Natural triterpenoids from Cecropia lyratiloba are cytotoxic to both sensitive and multidrug resistant leukemia cell lines

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 23, 2007, Pages 7355-7360

  Rocha, Gleice da Graça ^a   Simões, Marisol ^a   Lúcio, Kelly Araujo ^a   Oliveira, Rodrigo Rodrigues ^a   Coelho Kaplan, Maria Auxiliadora ^a   Gattass, Cerli Rocha ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Cancer; Cecropia lyratiloba; Cytotoxic activity; Multidrug resistance; Triterpenes

Indexed keywords

2ALPHA ACETYL TORMENTIC ACID; 3BETA ACETYL TORMENTIC ACID; CASPASE 3; GLYCOPROTEIN P; TORMENTIC ACID; TRITERPENOID; UNCLASSIFIED DRUG; VINCRISTINE;

APOPTOSIS; ARTICLE; CECROPIA; COUNTER CURRENT CHROMATOGRAPHY; CYTOTOXICITY; DRUG ACETYLATION; DRUG SENSITIVITY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA CELL LINE; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CECROPIA PLANT; CELL LINE, TUMOR; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; K562 CELLS; LEUKEMIA; MOLECULAR CONFORMATION; PLANT ROOTS; SENSITIVITY AND SPECIFICITY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRITERPENES;

CECROPIA; MORACEAE;

EID: 35148836262     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.07.020     Document Type: Article

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