메뉴 건너뛰기




Volumn 192, Issue 7, 1996, Pages 768-780

Molecular mechanisms of multidrug resistance in cancer chemotherapy

Author keywords

Circumvention of MDR; Clinical relevance; Multidrug resistance (MDR); Multidrug resistance gene (MDR1); Multidrug resistance associated protein (MRP); P glycoprotein (Pgp)

Indexed keywords

CARRIER PROTEIN; GLYCOPROTEIN; GLYCOPROTEIN P;

EID: 0029759985     PISSN: 03440338     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0344-0338(96)80099-9     Document Type: Article
Times cited : (194)

References (141)
  • 1
    • 0028025021 scopus 로고
    • Analysis of multidrug resistance-associated protein (MRP) messenger RNA in normal and malignant hematopoietic cells
    • Abbaszadegan MR, Futscher BW, Klimecki WT, List A, Dalton WS (1994) Analysis of multidrug resistance-associated protein (MRP) messenger RNA in normal and malignant hematopoietic cells. Cancer Res 54: 4676-4679
    • (1994) Cancer Res , vol.54 , pp. 4676-4679
    • Abbaszadegan, M.R.1    Futscher, B.W.2    Klimecki, W.T.3    List, A.4    Dalton, W.S.5
  • 2
    • 0023836456 scopus 로고
    • Most drugs that reverse multidrug resistance also inhibit photoaffinity labeling of P-glycoprotein by a vinblastine analog
    • Akiyama S, Cornwall MM, Kuwano M, Pastan I, Gottesman MM (1988) Most drugs that reverse multidrug resistance also inhibit photoaffinity labeling of P-glycoprotein by a vinblastine analog. Mol Pharmacol 33: 144-147
    • (1988) Mol Pharmacol , vol.33 , pp. 144-147
    • Akiyama, S.1    Cornwall, M.M.2    Kuwano, M.3    Pastan, I.4    Gottesman, M.M.5
  • 4
    • 0026638255 scopus 로고
    • ATP-dependent bacterial transporters and cystic fibrosis: Analogy between channels and transproters
    • Ames GF, Lecar H (1992) ATP-dependent bacterial transporters and cystic fibrosis: analogy between channels and transproters. FASEB J 6: 2660-2666
    • (1992) FASEB J , vol.6 , pp. 2660-2666
    • Ames, G.F.1    Lecar, H.2
  • 5
    • 0024307162 scopus 로고
    • Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish to confer multidrug resistance
    • Azzaria M, Schurr E, Gros P (1989) Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish to confer multidrug resistance. Mol Cell Biol 9: 5289-5297
    • (1989) Mol Cell Biol , vol.9 , pp. 5289-5297
    • Azzaria, M.1    Schurr, E.2    Gros, P.3
  • 6
    • 0024996306 scopus 로고
    • Non-P-glycoprotein mediated mechanism for multidrug resistance precedes P-glycoprotein expression during in vitro selection for doxorubicin resistance in a human lung cancer celll line
    • Baas F, Jongsma APM, Broxterman HJ, Arceci RJ, Housman D, Scheffer GL, Riethorst A, van Groeningen M, Nieuwint AWM, Joenje H (1990) Non-P-glycoprotein mediated mechanism for multidrug resistance precedes P-glycoprotein expression during in vitro selection for doxorubicin resistance in a human lung cancer celll line. Cancer Res 50: 5392-5398
    • (1990) Cancer Res , vol.50 , pp. 5392-5398
    • Baas, F.1    Jongsma, A.P.M.2    Broxterman, H.J.3    Arceci, R.J.4    Housman, D.5    Scheffer, G.L.6    Riethorst, A.7    Van Groeningen, M.8    Nieuwint, A.W.M.9    Joenje, H.10
  • 7
    • 0027473114 scopus 로고
    • Chemosensitisation and drug accumulation effects of cyclosporin A, PSC-833 and verapamil in human MDR large cell lung cancer cells expressing a 190 k membrane protein distinct from P-glycoprotein
    • Barrand MA, Rhodes T, Center MS, Twentyman PR (1993) Chemosensitisation and drug accumulation effects of cyclosporin A, PSC-833 and verapamil in human MDR large cell lung cancer cells expressing a 190 k membrane protein distinct from P-glycoprotein. Eur J Cancer 29A-408-415
    • (1993) Eur J Cancer , vol.29 A , pp. 408-415
    • Barrand, M.A.1    Rhodes, T.2    Center, M.S.3    Twentyman, P.R.4
  • 8
    • 0028155964 scopus 로고
    • A 190-Kilodalton protein overexpressed in non-P-glycoprotein-containing multidrug-resistant cells and its relationship to the MRP gene
    • Barrand MA, Heppell-Parton AC, Wright KA, Rabbitts PH, Twentyman PR (1994) A 190-Kilodalton protein overexpressed in non-P-glycoprotein-containing multidrug-resistant cells and its relationship to the MRP gene. J Natl Cancer Inst 86: 110-117
    • (1994) J Natl Cancer Inst , vol.86 , pp. 110-117
    • Barrand, M.A.1    Heppell-Parton, A.C.2    Wright, K.A.3    Rabbitts, P.H.4    Twentyman, P.R.5
  • 9
    • 0028130233 scopus 로고
    • High mdr1-and mrp-, but low topoisomerase IIα-gene expression in B-cell chronic lymphocytic leukaemias
    • Beck J, Niethammer D, Gekeler V (1994) High mdr1-and mrp-, but low topoisomerase IIα-gene expression in B-cell chronic lymphocytic leukaemias. Cancer Lett 86: 135-142
    • (1994) Cancer Lett , vol.86 , pp. 135-142
    • Beck, J.1    Niethammer, D.2    Gekeler, V.3
  • 10
    • 0021952694 scopus 로고
    • Isolation and characterization of an anthracycline-resistant human leukemic cell line
    • Bhalla K, Hindenburg A, Taub RN, Grant S (1985) Isolation and characterization of an anthracycline-resistant human leukemic cell line. Cancer Res 45: 3657-3662
    • (1985) Cancer Res , vol.45 , pp. 3657-3662
    • Bhalla, K.1    Hindenburg, A.2    Taub, R.N.3    Grant, S.4
  • 11
    • 0028043795 scopus 로고
    • Expression of the multidrug resistance-associated protein (MRP) gene correlates with amplification and overexpression of the N-myc oncogene in childhood neuroblastoma
    • Bordow SB, Haber M, Madafiglio J, Cheung B, Marshall GM, Norris MD (1994) Expression of the multidrug resistance-associated protein (MRP) gene correlates with amplification and overexpression of the N-myc oncogene in childhood neuroblastoma. Cancer Res 54: 503-5040
    • (1994) Cancer Res , vol.54 , pp. 503-5040
    • Bordow, S.B.1    Haber, M.2    Madafiglio, J.3    Cheung, B.4    Marshall, G.M.5    Norris, M.D.6
