SERCA2a gene transfer decreases sarcoplasmic reticulum calcium leak and reduces ventricular arrhythmias in a model of chronic heart failure

Circulation: Arrhythmia and Electrophysiology

Volumn 4, Issue 3, 2011, Pages 362-372

  Lyon, Alexander R ^a   Bannister, Mark L ^a   Collins, Tom ^a   Pearce, Emma ^a   Sepehripour, Amir H ^a   Dubb, Sukhpreet S ^a   Garcia, Edwin ^a   O'Gara, Peter ^a   Liang, Lifan ^b   Kohlbrenner, Erik ^b   Hajjar, Roger J ^b   Peters, Nicholas S ^a   Poole Wilson, Philip A ^a   Macleod, Ken T ^a   Harding, Sian E ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Arrhythmia; Calcium; Gene therapy; Heart failure; SERCA2a

Indexed keywords

ANTIARRHYTHMIC AGENT; RYANODINE RECEPTOR; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE 2A; UNCLASSIFIED DRUG; CALCIUM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIARRHYTHMIC ACTIVITY; ARRHYTHMOGENESIS; ARTICLE; CALCIUM HOMEOSTASIS; CONTROLLED STUDY; ELECTROCARDIOGRAPHY; ELECTROSTIMULATION; EX VIVO STUDY; GENE THERAPY; GENETIC TRANSFECTION; HEART FAILURE; HEART MUSCLE CELL; HEART VENTRICLE ARRHYTHMIA; IN VITRO STUDY; IN VIVO GENE TRANSFER; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; TELEMETRY; ANIMAL; COMPARATIVE STUDY; DISEASE COURSE; DISEASE MODEL; DRUG EFFECT; GENETICS; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE; HEART VENTRICLE TACHYCARDIA; METABOLISM; METHODOLOGY; PATHOLOGY; PHYSIOLOGY; SARCOPLASMIC RETICULUM; TREATMENT OUTCOME;

ANIMALS; CALCIUM; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; GENE THERAPY; HEART FAILURE; MYOCARDIUM; MYOCYTES, CARDIAC; RATS; SARCOPLASMIC RETICULUM; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; TACHYCARDIA, VENTRICULAR; TREATMENT OUTCOME; VENTRICULAR FUNCTION, LEFT;

EID: 80052342152     PISSN: 19413149     EISSN: 19413084     Source Type: Journal    
DOI: 10.1161/CIRCEP.110.961615     Document Type: Article

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