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Volumn 3, Issue APR, 2012, Pages

Secondary metabolites from plants inhibiting ABC transporters and reversing resistance of cancer cells and microbes to cytotoxic and antimicrobial agents

Author keywords

ABC transporter; MDR; MRP1; P gp; Review; Secondary metabolites

Indexed keywords


EID: 84867623825     PISSN: None     EISSN: 1664302X     Source Type: Journal    
DOI: 10.3389/fmicb.2012.00130     Document Type: Review
Times cited : (154)

References (199)
  • 1
    • 38149098601 scopus 로고    scopus 로고
    • Cytotoxicity and p-glycoprotein modulating effects of quinolones and indoloquinazolines from the Chinese herb Evodia rutaecarpa
    • Adams, M., Mahringer, A., Kunert, O., Fricker, G., Efferth, T., and Bauer, R. (2007). Cytotoxicity and p-glycoprotein modulating effects of quinolones and indoloquinazolines from the Chinese herb Evodia rutaecarpa. PlantaMed. 73, 1554-1557.
    • (2007) PlantaMed , vol.73 , pp. 1554-1557
    • Adams, M.1    Mahringer, A.2    Kunert, O.3    Fricker, G.4    Efferth, T.5    Bauer, R.6
  • 4
    • 79955627074 scopus 로고    scopus 로고
    • 5, 7-Dimethoxyflavone and multiple flavonoids in combination alter the ABCG2-mediated tissue distribution of mitoxantrone in mice
    • An, G., Wu, F., and Morris, M. E. (2011). 5,7-Dimethoxyflavone and multiple flavonoids in combination alter the ABCG2-mediated tissue distribution of mitoxantrone in mice. Pharm. Res. 28, 1090-1099.
    • (2011) Pharm. Res. , vol.28 , pp. 1090-1099
    • An, G.1    Wu, F.2    Morris, M.E.3
  • 5
    • 0033887430 scopus 로고    scopus 로고
    • The ABC transporter AtrB from Aspergillus nidulans mediates resistance to all major classes of fungicides and some natural toxic compounds
    • Andrade, A. C., Del Sorbo, G., Van Nistelrooy, J. G., and Waard, M. A. (2000). The ABC transporter AtrB from Aspergillus nidulans mediates resistance to all major classes of fungicides and some natural toxic compounds. Microbiology 146, 1987-1997.
    • (2000) Microbiology , vol.146 , pp. 1987-1997
    • Andrade, A.C.1    Del Sorbo, G.2    Van Nistelrooy, J.G.3    Waard, M.A.4
  • 6
    • 77955904034 scopus 로고    scopus 로고
    • Modulation of multidrug resistance p-glycoprotein activity by flavonoids and honokiol in human doxorubicin-resistant sarcoma cells (MES-SA/DX-5), implications for natural sedatives as chemosensitizing agents in cancer therapy
    • Angelini, A., Di Ilio, C., Castellani, M. L., Conti, P., and Cuccurullo, F. (2010). Modulation of multidrug resistance p-glycoprotein activity by flavonoids and honokiol in human doxorubicin-resistant sarcoma cells (MES-SA/DX-5), implications for natural sedatives as chemosensitizing agents in cancer therapy. J. Biol. Regul. Homeost. Agents 24, 197-205.
    • (2010) J. Biol. Regul. Homeost. Agents , vol.24 , pp. 197-205
    • Angelini, A.1    Di Ilio, C.2    Castellani, M.L.3    Conti, P.4    Cuccurullo, F.5
  • 8
    • 0037469098 scopus 로고    scopus 로고
    • Modulation of vinca-alkaloid induced P-glycoprotein expression by indole-3-carbinol
    • Arora, A., and Shukla, Y. (2003). Modulation of vinca-alkaloid induced P-glycoprotein expression by indole-3-carbinol. Cancer Lett. 189,167-173.
    • (2003) Cancer Lett , vol.189 , pp. 167-173
    • Arora, A.1    Shukla, Y.2
  • 9
    • 0023748077 scopus 로고
    • Effects of indole alkaloids on multidrug resistance and labeling of P-glycoprotein by a photoaffinity analog of vinblastine
    • Beck, W. T., Cirtain, M. C., Glover, C. J., Felsted, R. L., and Safa, A. R. (1988). Effects of indole alkaloids on multidrug resistance and labeling of P-glycoprotein by a photoaffinity analog of vinblastine. Biochem. Biophys. Res. Commun. 153, 959-966.
    • (1988) Biochem. Biophys. Res. Commun. , vol.153 , pp. 959-966
    • Beck, W.T.1    Cirtain, M.C.2    Glover, C.J.3    Felsted, R.L.4    Safa, A.R.5
  • 10
    • 1642424231 scopus 로고    scopus 로고
    • Phenolic metabolites of Dalea versi-color that enhance antibiotic activity against model pathogenic bacteria
    • Belofsky, G., Percivill, D., Lewis, K., Tegos, G. P., and Ekart, J. (2004). Phenolic metabolites of Dalea versi-color that enhance antibiotic activity against model pathogenic bacteria. J. Nat. Prod. 67,481-484.
    • (2004) J. Nat. Prod. , vol.67 , pp. 481-484
    • Belofsky, G.1    Percivill, D.2    Lewis, K.3    Tegos, G.P.4    Ekart, J.5
  • 11
    • 0035063168 scopus 로고    scopus 로고
    • Effects of naturally occurring glucosides, solasodine glucosides, ginsenosides and parishin derivatives on multidrug resistance of lymphoma cells and leukocyte functions
    • Berek, L., Szabo, D., Petri, I. B., Shoyama, Y., Lin, Y. H., and Molnar, J. (2001). Effects of naturally occurring glucosides, solasodine glucosides, ginsenosides and parishin derivatives on multidrug resistance of lymphoma cells and leukocyte functions. In vivo 15,151-156.
    • (2001) In vivo , vol.15 , pp. 151-156
    • Berek, L.1    Szabo, D.2    Petri, I.B.3    Shoyama, Y.4    Lin, Y.H.5    Molnar, J.6
  • 13
    • 0028822278 scopus 로고
    • A structure-function relationship among reserpine and yohimbine analogues in their ability to increase expression of mdr1 and P-glycoprotein in a human colon carcinoma cell line
    • Bhat, U. G., Winter, M. A., Pearce, H. L., andBeck,W.T. (1995). A structure-function relationship among reserpine and yohimbine analogues in their ability to increase expression of mdr1 and P-glycoprotein in a human colon carcinoma cell line. Mol. Pharmacol. 48, 682-689.
    • (1995) Mol. Pharmacol. , vol.48 , pp. 682-689
    • Bhat, U.G.1    Winter, M.A.2    Pearce, H.L.3    Beck, W.T.4
  • 14
    • 3242717109 scopus 로고    scopus 로고
    • Taxane-based reversal agents modulate drug resistance mediated by P-glycoprotein, multidrug resistance protein, and breast cancer resistance protein
    • Brooks, T. A., Minderman, H., O'Loughlin, K. L., Pera, P., Ojima, I., Baer, M. R., and Bernacki, R. J. (2003). Taxane-based reversal agents modulate drug resistance mediated by P-glycoprotein, multidrug resistance protein, and breast cancer resistance protein. Mol. Cancer Ther. 2,1195-1205.
    • (2003) Mol. Cancer Ther. , vol.2 , pp. 1195-1205
    • Brooks, T.A.1    Minderman, H.2    O'Loughlin, K.L.3    Pera, P.4    Ojima, I.5    Baer, M.R.6    Bernacki, R.J.7
  • 15
    • 0029997940 scopus 로고    scopus 로고
    • Transport and epithelial secretion of the cardiac glycoside, digoxin, by human intestinal epithelial (Caco-2) cells
    • Cavet, M. E., West, M., and Simmons, N. L. (1996). Transport and epithelial secretion of the cardiac glycoside, digoxin, by human intestinal epithelial (Caco-2) cells. Br. J. Pharmacol. 118, 1389-1396.
    • (1996) Br. J. Pharmacol. , vol.118 , pp. 1389-1396
    • Cavet, M.E.1    West, M.2    Simmons, N.L.3
  • 16
    • 78651336302 scopus 로고    scopus 로고
    • Stemona alkaloids, from traditional Thai medicine, increase chemosensitivity via P-glycoprotein-mediated multidrug resistance
    • Chanmahasathien, W., Ampasavate, C., Greger,H.,and Limtrakul,P. (2011). Stemona alkaloids, from traditional Thai medicine, increase chemosensitivity via P-glycoprotein-mediated multidrug resistance. Phytomedicine 18, 199-204.
    • (2011) Phytomedicine , vol.18 , pp. 199-204
    • Chanmahasathien, W.1    Ampasavate, C.2    Greger, H.3    Limtrakul, P.4
  • 17
    • 0025128368 scopus 로고
    • Potential usefulness of quinine to circumvent the anthracycline resistance in clinical practice
    • Chauffert, B., Pelletier, H., Corda, C., Solary, E., Bedenne, L., Caillot, D., and Martin, F. (1990). Potential usefulness of quinine to circumvent the anthracycline resistance in clinical practice. Br. J. Cancer 62, 395-397.
    • (1990) Br. J. Cancer , vol.62 , pp. 395-397
    • Chauffert, B.1    Pelletier, H.2    Corda, C.3    Solary, E.4    Bedenne, L.5    Caillot, D.6    Martin, F.7
  • 18
    • 0027322989 scopus 로고
    • Thaliblastine, a plant alkaloid, circumvents multidrug resistance by direct binding to P-glycoprotein
    • Chen, G., Ramachandran, C., and Krishan, A. (1993). Thaliblastine, a plant alkaloid, circumvents multidrug resistance by direct binding to P-glycoprotein. Cancer Res. 53, 2544-2547.
    • (1993) Cancer Res , vol.53 , pp. 2544-2547
    • Chen, G.1    Ramachandran, C.2    Krishan, A.3
  • 19
    • 0030513617 scopus 로고    scopus 로고
    • Differential interactions of Pgp inhibitor thaliblastine with adriamycin, etoposide, taxol and anthrapyrazole CI941 in sensitive and multidrug-resistant human MCF-7 breast cancer cells
    • Chen, G., Teicher, B. A., and Frei, E. (1996). Differential interactions of Pgp inhibitor thaliblastine with adriamycin, etoposide, taxol and anthrapyrazole CI941 in sensitive and multidrug-resistant human MCF-7 breast cancer cells. Anti-cancer Res. 16,3499-3505.
    • (1996) Anti-cancer Res , vol.16 , pp. 3499-3505
    • Chen, G.1    Teicher, B.A.2    Frei, E.3
  • 20
    • 0029151639 scopus 로고
    • Complete reversal by thaliblastine of 490-fold adriamycin resistance in multidrug-resistant (MDR) human breast cancer cells Evidence that multiple biochemical changes in MDR cells need not correspond to multiple functional determinants for drug resistance
    • Chen, G., and Waxman, D. J. (1995). Complete reversal by thaliblastine of 490-fold adriamycin resistance in multidrug-resistant (MDR) human breast cancer cells. Evidence that multiple biochemical changes in MDR cells need not correspond to multiple functional determinants for drug resistance. J. Pharmacol. Exp. Ther. 274, 1271-1277.
    • (1995) J. Pharmacol. Exp. Ther. , vol.274 , pp. 1271-1277
    • Chen, G.1    Waxman, D.J.2
  • 21
    • 77954383759 scopus 로고    scopus 로고
    • In vitro modulation of ABCB1/P-glycoprotein expression by polyphenols from Mangifera indica
    • Chieli, E., Romiti, N., Rodeiro, I., and Garrido, G. (2010). In vitro modulation of ABCB1/P-glycoprotein expression by polyphenols from Mangifera indica. Chem. Biol. Interact. 186,287-294.
    • (2010) Chem. Biol. Interact. , vol.186 , pp. 287-294
    • Chieli, E.1    Romiti, N.2    Rodeiro, I.3    Garrido, G.4
  • 22
    • 0037363620 scopus 로고    scopus 로고
    • Reversal of P-glycoprotein-mediated multidrug resistance by protopanaxatriol ginsenosides from Korean red ginseng
    • Choi, C. H., Kang, G., and Min, Y D. (2003). Reversal of P-glycoprotein-mediated multidrug resistance by protopanaxatriol ginsenosides from Korean red ginseng. Planta Med. 69, 235-240.
    • (2003) Planta Med , vol.69 , pp. 235-240
    • Choi, C.H.1    Kang, G.2    Min, Y.D.3
  • 23
    • 7144259744 scopus 로고    scopus 로고
    • The bisbenzylisoquinoline alkaloids, tetrandine and fangchinoline, enhance the cytotoxicity of multidrug resistance-related drugs via modulation of P-glycoprotein
    • Choi, S. U., Park, S. H., Kim, K. H., Choi, E. J., Kim, S., Park, W K., Zhang, Y H., Kim, H. S., Jung, N. P., and Lee, C. O. (1998). The bis-benzylisoquinoline alkaloids, tetrandine and fangchinoline, enhance the cytotoxicity of multidrug resistance-related drugs via modulation of P-glycoprotein. Anticancer Drugs 9, 255-261.