  • 16
    • 0028151280 scopus 로고
    • High expression of the multidrug resistance-associated protein (MRP) in chronic and prolymphocytic leukemia
    • Burger H, Nooter K, Sonneveld P, van Wingerden KE, Zaman GJR, Stoter G (1994b) High expression of the multidrug resistance-associated protein (MRP) in chronic and prolymphocytic leukemia. Br J Haematol 88: 348-356
    • (1994) Br J Haematol , vol.88 , pp. 348-356
    • Burger, H.1    Nooter, K.2    Sonneveld, P.3    Van Wingerden, K.E.4    Zaman, G.J.R.5    Stoter, G.6
  • 17
    • 0028060570 scopus 로고
    • The inability of the mouse mdr1 gene to confer multidrug resistance is linked to reduced drug binding to the protein
    • Buschman E, Gros P (1994) The inability of the mouse mdr1 gene to confer multidrug resistance is linked to reduced drug binding to the protein. Cancer Res 54: 4892-4898
    • (1994) Cancer Res , vol.54 , pp. 4892-4898
    • Buschman, E.1    Gros, P.2
  • 18
    • 0025945313 scopus 로고
    • Heavy metal resistance: A new role for P-glycoproteins in Leishmania
    • Callahan HL, Beverley SM (1991) Heavy metal resistance: a new role for P-glycoproteins in Leishmania. J Biol Chem 266: 18427-18430
    • (1991) J Biol Chem , vol.266 , pp. 18427-18430
    • Callahan, H.L.1    Beverley, S.M.2
  • 19
  • 20
    • 0026602155 scopus 로고
    • Clinical significance of multidrug resistance P-glycoprotein expression on acute nonlymphoblastic leukemia cells at diagnosis
    • Campos L, Guyotat D, Archimbaud E, Calmard-Oriol P, Tsuruo T, Troncy J, Treille D, Fiere D (1992) Clinical significance of multidrug resistance P-glycoprotein expression on acute nonlymphoblastic leukemia cells at diagnosis. Blood 79: 473-476
    • (1992) Blood , vol.79 , pp. 473-476
    • Campos, L.1    Guyotat, D.2    Archimbaud, E.3    Calmard-Oriol, P.4    Tsuruo, T.5    Troncy, J.6    Treille, D.7    Fiere, D.8
  • 21
    • 0027746492 scopus 로고
    • Non-P-glycoprotein multidrug resistance in cell lines which are defective in the cellular accumulation of drug
    • Center MS (1993) Non-P-glycoprotein multidrug resistance in cell lines which are defective in the cellular accumulation of drug. Cytotechnology 12: 109-125
    • (1993) Cytotechnology , vol.12 , pp. 109-125
    • Center, M.S.1
  • 22
    • 0025231784 scopus 로고
    • Immunohistochemical detection of P-glycoprotein: Prognostic correlation in soft tissue sarcoma of childhood
    • Chan HSL, Thorner PS, Haddad G, Ling V (1990) Immunohistochemical detection of P-glycoprotein: prognostic correlation in soft tissue sarcoma of childhood. J Clin Oncol 8: 689-704
    • (1990) J Clin Oncol , vol.8 , pp. 689-704
    • Chan, H.S.L.1    Thorner, P.S.2    Haddad, G.3    Ling, V.4
  • 24
    • 0025799513 scopus 로고
    • Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells
    • Chaudhary PM, Roninson IB (1991) Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells. Cell 66: 85-94
    • (1991) Cell , vol.66 , pp. 85-94
    • Chaudhary, P.M.1    Roninson, I.B.2
  • 25
    • 0022972654 scopus 로고
    • Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells
    • Chen C, Chin JE, Ueda K, Clark DP, Pastan I, Gottesman MM, Roninson IB (1986) Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells. Cell 47: 381-389
    • (1986) Cell , vol.47 , pp. 381-389
    • Chen, C.1    Chin, J.E.2    Ueda, K.3    Clark, D.P.4    Pastan, I.5    Gottesman, M.M.6    Roninson, I.B.7
  • 26
    • 0028249115 scopus 로고
    • The MDR superfamily of genes and its biological implications
    • DeVita VT, Hellman S, Rosenberg SA (Eds.) Lippincott, Philadelphia
    • Childs S, Ling V (1994) The MDR superfamily of genes and its biological implications. In: DeVita VT, Hellman S, Rosenberg SA (Eds.) Important Advances in Oncology, pp. 21-36. Lippincott, Philadelphia
    • (1994) Important Advances in Oncology , pp. 21-36
    • Childs, S.1    Ling, V.2
  • 27
    • 0024414605 scopus 로고
    • Structure and expression of the human MDR (P-glycoprotein) gene family
    • Chin JE, Soffir R, Noonan KE, Choi, Roninson IB (1989) Structure and expression of the human MDR (P-glycoprotein) gene family. Mol Cell Biol 9: 3808-3820
    • (1989) Mol Cell Biol , vol.9 , pp. 3808-3820
    • Chin, J.E.1    Soffir, R.2    Noonan, K.E.3    Choi4    Roninson, I.B.5
  • 28
    • 0024292717 scopus 로고
    • An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr-1 (P-glycoprotein) gene
    • Choi K, Chen C, Kriegler M, Roninson IB (1988) An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr-1 (P-glycoprotein) gene. Cell 53: 520-529
    • (1988) Cell , vol.53 , pp. 520-529
    • Choi, K.1    Chen, C.2    Kriegler, M.3    Roninson, I.B.4
  • 29
    • 0025939987 scopus 로고
    • Non-P-glycoprotein-mediated multidrug resistance in a small lung cancer cell line: Evidence for decreased susceptibility to drug-induced DNA damage and reduced levels of topoisomerase II
    • Cole SPC, Chanda ER, Dicke FP, Gerlach JH, Mirski SEL (1991) Non-P-glycoprotein-mediated multidrug resistance in a small lung cancer cell line: evidence for decreased susceptibility to drug-induced DNA damage and reduced levels of topoisomerase II. Cancer Res 51: 3345-3352
    • (1991) Cancer Res , vol.51 , pp. 3345-3352
    • Cole, S.P.C.1    Chanda, E.R.2    Dicke, F.P.3    Gerlach, J.H.4    Mirski, S.E.L.5
  • 30
    • 0026524548 scopus 로고
    • The 1991 Merck Frosst award. Multidrug resistance in small cell lung cancer
    • Cole SPC (1992) The 1991 Merck Frosst award. Multidrug resistance in small cell lung cancer. Can J Physiol Pharmacol 70: 313-329
    • (1992) Can J Physiol Pharmacol , vol.70 , pp. 313-329
    • Cole, S.P.C.1
  • 35
    • 0027736317 scopus 로고
    • P-glycoprotein structure and evolutionary homologies
