Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias

Cell

Volumn 123, Issue 1, 2005, Pages 25-35

  Lehnart, Stephan E ^a   Wehrens, Xander H T ^a   Reiken, Steven ^a   Warrier, Sunita ^b   Belevych, Andriy E ^b   Harvey, Robert D ^b   Richter, Wito ^c   Jin, S L Catherine ^c   Conti, Marco ^c   Marks, Andrew R ^a  

^a College of Physicians and Surgeons of Columbia University ^*  (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; PHOSPHODIESTERASE; PHOSPHODIESTERASE 4D3; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE IV INHIBITOR; PHOSPHODIESTERASE IVD; RYANODINE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOMYOPATHY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; EXCITATION CONTRACTION COUPLING; GENE INACTIVATION; HEART ARRHYTHMIA; HEART DISEASE; HEART FAILURE; HEART INFARCTION; HEART MUSCLE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 26244467287     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cell.2005.07.030     Document Type: Article

References (39)

1. C.L. Antos, N. Frey, S.O. Marx, S. Reiken, M. Gaburjakova, J.A. Richardson, A.R. Marks, and E.N. Olson Dilated cardiomyopathy and sudden death resulting from constitutive activation of protein kinase a Circ. Res. 89 2001 997 1004
2. G.S. Baillie, A. Sood, I. McPhee, I. Gall, S.J. Perry, R.J. Lefkowitz, and M.D. Houslay beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi Proc. Natl. Acad. Sci. USA 100 2003 940 945
3. P.J. Barnes Theophylline: new perspectives for an old drug Am. J. Respir. Crit. Care Med. 167 2003 813 818
4. G. Bittar, and H.S. Friedman The arrhythmogenicity of theophylline. A multivariate analysis of clinical determinants Chest 99 1991 1415 1420
5. J.J. Carlisle Michel, K.L. Dodge, W. Wong, N.C. Mayer, L.K. Langeberg, and J.D. Scott PKA-phosphorylation of PDE4D3 facilitates recruitment of the mAKAP signalling complex Biochem. J. 381 2004 587 592
6. M. Conti, W. Richter, C. Mehats, G. Livera, J.Y. Park, and C. Jin Cyclic AMP-specific PDE4 phosphodiesterases as critical components of cyclic AMP signaling J. Biol. Chem. 278 2003 5493 5496
7. K.L. Dodge, S. Khouangsathiene, M.S. Kapiloff, R. Mouton, E.V. Hill, M.D. Houslay, L.K. Langeberg, and J.D. Scott mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module EMBO J. 20 2001 1921 1930
8. M.A. Giembycz Development status of second generation PDE4 inhibitors for asthma and COPD: the story so far Monaldi Arch. Chest Dis. 57 2002 48 64
9. B. Gong, O.V. Vitolo, F. Trinchese, S. Liu, M. Shelanski, and O. Arancio Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment J. Clin. Invest. 114 2004 1624 1634
10. S. Gretarsdottir, G. Thorleifsson, S.T. Reynisdottir, A. Manolescu, S. Jonsdottir, T. Jonsdottir, T. Gudmundsdottir, S.M. Bjarnadottir, O.B. Einarsson, and H.M. Gudjonsdottir The gene encoding phosphodiesterase 4D confers risk of ischemic stroke Nat. Genet. 35 2003 131 138
11. M.D. Houslay, and D.R. Adams PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization Biochem. J. 370 2003 1 18
12. M.T. Jiang, A.J. Lokuta, E.F. Farrell, M.R. Wolff, R.A. Haworth, and H.H. Valdivia Abnormal Ca2+ release, but normal ryanodine receptors, in canine and human heart failure Circ. Res. 91 2002 1015 1022
13. S.L. Jin, F.J. Richard, W.P. Kuo, A.J. D'Ercole, and M. Conti Impaired growth and fertility of cAMP-specific phosphodiesterase PDE4D-deficient mice Proc. Natl. Acad. Sci. USA 96 1999 11998 12003
14. S.E. Lehnart, X.H. Wehrens, P.J. Laitinen, S.R. Reiken, S.X. Deng, Z. Cheng, D.W. Landry, K. Kontula, H. Swan, and A.R. Marks Sudden death in familial polymorphic ventricular tachycardia associated with calcium release channel (ryanodine receptor) leak Circulation 109 2004 3208 3214
15. S.O. Marx, S. Reiken, Y. Hisamatsu, T. Jayaraman, D. Burkhoff, N. Rosemblit, and A.R. Marks PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts Cell 101 2000 365 376
16. M. Mongillo, T. McSorley, S. Evellin, A. Sood, V. Lissandron, A. Terrin, E. Huston, A. Hannawacker, M.J. Lohse, and T. Pozzan Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases Circ. Res. 95 2004 67 75
17. M. Packer, J.R. Carver, R.J. Rodeheffer, R.J. Ivanhoe, R. DiBianco, S.M. Zeldis, G.H. Hendrix, W.J. Bommer, U. Elkayam, and M.L. Kukin Effect of oral milrinone on mortality in severe chronic heart failure. The PROMISE Study Research Group N. Engl. J. Med. 325 1991 1468 1475
18. S.J. Perry, G.S. Baillie, T.A. Kohout, I. McPhee, M.M. Magiera, K.L. Ang, W.E. Miller, A.J. McLean, M. Conti, M.D. Houslay, and R.J. Lefkowitz Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins Science 298 2002 834 836