    • (1998) Anticancer Drugs , vol.9 , pp. 255-261
    • Choi, S.U.1    Park, S.H.2    Kim, K.H.3    Choi, E.J.4    Kim, S.5    Park, W.K.6    Zhang, Y.H.7    Kim, H.S.8    Jung, N.P.9    Lee, C.O.10
  • 24
    • 30544440659 scopus 로고    scopus 로고
    • Inhibition of P-glycoprotein by natural products in human breast cancer cells
    • Chung, S. Y., Sung, M. K., Kim, N. H., Jang, J. O., Go, E. J., and Lee, H. J. (2005). Inhibition of P-glycoprotein by natural products in human breast cancer cells. Arch. Pharm. Res. 28, 823-828.
    • (2005) Arch. Pharm. Res. , vol.28 , pp. 823-828
    • Chung, S.Y.1    Sung, M.K.2    Kim, N.H.3    Jang, J.O.4    Go, E.J.5    Lee, H.J.6
  • 26
    • 0032544087 scopus 로고    scopus 로고
    • Flavonoids, a class of modulators with bifunctional interactions at vicinal ATP-and steroid-binding sites on mouse P-glycoprotein
    • Conseil, G., Baubichon-Cortay, H., Dayan, G., Jault, J. M., Barron, D., and Di Pietro, A. (1998). Flavonoids, a class of modulators with bifunctional interactions at vicinal ATP-and steroid-binding sites on mouse P-glycoprotein. Proc. Natl. Acad. Sci. U.S.A. 95, 9831-9836.
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 9831-9836
    • Conseil, G.1    Baubichon-Cortay, H.2    Dayan, G.3    Jault, J.M.4    Barron, D.5    Di Pietro, A.6
  • 29
    • 44349145027 scopus 로고    scopus 로고
    • Comparison of the cytotoxic activities of naturally occurring hydroxyanthraquinones and hydroxynaphthoquinones
    • Cui, X. R., Tsukada, M., Suzuki, N., Shimamura, T., Gao, L., Koyanagi, J., Komada, F., and Saito, S. (2008). Comparison of the cytotoxic activities of naturally occurring hydroxyanthraquinones and hydroxynaphthoquinones. Eur. J. Med. Chem. 43, 1206-1215.
    • (2008) Eur. J. Med. Chem. , vol.43 , pp. 1206-1215
    • Cui, X.R.1    Tsukada, M.2    Suzuki, N.3    Shimamura, T.4    Gao, L.5    Koyanagi, J.6    Komada, F.7    Saito, S.8
  • 30
    • 0035030729 scopus 로고    scopus 로고
    • Reversal of multidrug resistance by the P-glycoprotein modulator, LY335979, from the bench to the clinic
    • Dantzig, A. H., Law, K. L., Cao, J., and Starling, J. J. (2001). Reversal of multidrug resistance by the P-glycoprotein modulator, LY335979, from the bench to the clinic. Curr. Med. Chem. 8, 39-50.
    • (2001) Curr. Med. Chem. , vol.8 , pp. 39-50
    • Dantzig, A.H.1    Law, K.L.2    Cao, J.3    Starling, J.J.4
  • 31
    • 0029809499 scopus 로고    scopus 로고
    • Reversal of P-glycoprotein-mediated multidrug resistance by a potent cyclopropyldibenzosuberane modulator
    • LY335979
    • Dantzig, A. H., Shepard, R. L., Cao, J., Law, K. L., Ehlhardt, W J., Baughman, T. M., Bumol, T., and Starling, J. J. (1996). Reversal of P-glycoprotein-mediated multidrug resistance by a potent cyclopropyldibenzosuberane modulator, LY335979. Cancer Res. 56,4171-4179.
    • (1996) Cancer Res , vol.56 , pp. 4171-4179
    • Dantzig, A.H.1    Shepard, R.L.2    Cao, J.3    Law, K.L.4    Ehlhardt, W.J.5    Baughman, T.M.6    Bumol, T.7    Starling, J.J.8
  • 32
    • 35348973560 scopus 로고    scopus 로고
    • Grapefruit juice-drug interactions, grapefruit juice and its components inhibit P-glycoprotein (ABCB1) mediated transport of talinolol in Caco-2 cells
    • de Castro, W V., Mertens-Talcott, S., Derendorf, H., and Butterweck, V. (2007). Grapefruit juice-drug interactions, grapefruit juice and its components inhibit P-glycoprotein (ABCB1) mediated transport of talinolol in Caco-2 cells. J. Pharm. Sci. 96,2808-2817.
    • (2007) J. Pharm. Sci. , vol.96 , pp. 2808-2817
    • de Castro, W.V.1    Mertens-Talcott, S.2    Derendorf, H.3    Butterweck, V.4
  • 33
    • 47349108866 scopus 로고    scopus 로고
    • Effect of grapefruit juice, naringin, naringenin, and berg-amottin on the intestinal carrier-mediated transport of talinolol in rats
    • de Castro, W V., Mertens-Talcott, S., Derendorf, H., and Butterweck, V. (2008). Effect of grapefruit juice, naringin, naringenin, and bergamottin on the intestinal carrier-mediated transport of talinolol in rats. J. Agric. Food Chem. 56, 4840-4845.
    • (2008) J. Agric. Food Chem. , vol.56 , pp. 4840-4845
    • de Castro, W.V.1    Mertens-Talcott, S.2    Derendorf, H.3    Butterweck, V.4
  • 34
    • 0027102401 scopus 로고
    • The MDR1 gene product, P-glycoprotein, mediates the transport of the cardiac glycoside, digoxin
    • de Lannoy, I. A., and Silverman, M. (1992). The MDR1 gene product, P-glycoprotein, mediates the transport of the cardiac glycoside, digoxin. Biochem. Biophys. Res. Commun. 189,551-557.
    • (1992) Biochem. Biophys. Res. Commun. , vol.189 , pp. 551-557
    • de Lannoy, I.A.1    Silverman, M.2
  • 35
    • 0035964385 scopus 로고    scopus 로고
    • Sequence requirements of the ATP-binding site within the C-terminal nucleotide-binding domain of mouse P-glycoprotein, structure-activity relationships for flavonoid binding
    • de Wet, H., McIntosh, D. B., Conseil, G., Baubichon-Cortay, H., Krell, T., Jault, J. M., Daskiewicz, J. B., Barron, D., and Di Pietro, A. (2001). Sequence requirements of the ATP-binding site within the C-terminal nucleotide-binding domain of mouse P-glycoprotein, structure-activity relationships for flavonoid binding. Biochemistry 40, 10382-10391.
    • (2001) Biochemistry , vol.40 , pp. 10382-10391
    • de Wet, H.1    McIntosh, D.B.2    Conseil, G.3    Baubichon-Cortay, H.4    Krell, T.5    Jault, J.M.6    Daskiewicz, J.B.7    Barron, D.8    Di Pietro, A.9
  • 36
    • 0037090858 scopus 로고    scopus 로고
    • The alkaloid sanguinarine is effective against multidrug resistance in human cervical cells via bimodal cell death
    • Ding, Z., Tang, S. C., Weerasinghe, P., Yang, X., Pater, A., and Liepins, A. (2002). The alkaloid sanguinarine is effective against multidrug resistance in human cervical cells via bimodal cell death. Biochem. Pharmacol. 63, 1415-1421.
    • (2002) Biochem. Pharmacol. , vol.63 , pp. 1415-1421
    • Ding, Z.1    Tang, S.C.2    Weerasinghe, P.3    Yang, X.4    Pater, A.5    Liepins, A.6
  • 38
    • 0024496679 scopus 로고
    • Antitumor activity and murine pharmacokinetics of parenteral acronycine
    • Dorr, R. T., Liddil, J. D., Von Hoff, D. D., Soble, M., and Osborne, C. K. (1989). Antitumor activity and murine pharmacokinetics of parenteral acronycine. Cancer Res. 49, 340-344.
    • (1989) Cancer Res , vol.49 , pp. 340-344
    • Dorr, R.T.1    Liddil, J.D.2    Von Hoff, D.D.3    Soble, M.4    Osborne, C.K.5
  • 39
    • 33644534548 scopus 로고    scopus 로고
    • New macrocyclic lathyrane diterpenes, from Euphorbia lagascae, as inhibitors of multidrug resistance of tumour cells
    • Duarte, N., Gyemant, N., Abreu, P. M., Molnar, J., and Ferreira, M. J. (2006). New macrocyclic lathyrane diterpenes, from Euphorbia lagascae, as inhibitors of multidrug resistance of tumour cells. Planta Med. 72, 162-168.
    • (2006) Planta Med , vol.72 , pp. 162-168
    • Duarte, N.1    Gyemant, N.2    Abreu, P.M.3    Molnar, J.4    Ferreira, M.J.5
  • 40
    • 77954916701 scopus 로고    scopus 로고
    • Phenolic compounds as selective anti-neoplasic agents against multidrug-resistant human cancer cells
    • Duarte, N., Lage, H., Abrantes, M., and Ferreira, M. J. (2010). Phenolic compounds as selective anti-neoplasic agents against multidrug-resistant human cancer cells. Planta Med. 76, 975-980.
    • (2010) Planta Med , vol.76 , pp. 975-980
    • Duarte, N.1    Lage, H.2    Abrantes, M.3    Ferreira, M.J.4
  • 41
    • 75149181690 scopus 로고    scopus 로고
    • Multidrug resistance modulation and apoptosis induction of cancer cells by terpenic compounds isolated from Euphorbia species
    • Duarte, N., Ramalhete, C., Varga, A., Molnar, J., and Ferreira, M. J. (2009). Multidrug resistance modulation and apoptosis induction of cancer cells by terpenic compounds isolated from Euphorbia species. Anticancer Res. 29, 4467-4472.
    • (2009) Anticancer Res , vol.29 , pp. 4467-4472
    • Duarte, N.1    Ramalhete, C.2    Varga, A.3    Molnar, J.4    Ferreira, M.J.5
  • 42
    • 20344396408 scopus 로고    scopus 로고
    • Molecular determinants of response of tumor cells to berberine
    • Efferth, T., Chen, Z., Kaina, B., and Ag, W. (2005). Molecular determinants of response of tumor cells to berberine. Cancer Genomics Proteomics 2, 115-123.
    • (2005) Cancer Genomics Proteomics , vol.2 , pp. 115-123
    • Efferth, T.1    Chen, Z.2    Kaina, B.3    Ag, W.4
  • 43
    • 0037280015 scopus 로고    scopus 로고
    • Molecular modes of action of cephalotaxine and homoharring-tonine from the coniferous tree Cephalotaxus hainanensis in human tumor cell lines
    • Efferth, T., Sauerbrey, A., Halatsch, M. E., Ross, D. D., and Gebhart, E. (2003). Molecular modes of action of cephalotaxine and homoharring-tonine from the coniferous tree Cephalotaxus hainanensis in human tumor cell lines. Naunyn Schmiede-bergs Arch. Pharmacol. 367, 56-67.
    • (2003) Naunyn Schmiede-bergs Arch. Pharmacol. , vol.367 , pp. 56-67
    • Efferth, T.1    Sauerbrey, A.2    Halatsch, M.E.3    Ross, D.D.4    Gebhart, E.5
  • 44
    • 70649091119 scopus 로고    scopus 로고
    • Inhibition of P-glycoprotein activity by limonin and other secondary metabolites from Citrus species in human colon and leukaemia cell lines
    • El-Readi, M. Z., Hamdan, D., Farrag, N., El-Shazly, A., and Wink, M. (2010). Inhibition of P-glycoprotein activity by limonin and other secondary metabolites from Citrus species in human colon and leukaemia cell lines. Eur. J. Pharmacol. 626, 139-145.
    • (2010) Eur. J. Pharmacol. , vol.626 , pp. 139-145
    • El-Readi, M.Z.1    Hamdan, D.2    Farrag, N.3    El-Shazly, A.4    Wink, M.5
  • 45
    • 2342436512 scopus 로고    scopus 로고
    • PET studies on P-glycoprotein function in the blood-brain barrier, how it affects uptake and binding of drugs within the CNS
    • Elsinga, P. H., Hendrikse, N. H., Bart, J., Vaalburg, W., and van Waarde, A. (2004). PET studies on P-glycoprotein function in the blood-brain barrier, how it affects uptake and binding of drugs within the CNS. Curr. Pharm. Des. 10, 1493-1503.
    • (2004) Curr. Pharm. Des. , vol.10 , pp. 1493-1503
    • Elsinga, P.H.1    Hendrikse, N.H.2    Bart, J.3    Vaalburg, W.4    van Waarde, A.5
  • 46
    • 34547730805 scopus 로고    scopus 로고
    • An in vitro evaluation of cytochrome P450 inhibition and P-glycoprotein interaction with goldenseal, Ginkgo biloba, grape seed, milk thistle, and ginseng extracts and their constituents
    • Etheridge, A. S., Black, S. R., Patel, P. R., So, J., and Mathews, J. M. (2007). An in vitro evaluation of cytochrome P450 inhibition and P-glycoprotein interaction with goldenseal, Ginkgo biloba, grape seed, milk thistle, and ginseng extracts and their constituents. Planta Med. 73, 731-741.