    • Croop JM (1993) P-glycoprotein structure and evolutionary homologies. Cytotechnology 13: 1-32
    • (1993) Cytotechnology , vol.13 , pp. 1-32
    • Croop, J.M.1
  • 37
    • 0029002544 scopus 로고
    • Drug resistance mechanisms and MRP expression in response to epirubicin treatment in a human leukaemia cell line
    • Davey RA, Longhurst TJ, Davey MW,I Belov L, Harvie RM, Hancox D, Wheeler H (1995) Drug resistance mechanisms and MRP expression in response to epirubicin treatment in a human leukaemia cell line. Leukemia Res 19: 275-282
    • (1995) Leukemia Res , vol.19 , pp. 275-282
    • Davey, R.A.1    Longhurst, T.J.2    Davey, M.W.3    I Belov, L.4    Harvie, R.M.5    Hancox, D.6    Wheeler, H.7
  • 38
    • 0026561813 scopus 로고
    • Identification of distinct P-glycoprotein gene sequences in rat
    • Deuchars KL, Duthie M, Ling V (81992) Identification of distinct P-glycoprotein gene sequences in rat. Biochim Biophys Acta 1130: 157-165
    • (1992) Biochim Biophys Acta , vol.1130 , pp. 157-165
    • Deuchars, K.L.1    Duthie, M.2    Ling, V.3
  • 39
    • 0025253133 scopus 로고
    • Two members of the mouse MDR gene family confer multidrug resistance with overlapping but distinct drug specificity
    • Devault A, Gros P (1990) Two members of the mouse MDR gene family confer multidrug resistance with overlapping but distinct drug specificity. Mol Cell Biol 10: 1652-1663
    • (1990) Mol Cell Biol , vol.10 , pp. 1652-1663
    • Devault, A.1    Gros, P.2
  • 40
    • 0026556302 scopus 로고
    • Amino acid substitutions in the sixth transmembrane domain of P-glycoprotein alter multidrug resistance
    • Devine SE, Ling V, Melera PW (1992) Amino acid substitutions in the sixth transmembrane domain of P-glycoprotein alter multidrug resistance. Proc Natl Acad Sci USA 89: 4564-4568
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 4564-4568
    • Devine, S.E.1    Ling, V.2    Melera, P.W.3
  • 41
    • 0026755153 scopus 로고
    • Functional analysis of chimeric proteins constructed by exchanging homologous domains of 2 P-glycoproteins conferring distinct drug resistance profiles
    • Dhir R, Gros P (1992) Functional analysis of chimeric proteins constructed by exchanging homologous domains of 2 P-glycoproteins conferring distinct drug resistance profiles. Biochemistry 31: 6103-6110
    • (1992) Biochemistry , vol.31 , pp. 6103-6110
    • Dhir, R.1    Gros, P.2
  • 42
    • 0026489452 scopus 로고
    • Subpopulations of normal peripheral blood and bone marrow cells express a functional multidrug resistant phenotype
    • Drach D, Zhao S, Drach J, Mahadevia R, Gattringer C, Huber H, Andreeff M (1992) Subpopulations of normal peripheral blood and bone marrow cells express a functional multidrug resistant phenotype. Blood 80: 2729-2734
    • (1992) Blood , vol.80 , pp. 2729-2734
    • Drach, D.1    Zhao, S.2    Drach, J.3    Mahadevia, R.4    Gattringer, C.5    Huber, H.6    Andreeff, M.7
  • 43
    • 0028000734 scopus 로고
    • Immunochemical detection of multidrug resistance-associated protein MRP in human multidrug-resistant tumor cells by monoclonal antibodies
    • Flens MJ, Izquierdo MA, Scheffer GL, Fritz JM, Meijer CJLM, Scheper RJ, Zaman GJR (1994) Immunochemical detection of multidrug resistance-associated protein MRP in human multidrug-resistant tumor cells by monoclonal antibodies. Cancer Res 54: 4557-4563
    • (1994) Cancer Res , vol.54 , pp. 4557-4563
    • Flens, M.J.1    Izquierdo, M.A.2    Scheffer, G.L.3    Fritz, J.M.4    Meijer, C.J.L.M.5    Scheper, R.J.6    Zaman, G.J.R.7
  • 44
    • 0024338609 scopus 로고
    • Amplification of the multidrug resistance gene in some chloroquine-resistant isolates of P. falciparum
    • Foote SJ, Thompson JK, Cowman AF, Kemp DJ (1989) Amplification of the multidrug resistance gene in some chloroquine-resistant isolates of P. falciparum. Cell 57: 921-930
    • (1989) Cell , vol.57 , pp. 921-930
    • Foote, S.J.1    Thompson, J.K.2    Cowman, A.F.3    Kemp, D.J.4
  • 45
    • 0027714411 scopus 로고
    • Pharmacological circumvention of multidrug resistance
    • Ford JM, Hait WN (1993) Pharmacological circumvention of multidrug resistance. Cytotechnology 12: 171-212
    • (1993) Cytotechnology , vol.12 , pp. 171-212
    • Ford, J.M.1    Hait, W.N.2
  • 46
    • 0024432823 scopus 로고
    • Identification of the multidrug resistance-related P-glycoprotein as a cyclosporine binding protein
    • Foxwell BMJ, Mackie A, Ling V, Ryffel B (1989) Identification of the multidrug resistance-related P-glycoprotein as a cyclosporine binding protein. Mol Pharmacol 36: 543-546
    • (1989) Mol Pharmacol , vol.36 , pp. 543-546
    • Foxwell, B.M.J.1    Mackie, A.2    Ling, V.3    Ryffel, B.4
  • 49
    • 0023019651 scopus 로고
    • Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug-resistance
    • Gerlach JH, Endicott JA, Juranka PF, Henderson G, Sarangi F, Deuchars KL, Ling V (1986) Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug-resistance. Nature 324: 485-489
    • (1986) Nature , vol.324 , pp. 485-489
    • Gerlach, J.H.1    Endicott, J.A.2    Juranka, P.F.3    Henderson, G.4    Sarangi, F.5    Deuchars, K.L.6    Ling, V.7
  • 50
    • 0027748455 scopus 로고
    • Molecular analysis of the multidrug transporter
    • Germann UA (1993) Molecular analysis of the multidrug transporter. Cytotechnology 12: 33-62
    • (1993) Cytotechnology , vol.12 , pp. 33-62
    • Germann, U.A.1
  • 51
    • 0027314191 scopus 로고
    • Expression of the multidrug resistance-associated P-glycoprotein (P-170) in 59 cases of de novo acute lymphoblastic leukemia prognostic implications
    • Goasguen JE, Dossot JM, Fardel O, Le Mee F, Le Gall E, Leblay R, Leprise PY, Chaperon J, Fauchet R (1993) Expression of the multidrug resistance-associated P-glycoprotein (P-170) in 59 cases of de novo acute lymphoblastic leukemia prognostic implications. Blood 81: 2394-2398
