (2011). A human ventricular cell model for investigation of cardiac arrhythmias under hyperkalaemic conditions. Philos Transact A Math Phys Eng Sci 369, 4205-4232.
    • (2011) Philos Transact A Math Phys Eng Sci , vol.369 , pp. 4205-4232
    • Carro, J.1    Rodriguez, J.F.2    Laguna, P.3    Pueyo, E.4
  • 7
    • 51349134432 scopus 로고    scopus 로고
    • Properties of two human atrial cell models in tissue: restitution, memory, propagation, and reentry
    • Cherry EM & Evans SJ (2008). Properties of two human atrial cell models in tissue: restitution, memory, propagation, and reentry. J Theor Biol 254, 674-690.
    • (2008) J Theor Biol , vol.254 , pp. 674-690
    • Cherry, E.M.1    Evans, S.J.2
  • 8
    • 33846335191 scopus 로고    scopus 로고
    • A tale of two dogs: analyzing two models of canine ventricular electrophysiology
    • Cherry EM & Fenton FH (2007). A tale of two dogs: analyzing two models of canine ventricular electrophysiology. Am J Physiol Heart Circ Physiol 292, H43-H55.
    • (2007) Am J Physiol Heart Circ Physiol , vol.292
    • Cherry, E.M.1    Fenton, F.H.2
  • 9
    • 50049121040 scopus 로고    scopus 로고
    • Dynamics of human atrial cell models: restitution, memory, and intracellular calcium dynamics in single cells
    • Cherry EM, Hastings HM & Evans SJ (2008). Dynamics of human atrial cell models: restitution, memory, and intracellular calcium dynamics in single cells. Prog Biophys Mol Biol 98, 24-37.
    • (2008) Prog Biophys Mol Biol , vol.98 , pp. 24-37
    • Cherry, E.M.1    Hastings, H.M.2    Evans, S.J.3
  • 10
    • 80053605881 scopus 로고    scopus 로고
    • High-throughput functional curation of cellular electrophysiology models
    • Cooper J, Mirams GR & Niederer SA (2011). High-throughput functional curation of cellular electrophysiology models. Prog Biophys Mol Biol 107, 11-20.
    • (2011) Prog Biophys Mol Biol , vol.107 , pp. 11-20
    • Cooper, J.1    Mirams, G.R.2    Niederer, S.A.3
  • 11
    • 79955773125 scopus 로고    scopus 로고
    • Ionic mechanisms of electrophysiological properties and repolarization abnormalities in rabbit Purkinje fibers
    • Corrias A, Giles W & Rodriguez B (2011). Ionic mechanisms of electrophysiological properties and repolarization abnormalities in rabbit Purkinje fibers. Am J Physiol Heart Circ Physiol 300, H1806-H1813.
    • (2011) Am J Physiol Heart Circ Physiol , vol.300
    • Corrias, A.1    Giles, W.2    Rodriguez, B.3
  • 13
    • 2442556015 scopus 로고    scopus 로고
    • Parameter estimation in cardiac ionic models
    • Dokos S & Lovell NH (2004). Parameter estimation in cardiac ionic models. Prog Biophys Mol Biol 85, 407-431.
    • (2004) Prog Biophys Mol Biol , vol.85 , pp. 407-431
    • Dokos, S.1    Lovell, N.H.2
  • 14
    • 85088891526 scopus 로고    scopus 로고
    • A novel multiple objective optimization framework for constraining conductance-based neuron models by experimental data
    • Druckmann S, Banitt Y, Gidon A, Schurmann F, Markram H & Segev I (2007). A novel multiple objective optimization framework for constraining conductance-based neuron models by experimental data. Front Neurosci 1, 7-18.