    • (2007) Planta Med , vol.73 , pp. 731-741
    • Etheridge, A.S.1    Black, S.R.2    Patel, P.R.3    So, J.4    Mathews, J.M.5
  • 47
    • 70349933280 scopus 로고    scopus 로고
    • Modulation of drug resistance in Staphylococcus aureus by a kaempferol glycoside from Herissantia tiubae (Malvaceae)
    • Falcao-Silva, V. S., Silva, D. A., Souza Mde, F., and Siqueira-Junior, J. P. (2009). Modulation of drug resistance in Staphylococcus aureus by a kaempferol glycoside from Herissantia tiubae (Malvaceae). Phytother. Res. 23, 1367-1370.
    • (2009) Phytother. Res. , vol.23 , pp. 1367-1370
    • Falcao-Silva, V.S.1    Silva, D.A.2    Souza Mde, F.3    Siqueira-Junior, J.P.4
  • 48
    • 79953745272 scopus 로고    scopus 로고
    • Enhanced activity of antifungal drugs using natural phenolics against yeast strains of Candida and Cryptococcus
    • Faria, N. C. G., Kim, J. H., Goncalves, L., Martins, M., Chan, K. L., and, Campbell, B. (2011). Enhanced activity of antifungal drugs using natural phenolics against yeast strains of Candida and Cryptococcus. Lett. Appl. Micobiol. 5,506-513.
    • (2011) Lett. Appl. Micobiol. , vol.5 , pp. 506-513
    • Faria, N.C.G.1    Kim, J.H.2    Goncalves, L.3    Martins, M.4    Chan, K.L.5    Campbell, B.6
  • 49
    • 0037455921 scopus 로고    scopus 로고
    • Pentacyclic triterpenes from Chrysobalanaceae species, cytotoxicity on multidrug resistant and sensitive leukemia cell lines
    • Fernandes, J., Castilho, R. O., da Costa, M. R., Wagner-Souza, K., Coelho Kaplan, M. A., and Gattass, C. R. (2003). Pentacyclic triterpenes from Chrysobalanaceae species, cytotoxicity on multidrug resistant and sensitive leukemia cell lines. Cancer Lett. 190, 165-169.
    • (2003) Cancer Lett , vol.190 , pp. 165-169
    • Fernandes, J.1    Castilho, R.O.2    da Costa, M.R.3    Wagner-Souza, K.4    Coelho Kaplan, M.A.5    Gattass, C.R.6
  • 51
    • 1642299307 scopus 로고    scopus 로고
    • Characterization of tetrandrine, a potent inhibitor of P-glycoprotein-mediated multidrug resistance
    • Fu, L., Liang, Y., Deng, L., Ding, Y., Chen, L., Ye, Y., Yang, X., and Pan, Q. (2004). Characterization of tetrandrine, a potent inhibitor of P-glycoprotein-mediated multidrug resistance. Cancer Chemother. Pharmacol. 53, 349-356.
    • (2004) Cancer Chemother. Pharmacol. , vol.53 , pp. 349-356
    • Fu, L.1    Liang, Y.2    Deng, L.3    Ding, Y.4    Chen, L.5    Ye, Y.6    Yang, X.7    Pan, Q.8
  • 52
    • 0036164671 scopus 로고    scopus 로고
    • The multidrug resistance of tumour cells was reversed by tetrandrine in vitro and in xenografts derived from human breast adenocarcinoma MCF-7/adr cells
    • Fu, L. W., Zhang, Y. M., Liang, Y. J., Yang, X. P., and Pan, Q. C. (2002), The multidrug resistance of tumour cells was reversed by tetrandrine in vitro and in xenografts derived from human breast adenocarcinoma MCF-7/adr cells. Eur. J. Cancer 38, 418-426.
    • (2002) Eur. J. Cancer , vol.38 , pp. 418-426
    • Fu, L.W.1    Zhang, Y.M.2    Liang, Y.J.3    Yang, X.P.4    Pan, Q.C.5
  • 54
    • 0027972613 scopus 로고
    • Comparative effects of quinine and cinchonine in reversing multidrug resistance on human leukemic cell line K562/ADM
    • Genne, P., Duchamp, O., Solary, E., Pinard, D., Belon, J. P., Dimanche-Boitrel, M. T., and Chauffert, B. (1994). Comparative effects of quinine and cinchonine in reversing multidrug resistance on human leukemic cell line K562/ADM. Leukemia 8,160-164.
    • (1994) Leukemia , vol.8 , pp. 160-164
    • Genne, P.1    Duchamp, O.2    Solary, E.3    Pinard, D.4    Belon, J.P.5    Dimanche-Boitrel, M.T.6    Chauffert, B.7
  • 55
    • 0037355914 scopus 로고    scopus 로고
    • Activity of Zanthoxylum clava-herculis extracts against multi-drug resistant methicillin-resistant Staphylococcus aureus (mdr-MRSA)
    • Gibbons, S., Leimkugel, J., Oluwatuyi, M., and Heinrich, M. (2003). Activity of Zanthoxylum clavaherculis extracts against multi-drug resistant methicillin-resistant Staphylococcus aureus (mdr-MRSA). Phytother. Res. 17,274-275.
    • (2003) Phytother. Res. , vol.17 , pp. 274-275
    • Gibbons, S.1    Leimkugel, J.2    Oluwatuyi, M.3    Heinrich, M.4
  • 56
    • 0034024754 scopus 로고    scopus 로고
    • The effect of reserpine, a modulator of multidrug efflux pumps, on the in vitro activity of tetracycline against clinical isolates of methicillin resistant Staphylococcus aureus (MRSA) possessing the tet(K) determinant
    • Gibbons, S., and Udo, E. E. (2000). The effect of reserpine, a modulator of multidrug efflux pumps, on the in vitro activity of tetracycline against clinical isolates of methicillin resistant Staphylococcus aureus (MRSA) possessing the tet(K) determinant. Phytother. Res. 14, 139-140.
    • (2000) Phytother. Res. , vol.14 , pp. 139-140
    • Gibbons, S.1    Udo, E.E.2
  • 57
    • 10844235689 scopus 로고    scopus 로고
    • Microarray-based detection of multidrug resistance in human tumor cells by expression profiling of ATP-binding cassette transporter genes
    • Gillet, J. P., Efferth, T., Steinbach, D., Hamels, J., de Longueville, F., Bertholet, V., and Remacle, J. (2004). Microarray-based detection of multidrug resistance in human tumor cells by expression profiling of ATP-binding cassette transporter genes. Cancer Res. 64, 8987-8993.
    • (2004) Cancer Res , vol.64 , pp. 8987-8993
    • Gillet, J.P.1    Efferth, T.2    Steinbach, D.3    Hamels, J.4    de Longueville, F.5    Bertholet, V.6    Remacle, J.7
  • 58
    • 0036176510 scopus 로고    scopus 로고
    • Mechanisms of cancer drug resistance
    • Gottesman, M. M. (2002). Mechanisms of cancer drug resistance. Annu. Rev. Med. 53, 615-627.
    • (2002) Annu. Rev. Med. , vol.53 , pp. 615-627
    • Gottesman, M.M.1
  • 59
    • 0034970549 scopus 로고    scopus 로고
    • Uncommon P450-catalyzed reactions
    • Guengerich, F. P. (2001). Uncommon P450-catalyzed reactions. Curr. Drug Metab. 2,93-115.
    • (2001) Curr. Drug Metab. , vol.2 , pp. 93-115
    • Guengerich, F.P.1
  • 60
    • 39149124099 scopus 로고    scopus 로고
    • Plagiochin E, a botanic-derived phenolic compound, reverses fungal resistance to fluconazole relating to the efflux pump
    • Guo, X. L., Leng, P., Yang, Y., Yu, L. G., and Lou, H. X. (2008). Plagiochin E, a botanic-derived phenolic compound, reverses fungal resistance to fluconazole relating to the efflux pump. J. Appl. Microbiol. 104, 831-838.
    • (2008) J. Appl. Microbiol. , vol.104 , pp. 831-838
    • Guo, X.L.1    Leng, P.2    Yang, Y.3    Yu, L.G.4    Lou, H.X.5
  • 61
    • 0035905848 scopus 로고    scopus 로고
    • Flavonolignan and flavone inhibitors of a Staphylococcus aureus multidrug resistance pump, structure-activity relationships
    • Guz, N. R., Stermitz, F. R., Johnson, J. B., Beeson, T. D., Willen, S., Hsiang, J., and Lewis, K. (2001). Flavonolignan and flavone inhibitors of a Staphylococcus aureus multidrug resistance pump, structure-activity relationships. J. Med. Chem. 44, 261-268.
    • (2001) J. Med. Chem. , vol.44 , pp. 261-268
    • Guz, N.R.1    Stermitz, F.R.2    Johnson, J.B.3    Beeson, T.D.4    Willen, S.5    Hsiang, J.6    Lewis, K.7
  • 62
    • 16344368469 scopus 로고    scopus 로고
    • In vitro search for synergy between flavonoids and epirubicin on multidrug-resistant cancer cells
    • Gyemant, N., Tanaka, M., Antus, S., Hohmann, J., Csuka, O., Man-doky, L., and Molnar, J. (2005). In vitro search for synergy between flavonoids and epirubicin on multidrug-resistant cancer cells. In vivo 19,367-374.
    • (2005) In vivo , vol.19 , pp. 367-374
    • Gyemant, N.1    Tanaka, M.2    Antus, S.3    Hohmann, J.4    Csuka, O.5    Mandoky, L.6    Molnar, J.7
  • 63
    • 32144459525 scopus 로고    scopus 로고
    • Reversal of multidrug resistance of cancer cells in vitro, modification of drug resistance by selected carotenoids
    • Gyemant, N., Tanaka, M., Molnar, P., Deli, J., Mandoky, L., and Molnar, J. (2006), Reversal of multidrug resistance of cancer cells in vitro, modification of drug resistance by selected carotenoids. Anticancer Res. 26, 367-374.
    • (2006) Anticancer Res , vol.26 , pp. 367-374
    • Gyemant, N.1    Tanaka, M.2    Molnar, P.3    Deli, J.4    Mandoky, L.5    Molnar, J.6
  • 64
    • 46749147175 scopus 로고    scopus 로고
    • In vitro and in vivo evaluation of the effects of piperine on P-gp function and expression
    • Han, Y., Chin Tan, T. M., and Lim, L. Y (2008). In vitro and in vivo evaluation of the effects of piperine on P-gp function and expression. Toxicol. Appl. Pharmacol. 230, 283-289.
    • (2008) Toxicol. Appl. Pharmacol. , vol.230 , pp. 283-289
    • Han, Y.1    Chin Tan, T.M.2    Lim, L.Y.3
  • 65
    • 0036299716 scopus 로고    scopus 로고
    • Effects of various principles from Chinese herbal medicine on rhodamine123 accumulation in brain capillary endothelial cells
    • He, L., and Liu, G. Q. (2002). Effects of various principles from Chinese herbal medicine on rhodamine123 accumulation in brain capillary endothelial cells. Acta Pharmacol. Sin. 23,591-596.
    • (2002) Acta Pharmacol. Sin. , vol.23 , pp. 591-596
    • He, L.1    Liu, G.Q.2
  • 66
    • 0346216104 scopus 로고    scopus 로고
    • Cytotoxic activity of the seeds from Agrostemma githago var. githago
    • Hebestreit, P., and Melzig, M. (2003). Cytotoxic activity of the seeds from Agrostemma githago var. githago. Planta Med. 69,921-925.
    • (2003) Planta Med , vol.69 , pp. 921-925
    • Hebestreit, P.1    Melzig, M.2
  • 67
    • 0037030690 scopus 로고    scopus 로고
    • Discovery and biological evaluation of a new family of potent modulators of multidrug resistance, reversal of multidrug resistance of mouse lymphoma cells by new natural jatrophane diterpenoids isolated from Euphorbia species
    • Hohmann, J., Molnar, J., Redei, D., Evanics, F., Forgo, P., Kalman, A., Argay, G., and Szabo, P. (2002). Discovery and biological evaluation of a new family of potent modulators of multidrug resistance, reversal of multidrug resistance of mouse lymphoma cells by new natural jatrophane diterpenoids isolated from Euphorbia species. J. Med. Chem. 45, 2425-2431.
    • (2002) J. Med. Chem. , vol.45 , pp. 2425-2431
    • Hohmann, J.1    Molnar, J.2    Redei, D.3    Evanics, F.4    Forgo, P.5    Kalman, A.6    Argay, G.7    Szabo, P.8
  • 68
    • 44449088297 scopus 로고    scopus 로고
    • Curcuma drugs and curcumin regulate the expression and function of P-gp in Caco-2 cells in completely opposite ways
    • Hou, X. L., Takahashi, K., Tanaka, K., Tougou, K., Qiu, F., Komatsu, K., and Azuma, J. (2008). Curcuma drugs and curcumin regulate the expression and function of P-gp in Caco-2 cells in completely opposite ways. Int. J. Pharm. 358, 224-229.