    • (1993) Blood , vol.81 , pp. 2394-2398
    • Goasguen, J.E.1    Dossot, J.M.2    Fardel, O.3    Le Mee, F.4    Le Gall, E.5    Leblay, R.6    Leprise, P.Y.7    Chaperon, J.8    Fauchet, R.9
  • 53
    • 0027218689 scopus 로고
    • Biochemistry of multidrug resistance mediated by the multidrug transporter
    • Gottesman MM, Pastan I (1993) Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu Rev Biochem 62: 385-427
    • (1993) Annu Rev Biochem , vol.62 , pp. 385-427
    • Gottesman, M.M.1    Pastan, I.2
  • 54
    • 0028054888 scopus 로고
    • Overexpression of multidrug resistance-associated protein (MRP) increases resistance to natural product drugs
    • Grant CE, Valdimarsson G, Hipfner DR, Almquist KC, Cole SPC, Deeley RG (1994) Overexpression of multidrug resistance-associated protein (MRP) increases resistance to natural product drugs. Cancer Res 54: 357-361
    • (1994) Cancer Res , vol.54 , pp. 357-361
    • Grant, C.E.1    Valdimarsson, G.2    Hipfner, D.R.3    Almquist, K.C.4    Cole, S.P.C.5    Deeley, R.G.6
  • 56
    • 0022993652 scopus 로고
    • Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins
    • Gros P, Croop J, Housman D (1986) Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins. Cell 47: 371-380
    • (1986) Cell , vol.47 , pp. 371-380
    • Gros, P.1    Croop, J.2    Housman, D.3
  • 57
    • 0024044158 scopus 로고
    • Cloning and characterization of a second member of the mouse mdr gene family
    • Gros P, Raymond M, Bell J, Housman D (1988) Cloning and characterization of a second member of the mouse mdr gene family. Mol Cell Biol 8: 2770-2778
    • (1988) Mol Cell Biol , vol.8 , pp. 2770-2778
    • Gros, P.1    Raymond, M.2    Bell, J.3    Housman, D.4
  • 58
    • 0025766958 scopus 로고
    • A single amino acid substitution strongly modulates the activity and substrate specificity of the mouse mdr1 and mdr3 drug efflux pumps
    • Gros P, Dhir R, Croop T, Talbot F (1991) A single amino acid substitution strongly modulates the activity and substrate specificity of the mouse mdr1 and mdr3 drug efflux pumps. Proc Natl Acad Sci USA 88: 7289-7293
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 7289-7293
    • Gros, P.1    Dhir, R.2    Croop, T.3    Talbot, F.4
  • 59
    • 0028906671 scopus 로고
    • Predictive value for treatment outcome in acute myeloid leukemia of cellular daunorubicin accumulation and P-glycoprotein expression simultaneously determined by flow cytometry
    • Guerci A, Merlin JL, Missoum N, Feldmann L, Marchal S, Witz F, Rose C, Guerci O (1995) Predictive value for treatment outcome in acute myeloid leukemia of cellular daunorubicin accumulation and P-glycoprotein expression simultaneously determined by flow cytometry. Blood 85: 2147-2153
    • (1995) Blood , vol.85 , pp. 2147-2153
    • Guerci, A.1    Merlin, J.L.2    Missoum, N.3    Feldmann, L.4    Marchal, S.5    Witz, F.6    Rose, C.7    Guerci, O.8
  • 60
    • 0023813001 scopus 로고
    • Characterization of the ATPase activity of the Mr 170,000 to 180,000 membrane glycoprotein (P-glycoprotein) associated with multidrug resistance in K562/ADM cells
    • Hamada H, Tsuruo T (1988) Characterization of the ATPase activity of the Mr 170,000 to 180,000 membrane glycoprotein (P-glycoprotein) associated with multidrug resistance in K562/ADM cells. Cancer Res 48: 4926-4932
    • (1988) Cancer Res , vol.48 , pp. 4926-4932
    • Hamada, H.1    Tsuruo, T.2
  • 61
    • 0025341341 scopus 로고
    • Expression of mdr1 and mdr3 multidrug-resistance genes in human acute and chronic leukemias and association with stimulation of drug accumulation by cyclosporine
    • Herweijer H, Sonneveld P, Baas F, Nooter K (1990) Expression of mdr1 and mdr3 multidrug-resistance genes in human acute and chronic leukemias and association with stimulation of drug accumulation by cyclosporine. J Natl Cancer Inst 82: 1133-1140
    • (1990) J Natl Cancer Inst , vol.82 , pp. 1133-1140
    • Herweijer, H.1    Sonneveld, P.2    Baas, F.3    Nooter, K.4
  • 62
    • 0026621245 scopus 로고
    • ABC transporters from microorganisms to man
    • Higgins CF (1992) ABC transporters from microorganisms to man. Annu Rev Cell Biol 8: 67-113
    • (1992) Annu Rev Cell Biol , vol.8 , pp. 67-113
    • Higgins, C.F.1
  • 63
    • 0027726020 scopus 로고
    • Differing patterns of cross-resistance resulting from exposure to specific antitumor drugs or to radiation in vitro
    • Hill BT (1993) Differing patterns of cross-resistance resulting from exposure to specific antitumor drugs or to radiation in vitro. Cytotechnology 12: 265-288
    • (1993) Cytotechnology , vol.12 , pp. 265-288
    • Hill, B.T.1
  • 64
    • 0028171453 scopus 로고
    • Detection of the Mr 190,000 multidrug resistance protein, MRP, with monoclonal antibodies
    • Hipfner DR, Gauldie SD, Deeley RG, Cole SPC (1994) Detection of the Mr 190,000 multidrug resistance protein, MRP, with monoclonal antibodies. Cancer Res 54: 5788-5792
    • (1994) Cancer Res , vol.54 , pp. 5788-5792
    • Hipfner, D.R.1    Gauldie, S.D.2    Deeley, R.G.3    Cole, S.P.C.4
  • 65
    • 0027767437 scopus 로고
    • Topoisomerase II in multiple drug resistance
    • Hofmann GA, Mattern MR (1993) Topoisomerase II in multiple drug resistance. Cytotechnology 12: 137-154
    • (1993) Cytotechnology , vol.12 , pp. 137-154
    • Hofmann, G.A.1    Mattern, M.R.2
  • 66
    • 0025300891 scopus 로고
    • Glutathione-s-transferase pi expression in leukemia: A comparative analysis with mdr1 data
    • Holmes J, Wareing C, Jacobs A, Hayes JD, Padua RA, Wolf CR (1990) Glutathione-s-transferase pi expression in leukemia: a comparative analysis with mdr1 data. Br J Cancer 62: 209-212
