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Volumn 6, Issue 11, 2011, Pages 1155-1170

Searching for new cardiovascular drugs: Towards improved systems for drug screening?

Author keywords

assay; cardiovascular; drugs; platform; screening; systems; technology

Indexed keywords

CARDIOVASCULAR AGENT;

EID: 80755130608     PISSN: 17460441     EISSN: 1746045X     Source Type: Journal    
DOI: 10.1517/17460441.2011.625652     Document Type: Review
Times cited : (6)

References (121)
  • 1
    • 39749193540 scopus 로고    scopus 로고
    • Refocussing therapeutic strategies for cardiac arrhythmias: Defining viable molecular targets to restore cardiac ion flux
    • DOI 10.1517/13543776.18.1.1
    • George CH, Barberini-Jammaers SR, Muller CT. Refocussing therapeutic strategies for cardiac arrhythmias: defining viable molecular targets to restore cardiac ion flux. Expert Opin Ther Patents 2008;18:1-19 (Pubitemid 351291795)
    • (2008) Expert Opinion on Therapeutic Patents , vol.18 , Issue.1 , pp. 1-19
    • George, C.H.1    Barberini-Jammaers, S.R.2    Muller, C.T.3
  • 2
    • 80755151735 scopus 로고    scopus 로고
    • Available from:
    • Available from: http://www.fda.gov/ Drugs/default.htm.
  • 3
    • 44649145463 scopus 로고    scopus 로고
    • Anti-arrhythmic drug therapy for atrial fibrillation: Current anti-arrhythmic drugs, investigational agents, and innovative approaches
    • DOI 10.1093/europace/eun130
    • Savelieva I, Camm J. Anti-arrhythmic drug therapy for atrial fibrillation: current anti-arrhythmic drugs, investigational agents and innovative approaches. Europace 2008;10:647-65 (Pubitemid 351775283)
    • (2008) Europace , vol.10 , Issue.6 , pp. 647-665
    • Savelieva, I.1    Camm, J.2
  • 4
    • 59449108428 scopus 로고    scopus 로고
    • Potential novel pharmacological therapies for myocardial remodelling
    • Landmesser U, Wollert KC, Drexler H. Potential novel pharmacological therapies for myocardial remodelling. Cardiovasc Res 2009;81:519-27
    • (2009) Cardiovasc. Res. , vol.81 , pp. 519-527
    • Landmesser, U.1    Wollert, K.C.2    Drexler, H.3
  • 5
    • 33751527644 scopus 로고    scopus 로고
    • Innovative approaches to anti-arrhythmic drug therapy
    • DOI 10.1038/nrd2112, PII NRD2112
    • Nattel S, Carlsson L. Innovative approaches to anti-arrhythmic drug therapy. Nat Rev Drug Disc 2006;5:1034-49 (Pubitemid 44835130)
    • (2006) Nature Reviews Drug Discovery , vol.5 , Issue.12 , pp. 1034-1049
    • Nattel, S.1    Carlsson, L.2
  • 8
    • 80755177902 scopus 로고    scopus 로고
    • Vioxx storm to have lasting effects
    • November 12.
    • Bowe C. Vioxx storm to have lasting effects. Financial Times 2007; November 12.
    • (2007) Financial Times
    • Bowe, C.1
  • 9
    • 34250212715 scopus 로고    scopus 로고
    • Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
    • Nissen SE, Wolski K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N Engl J Med 2007;356:2457-71 (Pubitemid 46919772)
    • (2007) New England Journal of Medicine , vol.356 , Issue.24 , pp. 2457-2471
    • Nissen, S.E.1    Wolski, K.2
  • 10
    • 78650197947 scopus 로고    scopus 로고
    • Improving drug safety surveillance: Lessons from rosiglitazone
    • Masoudi FA. Improving drug safety surveillance: lessons from rosiglitazone. Circ Cardiovasc Qual Outcomes 2010;3:444-6
    • (2010) Circ. Cardiovasc. Qual. Outcomes. , vol.3 , pp. 444-446
    • Masoudi, F.A.1
  • 11
    • 34547770279 scopus 로고    scopus 로고
    • New uses for old drugs
    • DOI 10.1038/448645a, PII 448645A
    • Chong CR, Sullivan DJ. New uses for old drugs. Nature 2007;448:645-6 (Pubitemid 47236844)
    • (2007) Nature , vol.448 , Issue.7154 , pp. 645-646
    • Chong, C.R.1    Sullivan Jr., D.J.2
  • 12
    • 80755151731 scopus 로고    scopus 로고
    • Available from:
    • Available from: http://www.uspto.gov/.
  • 13
    • 80755161756 scopus 로고    scopus 로고
    • Available from:
    • Available from: http://www.epo.org/ searching/free/espacenet.html.