    • (2008) Int. J. Pharm. , vol.358 , pp. 224-229
    • Hou, X.L.1    Takahashi, K.2    Tanaka, K.3    Tougou, K.4    Qiu, F.5    Komatsu, K.6    Azuma, J.7
  • 69
    • 0029017629 scopus 로고
    • Rapid up-regulation of mdr1 expression by anthracyclines in a classical multidrug-resistant cell line
    • Hu, X. F., Slater, A., Wall, D. M., Kantharidis, P., Parkin, J. D., Cowman, A., and Zalcberg, J. R. (1995). Rapid up-regulation of mdr1 expression by anthracyclines in a classical multidrug-resistant cell line. Br. J. Cancer 71, 931-936.
    • (1995) Br. J. Cancer , vol.71 , pp. 931-936
    • Hu, X.F.1    Slater, A.2    Wall, D.M.3    Kantharidis, P.4    Parkin, J.D.5    Cowman, A.6    Zalcberg, J.R.7
  • 70
    • 0027524642 scopus 로고
    • In vitro and in vivo reversal of multidrug resistance by GF120918, an acridonecarboxamide derivative
    • Hyafil, F., Vergely, C., Du Vignaud, P., and Grand-Perret, T. (1993). In vitro and in vivo reversal of multidrug resistance by GF120918, an acridonecarboxamide derivative. Cancer Res. 53,4595-4602.
    • (1993) Cancer Res , vol.53 , pp. 4595-4602
    • Hyafil, F.1    Vergely, C.2    Du Vignaud, P.3    Grand-Perret, T.4
  • 71
    • 78651295896 scopus 로고    scopus 로고
    • Antimycobacterial activity of two natural alkaloids, vasicine acetate and 2-acetyl benzylamine, isolated from Indian shrub Adhatoda vasica Nees. leaves
    • Ignacimuthu, S., and Shanmugam, N. (2010). Antimycobacterial activity of two natural alkaloids, vasicine acetate and 2-acetyl benzylamine, isolated from Indian shrub Adhatoda vasica Nees. leaves. J. Biosci. 35, 565-570.
    • (2010) J. Biosci. , vol.35 , pp. 565-570
    • Ignacimuthu, S.1    Shanmugam, N.2
  • 73
    • 77951602981 scopus 로고    scopus 로고
    • The past, present and future of pharmacoepigenomics
    • Ingelman-Sundberg, M., and Gomez, A. (2010). The past, present and future of pharmacoepigenomics. Pharmacogenomics 11, 625-662.
    • (2010) Pharmacogenomics , vol.11 , pp. 625-662
    • Ingelman-Sundberg, M.1    Gomez, A.2
  • 74
    • 79955482542 scopus 로고    scopus 로고
    • Alkaloids derived from genus Veratrum and Peganum of Mongolian origin as multidrug resistance inhibitors of cancer cells
    • Ivanova, A., Serly, J., Christov, V., Stamboliyska, B., and Molnar, J. (2011). Alkaloids derived from genus Veratrum and Peganum of Mongolian origin as multidrug resistance inhibitors of cancer cells. Fitoterapia 82, 570-575.
    • (2011) Fitoterapia , vol.82 , pp. 570-575
    • Ivanova, A.1    Serly, J.2    Christov, V.3    Stamboliyska, B.4    Molnar, J.5
  • 75
    • 67650979464 scopus 로고    scopus 로고
    • Screening of some saponins and phenolic components of Tribulus terrestris and Smilax excelsa as MDR modulators
    • Ivanova, A., Serly, J., Dinchev, D., Ocsovszki, I., Kostova, I., and Molnar, J. (2009). Screening of some saponins and phenolic components of Tribulus terrestris and Smilax excelsa as MDR modulators. In vivo 23,545-550.
    • (2009) In vivo , vol.23 , pp. 545-550
    • Ivanova, A.1    Serly, J.2    Dinchev, D.3    Ocsovszki, I.4    Kostova, I.5    Molnar, J.6
  • 76
    • 33846698320 scopus 로고    scopus 로고
    • P-glycoprotein inhibitory activity of two phenolic compounds, (-)-syringaresinol and tricin from Sasa borealis
    • Jeong, Y H., Chung, S. Y., Han, A. R., Sung, M. K., Jang, D. S., Lee, J., Kwon, Y., Lee, H. J., and Seo, E. K. (2007). P-glycoprotein inhibitory activity of two phenolic compounds, (-)-syringaresinol and tricin from Sasa borealis. Chem. Biodivers. 4, 12-16.
    • (2007) Chem. Biodivers. , vol.4 , pp. 12-16
    • Jeong, Y.H.1    Chung, S.Y.2    Han, A.R.3    Sung, M.K.4    Jang, D.S.5    Lee, J.6    Kwon, Y.7    Lee, H.J.8    Seo, E.K.9
  • 77
    • 3843112419 scopus 로고    scopus 로고
    • Cytotoxic effects and reversal of multidrug resistance by ibogan and related indole alkaloids
    • Kam, T. S., Sim, K. M., Pang, H. S., Koyano, T., Hayashi, M., and Komiyama, K. (2004). Cytotoxic effects and reversal of multidrug resistance by ibogan and related indole alkaloids. Bioorg. Med. Chem. Lett. 14, 4487-4489.
    • (2004) Bioorg. Med. Chem. Lett. , vol.14 , pp. 4487-4489
    • Kam, T.S.1    Sim, K.M.2    Pang, H.S.3    Koyano, T.4    Hayashi, M.5    Komiyama, K.6
  • 79
    • 46449133480 scopus 로고    scopus 로고
    • Reversal of multidrug resistance by synthetic and natural compounds in drug-resistant MCF-7 cell lines
    • Kars, M. D., Iseri, O. D., Gunduz, U., and Molnar, J. (2008). Reversal of multidrug resistance by synthetic and natural compounds in drug-resistant MCF-7 cell lines. Chemotherapy 54,194-200.
    • (2008) Chemotherapy , vol.54 , pp. 194-200
    • Kars, M.D.1    Iseri, O.D.2    Gunduz, U.3    Molnar, J.4
  • 80
    • 79955469613 scopus 로고    scopus 로고
    • New29-nor-cycloartanes with a 3,4-seco-and a novel 2, 3-seco-structure from the leaves of Sinocalycanthus chinensis
    • Kashiwada, Y., Nishimura, K., Kurimoto, S., and Takaishi, Y. (2011). New29-nor-cycloartanes with a 3,4-seco-and a novel 2,3-seco-structure from the leaves of Sinocalycanthus chinensis. Bioorg. Med. Chem. 19, 2790-2796.
    • (2011) Bioorg. Med. Chem. , vol.19 , pp. 2790-2796
    • Kashiwada, Y.1    Nishimura, K.2    Kurimoto, S.3    Takaishi, Y.4
  • 81
    • 21644459020 scopus 로고    scopus 로고
    • Cepharanthine enhances adriamycin sensitivity by synergistically accelerating apoptosis for adriamycin-resistant osteosarcoma cell lines SaOS2-AR and SaOS2 F-AR
    • Katsui, K., Kuroda, M., Wang, Y., Komatsu, M., Himei, K., Takemoto, M., Akaki, S., Asaumi, J., Kanazawa, S., and Hiraki, Y (2004). Cepharanthine enhances adriamycin sensitivity by synergistically accelerating apoptosis for adriamycin-resistant osteosarcoma cell lines, SaOS2-AR and SaOS2 F-AR. Int. J. Oncol. 25, 47-56.
    • (2004) Int. J. Oncol. , vol.25 , pp. 47-56
    • Katsui, K.1    Kuroda, M.2    Wang, Y.3    Komatsu, M.4    Himei, K.5    Takemoto, M.6    Akaki, S.7    Asaumi, J.8    Kanazawa, S.9    Hiraki, Y.10
  • 82
    • 79952987543 scopus 로고    scopus 로고
    • Chemosensitization of afla-toxigenic fungi to antimycin A and strobilurin using salicylaldehyde, a volatile natural compound targeting cellular antioxidation system
    • Kim, J. H., Campbell, B. C., Mahoney, N., Chan, K. L., and Molyneux, R. J. (2010). Chemosensitization of afla-toxigenic fungi to antimycin A and strobilurin using salicylaldehyde, a volatile natural compound targeting cellular antioxidation system. Mycopathologia 171,291-298.
    • (2010) Mycopathologia , vol.171 , pp. 291-298
    • Kim, J.H.1    Campbell, B.C.2    Mahoney, N.3    Chan, K.L.4    Molyneux, R.J.5
  • 83
    • 34447625862 scopus 로고    scopus 로고
    • Enhanced activity of strobilurin and fludioxonil by using berberine and phenolic compounds to target fungal antioxidative stress response
    • Kim, J. H., Campbell, B. C., Mahoney, N., Chan, K. L., Molyneux, R. J., and May, G. (2007). Enhanced activity of strobilurin and fludioxonil by using berberine and phenolic compounds to target fungal antioxidative stress response. Lett. Appl. Microbiol. 45, 134-141.
    • (2007) Lett. Appl. Microbiol. , vol.45 , pp. 134-141
    • Kim, J.H.1    Campbell, B.C.2    Mahoney, N.3    Chan, K.L.4    Molyneux, R.J.5    May, G.6
  • 85
    • 0031796062 scopus 로고    scopus 로고
    • In vivo characterization of the drug resistance profile of the major ABC transporters and other components of the yeast pleiotropic drug resistance network
    • Kolaczkowski, M., Kolaczowska, A., Luczynski, J., Witek, S., and Goffeau, A. (1998). In vivo characterization of the drug resistance profile of the major ABC transporters and other components of the yeast pleiotropic drug resistance network. Microb. DrugResist. 4, 143-158.
    • (1998) Microb. DrugResist. , vol.4 , pp. 143-158
    • Kolaczkowski, M.1    Kolaczowska, A.2    Luczynski, J.3    Witek, S.4    Goffeau, A.5
  • 87
    • 77951240783 scopus 로고    scopus 로고
    • Efflux pumps are involved in the defense of Gramnegative bacteria against the natural products isobavachalcone and diospyrone
    • Kuete, V., Ngameni, B., Tangmouo, J. G., Bolla, J. M., Alibert-Franco, S., Ngadjui, B. T., and Pages, J. M. (2010). Efflux pumps are involved in the defense of Gramnegative bacteria against the natural products isobavachalcone and diospyrone. Antimicrob. Agents Chemother. 54,1749-1752.
    • (2010) Antimicrob. Agents Chemother. , vol.54 , pp. 1749-1752
    • Kuete, V.1    Ngameni, B.2    Tangmouo, J.G.3    Bolla, J.M.4    Alibert-Franco, S.5    Ngadjui, B.T.6    Pages, J.M.7
  • 88
    • 80053623753 scopus 로고    scopus 로고
    • Triterpenes and a triterpene glucoside from Dysoxylum cumingianum
    • Kurimoto, S., Kashiwada, Y., Lee, K. H., and Takaishi, Y (2011a). Triterpenes and a triterpene glucoside from Dysoxylum cumingianum. Phytochemistry 72, 2205-2211.
    • (2011) Phytochemistry , vol.72 , pp. 2205-2211
    • Kurimoto, S.1    Kashiwada, Y.2    Lee, K.H.3    Takaishi, Y.4
  • 90
    • 0035015140 scopus 로고    scopus 로고
    • Inhibitory effect of steroidal alkaloids on drug transport and multidrug resistance in human cancer cells
    • Lavie, Y., Harel-Orbital, T., Gaffield, W., and Liscovitch, M. (2001). Inhibitory effect of steroidal alkaloids on drug transport and multidrug resistance in human cancer cells. Anticancer Res. 21, 1189-1194.
    • (2001) Anticancer Res , vol.21 , pp. 1189-1194
    • Lavie, Y.1    Harel-Orbital, T.2    Gaffield, W.3    Liscovitch, M.4
  • 92
    • 79959894525 scopus 로고    scopus 로고
    • Hydrocin-chonine, cinchonine, and qiuinidine potentiate paclitaxel-induced cyto-toxicity and apoptosis via multidrug resistance reversal in MES-SA/DX5 uterine sarcoma cells
    • Lee, S. Y., Rhee, Y H., Jeong, S. J., Lee, H. J., Jung, M. H., Kim, S. H., Lee, E. O., and Ahn, K. S. (2011). Hydrocin-chonine, cinchonine, and qiuinidine potentiate paclitaxel-induced cyto-toxicity and apoptosis via multidrug resistance reversal in MES-SA/DX5 uterine sarcoma cells. Environ. Toxicol. 26,424-431.