    • (1990) Br J Cancer , vol.62 , pp. 209-212
    • Holmes, J.1    Wareing, C.2    Jacobs, A.3    Hayes, J.D.4    Padua, R.A.5    Wolf, C.R.6
  • 67
    • 0007630205 scopus 로고
    • ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells
    • Horio M, Gottesman MM, Pastan I (1988) ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells. Proc Natl Acad Sci USA 85: 3580-3584
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 3580-3584
    • Horio, M.1    Gottesman, M.M.2    Pastan, I.3
  • 68
    • 0024344261 scopus 로고
    • Differential overexpression of three mdr gene family members in multidrug-resistant J774.2 mouse cells
    • Hsu SI, Lothstein L, Horwitz SB (1989) Differential overexpression of three mdr gene family members in multidrug-resistant J774.2 mouse cells. J Biol Chem 264: 12053-12062
    • (1989) J Biol Chem , vol.264 , pp. 12053-12062
    • Hsu, S.I.1    Lothstein, L.2    Horwitz, S.B.3
  • 69
    • 0027533571 scopus 로고
    • Restoration of taxol sensitivity of multidrug-resistant cells by the cyclosporine SDZ PSC 833 and the cyclopeptolide SDZ 280-446
    • Jachez B, Nordmann R, Loor F (1993) Restoration of taxol sensitivity of multidrug-resistant cells by the cyclosporine SDZ PSC 833 and the cyclopeptolide SDZ 280-446. J Natl Cancer Inst 85: 478-483
    • (1993) J Natl Cancer Inst , vol.85 , pp. 478-483
    • Jachez, B.1    Nordmann, R.2    Loor, F.3
  • 70
    • 0028001416 scopus 로고
    • ATP-dependent transport of glutathione S-conjugates by the multidrug resistance-associated protein
    • Jedlitschky G, Leier I, Buchholz U, Center M, Keppler D (1994) ATP-dependent transport of glutathione S-conjugates by the multidrug resistance-associated protein. Cancer Res 54: 4833-4836
    • (1994) Cancer Res , vol.54 , pp. 4833-4836
    • Jedlitschky, G.1    Leier, I.2    Buchholz, U.3    Center, M.4    Keppler, D.5
  • 71
    • 0025305449 scopus 로고
    • Glutathione S-transferase activity, sulfhydryl group and glutathione levels, and DNA cross-linking activity with chlorambucil in chronic lymphocytic leukemia
    • Johnston JB, Israels LG, Goldenberg GJ, Anhalt CD, Verburg L, Mowat MR A, Begleiter A (1990) Glutathione S-transferase activity, sulfhydryl group and glutathione levels, and DNA cross-linking activity with chlorambucil in chronic lymphocytic leukemia. J Natl Cancer Inst 82: 776-779
    • (1990) J Natl Cancer Inst , vol.82 , pp. 776-779
    • Johnston, J.B.1    Israels, L.G.2    Goldenberg, G.J.3    Anhalt, C.D.4    Verburg, L.5    Mowat, M.R.A.6    Begleiter, A.7
  • 72
    • 33645830172 scopus 로고
    • A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants
    • Juliano RL, Ling V (1976) A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. Biochim Biophys Acta 455: 152-162
    • (1976) Biochim Biophys Acta , vol.455 , pp. 152-162
    • Juliano, R.L.1    Ling, V.2
  • 73
    • 0024779132 scopus 로고
    • P-glycoprotein: Multidrug resistance and a family of membrane-associated transport proteins
    • Juranka PF, Zastawny RL, Ling V (1989) P-glycoprotein: multidrug resistance and a family of membrane-associated transport proteins. FASEB J 3: 2583-2592
    • (1989) FASEB J , vol.3 , pp. 2583-2592
    • Juranka, P.F.1    Zastawny, R.L.2    Ling, V.3
  • 75
    • 0026611746 scopus 로고
    • Pharmacologic interactions between the resistance-modifying cyclosporine SDZ PSC 833 and etoposide (VP 16-213) enhance m vivo cytostatic activity and toxicity
    • Keller RP, Altermatt HJ, Donatsch P, Zihlmann H, Laissue JA, Hiestand PC {1992) Pharmacologic interactions between the resistance-modifying cyclosporine SDZ PSC 833 and etoposide (VP 16-213) enhance m vivo cytostatic activity and toxicity. Int J Cancer 51: 433-438
    • (1992) Int J Cancer , vol.51 , pp. 433-438
    • Keller, R.P.1    Altermatt, H.J.2    Donatsch, P.3    Zihlmann, H.4    Laissue, J.A.5    Hiestand, P.C.6
  • 76
    • 0027249710 scopus 로고
    • The MRP gene associated with a non-P-glycoprotein multidrug resistance encodes a 190-kDa membrane bound glycoprotein
    • Krishnamachary N, Center MS (1993) The MRP gene associated with a non-P-glycoprotein multidrug resistance encodes a 190-kDa membrane bound glycoprotein. Cancer Res 53: 3658-3661
    • (1993) Cancer Res , vol.53 , pp. 3658-3661
    • Krishnamachary, N.1    Center, M.S.2
  • 77
    • 0028268620 scopus 로고
    • Expression complementary DNA library transfer establishes mrp as a multidrug resistance gene
    • Kruh GD, Chan A, Myers K, Gaughan K, Miki A, Aaronson SA (1994) Expression complementary DNA library transfer establishes mrp as a multidrug resistance gene. Cancer Res 54: 1649-1652
    • (1994) Cancer Res , vol.54 , pp. 1649-1652
    • Kruh, G.D.1    Chan, A.2    Myers, K.3    Gaughan, K.4    Miki, A.5    Aaronson, S.A.6
  • 81
    • 0024316466 scopus 로고
    • DNA topoisomerase poisons as antitumor drugs
    • Liu LF (1989) DNA topoisomerase poisons as antitumor drugs. Annu Rev Biochem 58: 351-357
    • (1989) Annu Rev Biochem , vol.58 , pp. 351-357
    • Liu, L.F.1
  • 83
    • 0025914062 scopus 로고
    • Multidrug resistance (mdr1) gene expression in adult acute leukemias: Correlations with treatment outcome and in vitro drug sensitivity
    • Marie JP, Zittoun R, Sikic BI (1991) Multidrug resistance (mdr1) gene expression in adult acute leukemias: correlations with treatment outcome and in vitro drug sensitivity. Blood 78: 58-592
    • (1991) Blood , vol.78 , pp. 58-592
    • Marie, J.P.1    Zittoun, R.2    Sikic, B.I.3
  • 85
    • 0026749955 scopus 로고
    • Drug transport mechanisms in HL60 cells isolated for resistance to adriamycin: Evidence for nuclear drug accumulation and redistribution in resistant cells