  • 16
    • 33747146463 scopus 로고    scopus 로고
    • SCN5A polymorphism restores trafficking of a brugada syndrome mutation on a separate gene
    • Poelzing S, Forleo C, Samodell M, et al. SCN5A polymorphism restores trafficking of a Brugada syndrome mutation on a separate gene. Circulation 2006;114:368-75
    • (2006) Circulation , vol.114 , pp. 368-375
    • Poelzing, S.1    Forleo, C.2    Samodell, M.3
  • 17
    • 77949953074 scopus 로고    scopus 로고
    • Minimizing repolarization-related proarrhythmic risk in drug development and clinical practice
    • Farkas AS, Nattel S. Minimizing repolarization-related proarrhythmic risk in drug development and clinical practice. Drugs 2010;70:573-603
    • (2010) Drugs , vol.70 , pp. 573-603
    • Farkas, A.S.1    Nattel, S.2
  • 18
    • 61849084206 scopus 로고    scopus 로고
    • Model systems for the discovery and development of antiarrhythmic drugs
    • Nattel S, Duker G, Carlsson L. Model systems for the discovery and development of antiarrhythmic drugs. Prog Biophys Mol Biol 2008;98:328-39
    • (2008) Prog. Biophys. Mol. Biol. , vol.98 , pp. 328-339
    • Nattel, S.1    Duker, G.2    Carlsson, L.3
  • 19
    • 77952546520 scopus 로고    scopus 로고
    • Impact of new technologies for cellular screening along the drug value chain
    • Moller C, Slack M. Impact of new technologies for cellular screening along the drug value chain. Drug Discov Today 2010;15:384-90
    • (2010) Drug Discov Today , vol.15 , pp. 384-390
    • Moller, C.1    Slack, M.2
  • 20
    • 80755151730 scopus 로고    scopus 로고
    • Available from:
    • Available from: http://www.ema.europa. eu/docs/en-GB/document-library/ Scientific-guideline/2009/09/ WC500002841.pdf
  • 21
    • 80755161755 scopus 로고    scopus 로고
    • Available from:
    • Available from: http://www.fda.gov/ drugs/guidancecomplianceregulatory information/guidances/default.htm 2011.
    • (2011)
  • 22
    • 48149107589 scopus 로고    scopus 로고
    • Benchmarking safety pharmacology regulatory packages and best practice
    • Lindgren S, Bass AS, Briscoe R, et al. Benchmarking safety pharmacology regulatory packages and best practice. J Pharmacol Toxicol Methods 2008;58:99-109
    • (2008) J. Pharmacol. Toxicol. Methods , vol.58 , pp. 99-109
    • Lindgren, S.1    Bass, A.S.2    Briscoe, R.3
  • 23
    • 48149084580 scopus 로고    scopus 로고
    • Predicting drug-induced changes in QT interval and arrhythmias: QT-drugs point to gaps in the ICHS7B guidelines
    • Lu HR, Vlaminckx E, Hermans AN, et al. Predicting drug-induced changes in QT interval and arrhythmias: QT-drugs point to gaps in the ICHS7B guidelines. Br J Pharmacol 2008;154:1427-38
    • (2008) Br. J. Pharmacol. , vol.154 , pp. 1427-1438
    • Lu, H.R.1    Vlaminckx, E.2    Hermans, A.N.3
  • 24
    • 0142107369 scopus 로고    scopus 로고
    • + channels expressed in mammalian cell lines and Xenopus oocytes
    • DOI 10.1016/S1056-8719(03)00041-8
    • Witchel HJ, MIlnes JT, Mitcheson JS, et al. Troubleshooting problems with in vitro screening of drugs for QT interval prolongation using HERG K+ channels expressed in mammalian cell lines and xenopus oocytes. J Pharmacol Toxicol Methods 2002;48:65-80 (Pubitemid 37288933)
    • (2002) Journal of Pharmacological and Toxicological Methods , vol.48 , Issue.2 , pp. 65-80
    • Witchel, H.J.1    Milnes, J.T.2    Mitcheson, J.S.3    Hancox, J.C.4
  • 34
    • 79251602239 scopus 로고    scopus 로고
    • Drug-induced hERG block and long QT syndrome
    • Witchel HJ. Drug-induced hERG block and long QT syndrome. Cardiovasc Ther 2011;29:251-9
    • (2011) Cardiovasc Ther. , vol.29 , pp. 251-259
    • Witchel, H.J.1
  • 35
    • 80755177899 scopus 로고    scopus 로고
    • The potential for QT prolongation and proarrhythmia by non-antiarrhythmic drugs: Clinical and regulatory implications