    • (2011) Environ. Toxicol. , vol.26 , pp. 424-431
    • Lee, S.Y.1    Rhee, Y.H.2    Jeong, S.J.3    Lee, H.J.4    Jung, M.H.5    Kim, S.H.6    Lee, E.O.7    Ahn, K.S.8
  • 93
    • 10944253707 scopus 로고    scopus 로고
    • A novel ABC transporter gene ABC2 involved in multidrug susceptibility but not pathogenicity in rice blast fungus, Magnaporthe grisea
    • Lee,Y.-J.,Yamamoto,K., Hamamoto,H., Nakaune, R., and Hibi, T. (2005). A novel ABC transporter gene ABC2 involved in multidrug susceptibility but not pathogenicity in rice blast fungus, Magnaporthe grisea. Pestic. Biochem. Physiol. 81, 13-23.
    • (2005) Pestic. Biochem. Physiol. , vol.81 , pp. 13-23
    • Lee, Y.-J.1    Yamamoto, K.2    Hamamoto, H.3    Nakaune, R.4    Hibi, T.5
  • 94
    • 78049464180 scopus 로고    scopus 로고
    • Synergistic effect of emodin in combination with ampicillin or oxacillin against methicillin-resistant Staphylococcus aureus
    • Lee, Y S., Kang, O. H., Choi, J. G., Oh, Y C, Keum, J. H., Kim, S. B., Jeong, G. S., Kim, Y C, Shin, D. W., and Kwon, D. Y. (2010). Synergistic effect of emodin in combination with ampicillin or oxacillin against methicillin-resistant Staphylococcus aureus. Pharm. Biol. 48, 1285-1290.
    • (2010) Pharm. Biol. , vol.48 , pp. 1285-1290
    • Lee, Y.S.1    Kang, O.H.2    Choi, J.G.3    Oh, Y.C.4    Keum, J.H.5    Kim, S.B.6    Jeong, G.S.7    Kim, Y.C.8    Shin, D.W.9    Kwon, D.Y.10
  • 95
    • 0035033774 scopus 로고    scopus 로고
    • Modulation of multidrug resistance protein 1 (MRP1/ABCC1) transport and ATPase activities by interaction with dietary flavonoids
    • Leslie, E. M., Mao, Q., Oleschuk, C. J., Deeley, R. G., and Cole, S. P. (2001). Modulation of multidrug resistance protein 1 (MRP1/ABCC1) transport and ATPase activities by interaction with dietary flavonoids. Mol. Pharmacol. 59,1171-1180.
    • (2001) Mol. Pharmacol. , vol.59 , pp. 1171-1180
    • Leslie, E.M.1    Mao, Q.2    Oleschuk, C.J.3    Deeley, R.G.4    Cole, S.P.5
  • 96
    • 79959231158 scopus 로고    scopus 로고
    • Isolation of novel phenolic compounds with multidrug resistance (MDR) reversal properties from Onychiumjaponicum
    • Li, M.C.,Yao,Z., Takaishi, Y., Tang, S. A., and Duan, H. Q. (2011a). Isolation of novel phenolic compounds with multidrug resistance (MDR) reversal properties from Onychiumjaponicum. Chem. Biodivers. 8,1112-1120.
    • (2011) Chem. Biodivers. , vol.8 , pp. 1112-1120
    • Li, M.C.1    Yao, Z.2    Takaishi, Y.3    Tang, S.A.4    Duan, H.Q.5
  • 97
    • 82755197939 scopus 로고    scopus 로고
    • Piperine, a piperidine alkaloid from Piper nigrum resensitizes P-gp MRP1 and BCRP dependent multidrug resistant cancer cells
    • Li,S.,Lei,Y.,Jia,Y.,Li,N.,Wink,M., and Ma, Y (2011b). Piperine, a piperidine alkaloid from Piper nigrum resensitizes P-gp, MRP1 and BCRP dependent multidrug resistant cancer cells. Phytomedicine 19, 83-87.
    • (2011) Phytomedicine , vol.19 , pp. 83-87
    • Li, S.1    Lei, Y.2    Jia, Y.3    Li, N.4    Wink, M.5    Ma, Y.6
  • 98
    • 34447506459 scopus 로고    scopus 로고
    • Modulation of function of three ABC drug transporters, P-glycoprotein (ABCB1), mitox-antrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCC1) by tetrahydrocurcumin, a major metabolite of curcumin
    • Limtrakul, P., Chearwae, W., Shukla, S., Phisalphong, C., and Ambudkar, S. V. (2007). Modulation of function of three ABC drug transporters, P-glycoprotein (ABCB1), mitox-antrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCC1) by tetrahydrocurcumin, a major metabolite of curcumin. Mol. Cell. Biochem. 296, 85-95.
    • (2007) Mol. Cell. Biochem. , vol.296 , pp. 85-95
    • Limtrakul, P.1    Chearwae, W.2    Shukla, S.3    Phisalphong, C.4    Ambudkar, S.V.5
  • 100
    • 32044453808 scopus 로고    scopus 로고
    • Recent progress in understanding the mechanism of P-glycoprotein-mediated drug efflux
    • Loo, T. W., and Clarke, D. M. (2005). Recent progress in understanding the mechanism of P-glycoprotein-mediated drug efflux. J. Membr. Biol. 206, 173-185.
    • (2005) J. Membr. Biol. , vol.206 , pp. 173-185
    • Loo, T.W.1    Clarke, D.M.2
  • 101
    • 83555164705 scopus 로고    scopus 로고
    • The short-time treatment with curcumin sufficiently decreases cell viability, induces apoptosis and copper enhances these effects in multidrug-resistant K562/A02 cells
    • Lu, J. J., Cai, Y J., and Ding, J. (2012). The short-time treatment with curcumin sufficiently decreases cell viability, induces apoptosis and copper enhances these effects in multidrug-resistant K562/A02 cells. Mol. Cell. Biochem. 360, 253-260.
    • (2012) Mol. Cell. Biochem. , vol.360 , pp. 253-260
    • Lu, J.J.1    Cai, Y.J.2    Ding, J.3
  • 102
    • 48649092518 scopus 로고    scopus 로고
    • Lobeline, a piperidine alkaloid from Lobelia can reverse P-gp dependent multidrug resistance in tumor cells
    • Ma, Y., and Wink, M. (2008). Lobeline, a piperidine alkaloid from Lobelia can reverse P-gp dependent multidrug resistance in tumor cells. Phytomedicine 15, 754-758.
    • (2008) Phytomedicine , vol.15 , pp. 754-758
    • Ma, Y.1    Wink, M.2
  • 103
    • 84875667803 scopus 로고    scopus 로고
    • Reversal of multidrug resistance (MDR) by the isoquinoline alkaloid glaucine
    • eds A Meszaros and G. Balogh (Hauppauge: Nova Science Publishers)
    • Ma, Y., and Wink, M. (2009). 'Reversal of multidrug resistance (MDR) by the isoquinoline alkaloid glaucine,' in Multiple Drug Resistance, eds A. Meszaros and G. Balogh (Hauppauge: Nova Science Publishers), 1-19.
    • (2009) Multiple Drug Resistance , pp. 1-19
    • Ma, Y.1    Wink, M.2
  • 104
    • 74249085687 scopus 로고    scopus 로고
    • The betacarboline alkaloid harmine inhibits BCRP and can reverse resistance to the anticancer drugs mitoxantrone and camptothecin
    • Ma, Y., and Wink, M. (2010). The betacarboline alkaloid harmine inhibits BCRP and can reverse resistance to the anticancer drugs mitoxantrone and camptothecin. Phytother. Res. 24, 146-149.
    • (2010) Phytother. Res. , vol.24 , pp. 146-149
    • Ma, Y.1    Wink, M.2
  • 105
    • 2442443147 scopus 로고    scopus 로고
    • Effect of cycloartanes on reversal of multidrug resistance and apoptosis induction on mouse lymphoma cells
    • Madureira, A. M., Spengler, G., Molnar, A., Varga, A., Molnar, J., Abreu, P. M., and Ferreira, M. J. (2004). Effect of cycloartanes on reversal of multidrug resistance and apoptosis induction on mouse lymphoma cells. Anticancer Res. 24, 859-864.
    • (2004) Anticancer Res , vol.24 , pp. 859-864
    • Madureira, A.M.1    Spengler, G.2    Molnar, A.3    Varga, A.4    Molnar, J.5    Abreu, P.M.6    Ferreira, M.J.7
  • 106
    • 77957727364 scopus 로고    scopus 로고
    • BCRP at the blood-brain barrier, genomic regulation by 17β-estradiol
    • Mahringer, A., and Fricker, G. (2010). BCRP at the blood-brain barrier, genomic regulation by 17β-estradiol. Mol. Pharm. 7,1835-1847.
    • (2010) Mol. Pharm. , vol.7 , pp. 1835-1847
    • Mahringer, A.1    Fricker, G.2
  • 108
    • 27644480743 scopus 로고    scopus 로고
    • Role of the breast cancer resistance protein (ABCG2) in drug transport
    • Mao, Q., and Unadkat, J. D. (2005). Role of the breast cancer resistance protein (ABCG2) in drug transport. AAPSJ. 7, E118-E133.
    • (2005) AAPSJ , vol.7
    • Mao, Q.1    Unadkat, J.D.2
  • 110
    • 77951049110 scopus 로고    scopus 로고
    • Constituents of Carpobrotus edulis inhibit P-glycoprotein of MDR1-transfected mouse lymphoma cells
    • Martins, A., Vasas, A., Schelz, Z., Viveiros, M., Molnar, J., Hohmann, J., and Amaral, L. (2010). Constituents of Carpobrotus edulis inhibit P-glycoprotein of MDR1-transfected mouse lymphoma cells. Anticancer Res. 30,829-835.
    • (2010) Anticancer Res , vol.30 , pp. 829-835
    • Martins, A.1    Vasas, A.2    Schelz, Z.3    Viveiros, M.4    Molnar, J.5    Hohmann, J.6    Amaral, L.7
  • 111
    • 0027813132 scopus 로고
    • In vitro and in vivo effects of clinically important camptothecin analogues on multidrug-resistant cells
    • Mattern, M. R., Hofmann, G. A., Polsky, R. M., Funk, L. R., McCabe, F. L., and Johnson, R. K. (1993). In vitro and in vivo effects of clinically important camptothecin analogues on multidrug-resistant cells. Oncol. Res. 5, 467-474.
    • (1993) Oncol. Res. , vol.5 , pp. 467-474
    • Mattern, M.R.1    Hofmann, G.A.2    Polsky, R.M.3    Funk, L.R.4    McCabe, F.L.5    Johnson, R.K.6
  • 112
    • 5644297293 scopus 로고    scopus 로고
    • Reversal of cancer multidrug resistance by green tea polyphenols
    • Mei, Y., Qian, F., Wei, D., and Liu, J. (2004). Reversal of cancer multidrug resistance by green tea polyphenols. J. Pharm. Pharmacol. 56,1307-1314.
    • (2004) J. Pharm. Pharmacol. , vol.56 , pp. 1307-1314
    • Mei, Y.1    Qian, F.2    Wei, D.3    Liu, J.4
  • 113
    • 3042758649 scopus 로고    scopus 로고
    • Voacamine, a bisindolic alkaloid from Peschiera fuchsiaefolia, enhances the cytotoxic effect of doxorubicin on multidrug-resistant tumor cells
    • Meschini, S., Marra, M., Calcabrini, A., Federici, E., Galeffi, C., and Arancia, G. (2003). Voacamine, a bisindolic alkaloid from Peschiera fuchsiaefolia, enhances the cytotoxic effect of doxorubicin on multidrug-resistant tumor cells. Int. J. Oncol. 23, 1505-1513.
    • (2003) Int. J. Oncol. , vol.23 , pp. 1505-1513
    • Meschini, S.1    Marra, M.2    Calcabrini, A.3    Federici, E.4    Galeffi, C.5    Arancia, G.6
  • 114
    • 33644833121 scopus 로고    scopus 로고
    • Voacamine, an alkaloid extracted from Peschiera fuchsiaefolia, inhibits P-glycoprotein action in multidrug-resistant tumor cells
    • Meschini, S., Marra, M., Condello, M., Calcabrini, A., Federici, E., Dupuis, M. L., Cianfriglia, M., and Arancia, G. (2005). Voacamine, an alkaloid extracted from Peschiera fuchsiaefolia, inhibits P-glycoprotein action in multidrug-resistant tumor cells. Int. J. Oncol. 27, 1597-1603.
    • (2005) Int. J. Oncol. , vol.27 , pp. 1597-1603
    • Meschini, S.1    Marra, M.2    Condello, M.3    Calcabrini, A.4    Federici, E.5    Dupuis, M.L.6    Cianfriglia, M.7    Arancia, G.8
  • 116
    • 33748369899 scopus 로고    scopus 로고
    • Aporphine alkaloids and their reversal activity of multidrug resistance (MDR) from the stems and rhizomes of Sinomenium acutum
    • Min, Y D., Choi, S. U., and Lee, K. R. (2006a). Aporphine alkaloids and their reversal activity of multidrug resistance (MDR) from the stems and rhizomes of Sinomenium acutum. Arch. Pharm. Res. 29, 627-632.