    • Marquardt D, Center MS (1992) Drug transport mechanisms in HL60 cells isolated for resistance to adriamycin: evidence for nuclear drug accumulation and redistribution in resistant cells. Cancer Res 52: 315-3163
    • (1992) Cancer Res , vol.52 , pp. 315-3163
    • Marquardt, D.1    Center, M.S.2
  • 86
    • 0024375860 scopus 로고
    • The yeast STE6 gene encodes a homologue of the mammalian multidrug resistance P-glycoprotein
    • McGrath JP, Varshavsky A (1989) The yeast STE6 gene encodes a homologue of the mammalian multidrug resistance P-glycoprotein. Nature 340: 400-404
    • (1989) Nature , vol.340 , pp. 400-404
    • McGrath, J.P.1    Varshavsky, A.2
  • 87
    • 0027165237 scopus 로고
    • Topoisomerase II expression in normal haemopoietic cells and chronic lymphocytic leukaemia: Drug sensitivity or resistance
    • McKenna SL, Whittaker JA, Padua RA, Holmes JA (1993) Topoisomerase II expression in normal haemopoietic cells and chronic lymphocytic leukaemia: drug sensitivity or resistance. Leukemia 7: 1199-1203
    • (1993) Leukemia , vol.7 , pp. 1199-1203
    • McKenna, S.L.1    Whittaker, J.A.2    Padua, R.A.3    Holmes, J.A.4
  • 88
    • 0026051296 scopus 로고
    • P-glycoprotein expression in malignant lymphoma and reversal of clinical drug resistance with chemotherapy plus high-dose verapamil
    • Miller TP, Grogan TM, Dalton WS, Spier CM, Scheper RJ, Salmon SE (1991 ) P-glycoprotein expression in malignant lymphoma and reversal of clinical drug resistance with chemotherapy plus high-dose verapamil. J Clin Oncol 9: 17-24
    • (1991) J Clin Oncol , vol.9 , pp. 17-24
    • Miller, T.P.1    Grogan, T.M.2    Dalton, W.S.3    Spier, C.M.4    Scheper, R.J.5    Salmon, S.E.6
  • 89
    • 0023278796 scopus 로고
    • Multidrug resistance in a human small cell lung cancer cell line selected in Adriamycin
    • Mirski SEL, Gerlach JH, Cole SPC (1987) Multidrug resistance in a human small cell lung cancer cell line selected in Adriamycin. Cancer Res 47: 2594-2598
    • (1987) Cancer Res , vol.47 , pp. 2594-2598
    • Mirski, S.E.L.1    Gerlach, J.H.2    Cole, S.P.C.3
  • 90
    • 0028578004 scopus 로고
    • Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione 5-conjugate transport
    • Müller M, Meijer C, Zaman GJR, Borst P, Scheper RJ, Mulder NH, de Vries EGE, Jansen PLM (1994) Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione 5-conjugate transport. Proc Natl Acad Sci USA 91: 13033-13037
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 13033-13037
    • Müller, M.1    Meijer, C.2    Zaman, G.J.R.3    Borst, P.4    Scheper, R.J.5    Mulder, N.H.6    De Vries, E.G.E.7    Jansen, P.L.M.8
  • 91
    • 0026683638 scopus 로고
    • P-glycoprotein as multidrug transporter: A critical review of current multidrug resistant cell lines
    • Nielsen D, Skovsgaard T (1992) P-glycoprotein as multidrug transporter: a critical review of current multidrug resistant cell lines. Biochem Biophys acta 1139: 169-183
    • (1992) Biochem Biophys Acta , vol.1139 , pp. 169-183
    • Nielsen, D.1    Skovsgaard, T.2
  • 93
    • 0024536103 scopus 로고
    • Effect of cyclosporin a on daunorubicin accumulation in multidrug-resistant P388 leukemia cells measured by real-time flow cytometry
    • Nooter K, Oostrum R, Jonker R, van Dekken H, Stokdijk W, van den Engh G (1989) Effect of cyclosporin a on daunorubicin accumulation in multidrug-resistant P388 leukemia cells measured by real-time flow cytometry. Cancer Chemother Pharmacol 23: 296-300
    • (1989) Cancer Chemother Pharmacol , vol.23 , pp. 296-300
    • Nooter, K.1    Oostrum, R.2    Jonker, R.3    Van Dekken, H.4    Stokdijk, W.5    Van den Engh, G.6
  • 94
    • 0025828251 scopus 로고
    • Multidrug resistance (mdr) genes in human cancer
    • Nooter K, Herweijer H (1991) Multidrug resistance (mdr) genes in human cancer. Br J Cancer 63: 663 -669
    • (1991) Br J Cancer , vol.63 , pp. 663-669
    • Nooter, K.1    Herweijer, H.2
  • 95
    • 0027744961 scopus 로고
    • Multidrug resistance (MDR) genes in hematological malignancies
    • Nooter K, Sonneveld P (1993) Multidrug resistance (MDR) genes in hematological malignancies. Cytotechnology 12: 213-230
    • (1993) Cytotechnology , vol.12 , pp. 213-230
    • Nooter, K.1    Sonneveld, P.2
  • 96
    • 0028269030 scopus 로고
    • Clinical relevance of P-glycoprotein expression in hematological malignancies
    • Nooter K, Sonneveld P (1994) Clinical relevance of P-glycoprotein expression in hematological malignancies. Leukemia Res 18: 233-243
    • (1994) Leukemia Res , vol.18 , pp. 233-243
    • Nooter, K.1    Sonneveld, P.2
  • 98
    • 0042962641 scopus 로고
    • Multidrug resistance-associated protein (MRP) in haematological malignancies
    • Nooter K, Burger H, Stoter G (1995b) Multidrug resistance-associated protein (MRP) in haematological malignancies. Leuk Lymphoma 18: 179-184
    • (1995) Leuk Lymphoma , vol.18 , pp. 179-184
    • Nooter, K.1    Burger, H.2    Stoter, G.3
  • 100
    • 84939594316 scopus 로고    scopus 로고
    • unpublished results
    • Nooter K, unpublished results
    • Nooter, K.1
  • 102
    • 0027136660 scopus 로고
    • Clinical trials of agents that reverse multidrug resistance
    • Raderer M, Scheithauer W (1993) Clinical trials of agents that reverse multidrug resistance. Cancer 72: 3553-3563
    • (1993) Cancer , vol.72 , pp. 3553-3563
    • Raderer, M.1    Scheithauer, W.2
  • 103
    • 0026585065 scopus 로고
    • Functional complementation of yeast ste6 by a mammalian multidrug resistance mdr gene
    • Raymond M, Gros P, Whiteway M, Thomas DY (1992) Functional complementation of yeast ste6 by a mammalian multidrug resistance mdr gene. Science 256: 232-234
    • (1992) Science , vol.256 , pp. 232-234
    • Raymond, M.1    Gros, P.2    Whiteway, M.3    Thomas, D.Y.4
  • 105
    • 0025829126 scopus 로고