    • (2007) Front Neurosci , vol.1 , pp. 7-18
    • Druckmann, S.1    Banitt, Y.2    Gidon, A.3    Schurmann, F.4    Markram, H.5    Segev, I.6
  • 17
    • 34447250066 scopus 로고    scopus 로고
    • Regional and tissue specific transcript signatures of ion channel genes in the non-diseased human heart
    • Gaborit N, Le Bouter S, Szuts V, Varro A, Escande D, Nattel S & Demolombe S (2007). Regional and tissue specific transcript signatures of ion channel genes in the non-diseased human heart. J Physiol 582, 675-693.
    • (2007) J Physiol , vol.582 , pp. 675-693
    • Gaborit, N.1    Le Bouter, S.2    Szuts, V.3    Varro, A.4    Escande, D.5    Nattel, S.6    Demolombe, S.7
  • 18
    • 0036092811 scopus 로고    scopus 로고
    • Failure of averaging in the construction of a conductance-based neuron model
    • Golowasch J, Goldman MS, Abbott LF & Marder E (2002). Failure of averaging in the construction of a conductance-based neuron model. J Neurophysiol 87, 1129-1131.
    • (2002) J Neurophysiol , vol.87 , pp. 1129-1131
    • Golowasch, J.1    Goldman, M.S.2    Abbott, L.F.3    Marder, E.4
  • 19
    • 73049094376 scopus 로고    scopus 로고
    • A novel computational model of the human ventricular action potential and Ca transient
    • Grandi E, Pasqualini FS & Bers DM (2010). A novel computational model of the human ventricular action potential and Ca transient. J Mol Cell Cardiol 48, 112-121.
    • (2010) J Mol Cell Cardiol , vol.48 , pp. 112-121
    • Grandi, E.1    Pasqualini, F.S.2    Bers, D.M.3
  • 20
    • 67650917925 scopus 로고    scopus 로고
    • Reliable neuromodulation from circuits with variable underlying structure
    • Grashow R, Brookings T & Marder E (2009). Reliable neuromodulation from circuits with variable underlying structure. Proc Natl Acad Sci U S A 106, 11742-11746.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 11742-11746
    • Grashow, R.1    Brookings, T.2    Marder, E.3
  • 21
    • 77954473192 scopus 로고    scopus 로고
    • Compensation for variable intrinsic neuronal excitability by circuit-synaptic interactions
    • Grashow R, Brookings T & Marder E (2010). Compensation for variable intrinsic neuronal excitability by circuit-synaptic interactions. J Neurosci 30, 9145-9156.
    • (2010) J Neurosci , vol.30 , pp. 9145-9156
    • Grashow, R.1    Brookings, T.2    Marder, E.3
  • 22
    • 79251626458 scopus 로고    scopus 로고
    • Integrative systems models of cardiac excitation-contraction coupling
    • Greenstein JL & Winslow RL (2011). Integrative systems models of cardiac excitation-contraction coupling. Circ Res 108, 70-84.
    • (2011) Circ Res , vol.108 , pp. 70-84
    • Greenstein, J.L.1    Winslow, R.L.2
  • 24
    • 78049282472 scopus 로고    scopus 로고
    • Conductance ratios and cellular identity
    • Hudson AE & Prinz AA (2010). Conductance ratios and cellular identity. PLoS Comput Biol 6, e1000838.
    • (2010) PLoS Comput Biol , vol.6
    • Hudson, A.E.1    Prinz, A.A.2
  • 25
    • 8744246332 scopus 로고    scopus 로고
    • Rate dependence and regulation of action potential and calcium transient in a canine cardiac ventricular cell model
    • Hund TJ & Rudy Y (2004). Rate dependence and regulation of action potential and calcium transient in a canine cardiac ventricular cell model. Circulation 110, 3168-3174.
    • (2004) Circulation , vol.110 , pp. 3168-3174
    • Hund, T.J.1    Rudy, Y.2
  • 26
    • 0030031969 scopus 로고    scopus 로고
    • Ionic mechanism of action potential prolongation in ventricular myocytes from dogs with pacing-induced heart failure
    • Kaab S, Nuss HB, Chiamvimonvat N, O'Rourke B, Pak PH, Kass DA, Marban E & Tomaselli GF (1996). Ionic mechanism of action potential prolongation in ventricular myocytes from dogs with pacing-induced heart failure. Circ Res 78, 262-273.