    • (2006) Arch. Pharm. Res. , vol.29 , pp. 627-632
    • Min, Y.D.1    Choi, S.U.2    Lee, K.R.3
  • 117
    • 33749331556 scopus 로고    scopus 로고
    • Protoberberine alkaloids and their reversal activity of P-gp expressed multidrug resistance (MDR) from the rhizome of Coptis japonica Makino
    • Min, Y D., Yang, M. C., Lee, K. H., Kim, K. R., Choi, S. U., and Lee, K. R. (2006b). Protoberberine alkaloids and their reversal activity of P-gp expressed multidrug resistance (MDR) from the rhizome of Coptis japonica Makino. Arch. Pharm. Res. 29,757-761.
    • (2006) Arch. Pharm. Res. , vol.29 , pp. 757-761
    • Min, Y.D.1    Yang, M.C.2    Lee, K.H.3    Kim, K.R.4    Choi, S.U.5    Lee, K.R.6
  • 118
    • 33846847551 scopus 로고    scopus 로고
    • Isolation of limonoids and alkaloids from Phellodendron amurense and their multidrug resistance (MDR) reversal activity
    • Min, Y D., Kwon, H. C., Yang, M. C., Lee, K. H., Choi, S. U., and Lee, K. R. (2007). Isolation of limonoids and alkaloids from Phellodendron amurense and their multidrug resistance (MDR) reversal activity. Arch. Pharm. Res. 30, 58-63.
    • (2007) Arch. Pharm. Res. , vol.30 , pp. 58-63
    • Min, Y.D.1    Kwon, H.C.2    Yang, M.C.3    Lee, K.H.4    Choi, S.U.5    Lee, K.R.6
  • 119
    • 33750420503 scopus 로고    scopus 로고
    • Reduction of cytotoxicity of the alkaloid emetine through P-glycoprotein (MDR1/ABCB1) in human Caco-2 cells and leukaemia cell lines
    • Möller, M., Weiss, J., and Wink, M. (2006). Reduction of cytotoxicity of the alkaloid emetine through P-glycoprotein (MDR1/ABCB1) in human Caco-2 cells and leukaemia cell lines. Planta Med. 72, 1121-1126.
    • (2006) Planta Med , vol.72 , pp. 1121-1126
    • Möller, M.1    Weiss, J.2    Wink, M.3
  • 120
    • 77951040996 scopus 로고    scopus 로고
    • Multidrug resistance reversal in cancer cells by selected carotenoids, flavonoids and anthocyanins
    • ed. N. Motohashi (Berlin: Springer), [Topics in Heterocyclic Chemistry]
    • Molnár, J., Engi, H., Gyémánt, N., Schelz, Z., Spengler, G., Ocsovski, I., Szücs, M., Hohmann, J., Szabo, M., and Tanács, L. (2008). 'Multidrug resistance reversal in cancer cells by selected carotenoids, flavonoids and anthocyanins,' in Bioactive Hetero-cycles VI, Vol. 15, ed. N. Motohashi (Berlin: Springer), 133-159. [Topics in Heterocyclic Chemistry].
    • (2008) Bioactive Hetero-cycles VI , vol.15 , pp. 133-159
    • Molnár, J.1    Engi, H.2    Gyémánt, N.3    Schelz, Z.4    Spengler, G.5    Ocsovski, I.6    Szücs, M.7    Hohmann, J.8    Szabo, M.9    Tanács, L.10
  • 124
    • 0036237136 scopus 로고    scopus 로고
    • A novel ABC transporter gene, is involved in multidrug resistance in the phytopathogenic fungus Penicillium digitatum
    • Nakaune, R. N., Hamamoto, H. H., Imada, J. I., Akutsu, K. A., and Hibi, T. H. (2002). A novel ABC transporter gene, is involved in multidrug resistance in the phytopathogenic fungus Penicillium digitatum. Mol. Genet. Genomics 267, 179-185.
    • (2002) Mol. Genet. Genomics , vol.267 , pp. 179-185
    • Nakaune, R.N.1    Hamamoto, H.H.2    Imada, J.I.3    Akutsu, K.A.4    Hibi, T.H.5
  • 125
  • 126
    • 0026683638 scopus 로고
    • P-Glycoprotein as multidrug transporter-a critical-review of current multidrug resistant celllines
    • Nielsen, D., and Skovsgaard, T. (1992). P-Glycoprotein as multidrug transporter-a critical-review of current multidrug resistant celllines. Biochim. Biophys. Acta 1139, 169-183.
    • (1992) Biochim. Biophys. Acta , vol.1139 , pp. 169-183
    • Nielsen, D.1    Skovsgaard, T.2
  • 127
    • 18044369636 scopus 로고    scopus 로고
    • Flavonoid binding to a multi-drug-resistance transporter protein, an STD-NMR study
    • Nissler, L., Gebhardt, R., and Berger, S. (2004). Flavonoid binding to a multi-drug-resistance transporter protein, an STD-NMR study. Anal. Bioanal. Chem. 379, 1045-1049.
    • (2004) Anal. Bioanal. Chem. , vol.379 , pp. 1045-1049
    • Nissler, L.1    Gebhardt, R.2    Berger, S.3
  • 128
    • 0029759985 scopus 로고    scopus 로고
    • Molecular mechanisms of multidrug resistance in cancer chemotherapy
    • Nooter, K., and Stoter, G. (1996). Molecular mechanisms of multidrug resistance in cancer chemotherapy. Pathol. Res. Pract. 192, 768-780.
    • (1996) Pathol. Res. Pract. , vol.192 , pp. 768-780
    • Nooter, K.1    Stoter, G.2
  • 129
    • 34447520007 scopus 로고    scopus 로고
    • Antibacterial activity of two canthin-6-one alkaloids from Allium neapolitanum
    • O'Donnell, G., and Gibbons, S. (2007). Antibacterial activity of two canthin-6-one alkaloids from Allium neapolitanum. Phytother. Res. 21,653-657.
    • (2007) Phytother. Res. , vol.21 , pp. 653-657
    • O'Donnell, G.1    Gibbons, S.2
  • 130
    • 33750198264 scopus 로고    scopus 로고
    • Bidirectional membrane transport, simulations of transport inhibition in uptake studies explain data obtained with flavonoids
    • Ofer, M., Langguth, P., and Spahn-Langguth, H. (2006). Bidirectional membrane transport, simulations of transport inhibition in uptake studies explain data obtained with flavonoids. Eur. J. Pharm. Sci. 29, 251-258.
    • (2006) Eur. J. Pharm. Sci. , vol.29 , pp. 251-258
    • Ofer, M.1    Langguth, P.2    Spahn-Langguth, H.3
  • 131
    • 19444385262 scopus 로고    scopus 로고
    • Modulation of drug transport by selected flavonoids: involvement of P-gp and OCT? Eur
    • Ofer, M., Wolffram, S., Koggel, A., Spahn-Langguth, H., and Langguth, P. (2005). Modulation of drug transport by selected flavonoids: involvement of P-gp and OCT? Eur. J. Pharm. Sci. 25,263-271.
    • (2005) J. Pharm. Sci. , vol.25 , pp. 263-271
    • Ofer, M.1    Wolffram, S.2    Koggel, A.3    Spahn-Langguth, H.4    Langguth, P.5
  • 132
    • 34548590341 scopus 로고    scopus 로고
    • Effects of various methoxyflavones on vincristine uptake and multidrug resistance to vincristine in P-gp-overexpressing K562/ADM cells
    • Ohtani, H., Ikegawa, T., Honda, Y., Kohyama, N., Morimoto, S., Shoyama, Y., Juichi, M., Naito, M., Tsuruo, T., and Sawada, Y (2007). Effects of various methoxyflavones on vincristine uptake and multidrug resistance to vincristine in P-gp-overexpressing K562/ADM cells. Pharm. Res. 24, 1936-1943.
    • (2007) Pharm. Res. , vol.24 , pp. 1936-1943
    • Ohtani, H.1    Ikegawa, T.2    Honda, Y.3    Kohyama, N.4    Morimoto, S.5    Shoyama, Y.6    Juichi, M.7    Naito, M.8    Tsuruo, T.9    Sawada, Y.10
  • 133
    • 76049117213 scopus 로고    scopus 로고
    • Effects of dietary ingredients on function and expression of P-glycoprotein in human intestinal epithelial cells
    • Okura, T., Ibe, M., Umegaki, K., Shinozuka, K., and Yamada, S. (2010). Effects of dietary ingredients on function and expression of P-glycoprotein in human intestinal epithelial cells. Biol. Pharm. Bull. 33, 255-259.
    • (2010) Biol. Pharm. Bull. , vol.33 , pp. 255-259
    • Okura, T.1    Ibe, M.2    Umegaki, K.3    Shinozuka, K.4    Yamada, S.5
  • 134
    • 0037512451 scopus 로고    scopus 로고
    • Carpobrotus edulis methanol extract inhibits the MDR efflux pumps, enhances killing of phagocytosed S. aureus and promotes immune modulation
    • Ordway, D., Hohmann, J., Viveiros, M., Viveiros, A., Molnar, J., Leandro, C., Arroz, M. J., Gracio, M. A., and Amaral, L. (2003). Carpobrotus edulis methanol extract inhibits the MDR efflux pumps, enhances killing of phagocytosed S. aureus and promotes immune modulation. Phytother. Res. 17,512-519.
    • (2003) Phytother. Res. , vol.17 , pp. 512-519
    • Ordway, D.1    Hohmann, J.2    Viveiros, M.3    Viveiros, A.4    Molnar, J.5    Leandro, C.6    Arroz, M.J.7    Gracio, M.A.8    Amaral, L.9
  • 135
    • 0039552151 scopus 로고    scopus 로고
    • Correlation between the affinity of flavonoids binding to the cytosolic site of Leish-mania tropica multidrug transporter and their efficiency to revert parasite resistance to daunomycin
    • Perez-Victoria, J. M., Chiquero, M. J., Conseil, G., Dayan, G., Di Pietro, A., Barron, D., Castanys, S., and Gamarro, F. (1999). Correlation between the affinity of flavonoids binding to the cytosolic site of Leish-mania tropica multidrug transporter and their efficiency to revert parasite resistance to daunomycin. Biochemistry 38, 1736-1743.
    • (1999) Biochemistry , vol.38 , pp. 1736-1743
    • Perez-Victoria, J.M.1    Chiquero, M.J.2    Conseil, G.3    Dayan, G.4    Di Pietro, A.5    Barron, D.6    Castanys, S.7    Gamarro, F.8
  • 137
    • 0242331085 scopus 로고    scopus 로고
    • Multidrug resistance reversal agents
    • Robert, J., and Jarry, C. (2003). Multidrug resistance reversal agents. J. Med. Chem. 46,4805-4817.
    • (2003) J. Med. Chem. , vol.46 , pp. 4805-4817
    • Robert, J.1    Jarry, C.2
  • 138
    • 35148836262 scopus 로고    scopus 로고
    • Natural triterpenoids from Cecropia lyratiloba are cytotoxic to both sensitive and multidrug resistant leukemia cell lines
    • Rocha Gda, G., Simoes, M., Lucio, K. A., Oliveira, R. R., Coelho Kaplan, M. A., and Gattass, C. R. (2007). Natural triterpenoids from Cecropia lyratiloba are cytotoxic to both sensitive and multidrug resistant leukemia cell lines. Bioorg. Med. Chem. 15, 7355-7360.
    • (2007) Bioorg. Med. Chem. , vol.15 , pp. 7355-7360
    • Rocha Gda, G.1    Simoes, M.2    Lucio, K.A.3    Oliveira, R.R.4    Coelho Kaplan, M.A.5    Gattass, C.R.6
  • 141
    • 0037457802 scopus 로고    scopus 로고
    • Mammalian drug efflux transporters of the ATP binding cassette (ABC) family, an overview
    • Schinkel, A. H., and Jonker, J. W. (2003). Mammalian drug efflux transporters of the ATP binding cassette (ABC) family, an overview. Adv. DrugDeliv. Rev. 55, 3-29.
    • (2003) Adv. DrugDeliv. Rev. , vol.55 , pp. 3-29
    • Schinkel, A.H.1    Jonker, J.W.2
  • 142
    • 0036189651 scopus 로고    scopus 로고
    • Transfer of cationic antibacterial agents berberine, palmatine, and benzalkonium through bimolecular planar phospholipid film and Staphylococcus aureus membrane
    • Severina, I. I., Muntyan, M. S., Lewis, K., and Skulachev, V P. (2001). Transfer of cationic antibacterial agents berberine, palmatine, and benzalkonium through bimolecular planar phospholipid film and Staphylococcus aureus membrane. IUBMB Life 52,321-324.
    • (2001) IUBMB Life , vol.52 , pp. 321-324
    • Severina, I.I.1    Muntyan, M.S.2    Lewis, K.3    Skulachev, V.P.4
  • 143
    • 0031581819 scopus 로고    scopus 로고
    • Effect of quercetin on Hoechst 33342 transport by purified and reconstituted P-glycoprotein
    • Shapiro, A. B., and Ling, V. (1997). Effect of quercetin on Hoechst 33342 transport by purified and reconstituted P-glycoprotein. Biochem. Pharmacol. 53, 587-596.