19. B. Pieske, L.S. Maier, D.M. Bers, and G. Hasenfuss Ca2+ handling and sarcoplasmic reticulum Ca2+ content in isolated failing and nonfailing human myocardium Circ. Res. 85 1999 38 46
20. V. Regitz-Zagrosek, R. Hertrampf, C. Steffen, A. Hildebrandt, and E. Fleck Myocardial cyclic AMP and norepinephrine content in human heart failure Eur. Heart J. 15 Suppl. D 1994 7 13
21. S. Reiken, M. Gaburjakova, S. Guatimosim, A.M. Gomez, J. D'Armiento, D. Burkhoff, J. Wang, G. Vassort, W.J. Lederer, and A.R. Marks Protein kinase A phosphorylation of the cardiac calcium release channel (ryanodine receptor) in normal and failing hearts. Role of phosphatases and response to isoproterenol J. Biol. Chem. 278 2003 444 453
22. S. Reiken, X.H. Wehrens, J.A. Vest, A. Barbone, S. Klotz, D. Mancini, D. Burkhoff, and A.R. Marks Beta-blockers restore calcium release channel function and improve cardiac muscle performance in human heart failure Circulation 107 2003 2459 2466
23. W. Richter, S.L. Jin, and M. Conti Splice variants of the cyclic nucleotide phosphodiesterase PDE4D are differentially expressed and regulated in rat tissue Biochem. J. 388 2005 803 811
24. M.L. Ruehr, M.A. Russell, D.G. Ferguson, M. Bhat, J. Ma, D.S. Damron, J.D. Scott, and M. Bond Targeting of protein kinase A by muscle A kinase-anchoring protein (mAKAP) regulates phosphorylation and function of the skeletal muscle ryanodine receptor J. Biol. Chem. 278 2003 24831 24836
25. C. Sette, and M. Conti Phosphorylation and activation of a cAMP-specific phosphodiesterase by the cAMP-dependent protein kinase. Involvement of serine 54 in the enzyme activation J. Biol. Chem. 271 1996 16526 16534
26. T.R. Shannon, S.M. Pogwizd, and D.M. Bers Elevated sarcoplasmic reticulum Ca2+ leak in intact ventricular myocytes from rabbits in heart failure Circ. Res. 93 2003 592 594
27. S. Suissa, B. Hemmelgarn, L. Blais, and P. Ernst Bronchodilators and acute cardiac death Am. J. Respir. Crit. Care Med. 154 1996 1598 1602
28. K.A. Tasken, P. Collas, W.A. Kemmner, O. Witczak, M. Conti, and K. Tasken Phosphodiesterase 4D and protein kinase a type II constitute a signaling unit in the centrosomal area J. Biol. Chem. 276 2001 21999 22002
29. I. Verde, G. Vandecasteele, F. Lezoualc'h, and R. Fischmeister Characterization of the cyclic nucleotide phosphodiesterase subtypes involved in the regulation of the L-type Ca2+ current in rat ventricular myocytes Br. J. Pharmacol. 127 1999 65 74
30. A.M. Vignola PDE4 inhibitors in COPD - a more selective approach to treatment Respir. Med. 98 2004 495 503
31. D. Wang, C. Deng, B. Bugaj-Gaweda, M. Kwan, C. Gunwaldsen, C. Leonard, X. Xin, Y. Hu, A. Unterbeck, and M. De Vivo Cloning and characterization of novel PDE4D isoforms PDE4D6 and PDE4D7 Cell. Signal. 15 2003 883 891
32. X.H. Wehrens, S.E. Lehnart, F. Huang, J.A. Vest, S.R. Reiken, P.J. Mohler, J. Sun, S. Guatimosim, L.S. Song, and N. Rosemblit FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death Cell 113 2003 829 840
33. X.H. Wehrens, S.E. Lehnart, S.R. Reiken, S.X. Deng, J.A. Vest, D. Cervantes, J. Coromilas, D.W. Landry, and A.R. Marks Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2 Science 304 2004 292 296
34. X.H. Wehrens, S.E. Lehnart, S. Reiken, R. van der Nagel, R. Morales, J. Sun, Z. Cheng, S.X. Deng, L.J. de Windt, D.W. Landry, and A.R. Marks Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure Proc. Natl. Acad. Sci. USA 102 2005 9607 9612
35. Y. Xiang, F. Naro, M. Zoudilova, S.L. Jin, M. Conti, and B. Kobilka Phosphodiesterase 4D is required for beta2 adrenoceptor subtype-specific signaling in cardiac myocytes Proc. Natl. Acad. Sci. USA 102 2005 909 914
36. J. Yang, J.A. Drazba, D.G. Ferguson, and M. Bond A-kinase anchoring protein 100 (AKAP100) is localized in multiple subcellular compartments in the adult rat heart J. Cell Biol. 142 1998 511 522
37. M. Yano, K. Ono, T. Ohkusa, M. Suetsugu, M. Kohno, T. Hisaoka, S. Kobayashi, Y. Hisamatsu, T. Yamamoto, and N. Noguchi Altered stoichiometry of FKBP12.6 versus ryanodine receptor as a cause of abnormal Ca(2+) leak through ryanodine receptor in heart failure Circulation 102 2000 2131 2136
38. M. Yano, S. Kobayashi, M. Kohno, M. Doi, T. Tokuhisa, S. Okuda, M. Suetsugu, T. Hisaoka, M. Obayashi, T. Ohkusa, and M. Matsuzaki FKBP12.6-mediated stabilization of calcium-release channel (ryanodine receptor) as a novel therapeutic strategy against heart failure Circulation 107 2003 477 484
39. M. Zaccolo, and T. Pozzan Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes Science 295 2002 1711 1715