    • (1996) Circ Res , vol.78 , pp. 262-273
    • Kaab, S.1    Nuss, H.B.2    Chiamvimonvat, N.3    O'Rourke, B.4    Pak, P.H.5    Kass, D.A.6    Marban, E.7    Tomaselli, G.F.8
  • 28
    • 80053050729 scopus 로고    scopus 로고
    • Factors affecting the degree of QT prolongation with drug challenge in a large cohort of normal volunteers
    • Kannankeril PJ, Norris KJ, Carter S & Roden DM (2011). Factors affecting the degree of QT prolongation with drug challenge in a large cohort of normal volunteers. Heart Rhythm 8, 1530-1534.
    • (2011) Heart Rhythm , vol.8 , pp. 1530-1534
    • Kannankeril, P.J.1    Norris, K.J.2    Carter, S.3    Roden, D.M.4
  • 29
    • 80051946732 scopus 로고    scopus 로고
    • Cardiac myocyte model parameter sensitivity analysis and model transformation using a genetic algorithm
    • Kherlopian AR, Ortega FA & Christini DJ (2011). Cardiac myocyte model parameter sensitivity analysis and model transformation using a genetic algorithm. Genetic and Evolutionary Computation 755-758.
    • (2011) Genetic and Evolutionary Computation , pp. 755-758
    • Kherlopian, A.R.1    Ortega, F.A.2    Christini, D.J.3
  • 30
    • 25844524921 scopus 로고    scopus 로고
    • K1-downregulated human ventricular myocytes: insights from bifurcation analyses of a mathematical model
    • K1-downregulated human ventricular myocytes: insights from bifurcation analyses of a mathematical model. Biophys J 89, 2865-2887.
    • (2005) Biophys J , vol.89 , pp. 2865-2887
    • Kurata, Y.1    Hisatome, I.2    Matsuda, H.3    Shibamoto, T.4
  • 31
    • 0037426924 scopus 로고    scopus 로고
    • Activity-independent homeostasis in rhythmically active neurons
    • MacLean JN, Zhang Y, Johnson BR & Harris-Warrick RM (2003). Activity-independent homeostasis in rhythmically active neurons. Neuron 37, 109-120.
    • (2003) Neuron , vol.37 , pp. 109-120
    • MacLean, J.N.1    Zhang, Y.2    Johnson, B.R.3    Harris-Warrick, R.M.4
  • 32
    • 80053141839 scopus 로고    scopus 로고
    • Variability, compensation, and modulation in neurons and circuits
    • Marder E (2011). Variability, compensation, and modulation in neurons and circuits. Proc Natl Acad Sci U S A 108, 15542-15548.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 15542-15548
    • Marder, E.1
  • 33
    • 79251541199 scopus 로고    scopus 로고
    • Multiple models to capture the variability in biological neurons and networks
    • Marder E & Taylor AL (2011). Multiple models to capture the variability in biological neurons and networks. Nat Neurosci 14, 133-138.
    • (2011) Nat Neurosci , vol.14 , pp. 133-138
    • Marder, E.1    Taylor, A.L.2
  • 34
    • 0034640113 scopus 로고    scopus 로고
    • PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts
    • Marx SO, Reiken S, Hisamatsu Y, Jayaraman T, Burkhoff D, Rosemblit N & Marks AR (2000). PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Cell 101, 365-376.
    • (2000) Cell , vol.101 , pp. 365-376
    • Marx, S.O.1    Reiken, S.2    Hisamatsu, Y.3    Jayaraman, T.4    Burkhoff, D.5    Rosemblit, N.6    Marks, A.R.7
  • 35
    • 65549085736 scopus 로고    scopus 로고
    • Models of spatially restricted biochemical reaction systems
    • Neves SR & Iyengar R (2009). Models of spatially restricted biochemical reaction systems. J Biol Chem 284, 5445-5449.