    • Haverkamp W, Breithardt G, Camm AJ, et al. The potential for QT prolongation and proarrhythmia by non-antiarrhythmic drugs: clinical and regulatory implications. Eur Heart J 2001;3(Suppl K):81-9
    • (2001) Eur. Heart J. , vol.3 , pp. 81-89
    • Haverkamp, W.1    Breithardt, G.2    Camm, A.J.3
  • 36
    • 77952573272 scopus 로고    scopus 로고
    • Keeping the rhythm: Herg and beyond in cardiovascular safety pharmacology
    • Moller C. Keeping the rhythm: hERG and beyond in cardiovascular safety pharmacology. Expert Rev Clin Pharmacol 2010;3:321-9
    • (2010) Expert Rev. Clin. Pharmacol. , vol.3 , pp. 321-329
    • Moller, C.1
  • 37
    • 44949260672 scopus 로고    scopus 로고
    • The QT interval as it relates to the safety on non-cardiac drugs
    • Kowey PR, Malik M. The QT interval as it relates to the safety on non-cardiac drugs. Eur Heart J 2007;9(Suppl G):G3-8
    • (2007) Eur. Heart J. , vol.9
    • Kowey, P.R.1    Malik, M.2
  • 38
    • 78751604246 scopus 로고    scopus 로고
    • Novel chemical suppressors of long QT syndrome identified by an in vivo functional screen
    • Peal DS, Mills RW, Lynch SN, et al. Novel chemical suppressors of long QT syndrome identified by an in vivo functional screen. Circulation 2011;123:23-30
    • (2011) Circulation , vol.123 , pp. 23-30
    • Peal, D.S.1    Mills, R.W.2    Lynch, S.N.3
  • 39
    • 4644271084 scopus 로고    scopus 로고
    • Magic shotguns versus magic bullets: Selectively non-selective drugs for mood disorders and schizophrenia
    • Roth BL, Sheffler DJ, Kroeze WK. Magic shotguns versus magic bullets: selectively non-selective drugs for moods disorders and schizophrenia. Nat Rev Drug Disc 2004;3-353-9 (Pubitemid 38499762)
    • (2004) Nature Reviews Drug Discovery , vol.3 , Issue.4 , pp. 353-359
    • Roth, B.L.1    Sheffer, D.J.2    Kroeze, W.K.3
  • 41
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • DOI 10.1016/j.cell.2006.07.024, PII S0092867406009767
    • Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006;126:663-76 (Pubitemid 44233629)
    • (2006) Cell , vol.126 , Issue.4 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 42
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • DOI 10.1016/j.cell.2007.11.019, PII S0092867407014717
    • Takahashi H, Tanabe K, Ohnuki M, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007;131:861-72 (Pubitemid 350138099)
    • (2007) Cell , vol.131 , Issue.5 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3    Narita, M.4    Ichisaka, T.5    Tomoda, K.6    Yamanaka, S.7
  • 43
    • 36749043230 scopus 로고    scopus 로고
    • Induced pluripotent stem cell lines derived from human somatic cells
    • Yu J, Vodyanik MA, Smuga-Otoo K, et al. Induced pluripotent stem cell lines derived from human somatic cells. Science 2007;318:1917-20
    • (2007) Science , vol.318 , pp. 1917-1920
    • Yu, J.1    Vodyanik, M.A.2    Smuga-Otoo, K.3
  • 44
    • 38049187707 scopus 로고    scopus 로고
    • Reprogramming of human somatic cells to pluripotency with defined factors
    • Park I-H, Zhao R, West JA, et al. Reprogramming of human somatic cells to pluripotency with defined factors. Nature 2008;451:141-6
    • (2008) Nature , vol.451 , pp. 141-146
    • Park, I.-H.1    Zhao, R.2    West, J.A.3
  • 45
    • 61949300076 scopus 로고    scopus 로고
    • Functional cardiomyocytes derived from human induced pluripotent stem cells
    • Zhang J, Wilson GF, Soerens AG, et al. Functional cardiomyocytes derived from human induced pluripotent stem cells. Circ Res 2009;104:e30-41
    • (2009) Circ. Res. , vol.104
    • Zhang, J.1    Wilson, G.F.2    Soerens, A.G.3
  • 46
    • 80755161749 scopus 로고    scopus 로고
    • Embryonic stem cells produced via embryo destruction are not patentable
    • Not assigned.