    • Phase II study of combining vinblastine and cyclosporin-A to circumvent multidrug resistance in renal cell cancer
    • Rodenburg CJ, Nooter K, Herweijer H, Seynaevec C, Oosterom R, Stoter G, Verweij J (1991) Phase II study of combining vinblastine and cyclosporin-A to circumvent multidrug resistance in renal cell cancer. Ann Oncol 2: 305-306
    • (1991) Ann Oncol , vol.2 , pp. 305-306
    • Rodenburg, C.J.1    Nooter, K.2    Herweijer, H.3    Seynaevec, C.4    Oosterom, R.5    Stoter, G.6    Verweij, J.7
  • 107
    • 0028307550 scopus 로고
    • Phospharidykholine translocase: A physiological role for the mdr2 gene
    • Ruetz S, Gros P (1994) Phospharidykholine translocase: a physiological role for the mdr2 gene. Cell 77: 1071-1082
    • (1994) Cell , vol.77 , pp. 1071-1082
    • Ruetz, S.1    Gros, P.2
  • 108
    • 0025893114 scopus 로고
    • Charaterization of the human mdr3 P-glycoprotein and its recognition by P-glycoprotein-specific monoclonal antibodies
    • Schinkel AH, Roelofs MEM, Borst P (1991) Charaterization of the human mdr3 P-glycoprotein and its recognition by P-glycoprotein-specific monoclonal antibodies. Cancer Res 51: 2628-2635
    • (1991) Cancer Res , vol.51 , pp. 2628-2635
    • Schinkel, A.H.1    Roelofs, M.E.M.2    Borst, P.3
  • 109
    • 0027408359 scopus 로고
    • N-glycosylation and deletion mutants of the human MDR1 P-glycoprotein
    • Schinkel A, Kemp S, Dolle M, Rudenko G, Wagenaar E (1993) N-glycosylation and deletion mutants of the human MDR1 P-glycoprotein. J Biol Chem 268: 7474-7481
    • (1993) J Biol Chem , vol.268 , pp. 7474-7481
    • Schinkel, A.1    Kemp, S.2    Dolle, M.3    Rudenko, G.4    Wagenaar, E.5
  • 111
    • 0028009810 scopus 로고
    • Multidrug resistance-associated protein overexpression and reduced drug sensitivity of topoisomerase II in a human breast carcinoma MCF7 cell line selected for etoposide esistance
    • Schneider E, Horton JK, Yang CH, Nakagawa M, Cowan KH (1994) Multidrug resistance-associated protein overexpression and reduced drug sensitivity of topoisomerase II in a human breast carcinoma MCF7 cell line selected for etoposide esistance. Cancer Res 54: 152-158
    • (1994) Cancer Res , vol.54 , pp. 152-158
    • Schneider, E.1    Horton, J.K.2    Yang, C.H.3    Nakagawa, M.4    Cowan, K.H.5
  • 112
    • 0028930054 scopus 로고
    • Buthionine sulfoximine-mediated sensitisation of etoposide-resistant human breast cancer MCF7 cells overexpressing the multidrug resistance-associated protein involves increased drug accumulation
    • Schneider E, Yamazaki H, Sinha BK, Cowan KH (1995a) Buthionine sulfoximine-mediated sensitisation of etoposide-resistant human breast cancer MCF7 cells overexpressing the multidrug resistance-associated protein involves increased drug accumulation. Br J Cancer 71: 738-743
    • (1995) Br J Cancer , vol.71 , pp. 738-743
    • Schneider, E.1    Yamazaki, H.2    Sinha, B.K.3    Cowan, K.H.4
  • 114
    • 0025946645 scopus 로고
    • Cloning and characterization of a member of the rat multidrug resistance (mdr) gene family
    • Silverman JA, Raunio H, Gant TW, Thorgeirsson SS (1991) Cloning and characterization of a member of the rat multidrug resistance (mdr) gene family. Gene 106: 229-236
    • (1991) Gene , vol.106 , pp. 229-236
    • Silverman, J.A.1    Raunio, H.2    Gant, T.W.3    Thorgeirsson, S.S.4
  • 115
    • 0023892263 scopus 로고
    • Pharmacological and biological evidence for differing mechanisms of doxorubicin resistance in two human tumor cell lines
    • Slovak ML, Hoeltge GA, Dalton WS, Trent JM (1988) Pharmacological and biological evidence for differing mechanisms of doxorubicin resistance in two human tumor cell lines. Cancer Res 48: 2793-2797
    • (1988) Cancer Res , vol.48 , pp. 2793-2797
    • Slovak, M.L.1    Hoeltge, G.A.2    Dalton, W.S.3    Trent, J.M.4
  • 116
    • 0027161846 scopus 로고
    • Localization of a novel multidrug resistance-associated gene in the HT1080/DR4 and H69AR human tumor cell lines
    • Slovak ML, Pelkey HJ, Bhardwaj G, Kurz EU, Deeley RG, Cole SPC (1993) Localization of a novel multidrug resistance-associated gene in the HT1080/DR4 and H69AR human tumor cell lines. Cancer Res 53: 3221-3225
    • (1993) Cancer Res , vol.53 , pp. 3221-3225
    • Slovak, M.L.1    Pelkey, H.J.2    Bhardwaj, G.3    Kurz, E.U.4    Deeley, R.G.5    Cole, S.P.C.6
  • 118
    • 0025284331 scopus 로고
    • Reversal of drug-resistance by cyclosporin-A in a patient with acute myelocytic leukaemia
    • Sonneveld P, Nooter K (1990) Reversal of drug-resistance by cyclosporin-A in a patient with acute myelocytic leukaemia. Br J Haematol 75: 208-211
    • (1990) Br J Haematol , vol.75 , pp. 208-211
    • Sonneveld, P.1    Nooter, K.2
  • 120
    • 0028094485 scopus 로고
    • Clinical modulation of multidrug resistance in multiple myeloma: Effect of cyclosporine on resistant tumor cells
    • Sonneveld P, Schoester M, de Leeuw K (1994) Clinical modulation of multidrug resistance in multiple myeloma: effect of cyclosporine on resistant tumor cells. J Clin Oncol 12: 1584-1591
    • (1994) J Clin Oncol , vol.12 , pp. 1584-1591
    • Sonneveld, P.1    Schoester, M.2    De Leeuw, K.3
  • 121
    • 0028285002 scopus 로고
    • Kinetic evidence suggesting that the multidrug transporter differentially handles influx and efflux of its substates
    • Stein WD, Cardarelli C, Pastan I, Gottesman MM (1994) Kinetic evidence suggesting that the multidrug transporter differentially handles influx and efflux of its substates. Mol Pharmacol 45: 763-772
    • (1994) Mol Pharmacol , vol.45 , pp. 763-772
    • Stein, W.D.1    Cardarelli, C.2    Pastan, I.3    Gottesman, M.M.4
  • 122
    • 0028106016 scopus 로고
    • Glutathione-associated enzymes in anticancer drug restance