    • (2009) J Biol Chem , vol.284 , pp. 5445-5449
    • Neves, S.R.1    Iyengar, R.2
  • 36
    • 64749109727 scopus 로고    scopus 로고
    • A meta-analysis of cardiac electrophysiology computational models
    • Niederer SA, Fink M, Noble D & Smith NP (2009). A meta-analysis of cardiac electrophysiology computational models. Exp Physiol 94, 486-495.
    • (2009) Exp Physiol , vol.94 , pp. 486-495
    • Niederer, S.A.1    Fink, M.2    Noble, D.3    Smith, N.P.4
  • 38
    • 84856162498 scopus 로고    scopus 로고
    • Arrhythmia formation in subclinical ("silent") long QT syndrome requires multiple insults: quantitative mechanistic study using the KCNQ1 mutation Q357R as example
    • O'Hara T & Rudy Y (2011). Arrhythmia formation in subclinical ("silent") long QT syndrome requires multiple insults: quantitative mechanistic study using the KCNQ1 mutation Q357R as example. Heart Rhythm 9, 275-282.
    • (2011) Heart Rhythm , vol.9 , pp. 275-282
    • O'Hara, T.1    Rudy, Y.2
  • 39
    • 79958158591 scopus 로고    scopus 로고
    • Simulation of the undiseased human cardiac ventricular action potential: model formulation and experimental validation
    • O'Hara T, Virag L, Varro A & Rudy Y (2011). Simulation of the undiseased human cardiac ventricular action potential: model formulation and experimental validation. PLoS Comput Biol 7, e1002061.
    • (2011) PLoS Comput Biol , vol.7
    • O'Hara, T.1    Virag, L.2    Varro, A.3    Rudy, Y.4
  • 40
    • 0348012925 scopus 로고    scopus 로고
    • Alternative to hand-tuning conductance-based models: construction and analysis of databases of model neurons
    • Prinz AA, Billimoria CP & Marder E (2003). Alternative to hand-tuning conductance-based models: construction and analysis of databases of model neurons. J Neurophysiol 90, 3998-4015.
    • (2003) J Neurophysiol , vol.90 , pp. 3998-4015
    • Prinz, A.A.1    Billimoria, C.P.2    Marder, E.3
  • 41
    • 13744259954 scopus 로고    scopus 로고
    • Similar network activity from disparate circuit parameters
    • Prinz AA, Bucher D & Marder E (2004). Similar network activity from disparate circuit parameters. Nat Neurosci 7, 1345-1352.
    • (2004) Nat Neurosci , vol.7 , pp. 1345-1352
    • Prinz, A.A.1    Bucher, D.2    Marder, E.3
  • 42
    • 0032066007 scopus 로고    scopus 로고
    • Taking the "idio" out of "idiosyncratic": predicting torsades de pointes
    • Roden DM (1998). Taking the "idio" out of "idiosyncratic": predicting torsades de pointes. Pacing Clin Electrophysiol 21, 1029-1034.
    • (1998) Pacing Clin Electrophysiol , vol.21 , pp. 1029-1034
    • Roden, D.M.1
  • 43
    • 77953811461 scopus 로고    scopus 로고
    • The systems biology approach to drug development: application to toxicity assessment of cardiac drugs
    • Rodriguez B, Burrage K, Gavaghan D, Grau V, Kohl P & Noble D (2010). The systems biology approach to drug development: application to toxicity assessment of cardiac drugs. Clin Pharmacol Ther 88, 130-134.
    • (2010) Clin Pharmacol Ther , vol.88 , pp. 130-134
    • Rodriguez, B.1    Burrage, K.2    Gavaghan, D.3    Grau, V.4    Kohl, P.5    Noble, D.6
  • 44
    • 80053583205 scopus 로고    scopus 로고
    • Systematic characterization of the ionic basis of rabbit cellular electrophysiology using two ventricular models
    • Romero L, Carbonell B, Trenor B, Rodriguez B, Saiz J & Ferrero JM (2011). Systematic characterization of the ionic basis of rabbit cellular electrophysiology using two ventricular models. Prog Biophys Mol Biol 107, 60-73.
