Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene

Journal of Molecular and Cellular Cardiology

Volumn 47, Issue 2, 2009, Pages 180-187

  Andersson, Kristin Brevik ^a,b   Birkeland, Jon Arne Kro ^a,b   Finsen, Alexandra Vanessa ^a,b   Louch, William E ^a,b   Sjaastad, Ivar ^a,b   Wang, Yibin ^c   Chen, Ju ^d   Molkentin, Jeffery D ^e   Chien, Kenneth R ^f   Sejersted, Ole M ^a,b   Christensen, Geir ^a,b  

^a ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^f MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Ca2+ membrane fluxes; Conditional gene excision; Heart failure; LoxP; Sarcoplasmic reticulum; Serca2; SR Ca2+ ATPase

Indexed keywords

CALCIUM CHANNEL L TYPE; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE 2; SODIUM CALCIUM EXCHANGE PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CONTROLLED STUDY; DIASTOLIC DYSFUNCTION; GENE LOCATION; HEART FAILURE; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; MOUSE; MYOFILAMENT; NONHUMAN; PRIORITY JOURNAL; SARCOPLASMIC RETICULUM; SYMPATHETIC TONE; SYSTOLIC DYSFUNCTION;

ANIMALS; CALCIUM; CALCIUM SIGNALING; CELL MEMBRANE; CELL SEPARATION; GENE DELETION; HEART; HEART FUNCTION TESTS; MICE; MICE, KNOCKOUT; MICROFILAMENTS; MYOCARDIAL CONTRACTION; MYOCARDIUM; MYOCYTES, CARDIAC; ORGAN SPECIFICITY; SARCOPLASMIC RETICULUM; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; TAMOXIFEN;

MAMMALIA; MUS;

EID: 67649114167     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2009.03.013     Document Type: Article

References (23)

1. MacLennan D.H. Purification and properties of an adenosine triphosphatase from sarcoplasmic reticulum. J. Biol. Chem. 245 (1970) 4508-4518
2. MacLennan D.H., and Kranias E.G. Phospholamban: a crucial regulator of cardiac contractility. Nat. Rev. Mol. Cell Biol. 4 (2003) 566-577
3. Bers D.M. Cardiac excitation-contraction coupling. Nature. 415 (2002) 198-205
4. Colucci W.S., and Braunwald E. Pathophysiology of Heart Failure. In: Zipes D.P., Libby P., Bonow R.O., and Braunwald E. (Eds). Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 7th ed (2005), Elsevier Saunders, Philadelphia, PA 519-520
5. 2+-isoform 2 (SERCA2) gene. J. Biol. Chem. 274 (1999) 2556-2562
6. Sohal D.S., Nghiem M., Crackower M.A., Witt S.A., Kimball T.R., Tymitz K.M., et al. Temporally regulated and tissue-specific gene manipulations in the adult and embryonic heart using a tamoxifen-inducible Cre protein. Circ. Res. 89 (2001) 20-25
7. 2+ signaling in human valvular myofibroblasts. J. Mol. Cell Cardiol. 35 (2003) 379-388
8. Strehler E.E., and Treiman M. Calcium pumps of plasma membrane and cell interior. Curr. Mol. Med. 4 (2004) 323-335
9. Finsen A.V., Christensen G., and Sjaastad I. Echocardiographic parameters discriminating myocardial infarction with pulmonary congestion from myocardial infarction without congestion in the mouse. J. Appl. Physiol. 98 (2005) 680-689
10. Li L., Chu G., Kranias E.G., and Bers D.M. Cardiac myocyte calcium transport in phospholamban knockout mouse: relaxation and endogenous CaMKII effects. Am. J. Physiol. 274 (1998) H1335-H1347
11. 2+-ATPase isoform SERCA2a by the nonmuscle SERCA2b homologue causes mild concentric hypertrophy and impairs contraction-relaxation of the heart. Circ. Res. 89 (2001) 838-846
12. 2+-ATPase superinhibition and cardiac remodeling. Circulation 113 (2006) 995-1004
13. 2+ transport. Circ. Res. 92 (2003) 769-776
14. Shannon T.R., Ginsburg K.S., and Bers D.M. Potentiation of fractional sarcoplasmic reticulum calcium release by total and free intra-sarcoplasmic reticulum calcium concentration. Biophys. J. 78 (2000) 334-343
15. Trafford A.W., Diaz M.E., and Eisner D.A. Coordinated control of cell Ca(2+) loading and triggered release from the sarcoplasmic reticulum underlies the rapid inotropic response to increased L-type Ca(2+) current. Circ. Res. 88 (2001) 195-201
16. Miriyala J., Nguyen T., Yue D.T., and Colecraft H.M. Role of CaVbeta subunits, and lack of functional reserve, in protein kinase A modulation of cardiac CaV1.2 channels. Circ. Res. 102 (2008) e54-e64
17. 2+] during the cardiac action potential. Circ. Res. 90 (2002) 182-189
18. 2+ release in cardiomyocytes. Biophys. J. 91 (2006) 779-792
19. 2+ exchange: cardiac-specific knockout of NCX1. Circ. Res. 95 (2004) 604-611
20. Dobrzynski H., and Boyett M.R. What do we learn from double Cx40/Cx45-deficient mice about cardiac morphogenetic defects and conduction abnormalities?. J. Mol. Cell Cardiol. 41 (2006) 774-777
21. 2+ clock and membrane ion channel clock underlie robust initiation and regulation of cardiac pacemaker function. Cardiovasc. Res. 77 (2008) 274-284
22. Bers D.M. Altered cardiac myocyte Ca regulation in heart failure. Physiology (Bethesda, MD). 21 (2006) 380-387
23. Hamdani N., Kooij V., van Dijk S., Merkus D., Paulus W.J., Remedios C.D., et al. Sarcomeric dysfunction in heart failure. Cardiovasc. Res. 77 (2008) 649-658