Reversal of multidrug resistance of cancer cells in vitro: Modification of drug resistance by selected carotenoids

Anticancer Research

Volumn 26, Issue 1 A, 2006, Pages 367-374

  Gyémánt, Nóra ^a   Tanaka, Masaru ^a   Molnár, Péter ^b   Deli, József ^b   Mándoky, László ^c   Molnár, Joseph ^a,d  

^a UNIVERSITY OF SZEGED   (Hungary)

^b UNIVERSITY OF PÉCS   (Hungary)

^c NATIONAL INSTITUTE OF ONCOLOGY   (Hungary)

^d UNIVERSITY OF SZEGED   (Hungary)

Author keywords

Cancer cells; Carotenoids; Multidrug resistance

Indexed keywords

15,15' DEHYDRODIEPOXY BETA CAROTENE; ANTHRACYCLINE; AUROCHROME; CAPSOCHROME; CAROTENOID; CHRYSANTHEMAXANTHIN; DIEPOXY BETA CAROTENE; EPIRUBICIN; FLAVOXANTHIN; LUTEOCHROME; LUTEOXANTHIN; MONOEPOXY ALPHA CAROTENE; MONOEPOXY BETA CAROTENE; MULTIDRUG RESISTANCE PROTEIN 1; NEOXANTHIN; UNCLASSIFIED DRUG; VIOLAXANTHIN; XANTHOPHYLL; ZEAXANTHIN;

ANIMAL CELL; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CELL STRAIN MCF 7; CONTROLLED STUDY; CULTURE MEDIUM; DRUG ACCUMULATION; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; DRUG POTENTIATION; DRUG STRUCTURE; FLOW CYTOMETRY; FLUORESCENCE; GENE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LYMPHOMA CELL LINE; MDR1 GENE; MOUSE; MULTIDRUG RESISTANCE; MUTATOCHROME; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION;

ANIMALS; CAROTENOIDS; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; DRUG SYNERGISM; LEUKEMIA L5178; MICE; P-GLYCOPROTEIN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; VERAPAMIL;

EID: 32144459525     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Molnár J, Szabó D, Pusztai R, Mucsi I, Berek L, Ocsovszki I, Kawata E and Shoyama Y: Membrane associated antitumor effects of crocine, ginsenoside-, and cannabinoid derivatives. Anticancer Res 20: 861-868, 2000.
2. Molnár J, Gyémánt N, Mucsi I, Molnár A-M, Szabó M, Körtvélyesi T, Varga A, Molnár P and Tóth G: Modulation of multidrug resistance and apoptosis of cancer cells by selected carotenoids. In Vivo 18: 237-244, 2004.
3. Molnár J, Mucsi I, Nacsa J, Hevér A, Gyémánt N, Ugocsai K, Hegyes P, Kiessig St, Gaál D, Lage H and Varga A: New silicon compounds as resistance modifiers against multidrug resistant cancer cells. Anticancer Res 24: 865-872, 2004.
4. Heber D and Lu QY. Overview of mechanisms of action of lycopene. Exp Biol Med (Maywood) 227: 920-923, 2002.
5. Karas M, Amir H, Fishmann D, Danilenko M, Segal S, Nahum A, Koifmann A, Giat Y, Levy J and Sharoni Y: Lycopene interferes with cell cycle progression and insuline-like growth factor I signaling in mammary cancerr cells. Nutr Cancer 33: 105-112, 1999.
6. Motohashi N (Ed.): Functional Polyphenols and Carotenes with Antioxidative Action. Trivandrum (Keraia, India), pp. 111-131, 2005.
7. Cornwell MM, Pastan I and Gottesmann MM: Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein. J Biol Chem 262: 2166-2170, 1987.
8. Ozols RF, Cunnion RE, Klecke Jr RW, Hamilton TC, Ostchega Y, Parrillo JE and Young RC: Verapamil and adriamycin in the treatment of drug-resistant ovarian cancer patients. J Clin Oncol 5: 1097-1102, 1987.
9. Salamon SE, Dalton WS, Grogan TM, Plezia P, Lehnert M, Roe DJ and Miller TP: Multidrug resistance myeloma: laboratory and clinical effects of verapamil as chemosensitiser. Blood 78: 44-50, 1991.
10. Abulrob ANG, Mason M, Bryce R and Gumbleton M: The effect of fatty acids and analogues upon intracellular levels of doxorubicin in cell displaying P-glycoprotein mediated multidrug resistance. J Drug Targeting 0: 1-10, 2000.
11. Motohashi N, Kurihara T, Wakabayashi H, Yaji M, Mucsi I, Molnar J, Maruyama S, Sakagami H, Nakasima H, Tani S, Shirataki Y and Kawase M: Biological activity of a fruit vegetable "Anastasia green" species of sweet pepper. In Vivo 15: 437-442, 2001.
12. Michalak K, Hendrich AB, Wesolowska O and Pola A: Compounds that modulate multidrug resistance in cancer cells. Cell Biol Mol Lett 6: 362-368, 2001.
13. Callaghan R, Stafford A and Epand RM: Increased accumulation of drugs in a multidrug resistant cell line by alteration of membrane biophysical properties. Biochim Biophys Acta 1175: 277-282, 1993.
14. Sharom FJ: The P-glycoprotein efflux pump: how does it transport drugs? J Membr Biol 160: 161-175, 1997.
15. Hendrich AB, Michalak K: Lipids as a target for drugs modulating multidrug resistance of cancer cells. Curr Drug Targets 4: 23-30, 2003.
16. Gruszecki WI, Frank HA, Young AJ and Britton G (Eds.): The Photochemistry of Carotenoids. Kluwer Acad Publ (Dordrecht/Boston/London), pp. 363-369, 1999.
17. Parker RS: Absorption, metabolism and transport of carotenoids. FASEB J 10: 185-197, 1996.
18. Socaciu C, Bojarski P, Aberle L and Diehl HA: Different ways to insert carotenoids into liposomes affect structure and dynamics of the lipid bilayer differently. Biophys Chem 99: 1-15, 2002.
19. Wisniewska A, Draus J and Subczynski WK: Is a fluid-mosaic model of biological membranes fully relevant? Studies on lipid organization in model and biological membrabes. Cell Biol Mol Lett 8: 147-159, 2003.
20. Cai C, Zhu H and Chen J: Overexpression of caveolin-1 increases plasma membrane fluidity and reduces P-glycoprotein function in Hs578T/Dox. Biochem Biophys Res Commun 320: 868-874, 2004.
21. Hugger ED, Novak BL, Burton PS, Audus KL and Borchardt RT. A comparison of commonly used polyethoxylated pharmaceutical excipients on their ability to inhibit P-glycoprotein activity in vitro. J Pharm Sci 91: 1991-2002, 2002.
22. Socaciu C, Jessel R and Diehl HA: Competitive carotenoid and cholesterol incorporation into liposomes: effects on membrane phase transition, fluidity, polarity and anisotropy Chem Phys Lipids 106: 79-88, 2002.