A Coupled SYSTEM of intracellular Ca2+ clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart's pacemaker

Circulation Research

Volumn 106, Issue 4, 2010, Pages 659-673

  Lakatta, Edward G ^a   Maltsev, Victor A ^a   Vinogradova, Tatiana M ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Ion channels; Local Ca2+ releases; Ryanodine receptors; Sarcoplasmic reticulum; Sinoatrial node cells

Indexed keywords

CALCIUM ION; CYCLIC AMP DEPENDENT PROTEIN KINASE; G PROTEIN COUPLED RECEPTOR; RYANODINE RECEPTOR;

CALCIUM CELL LEVEL; CALCIUM CURRENT; CALCIUM TRANSPORT; HEART DEPOLARIZATION; HEART MUSCLE FIBER MEMBRANE; HUMAN; MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVIEW; SARCOPLASMIC RETICULUM; SINUS NODE; VOLTAGE CLAMP;

ACTION POTENTIALS; ANIMALS; BIOLOGICAL CLOCKS; CALCIUM CHANNELS; CALCIUM SIGNALING; CIRCADIAN RHYTHM; EXCITATION CONTRACTION COUPLING; HEART RATE; HUMANS; KINETICS; MYOCARDIAL CONTRACTION; PHOSPHORYLATION; RECEPTORS, G-PROTEIN-COUPLED; SINOATRIAL NODE;

EID: 77949379471     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.109.206078     Document Type: Review

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