    • (2011) Prog Biophys Mol Biol , vol.107 , pp. 60-73
    • Romero, L.1    Carbonell, B.2    Trenor, B.3    Rodriguez, B.4    Saiz, J.5    Ferrero, J.M.6
  • 45
    • 70349632890 scopus 로고    scopus 로고
    • Impact of ionic current variability on human ventricular cellular electrophysiology
    • Romero L, Pueyo E, Fink M & Rodriguez B (2009). Impact of ionic current variability on human ventricular cellular electrophysiology. Am J Physiol Heart Circ Physiol 297, H1436-H1445.
    • (2009) Am J Physiol Heart Circ Physiol , vol.297
    • Romero, L.1    Pueyo, E.2    Fink, M.3    Rodriguez, B.4
  • 46
    • 1842841337 scopus 로고    scopus 로고
    • Regulation of ion channel expression
    • Rosati B & McKinnon D (2004). Regulation of ion channel expression. Circ Res 94, 874-883.
    • (2004) Circ Res , vol.94 , pp. 874-883
    • Rosati, B.1    McKinnon, D.2
  • 47
    • 78049436203 scopus 로고    scopus 로고
    • Regression analysis for constraining free parameters in electrophysiological models of cardiac cells
    • Sarkar AX & Sobie EA (2010). Regression analysis for constraining free parameters in electrophysiological models of cardiac cells. PLoS Comput Biol 6, e1000914.
    • (2010) PLoS Comput Biol , vol.6
    • Sarkar, A.X.1    Sobie, E.A.2
  • 48
    • 80054994249 scopus 로고    scopus 로고
    • Quantification of repolarization reserve to understand interpatient variability in the response to proarrhythmic drugs: a computational analysis
    • Sarkar AX & Sobie EA (2011). Quantification of repolarization reserve to understand interpatient variability in the response to proarrhythmic drugs: a computational analysis. Heart Rhythm 8, 1749-1755.
    • (2011) Heart Rhythm , vol.8 , pp. 1749-1755
    • Sarkar, A.X.1    Sobie, E.A.2
  • 49
    • 2442587536 scopus 로고    scopus 로고
    • Mechanistic systems models of cell signaling networks: a case study of myocyte adrenergic regulation
    • Saucerman JJ & McCulloch AD (2004). Mechanistic systems models of cell signaling networks: a case study of myocyte adrenergic regulation. Prog Biophys Mol Biol 85, 261-278.
    • (2004) Prog Biophys Mol Biol , vol.85 , pp. 261-278
    • Saucerman, J.J.1    McCulloch, A.D.2
  • 50
    • 33344464699 scopus 로고    scopus 로고
    • Variable channel expression in identified single and electrically coupled neurons in different animals
    • Schulz DJ, Goaillard JM & Marder E (2006). Variable channel expression in identified single and electrically coupled neurons in different animals. Nat Neurosci 9, 356-362.
    • (2006) Nat Neurosci , vol.9 , pp. 356-362
    • Schulz, D.J.1    Goaillard, J.M.2    Marder, E.3
  • 51
    • 34548760721 scopus 로고    scopus 로고
    • Quantitative expression profiling of identified neurons reveals cell-specific constraints on highly variable levels of gene expression
    • Schulz DJ, Goaillard JM & Marder EE (2007). Quantitative expression profiling of identified neurons reveals cell-specific constraints on highly variable levels of gene expression. Proc Natl Acad Sci U S A 104, 13187-13191.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 13187-13191
    • Schulz, D.J.1    Goaillard, J.M.2    Marder, E.E.3
  • 52
    • 28444498920 scopus 로고    scopus 로고
    • Regulation of cardiac sarcoplasmic reticulum Ca release by luminal [Ca] and altered gating assessed with a mathematical model
    • Shannon TR, Wang F & Bers DM (2005). Regulation of cardiac sarcoplasmic reticulum Ca release by luminal [Ca] and altered gating assessed with a mathematical model. Biophys J 89, 4096-4110.