    • Not assigned. Embryonic stem cells produced via embryo destruction are not patentable. Nat Rev Drug Disc 2011;10:330
    • (2011) Nat. Rev. Drug Disc , vol.10 , pp. 330
  • 47
    • 52149120596 scopus 로고    scopus 로고
    • Japan fast-tracks stem-cell patent
    • Cyranoski D. Japan fast-tracks stem-cell patent. Nature 2008;455:269
    • (2008) Nature , vol.455 , pp. 269
    • Cyranoski, D.1
  • 48
    • 45749114189 scopus 로고    scopus 로고
    • Japan ramps up patent effort to keep iPS lead
    • DOI 10.1038/453962a, PII 453962A
    • Cyranoski D. Japan ramps up patent effort to keep iPS lead. Nature 2008;453:962-3 (Pubitemid 351871702)
    • (2008) Nature , vol.453 , Issue.7198 , pp. 962-963
    • Cyranoski, D.1
  • 49
    • 70449342703 scopus 로고    scopus 로고
    • The gold rush for induced pluripotent stem cells
    • Webb S. The gold rush for induced pluripotent stem cells. Nat Biotechnol 2009;27:977-9
    • (2009) Nat. Biotechnol. , vol.27 , pp. 977-979
    • Webb, S.1
  • 57
    • 64749111225 scopus 로고    scopus 로고
    • Virus-free induction of pluripotency and subsequent excision of reprogramming factors
    • Kaji K, Norrby K, Paca A, et al. Virus-free induction of pluripotency and subsequent excision of reprogramming factors. Nature 2009;458:771-5
    • (2009) Nature , vol.458 , pp. 771-775
    • Kaji, K.1    Norrby, K.2    Paca, A.3
  • 58
    • 66049143859 scopus 로고    scopus 로고
    • Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins
    • Kim D, Kim C-H, Moon J-I, et al. Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins. Cell Stem Cell 2009;4:472-6
    • (2009) Cell Stem. Cell , vol.4 , pp. 472-476
    • Kim, D.1    Kim, C.-H.2    Moon, J.-I.3
  • 59
    • 43749115772 scopus 로고    scopus 로고
    • Regenerative medicine and human models of human disease
    • DOI 10.1038/nature07037, PII NATURE07037
    • Chien KR. Regenerative medicine and human models of human disease. Nature 2008;453:302-5 (Pubitemid 351693135)
    • (2008) Nature , vol.453 , Issue.7193 , pp. 302-305
    • Chien, K.R.1
  • 60
    • 43749100265 scopus 로고    scopus 로고
    • Stem-cell-based therapy and lessons from the heart
    • DOI 10.1038/nature07040, PII NATURE07040
    • Passier R, van Laake LW, Mummery CL. Stem-cell-based therapy and lessons from the heart. Nature 2008;453:322-9 (Pubitemid 351693138)
    • (2008) Nature , vol.453 , Issue.7193 , pp. 322-329
    • Passier, R.1    Van Laake, L.W.2    Mummery, C.L.3
  • 61
    • 70349173392 scopus 로고    scopus 로고
    • Cardiomyocytes from human pluripotent stem cells in regenerative medicine and drug discovery
    • Braam SR, Passier R, Mummery CL. Cardiomyocytes from human pluripotent stem cells in regenerative medicine and drug discovery. Trends Pharm Sci 2009;30:536-45
    • (2009) Trends. Pharm. Sci. , vol.30 , pp. 536-545
    • Braam, S.R.1    Passier, R.2    Mummery, C.L.3
  • 62
    • 77955449906 scopus 로고    scopus 로고
    • Epigenetic memory in induced pluripotent stem cells
    • Kim K, Doi A, Wen B, et al. Epigenetic memory in induced pluripotent stem cells. Nature 2010;467:285-90
    • (2010) Nature , vol.467 , pp. 285-290
    • Kim, K.1    Doi, A.2    Wen, B.3
  • 63
    • 77956925992 scopus 로고    scopus 로고
    • Troublesome memories
    • Zwaka TP. Troublesome memories. Nature 2010;437:280-1
    • (2010) Nature , vol.437 , pp. 280-281
    • Zwaka, T.P.1
  • 64
    • 79952258224 scopus 로고    scopus 로고
    • Somatic coding mutations in human induced pluripotent stem cells
    • Gore A, Li Z, Fung H-L, et al. Somatic coding mutations in human induced pluripotent stem cells. Nature 2011;471:63-7
    • (2011) Nature , vol.471 , pp. 63-37
    • Gore, A.1    Li, Z.2    Fung, H.-L.3
  • 65
    • 79952264847 scopus 로고    scopus 로고
    • Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells
    • Lister R, Pelizzola M, Kida YS, et al. Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells. Nature 2011;471:68-73
    • (2011) Nature , vol.471 , pp. 68-73
    • Lister, R.1    Pelizzola, M.2    Kida, Y.S.3
  • 66
    • 0347135824 scopus 로고    scopus 로고
    • Embryonic stem cells in drug discovery