    • (1997) Biochem. Pharmacol. , vol.53 , pp. 587-596
    • Shapiro, A.B.1    Ling, V.2
  • 144
    • 77954710540 scopus 로고    scopus 로고
    • Piperine as an inhibitor of Rv1258c, a putative multidrug efflux pump of Mycobacterium tuberculosis
    • Sharma, S., Kumar, M., Nargotra, A., Koul, S., and Khan, I. A. (2010). Piperine as an inhibitor of Rv1258c, a putative multidrug efflux pump of Mycobacterium tuberculosis. J. Antimicrob. Chemother. 65, 1694-1701.
    • (2010) J. Antimicrob. Chemother. , vol.65 , pp. 1694-1701
    • Sharma, S.1    Kumar, M.2    Nargotra, A.3    Koul, S.4    Khan, I.A.5
  • 146
    • 17744390861 scopus 로고    scopus 로고
    • Phase I study of cinchonine, a multidrug resistance reversing agent, combined with the CHVP regimen in relapsed and refractory lympho-proliferative syndromes
    • Solary, E., Mannone, L., Moreau, D., Caillot, D., Casasnovas, R. O., Guy, H., Grandjean, M., Wolf, J. E., Andre, F., and Fenaux, P. (2000). Phase I study of cinchonine, a multidrug resistance reversing agent, combined with the CHVP regimen in relapsed and refractory lympho-proliferative syndromes. Leukemia 14, 2085-2094.
    • (2000) Leukemia , vol.14 , pp. 2085-2094
    • Solary, E.1    Mannone, L.2    Moreau, D.3    Caillot, D.4    Casasnovas, R.O.5    Guy, H.6    Grandjean, M.7    Wolf, J.E.8    Andre, F.9    Fenaux, P.10
  • 147
    • 0029888822 scopus 로고    scopus 로고
    • Mechanisms of fungicide resistance in phytopathogenic fungi
    • Steffens, J. J., Pell, E. J., and Tien, M. (1996). Mechanisms of fungicide resistance in phytopathogenic fungi. Curr. Opin. Biotechnol. 7, 348-355.
    • (1996) Curr. Opin. Biotechnol. , vol.7 , pp. 348-355
    • Steffens, J.J.1    Pell, E.J.2    Tien, M.3
  • 148
    • 0036052296 scopus 로고    scopus 로고
    • BCRP gene expression is associated with a poor response to remission induction therapy in childhood acute myeloid leukemia
    • Steinbach, D., Sell, W., Voigt, A., Hermann, J., Zintl, F., and Sauerbrey, A. (2002). BCRP gene expression is associated with a poor response to remission induction therapy in childhood acute myeloid leukemia. Leukemia 16, 1443-1447.
    • (2002) Leukemia , vol.16 , pp. 1443-1447
    • Steinbach, D.1    Sell, W.2    Voigt, A.3    Hermann, J.4    Zintl, F.5    Sauerbrey, A.6
  • 149
    • 0034946174 scopus 로고    scopus 로고
    • Staphylococcus aureus MDR efflux pump inhibitors from a Berberis and a Mahonia (sensu strictu) species
    • Stermitz, F. R., Beeson, T. D., Mueller, P. J., Hsiang, J., and Lewis, K. (2001). Staphylococcus aureus MDR efflux pump inhibitors from a Berberis and a Mahonia (sensu strictu) species. Biochem. Syst. Ecol. 29, 793-798.
    • (2001) Biochem. Syst. Ecol. , vol.29 , pp. 793-798
    • Stermitz, F.R.1    Beeson, T.D.2    Mueller, P.J.3    Hsiang, J.4    Lewis, K.5
  • 150
    • 0034652383 scopus 로고    scopus 로고
    • Synergy in a medicinal plant, antimicrobial action of berberine potentiated by 5'-methoxyhydnocarpin, a multidrug pump inhibitor
    • Stermitz, F. R., Lorenz, P., Tawara, J. N., Zenewicz, L. A., and Lewis, K. (2000a). Synergy in a medicinal plant, antimicrobial action of berberine potentiated by 5'-methoxyhydnocarpin, a multidrug pump inhibitor. Proc. Natl. Acad. Sci. U.S.A. 97, 1433-1437.
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , pp. 1433-1437
    • Stermitz, F.R.1    Lorenz, P.2    Tawara, J.N.3    Zenewicz, L.A.4    Lewis, K.5
  • 152
    • 0036970135 scopus 로고    scopus 로고
    • Two flavonols from Artemisia annua which potentiate the activity of berberine and norfloxacin against a resistant strain of Staphylococcus aureus
    • Stermitz, F. R., Scriven, L. N., Tegos, G., and Lewis, K. (2002). Two flavonols from Artemisia annua which potentiate the activity of berberine and norfloxacin against a resistant strain of Staphylococcus aureus. Planta Med. 68,1140-1141.
    • (2002) Planta Med , vol.68 , pp. 1140-1141
    • Stermitz, F.R.1    Scriven, L.N.2    Tegos, G.3    Lewis, K.4
  • 153
    • 77953552264 scopus 로고    scopus 로고
    • Differential chemosensitization of P-glycoprotein overex-pressing K562/Adr cells by with-aferin A and Siamois polyphenols
    • Suttana, W., Mankhetkorn, S., Poompimon, W., Palagani, A., Zhokhov, S., Gerlo, S., Haegeman, G., and Berghe, W. V (2010). Differential chemosensitization of P-glycoprotein overex-pressing K562/Adr cells by with-aferin A and Siamois polyphenols. Mol. Cancer 9, 99.
    • (2010) Mol. Cancer , vol.9 , pp. 99
    • Suttana, W.1    Mankhetkorn, S.2    Poompimon, W.3    Palagani, A.4    Zhokhov, S.5    Gerlo, S.6    Haegeman, G.7    Berghe, W.V.8
  • 154
    • 77950874476 scopus 로고    scopus 로고
    • Selective regulation of multidrug resistance protein in vascular smooth muscle cells by the isoquinoline alkaloid coptisine
    • Suzuki, H., Tanabe, H., Mizukami, H., and Inoue, M. (2010). Selective regulation of multidrug resistance protein in vascular smooth muscle cells by the isoquinoline alkaloid coptisine. Biol. Pharm. Bull. 33, 677-682.
    • (2010) Biol. Pharm. Bull. , vol.33 , pp. 677-682
    • Suzuki, H.1    Tanabe, H.2    Mizukami, H.3    Inoue, M.4
  • 156
    • 56749164877 scopus 로고    scopus 로고
    • Effects of dietary flavonoids on the transport of cimetidine via P-glycoprotein and cationic transporters in Caco-2 and LLC-PK1 cell models
    • Taur, J. S., and Rodriguez-Proteau, R. (2008). Effects of dietary flavonoids on the transport of cimetidine via P-glycoprotein and cationic transporters in Caco-2 and LLC-PK1 cell models. Xenobiotica 38,1536-1550.
    • (2008) Xenobiotica , vol.38 , pp. 1536-1550
    • Taur, J.S.1    Rodriguez-Proteau, R.2
  • 157
    • 0030825773 scopus 로고    scopus 로고
    • Modulation of multidrug resistance by three bisbenzylisoquinolines in comparison with verapamil
    • Tian,H.,andPan,O.C. (1997).Modulation of multidrug resistance by three bisbenzylisoquinolines in comparison with verapamil. Zhongguo Yao Li XueBao 18,455-458.
    • (1997) Zhongguo Yao Li XueBao , vol.18 , pp. 455-458
    • Tian, H.1    Pan, O.C.2
  • 158
    • 77957221891 scopus 로고    scopus 로고
    • Interaction of drugs of abuse and maintenance treatments with human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2)
    • Tournier, N., Chevillard, L., Megarbane, B., Pirnay, S., Scherrmann, J. M., and Decleves, X. (2010). Interaction of drugs of abuse and maintenance treatments with human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2). Int. J. Neuropsychopharmacol. 13, 905-915.
    • (2010) Int. J. Neuropsychopharmacol. , vol.13 , pp. 905-915
    • Tournier, N.1    Chevillard, L.2    Megarbane, B.3    Pirnay, S.4    Scherrmann, J.M.5    Decleves, X.6
  • 160
    • 0026353317 scopus 로고
    • Resistance modification by PSC-833, a novel non-immunosuppressive cyclosporin
    • Twentyman, P. R., and Bleehen, N. M. (1991). Resistance modification by PSC-833, a novel non-immunosuppressive cyclosporin. Eur. J. Cancer 27, 1639-1642.
    • (1991) Eur. J. Cancer , vol.27 , pp. 1639-1642
    • Twentyman, P.R.1    Bleehen, N.M.2
  • 161
    • 0032605942 scopus 로고    scopus 로고
    • Multidrug resistance protein MRP1, glutathione, and related enzymes-their importance in acute myeloid leukemia
    • van der Kolk, D. M., Vellenga, E., Müller, M., and De Vries, E. G. E. (1999). Multidrug resistance protein MRP1, glutathione, and related enzymes-their importance in acute myeloid leukemia. Adv. Exp. Med. Biol. 457, 187-198.
    • (1999) Adv. Exp. Med. Biol. , vol.457 , pp. 187-198
    • van der Kolk, D.M.1    Vellenga, E.2    Müller, M.3    De Vries, E.G.E.4
  • 162
    • 0037029699 scopus 로고    scopus 로고
    • Cytotoxicity of rhein, the active metabolite of sennoside laxatives, is reduced by multidrug resistance-associated protein 1
    • van Gorkom, B. A., Timmer-Bosscha, H., de Jong, S., van der Kolk, D. M., Kleibeuker, J. H., and de Vries, E. G. (2002). Cytotoxicity of rhein, the active metabolite of sennoside laxatives, is reduced by multidrug resistance-associated protein 1. Br. J. Cancer 86, 1494-1500.
    • (2002) Br. J. Cancer , vol.86 , pp. 1494-1500
    • van Gorkom, B.A.1    Timmer-Bosscha, H.2    de Jong, S.3    van der Kolk, D.M.4    Kleibeuker, J.H.5    de Vries, E.G.6
  • 163
    • 0028136603 scopus 로고
    • Competitive inhibition by genistein and ATP dependence of daunorubicin transport in intact MRP overexpressing human small cell lung cancer cells
    • Versantvoort, C. H., Broxterman, H. J., Lankelma, J., Feller, N., and Pinedo, H. M. (1994). Competitive inhibition by genistein and ATP dependence of daunorubicin transport in intact MRP overexpressing human small cell lung cancer cells. Biochem. Pharmacol. 48, 1129-1136.
    • (1994) Biochem. Pharmacol. , vol.48 , pp. 1129-1136
    • Versantvoort, C.H.1    Broxterman, H.J.2    Lankelma, J.3    Feller, N.4    Pinedo, H.M.5
  • 164
    • 0030469817 scopus 로고    scopus 로고
    • Acceleration of MRP-associated efflux of rhodamine 123 by genistein and related compounds
    • Versantvoort, C. H., Rhodes, T., and Twentyman, P. R. (1996). Acceleration of MRP-associated efflux of rhodamine 123 by genistein and related compounds. Br. J. Cancer 74, 1949-1954.
    • (1996) Br. J. Cancer , vol.74 , pp. 1949-1954
    • Versantvoort, C.H.1    Rhodes, T.2    Twentyman, P.R.3
  • 165
    • 26444507869 scopus 로고    scopus 로고
    • Reversal of P-glycoprotein-dependent resistance to vinblastine by newly synthesized bisbenzylisoquinoline alkaloids in mouse leukemia P388 cells
    • Wang, F. P., Wang, L., Yang, J. S., Nomura, M., and Miyamoto, K. (2005). Reversal of P-glycoprotein-dependent resistance to vinblastine by newly synthesized bisbenzylisoquinoline alkaloids in mouse leukemia P388 cells. Biol. Pharm. Bull. 28, 1979-1982.
    • (2005) Biol. Pharm. Bull. , vol.28 , pp. 1979-1982
    • Wang, F.P.1    Wang, L.2    Yang, J.S.3    Nomura, M.4    Miyamoto, K.5
  • 167
    • 0028941366 scopus 로고
    • Comparative study on reversal efficacy of SDZ PSC 833 cyclosporin A and verapamil on multidrug resistance in vitro and in vivo
    • Watanabe, T., Tsuge, H., Oh-Hara, T., Naito, M., and Tsuruo, T. (1995). Comparative study on reversal efficacy of SDZ PSC 833, cyclosporin A and verapamil on multidrug resistance in vitro and in vivo. Acta Oncol 34,235-241.
    • (1995) Acta Oncol , vol.34 , pp. 235-241
    • Watanabe, T.1    Tsuge, H.2    Oh-Hara, T.3    Naito, M.4    Tsuruo, T.5
  • 168
    • 33746374708 scopus 로고    scopus 로고
    • Sanguinarine overcomes P-glycoprotein-mediated multidrug-resistance via induction of apoptosis and oncosis in CEM-VLB 1000 cells
    • Weerasinghe, P., Hallock, S., Tang, S. C., Trump, B., and Liepins, A. (2006). Sanguinarine overcomes P-glycoprotein-mediated multidrug-resistance via induction of apoptosis and oncosis in CEM-VLB 1000 cells. Exp. Toxicol. Pathol. 58, 21-30.