    • (2005) Biophys J , vol.89 , pp. 4096-4110
    • Shannon, T.R.1    Wang, F.2    Bers, D.M.3
  • 53
    • 62649089030 scopus 로고    scopus 로고
    • Parameter sensitivity analysis in electrophysiological models using multivariable regression
    • Sobie EA (2009). Parameter sensitivity analysis in electrophysiological models using multivariable regression. Biophys J 96, 1264-1274.
    • (2009) Biophys J , vol.96 , pp. 1264-1274
    • Sobie, E.A.1
  • 54
    • 62749121668 scopus 로고    scopus 로고
    • Excitation-contraction coupling gain in ventricular myocytes: insights from a parsimonious model
    • Sobie EA & Ramay HR (2009). Excitation-contraction coupling gain in ventricular myocytes: insights from a parsimonious model. J Physiol 587, 1293-1299.
    • (2009) J Physiol , vol.587 , pp. 1293-1299
    • Sobie, E.A.1    Ramay, H.R.2
  • 57
    • 17044407383 scopus 로고    scopus 로고
    • Robustness of burst firing in dissociated purkinje neurons with acute or long-term reductions in sodium conductance
    • Swensen AM & Bean BP (2005). Robustness of burst firing in dissociated purkinje neurons with acute or long-term reductions in sodium conductance. J Neurosci 25, 3509-3520.
    • (2005) J Neurosci , vol.25 , pp. 3509-3520
    • Swensen, A.M.1    Bean, B.P.2
  • 58
    • 29244444510 scopus 로고    scopus 로고
    • Atrial cell action potential parameter fitting using genetic algorithms
    • Syed Z, Vigmond E, Nattel S & Leon LJ (2005). Atrial cell action potential parameter fitting using genetic algorithms. Med Biol Eng Comput 43, 561-571.
    • (2005) Med Biol Eng Comput , vol.43 , pp. 561-571
    • Syed, Z.1    Vigmond, E.2    Nattel, S.3    Leon, L.J.4
  • 59
    • 65649117293 scopus 로고    scopus 로고
    • How multiple conductances determine electrophysiological properties in a multicompartment model
    • Taylor AL, Goaillard JM & Marder E (2009). How multiple conductances determine electrophysiological properties in a multicompartment model. J Neurosci 29, 5573-5586.
    • (2009) J Neurosci , vol.29 , pp. 5573-5586
    • Taylor, A.L.1    Goaillard, J.M.2    Marder, E.3
  • 60
    • 0031014835 scopus 로고    scopus 로고
    • Heart rate variability standards
    • Taylor JA & Lipsitz LA (1997). Heart rate variability standards. Circulation 95, 280-281.
    • (1997) Circulation , vol.95 , pp. 280-281
    • Taylor, J.A.1    Lipsitz, L.A.2
  • 61
    • 28344435526 scopus 로고    scopus 로고
    • Comparison of electrophysiological models for human ventricular cells and tissues
    • Ten Tusscher KH, Bernus O, Hren R & Panfilov AV (2006). Comparison of electrophysiological models for human ventricular cells and tissues. Prog Biophys Mol Biol 90, 326-345.
    • (2006) Prog Biophys Mol Biol , vol.90 , pp. 326-345
    • Ten Tusscher, K.H.1    Bernus, O.2    Hren, R.3    Panfilov, A.V.4
  • 63
    • 45949105567 scopus 로고    scopus 로고
    • Using Physiome standards to couple cellular functions for rat cardiac excitation-contraction
    • Terkildsen JR, Niederer S, Crampin EJ, Hunter P & Smith NP (2008). Using Physiome standards to couple cellular functions for rat cardiac excitation-contraction. Exp Physiol 93, 919-929.