    • McNeish J. Embryonic stem cells in drug discovery. Nat Rev Drug Discov 2004;3:70-80 (Pubitemid 38088699)
    • (2004) Nature Reviews Drug Discovery , vol.3 , Issue.1 , pp. 70-80
    • McNeish, J.1
  • 67
    • 34547620338 scopus 로고    scopus 로고
    • Embryonic stem cells as a source of models for drug discovery
    • DOI 10.1038/nrd2194, PII NRD2194
    • Pouton C, Haynes JM. Embryonic stem cells as a source of models for drug discovery. Nat Rev Drug Discov 2007;6:605-16 (Pubitemid 47202486)
    • (2007) Nature Reviews Drug Discovery , vol.6 , Issue.8 , pp. 605-616
    • Pouton, C.W.1    Haynes, J.M.2
  • 68
    • 77955937897 scopus 로고    scopus 로고
    • Evaluating the utility of cardiomyocytes from human pluripotent stem cells for drug screening
    • Dick E, Rajamohan D, Ronksley J, et al. Evaluating the utility of cardiomyocytes from human pluripotent stem cells for drug screening. Biochem Soc Trans 2010;38:1037-45
    • (2010) Biochem. Soc. Trans. , vol.38 , pp. 1037-1045
    • Dick, E.1    Rajamohan, D.2    Ronksley, J.3
  • 69
    • 68249108915 scopus 로고    scopus 로고
    • The effects of cardioactive drugs on cardiomyocytes derived from human induced pluripotent stem cells
    • Yokoo N, Baba S, Kaichi S, et al. The effects of cardioactive drugs on cardiomyocytes derived from human induced pluripotent stem cells. Biochem Biophys Res Commun 2009;387:482-8
    • (2009) Biochem. Biophys. Res. Commun. , vol.387 , pp. 482-488
    • Yokoo, N.1    Baba, S.2    Kaichi, S.3
  • 71
    • 79251554060 scopus 로고    scopus 로고
    • Cardiomyocyte differentiation of pluripotent stem cells and their use as cardiac disease models
    • Dambrot C, Passier R, Atsma D, et al. Cardiomyocyte differentiation of pluripotent stem cells and their use as cardiac disease models. Biochem J 2011;434:25-35
    • (2011) Biochem. J. , vol.434 , pp. 25-35
    • Dambrot, C.1    Passier, R.2    Atsma, D.3
  • 72
    • 77957729169 scopus 로고    scopus 로고
    • Patient-specific induced pluripotent stem-cell models for Long-QT syndrome
    • Moretti A, Bellin M, Welling A, et al. Patient-specific induced pluripotent stem-cell models for Long-QT syndrome. N Engl J Med 2010;363:1397-409
    • (2010) N. Engl. J. Med. , vol.363 , pp. 1397-1409
    • Moretti, A.1    Bellin, M.2    Welling, A.3
  • 73
    • 79952446402 scopus 로고    scopus 로고
    • Modelling the long QT syndrome with induced pluripotent stem cells
    • Itzhaki I, Maizels L, Huber I, et al. Modelling the long QT syndrome with induced pluripotent stem cells. Nature 2011;471:225-9
    • (2011) Nature , vol.471 , pp. 225-229
    • Itzhaki, I.1    Maizels, L.2    Huber, I.3
  • 74
    • 79954523845 scopus 로고    scopus 로고
    • Drug evaluation in cardiomyocytesderived from human induced pluripotent stem cells carrying a long QT syndrome type 2 mutation
    • Matsa E, Rajamohan D, Dick E, et al. Drug evaluation in cardiomyocytesderived from human induced pluripotent stem cells carrying a long QT syndrome type 2 mutation. Eur Heart J 2011;32:952-62
    • (2011) Eur. Heart J. , vol.32 , pp. 952-962
    • Matsa, E.1    Rajamohan, D.2    Dick, E.3
  • 75
    • 79952438377 scopus 로고    scopus 로고
    • Using induced pluripotent stem cells to investigate cardiac phenotypes in timothy syndrome
    • Yazawa M, Hseuh B, Jia X, et al. Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy Syndrome. Nature 2011;471:230-4
    • (2011) Nature , vol.471 , pp. 230-234
    • Yazawa, M.1    Hseuh, B.2    Jia, X.3
  • 76
    • 34347343911 scopus 로고    scopus 로고
    • The brain-heart connection
    • DOI 10.1161/CIRCULATIONAHA.106.678995, PII 0000301720070703000014
    • Samuels MA. The Brain-Heart connection. Circulation 2007;116:77-84 (Pubitemid 47016249)
    • (2007) Circulation , vol.116 , Issue.1 , pp. 77-84
    • Samuels, M.A.1
  • 77
    • 77955321344 scopus 로고    scopus 로고
    • Direct reprogamming of fibroblasts into functional cardiomyocytes by defined factors
    • Ieda M, Fu J-D, Delgado-Olguin P, et al. Direct reprogamming of fibroblasts into functional cardiomyocytes by defined factors. Cell 2010;142:375-86