    • (2006) Exp. Toxicol. Pathol. , vol.58 , pp. 21-30
    • Weerasinghe, P.1    Hallock, S.2    Tang, S.C.3    Trump, B.4    Liepins, A.5
  • 169
    • 0037298323 scopus 로고    scopus 로고
    • Quantification of doxorubicin and validation of reversal effect of tea polyphenols on multidrug resistance in human carcinoma cells
    • Wei, D., Mei, Y., and Liu, J. (2003). Quantification of doxorubicin and validation of reversal effect of tea polyphenols on multidrug resistance in human carcinoma cells. Biotechnol. Lett. 25,291-294.
    • (2003) Biotechnol. Lett. , vol.25 , pp. 291-294
    • Wei, D.1    Mei, Y.2    Liu, J.3
  • 171
    • 37549037789 scopus 로고    scopus 로고
    • Inhibition of MRP1 transport activity by phenolic and terpenic compounds isolated from Euphorbia species
    • Wesolowska, O., Wisniewski, J., Duarte, N., Ferreira, M. J., and Michalak, K. (2007). Inhibition of MRP1 transport activity by phenolic and terpenic compounds isolated from Euphorbia species. Anticancer Res. 27,4127-4133.
    • (2007) Anticancer Res , vol.27 , pp. 4127-4133
    • Wesolowska, O.1    Wisniewski, J.2    Duarte, N.3    Ferreira, M.J.4    Michalak, K.5
  • 173
    • 34250104703 scopus 로고
    • Plant breeding: importance of plant secondary metabolites for protection against pathogens and herbivores
    • Wink, M. (1988). Plant breeding: importance of plant secondary metabolites for protection against pathogens and herbivores. Theor. Appl. Genet. 75, 225-233.
    • (1988) Theor. Appl. Genet. , vol.75 , pp. 225-233
    • Wink, M.1
  • 174
    • 77957084883 scopus 로고
    • Allelochemical properties and the raison d'être of alkaloids
    • Wink, M. (1993). Allelochemical properties and the raison d'être of alkaloids. Alkaloids Chem. Biol. 43, 1-118.
    • (1993) Alkaloids Chem. Biol. , vol.43 , pp. 1-118
    • Wink, M.1
  • 175
    • 77957131858 scopus 로고    scopus 로고
    • Interference of alkaloids with neuroreceptors and ion channels
    • Wink, M. (2000). Interference of alkaloids with neuroreceptors and ion channels. Nat. Prod. Res. 21, 3-129.
    • (2000) Nat. Prod. Res. , vol.21 , pp. 3-129
    • Wink, M.1
  • 176
    • 0042823585 scopus 로고    scopus 로고
    • Evolution of secondary metabolites from an ecological and molecular phylogenetic perspective
    • Wink, M. (2003). Evolution of secondary metabolites from an ecological and molecular phylogenetic perspective. Phytochemistry 64, 3-19.
    • (2003) Phytochemistry , vol.64 , pp. 3-19
    • Wink, M.1
  • 177
    • 36049040984 scopus 로고    scopus 로고
    • Molecular modes of action of cytotoxic alkaloids-from DNA intercalation, spindle poisoning, topoisomerase inhibition to apoptosis and multiple drug resistance
    • Wink, M. (2007). Molecular modes of action of cytotoxic alkaloids-from DNA intercalation, spindle poisoning, topoisomerase inhibition to apoptosis and multiple drug resistance. Alkaloids Chem. Biol. 64,1-48.
    • (2007) Alkaloids Chem. Biol. , vol.64 , pp. 1-48
    • Wink, M.1
  • 178
    • 57649151841 scopus 로고    scopus 로고
    • Plant secondary metabolism: diversity, function and its evolution
    • Wink, M. (2008a). Plant secondary metabolism: diversity, function and its evolution. Nat. Prod. Commun. 3, 1205-1216.
    • (2008) Nat. Prod. Commun. , vol.3 , pp. 1205-1216
    • Wink, M.1
  • 179
    • 62749198712 scopus 로고    scopus 로고
    • Evolutionary advantage and molecular modes of action of multi-component mixtures used in phytomedicine
    • Wink, M. (2008b). Evolutionary advantage and molecular modes of action of multi-component mixtures used in phytomedicine. Curr. DrugMetab. 9, 996-1009.
    • (2008) Curr. DrugMetab. , vol.9 , pp. 996-1009
    • Wink, M.1
  • 182
    • 84948947576 scopus 로고    scopus 로고
    • Molecular modes of action of defensive secondary metabolites
    • ed. M. Wink (Chichester: Wiley-Blackwell)
    • Wink, M., and Schimmer, O. (2010). 'Molecular modes of action of defensive secondary metabolites,' in Functions and Biotechnology of Plant Secondary Metabolites,Vol. 39, ed. M. Wink (Chichester: Wiley-Blackwell), 21-161.
    • (2010) Functions and Biotechnology of Plant Secondary Metabolites , vol.39 , pp. 21-161
    • Wink, M.1    Schimmer, O.2
  • 183
    • 32844461208 scopus 로고    scopus 로고
    • Combination of tetrandrine as a potential-reversing agent with daunorubicin, etoposide and cytarabine for the treatment of refractory and relapsed acute myelogenous leukemia
    • Xu, W L.,Shen, H. L., Ao,Z. F., Chen, B. A., Xia, W., Gao, F., and Zhang, Y. N. (2006). Combination of tetrandrine as a potential-reversing agent with daunorubicin, etoposide and cytarabine for the treatment of refractory and relapsed acute myelogenous leukemia. Leuk. Res. 30,407-413.
    • (2006) Leuk. Res. , vol.30 , pp. 407-413
    • Xu, W.L.1    Shen, H.L.2    Ao, Z.F.3    Chen, B.A.4    Xia, W.5    Gao, F.6    Zhang, Y.N.7
  • 185
    • 67449085431 scopus 로고    scopus 로고
    • Reversal effect and its mechanism of ampelopsin on multidrug resistance in K562/ADR cells
    • Ye, J., Zheng, Y., and Liu, D. (2009). Reversal effect and its mechanism of ampelopsin on multidrug resistance in K562/ADR cells. Zhongguo Zhong YaoZaZhi 34,761-765.
    • (2009) Zhongguo Zhong YaoZaZhi , vol.34 , pp. 761-765
    • Ye, J.1    Zheng, Y.2    Liu, D.3
  • 186
    • 34848835701 scopus 로고    scopus 로고
    • Effects of diosmin, a flavonoid glycoside in citrus fruits, on P-glycoprotein-mediated drug efflux in human intestinal Caco-2 cells
    • Yoo, H. H., Lee, M., Chung, H. J., Lee, S. K., and Kim, D.-H. (2007). Effects of diosmin, a flavonoid glycoside in citrus fruits, on P-glycoprotein-mediated drug efflux in human intestinal Caco-2 cells. J. Agric. Food Chem. 55, 7620-7625.
    • (2007) J. Agric. Food Chem. , vol.55 , pp. 7620-7625
    • Yoo, H.H.1    Lee, M.2    Chung, H.J.3    Lee, S.K.4    Kim, D.-H.5
  • 187
    • 27744472381 scopus 로고    scopus 로고
    • Inhibition of P-glycoprotein-mediated transport by extracts of and monoterpenoids contained in Zanthoxyli fructus
    • Yoshida, N., Takagi, A., Kitazawa, H., Kawakami, J., and Adachi, I. (2005). Inhibition of P-glycoprotein-mediated transport by extracts of and monoterpenoids contained in Zanthoxyli fructus. Toxicol. Appl. Pharmacol. 209, 167-173.
    • (2005) Toxicol. Appl. Pharmacol. , vol.209 , pp. 167-173
    • Yoshida, N.1    Takagi, A.2    Kitazawa, H.3    Kawakami, J.4    Adachi, I.5
  • 189
    • 0028579676 scopus 로고
    • Indole alkaloids from Peschiera laeta that enhance vinblastine-mediated cytotoxicity with multidrug-resistant cells
    • You, M., Ma, X., Mukherjee, R., Farnsworth, N. R., Cordell, G. A., Kinghorn, A. D., and Pezzuto, J. M. (1994). Indole alkaloids from Peschiera laeta that enhance vinblastine-mediated cytotoxicity with multidrug-resistant cells. J. Nat. Prod. 57, 1517-1522.
    • (1994) J. Nat. Prod. , vol.57 , pp. 1517-1522
    • You, M.1    Ma, X.2    Mukherjee, R.3    Farnsworth, N.R.4    Cordell, G.A.5    Kinghorn, A.D.6    Pezzuto, J.M.7
  • 191
    • 0023898749 scopus 로고
    • Physical-chemical properties shared by compounds that modulate multidrug resistance in human leukemic cells
    • Zamora, J. M., Pearce, H. L., and Beck, W T. (1988). Physical-chemical properties shared by compounds that modulate multidrug resistance in human leukemic cells. Mol. Pharmacol. 33, 454-462.
    • (1988) Mol. Pharmacol. , vol.33 , pp. 454-462
    • Zamora, J.M.1    Pearce, H.L.2    Beck, W.T.3
  • 192
    • 0037371275 scopus 로고    scopus 로고
    • Effects of the flavonoids biochanin A, morin, phloretin, and silymarin on P-glycoprotein-mediated transport
    • Zhang, S., and Morris, M. E. (2003). Effects of the flavonoids biochanin A, morin, phloretin, and silymarin on P-glycoprotein-mediated transport. J. Pharmacol. Exp. Ther. 304, 1258-1267.
    • (2003) J. Pharmacol. Exp. Ther. , vol.304 , pp. 1258-1267
    • Zhang, S.1    Morris, M.E.2
  • 193
    • 2142711101 scopus 로고    scopus 로고
    • Flavonoids are inhibitors of breast cancer resistance protein (ABCG2)-mediated transport
    • Zhang, S., Yang, X., and Morris, M. E. (2004). Flavonoids are inhibitors of breast cancer resistance protein (ABCG2)-mediated transport. Mol. Pharmacol. 65, 1208-1216.
    • (2004) Mol. Pharmacol. , vol.65 , pp. 1208-1216
    • Zhang, S.1    Yang, X.2    Morris, M.E.3
  • 195
    • 0029622340 scopus 로고
    • Homoharringtonine, an effective new natural product in cancer chemotherapy
    • Zhou, D. C., Zittoun, R., and Marie, J. P. (1995). Homoharringtonine, an effective new natural product in cancer chemotherapy. Bull. Cancer 82, 987-995.
    • (1995) Bull. Cancer , vol.82 , pp. 987-995
    • Zhou, D.C.1    Zittoun, R.2    Marie, J.P.3
  • 196
    • 1642360726 scopus 로고    scopus 로고
    • Herbal modulation of P-glycoprotein
    • Zhou, S., Lim, L. Y., and Chowbay, B. (2004). Herbal modulation of P-glycoprotein. Drug Metab. Rev. 36, 57-104.
    • (2004) Drug Metab. Rev. , vol.36 , pp. 57-104
    • Zhou, S.1    Lim, L.Y.2    Chowbay, B.3
  • 197
    • 0034892126 scopus 로고    scopus 로고
    • Study of tea polyphenol as a reversal agent for carcinoma cell lines' multidrug resistance (study of TP as a MDR reversal agent)
    • Zhu, A., Wang, X., and Guo, Z. (2001). Study of tea polyphenol as a reversal agent for carcinoma cell lines' multidrug resistance (study of TP as a MDR reversal agent). Nucl. Med. Biol. 28, 735-740.
    • (2001) Nucl. Med. Biol. , vol.28 , pp. 735-740
    • Zhu, A.1    Wang, X.2    Guo, Z.3
  • 198
    • 21344445915 scopus 로고    scopus 로고
    • In vitro and in vivo characterizations of tetrandrine on the reversal of P-glycoprotein-mediated drug resistance to paclitaxel
    • Zhu, X., Sui, M., and Fan, W (2005). In vitro and in vivo characterizations of tetrandrine on the reversal of P-glycoprotein-mediated drug resistance to paclitaxel. Anticancer Res. 25,1953-1962.
    • (2005) Anticancer Res , vol.25 , pp. 1953-1962
    • Zhu, X.1    Sui, M.2    Fan, W.3
  • 199
    • 63049131969 scopus 로고    scopus 로고
    • Antitumor activity of alkaloids derived from Amaryllidaceae species
    • Zupko, I., Rethy, B., Hohmann, J., Molnar, J., Ocsovszki, I., and Falkay, G. (2009). Antitumor activity of alkaloids derived from Amaryllidaceae species. In vivo 23, 41-48.
    • (2009) In vivo , vol.23 , pp. 41-48
    • Zupko, I.1    Rethy, B.2    Hohmann, J.3    Molnar, J.4    Ocsovszki, I.5    Falkay, G.6


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