    • (2008) Exp Physiol , vol.93 , pp. 919-929
    • Terkildsen, J.R.1    Niederer, S.2    Crampin, E.J.3    Hunter, P.4    Smith, N.P.5
  • 65
    • 79961230591 scopus 로고    scopus 로고
    • Cardiac ventricular repolarization reserve: a principle for understanding drug-related proarrhythmic risk
    • Varro A & Baczko I (2011). Cardiac ventricular repolarization reserve: a principle for understanding drug-related proarrhythmic risk. Br J Pharmacol 164, 14-36.
    • (2011) Br J Pharmacol , vol.164 , pp. 14-36
    • Varro, A.1    Baczko, I.2
  • 66
    • 0034646287 scopus 로고    scopus 로고
    • Cellular arrhythmogenic effects of congenital and acquired long-QT syndrome in the heterogeneous myocardium
    • Viswanathan PC & Rudy Y (2000). Cellular arrhythmogenic effects of congenital and acquired long-QT syndrome in the heterogeneous myocardium. Circulation 101, 1192-1198.
    • (2000) Circulation , vol.101 , pp. 1192-1198
    • Viswanathan, P.C.1    Rudy, Y.2
  • 67
    • 38949149429 scopus 로고    scopus 로고
    • Neuronal firing sensitivity to morphologic and active membrane parameters
    • Weaver CM & Wearne SL (2008). Neuronal firing sensitivity to morphologic and active membrane parameters. PLoS Comput Biol 4, e11.
    • (2008) PLoS Comput Biol , vol.4
    • Weaver, C.M.1    Wearne, S.L.2
  • 68
    • 77953123168 scopus 로고    scopus 로고
    • Models of cardiac excitation-contraction coupling in ventricular myocytes
    • Williams GS, Smith GD, Sobie EA & Jafri MS (2010). Models of cardiac excitation-contraction coupling in ventricular myocytes. Math Biosci 226, 1-15.
    • (2010) Math Biosci , vol.226 , pp. 1-15
    • Williams, G.S.1    Smith, G.D.2    Sobie, E.A.3    Jafri, M.S.4
  • 70
    • 0033583266 scopus 로고    scopus 로고
    • Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, II: model studies
    • Winslow RL, Rice J, Jafri S, Marban E & O'Rourke B (1999). Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, II: model studies. Circ Res 84, 571-586.
    • (1999) Circ Res , vol.84 , pp. 571-586
    • Winslow, R.L.1    Rice, J.2    Jafri, S.3    Marban, E.4    O'Rourke, B.5
  • 71
    • 76749160779 scopus 로고    scopus 로고
    • Acute effects of sex steroid hormones on susceptibility to cardiac arrhythmias: a simulation study
    • Yang PC, Kurokawa J, Furukawa T & Clancy CE (2010). Acute effects of sex steroid hormones on susceptibility to cardiac arrhythmias: a simulation study. PLoS Comput Biol 6, e1000658.
    • (2010) PLoS Comput Biol , vol.6
    • Yang, P.C.1    Kurokawa, J.2    Furukawa, T.3    Clancy, C.E.4
  • 72
    • 80052520869 scopus 로고    scopus 로고
    • 3D current-voltage-time surfaces unveil critical repolarization differences underlying similar cardiac action potentials: A model study
    • Zaniboni M (2011). 3D current-voltage-time surfaces unveil critical repolarization differences underlying similar cardiac action potentials: A model study. Math Biosci 233, 98-110.
    • (2011) Math Biosci , vol.233 , pp. 98-110
    • Zaniboni, M.1
  • 73
    • 77957689682 scopus 로고    scopus 로고
    • How different two almost identical action potentials can be: a model study on cardiac repolarization
    • Zaniboni M, Riva I, Cacciani F & Groppi M (2010). How different two almost identical action potentials can be: a model study on cardiac repolarization. Math Biosci 228, 56-70.
    • (2010) Math Biosci , vol.228 , pp. 56-70
    • Zaniboni, M.1    Riva, I.2    Cacciani, F.3    Groppi, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.