    • (2010) Cell , vol.142 , pp. 375-386
    • Ieda, M.1    Fu, J.-D.2    Delgado-Olguin, P.3
  • 78
    • 79952273710 scopus 로고    scopus 로고
    • Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy
    • Efe JA, Hilcove S, Kim J, et al. Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy. Nat Cell Biol 2011;13:215-22
    • (2011) Nat. Cell Biol. , vol.13 , pp. 215-222
    • Efe, J.A.1    Hilcove, S.2    Kim, J.3
  • 79
    • 79957510296 scopus 로고    scopus 로고
    • Repair of the injured adult heart involves new myocytes potentially derived from resident cardiac stem cells
    • Angert D, Berretta RM, Kubo H, et al. Repair of the injured adult heart involves new myocytes potentially derived from resident cardiac stem cells. Circ Res 2011;108:1226-37
    • (2011) Circ. Res. , vol.108 , pp. 1226-1237
    • Angert, D.1    Berretta, R.M.2    Kubo, H.3
  • 80
    • 77955172516 scopus 로고    scopus 로고
    • Cardiomyogenesis in the adult human heart
    • Kajstura J, Urbanek K, Perl S, et al. Cardiomyogenesis in the adult human heart. Circ Res 2010;107:305-15
    • (2010) Circ. Res. , vol.107 , pp. 305-315
    • Kajstura, J.1    Urbanek, K.2    Perl, S.3
  • 81
    • 77954760209 scopus 로고    scopus 로고
    • Development of a drug screening platform based on engineered heart tissue
    • Hansen A, Eder A, Bonstrup M, et al. Development of a drug screening platform based on engineered heart tissue. Circ Res 2010;107:35-44
    • (2010) Circ. Res. , vol.107 , pp. 35-44
    • Hansen, A.1    Eder, A.2    Bonstrup, M.3
  • 82
    • 59849092074 scopus 로고    scopus 로고
    • Electrical stimulation systems for cardiac tissue
    • Tandon N, Cannizzaro C, Chao P-HG, et al. Electrical stimulation systems for cardiac tissue. Nat Protocols 2009;4:155-73
    • (2009) Nat. Protocols. , vol.4 , pp. 155-173
    • Tandon, N.1    Cannizzaro, C.2    Chao, P.-H.G.3
  • 85
    • 77956230882 scopus 로고    scopus 로고
    • Purkinje cells from RyR2 mutant mice are highly arrhythmogenic but responsive to targeted therapy
    • Kang G, Giovannone SF, Liu N, et al. Purkinje cells from RyR2 mutant mice are highly arrhythmogenic but responsive to targeted therapy. Circ Res 2010;107:512-19
    • (2010) Circ. Res. , vol.107 , pp. 512-519
    • Kang, G.1    Giovannone, S.F.2    Liu, N.3
  • 86
    • 80755161746 scopus 로고    scopus 로고
    • Anti- or profibrillatory effects of Na+ channel blockade depend on the site of application relative to gradients in repolarization
    • Coronel R, Wilms-Schopman JG, Janse MJ. Anti- or profibrillatory effects of Na+ channel blockade depend on the site of application relative to gradients in repolarization. Front Physiol 2010;1:1-9
    • (2010) Front. Physiol. , vol.1 , pp. 1-9
    • Coronel, R.1    Wilms-Schopman, J.G.2    Janse, M.J.3
  • 87
    • 77953783017 scopus 로고    scopus 로고
    • Electrophysiologic and antiarrhythmic effects of AZD1305 in canine pulmonary vein sleeves
    • Sicouri S, Carlsson L, Antzelevitch C. Electrophysiologic and antiarrhythmic effects of AZD1305 in canine pulmonary vein sleeves. J Pharm Exp Ther 2010;334:255-9
    • (2010) J. Pharm. Exp. Ther. , vol.334 , pp. 255-259
    • Sicouri, S.1    Carlsson, L.2    Antzelevitch, C.3
  • 88
    • 0035901578 scopus 로고    scopus 로고
    • Instability and triangulation of the action potential predict serious proarrhythmia, but action potential duration prolongation is antiarrhythmic
    • Hondeghem LM, Carlsson L, Duker G. Instability and triangulation of the action potential predict serious proarrhythmia, but action potential duration prolongation is antiarrhythmic. Circulation 2001;103:2004-13 (Pubitemid 32322230)
    • (2001) Circulation , vol.103 , Issue.15 , pp. 2004-2013
    • Hondeghem, L.M.1    Carlsson, L.2    Duker, G.3
  • 89
    • 64749110869 scopus 로고    scopus 로고
    • The cardiac physiome: Perspectives for the future
    • Bassingthwaighte J, Hunter P, Noble D. The cardiac physiome: perspectives for the future. Exp Physiol 2009;94.5:597-605
    • (2009) Exp. Physiol. , vol.94 , Issue.5 , pp. 597-605
    • Bassingthwaighte, J.1    Hunter, P.2    Noble, D.3
  • 90
