A directed protein interaction network for investigating intracellular signal transduction

Science Signaling

Volumn 4, Issue 189, 2011, Pages

  Vinayagam, Arunachalam ^a,d   Stelzl, Ulrich ^a,b   Foulle, Raphaele ^a   Plassmann, Stephanie ^a   Zenkner, Martina ^a   Timm, Jan ^a   Assmus, Heike E ^c   Andrade Navarro, Miguel A ^a   Wanker, Erich E ^a  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

^c UNIVERSITY OF ROSTOCK   (Germany)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR; MEMBRANE RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR;

ARTICLE; BAYES THEOREM; BIOLOGY; DYNAMICS; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; MAMMAL CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; TWO HYBRID SYSTEM; CELL COMMUNICATION; GENETICS; METABOLISM; METHODOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION;

MAMMALIA;

BAYES THEOREM; CELL COMMUNICATION; COMPUTATIONAL BIOLOGY; EPIDERMAL GROWTH FACTOR; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; PROTEIN INTERACTION MAPS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 80052592002     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2001699     Document Type: Article

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69. Acknowledgments: We thank K. Rau, I. Hoyer, and A. Redel for experimental assistance; S. Schnoegl for editorial support and critical reading of the manuscript; and A. Großmann and M. Lalowski for discussions. Funding: The work was supported by the Deutsche Forschungsgemeinschaft (SFB618 and SFB740), the Bundesministerium für Bildung, Wissenschaft, Forschung und Technologie (NGFN2 KB-P04T03/T05, 01GR0471, 01GR0475; NGFNp NeuroNet-TP1/TP3/TP8, 01GS08170, and 01GS08171), and the Helmholtz Association (MSBN, TP3, and TP5). Author contributions: A.V., U.S., and E.E.W. conceived the idea, designed the project, and wrote the manuscript. A.V. performed all computational analyses. U.S. designed the experimental part and coordinated the project. E.E.W. coordinated and supervised the project. U.S., R.F., and S.P. performed the cell culture experiments. U.S., M.Z., and J.T. performed the Y2H screening. H.E.A. and M.A.A.-N. contributed with analysis and discussion. Competing interests: The authors declare that they have no competing interests. Accession numbers: The PPI data are available in a searchable form from the PPI database MINT (MINT publication id: MINT-8089645).