    • Tew KD (1994) Glutathione-associated enzymes in anticancer drug restance. Cancer Res 54: 4313-4320
    • (1994) Cancer Res , vol.54 , pp. 4313-4320
    • Tew, K.D.1
  • 124
    • 0024576304 scopus 로고
    • Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: Evidence for localization in brain capillaries and cross-reactivity of one antibody with a muscle protein
    • Thiebaut F, Tsuruo T, Hamada H, Gottesman MM, Pastan I, Willingham MC (1989) Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and cross-reactivity of one antibody with a muscle protein. J Histochem Cytochem 37: 159-164
    • (1989) J Histochem Cytochem , vol.37 , pp. 159-164
    • Thiebaut, F.1    Tsuruo, T.2    Hamada, H.3    Gottesman, M.M.4    Pastan, I.5    Willingham, M.C.6
  • 125
    • 0028034463 scopus 로고
    • Expression of the multidrug resistance-associated protein (MRP) gene in human lung tumours and normal tissues as determined by in situ hybridisation
    • Thomas GA, Barrand MA, Stewart S, Rabbitts PH, Williams ED, Twentyman PR (1994) Expression of the multidrug resistance-associated protein (MRP) gene in human lung tumours and normal tissues as determined by in situ hybridisation. Eur J Cancer 30A: 1705-1709
    • (1994) Eur J Cancer , vol.30 A , pp. 1705-1709
    • Thomas, G.A.1    Barrand, M.A.2    Stewart, S.3    Rabbitts, P.H.4    Williams, E.D.5    Twentyman, P.R.6
  • 126
    • 0019430432 scopus 로고
    • Over-coming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verypamil
    • Tsuruo T, Iida H, Tsukagoshi S, Sakurai Y ( 1981 ) Over-coming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verypamil. Cancer Res 41: 1967-1972
    • (1981) Cancer Res , vol.41 , pp. 1967-1972
    • Tsuruo, T.1    Iida, H.2    Tsukagoshi, S.3    Sakurai, Y.4
  • 127
    • 0026584396 scopus 로고
    • Cyclosporins as drug resistance modifiers
    • Twentyman PR (1992) Cyclosporins as drug resistance modifiers. Biochem Biopharmacol 43: 109-117
    • (1992) Biochem Biopharmacol , vol.43 , pp. 109-117
    • Twentyman, P.R.1
  • 128
    • 0028089659 scopus 로고
    • A comparison of rhodamine 123 accumulation and efflux in cells with P-glycoprotein-mediated and MRP-associated multidrug resistance phenotypes
    • Twentyman PR, Rhodes T, Rayner S (1994) A comparison of rhodamine 123 accumulation and efflux in cells with P-glycoprotein-mediated and MRP-associated multidrug resistance phenotypes. Eur J Cancer 30A: 1360-1369
    • (1994) Eur J Cancer , vol.30 A , pp. 1360-1369
    • Twentyman, P.R.1    Rhodes, T.2    Rayner, S.3
  • 129
    • 0008632564 scopus 로고
    • Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine
    • Ueda K, Cardarelli C, Gottesman MM, Pastan I (1987) Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine. Proc Natl Acad Sci USA 84: 3004-3008
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 3004-3008
    • Ueda, K.1    Cardarelli, C.2    Gottesman, M.M.3    Pastan, I.4
  • 133
    • 0026326003 scopus 로고
    • P-glycoprotein expression and DNA topoisomerase I and II activity in benign tumors of the ovary and in malignant of the ovary, before and after platinum/cyclophosphamide chemotherapy
    • Van der Zee AGJ, Hollema H, De Jong S, Boonstra H, Gouw A, Willemse PHB, Zijlstra JG, de Vries EGE (1991 ) P-glycoprotein expression and DNA topoisomerase I and II activity in benign tumors of the ovary and in malignant of the ovary, before and after platinum/cyclophosphamide chemotherapy. Cancer Res 51: 5915-5920
    • (1991) Cancer Res , vol.51 , pp. 5915-5920
    • Van der Zee, A.G.J.1    Hollema, H.2    De Jong, S.3    Boonstra, H.4    Gouw, A.5    Willemse, P.H.B.6    Zijlstra, J.G.7    De Vries, E.G.E.8
  • 134
    • 0027979432 scopus 로고
    • Quantitative and qualitative aspects of topoisomerase I and II alpha and beta in untreated and platinum/cyclophosphamide treated malignant ovarian tumors
    • Van der Zee AGJ, de Jong S, Keith WN, Hollema H, Boonstra H, de Vries EGE (1994) Quantitative and qualitative aspects of topoisomerase I and II alpha and beta in untreated and platinum/cyclophosphamide treated malignant ovarian tumors. Cancer Res 54: 749-755
    • (1994) Cancer Res , vol.54 , pp. 749-755
    • Van der Zee, A.G.J.1    De Jong, S.2    Keith, W.N.3    Hollema, H.4    Boonstra, H.5    De Vries, E.G.E.6
  • 135
    • 0026532008 scopus 로고
    • Energy-dependent processes involved in reduced drug accumulation in multidrug-resistant human lung cancer cell lines without P-glycoprotein expression
    • Versantvoort CHM, Broxterman HJ, Pinedo HM, de Vries EGE, Feller N, Kuiper CM, Lankeima J (1992) Energy-dependent processes involved in reduced drug accumulation in multidrug-resistant human lung cancer cell lines without P-glycoprotein expression. Cancer Res 52: 17-23
    • (1992) Cancer Res , vol.52 , pp. 17-23
    • Versantvoort, C.H.M.1    Broxterman, H.J.2    Pinedo, H.M.3    De Vries, E.G.E.4    Feller, N.5    Kuiper, C.M.6    Lankeima, J.7
  • 137
    • 0028116322 scopus 로고
    • Multidrug resistance in lymphomas
    • Yuen AR, Sikic BI (1994) Multidrug resistance in lymphomas. J Clin Oncol 12: 2453-2459
    • (1994) J Clin Oncol , vol.12 , pp. 2453-2459
    • Yuen, A.R.1    Sikic, B.I.2
  • 140
    • 84939594317 scopus 로고    scopus 로고
    • personal communication
    • Zaman GJR, personal communication
    • Zaman, G.J.R.1
  • 141
    • 0023140620 scopus 로고
    • Multifactorial drug resistance in an adriamycin-resistant human small cell lung carcinoma cell line
    • Zijlstra JG, de Vries EGE, Mulder NH (1987) Multifactorial drug resistance in an adriamycin-resistant human small cell lung carcinoma cell line. Cancer Res 47: 1780-1784
    • (1987) Cancer Res , vol.47 , pp. 1780-1784
    • Zijlstra, J.G.1    De Vries, E.G.E.2    Mulder, N.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.