    • 77953656472 scopus 로고    scopus 로고
    • Small animal models of heart failure: Development of novel therapies, past and present
    • Patten RD, Hall-Porter MR. Small animal models of heart failure: development of novel therapies, past and present. Circ Heart Fail 2009;2:138-44
    • (2009) Circ. Heart Fail. , vol.2 , pp. 138-144
    • Patten, R.D.1    Hall-Porter, M.R.2
  • 95
    • 0037453021 scopus 로고    scopus 로고
    • Drugs that induce repolarization abnormalities cause bradycardia in zebrafish
    • DOI 10.1161/01.CIR.0000061912.88753.87
    • Milan DJ, Peterson TA, Ruskin JN, et al. Drugs that induce repolarization abnormalities cause bradycardia in zebrafish. Circulation 2003;107:1355-8 (Pubitemid 36350731)
    • (2003) Circulation , vol.107 , Issue.10 , pp. 1355-1358
    • Milan, D.J.1    Peterson, T.A.2    Ruskin, J.N.3    Peterson, R.T.4    MacRae, C.A.5
  • 97
    • 0036806199 scopus 로고    scopus 로고
    • A window to the heart: Can zebrafish mutants help us understand heart disease in humans
    • DOI 10.1016/S0168-9525(02)02766-X, PII S016895250202766X
    • Sehnert A, Stainier DYR. A window to the heart: can zebrafish mutants help us understand heart disease in humans? Trends Genet 2002;18:491-4 (Pubitemid 35287017)
    • (2002) Trends in Genetics , vol.18 , Issue.10 , pp. 491-494
    • Sehnert, A.J.1    Stainier, D.Y.R.2
  • 98
    • 80755157252 scopus 로고    scopus 로고
    • Available from:
    • Available from: http://www.sanger.ac.uk/ Projects/D-rerio/mutres/.
  • 99
    • 75149125686 scopus 로고    scopus 로고
    • Recent advances and method development for drug target identification
    • Chan JNY, Nislow C, Emili A. Recent advances and method development for drug target identification. Trends Pharm Sci 2009;31:82-8
    • (2009) Trends. Pharm. Sci. , vol.31 , pp. 82-88
    • Chan, J.N.Y.1    Nislow, C.2    Emili, A.3
  • 100
    • 70449634957 scopus 로고    scopus 로고
    • Predicting new molecular targets for known drugs
    • Keiser MJ, Setola V, Irwin JJ, et al. Predicting new molecular targets for known drugs. Nature 2009;462:175-81
    • (2009) Nature , vol.462 , pp. 175-181
    • Keiser, M.J.1    Setola, V.2    Irwin, J.J.3
  • 101
    • 70350765132 scopus 로고    scopus 로고
    • Can literature analysis identify innovation drivers in drug discovery
    • Agarwal P, Searls DB. Can literature analysis identify innovation drivers in drug discovery. Nat Rev Drug Discov 2009;8:865-78
    • (2009) Nat. Rev. Drug. Discov. , vol.8 , pp. 865-878
    • Agarwal, P.1    Searls, D.B.2
  • 102
    • 63449136073 scopus 로고    scopus 로고
    • Common variants at ten loci influence QT interval duration in the qtgen study
    • Newton-Cheh C, Eijgelsheim M, Rice KM, et al. Common variants at ten loci influence QT interval duration in the QTGEN Study. Nat Genet 2009;41:399-406
    • (2009) Nat. Genet. , vol.41 , pp. 399-406
    • Newton-Cheh, C.1    Eijgelsheim, M.2    Rice, K.M.3
  • 103
    • 63449109595 scopus 로고    scopus 로고
    • Common variants at ten loci modulate the QT interval duration in the QTSCD study
    • Pfeufer A, Sanna S, Arking DE, et al. Common variants at ten loci modulate the QT interval duration in the QTSCD Study. Nat Genet 2009;41:407-14
    • (2009) Nat. Genet. , vol.41 , pp. 407-414
    • Pfeufer, A.1    Sanna, S.2    Arking, D.E.3
  • 104
    • 84947899543 scopus 로고    scopus 로고
    • Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction
    • Sotoodehnia N, Isaacs A, de Bakker PIW, et al. Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. Nat Genet 2010;42:1068-76
    • (2010) Nat. Genet. , vol.42 , pp. 1068-1076
    • Sotoodehnia, N.1    Isaacs, A.2    De Bakker, P.I.W.3
  • 105
    • 77955492704 scopus 로고    scopus 로고
    • The case for hypoglycaemia as a proarrhythmic event: Basic and clinical evidence
    • Nordin C. The case for hypoglycaemia as a proarrhythmic event: basic and clinical evidence. Diabetologia 2010;53:1552-61
    • (2010) Diabetologia , vol.53 , pp. 1552-1561
    • Nordin, C.1
  • 106
    • 79955645459 scopus 로고    scopus 로고
    • Pfizer reaches out to academia-again
    • Ratner M. Pfizer reaches out to academia- again. Nat Biotechnol 2010;29:3-4
    • (2010) Nat. Biotechnol. , vol.29 , pp. 3-4
    • Ratner, M.1
  • 107
    • 60549097431 scopus 로고    scopus 로고
    • Effect of dronedarone on cardiovascular events in atrial fibrillation
    • Hohnloser SH, Crijns HJGM, van Eickels M, et al. Effect of dronedarone on cardiovascular events in atrial fibrillation. N Engl J Med 2009;360:668-78
    • (2009) N. Engl. J. Med. , vol.360 , pp. 668-678
    • Hohnloser, S.H.1    Crijns, H.J.G.M.2    Van Eickels, M.3
  • 109
    • 64149085800 scopus 로고    scopus 로고
    • Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans
    • Watanabe H, Chopra N, Laver D, et al. Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans. Nat Med 2009;15:380-3
    • (2009) Nat. Med. , vol.15 , pp. 380-383
    • Watanabe, H.1    Chopra, N.2    Laver, D.3
  • 110
    • 0026011647 scopus 로고
    • Mortality and morbidity in patient receiving encainide flecainide or placebo the cardiac arrhythmia suppression trial
    • Echt DS, Liebson PR, Mitchell LB, et al. Mortality and morbidity in patient receiving encainide, flecainide, or placebo. The cardiac arrhythmia suppression trial. N Engl J Med 1991;324:781-4
    • (1991) N. Engl. J. Med. , vol.324 , pp. 781-784
    • Echt, D.S.1    Liebson, P.R.2    Mitchell, L.B.3
  • 111
    • 0034945769 scopus 로고    scopus 로고
    • Is gender a risk factor for adverse drug reactions the example of drug-induced long QT syndrome
    • Drici M-D, Clement N. Is gender a risk factor for adverse drug reactions? The example of drug-induced long QT syndrome. Drug Saf 2001;24:575-85
    • (2001) Drug. Saf. , vol.24 , pp. 575-55
    • Drici, M.-D.1    Clement, N.2
  • 112
    • 22544457526 scopus 로고    scopus 로고
    • Proarrhythmia as a pharmacogenomic entity: A critical review and formulation of a unifying hypothesis
    • DOI 10.1016/j.cardiores.2005.04.022, PII S0008636305002075
    • Roden DM. Proarrhythmia as a pharmacogenomic entity: a critical review and formulation of a unifying hypothesis. Cardiovasc Res 2005;67:419-25 (Pubitemid 41019549)
    • (2005) Cardiovascular Research , vol.67 , Issue.3 , pp. 419-425
    • Roden, D.M.1
  • 117
    • 11144322265 scopus 로고    scopus 로고
    • Sex and strain differences in adult mouse cardiac repolarization: Importance of androgens
    • DOI 10.1016/j.cardiores.2004.09.012, PII S0008636304003980
    • Brouillette J, Rivard K, Lizotte E, et al. Sex and strain differences in adult mouse cardiac repolarization: importance of androgens. Cardiovasc Res 2005;65:148-57 (Pubitemid 40038487)
    • (2005) Cardiovascular Research , vol.65 , Issue.1 , pp. 148-157
    • Brouillette, J.1    Rivard, K.2    Lizotte, E.3    Fiset, C.4
  • 118
    • 69549137037 scopus 로고    scopus 로고
    • Cardiac action potential duration and calcium regulation in males and females
    • Mason SA, MacLeod KT. Cardiac action potential duration and calcium regulation in males and females. Biochem Biophys Res Commun 2009;388:565-70
    • (2009) Biochem. Biophys. Res. Commun. , vol.388 , pp. 565-570
    • Mason, S.A.1    MacLeod, K.T.2
  • 119
    • 77955887705 scopus 로고    scopus 로고
    • Genetic background affects function and intracellular calcium regulation of mouse hearts
    • Shah AP, Siedlecka U, Gandhi A, et al. Genetic background affects function and intracellular calcium regulation of mouse hearts. Cardiovasc Res 2010;87:683-93
    • (2010) Cardiovasc Res. , vol.87 , pp. 683-693
    • Shah, A.P.1    Siedlecka, U.2    Gandhi, A.3
  • 120
    • 80755157251 scopus 로고    scopus 로고
    • Pharmaceuticals: Perils for pill pushers
    • Sept 21 2010.
    • Jack A. Pharmaceuticals: perils for pill pushers. Financial Times 2010; Sept 21 2010.
    • (2010) Financial Times
    • Jack, A.1
  • 121
    • 79956321804 scopus 로고    scopus 로고
    • Drug safety sciences and the bottleneck in drug development
    • Watkins PB. Drug safety sciences and the bottleneck in drug development. Clin Pharmacol Ther 2011;89:788-90
    • (2011) Clin. Pharmacol. Ther. , vol.89 , pp. 788-790
    • Watkins, P.B.1


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