Flavonolignan and flavone inhibitors of a Staphylococcus aureus multidrug resistance pump: Structure-activity relationships

Journal of Medicinal Chemistry

Volumn 44, Issue 2, 2001, Pages 261-268

  Guz, N R ^a   Stermitz, F R ^a   Johnson, J B ^a   Beeson, T D ^a   Willen, S ^b   Hsiang, J F ^b   Lewis, K ^b  

^a Veterinary Dentistry and Oral Surgery   (United States)

^b TUFTS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5' METHOXYHYDNOCARPIN D; FLAVONE DERIVATIVE; FLAVONOLIGNAN DERIVATIVE; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG ISOLATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; MULTIDRUG RESISTANCE; NONHUMAN; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION;

CELLS, CULTURED; DRUG RESISTANCE, MICROBIAL; DRUG RESISTANCE, MULTIPLE; FLAVONOIDS; LIGNANS; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; P-GLYCOPROTEIN; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035905848     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0004190     Document Type: Article

References (34)

1. Cell biological mechanisms of multidrug resistance in tumors
2. Biochemistry of multidrug resistance mediated by the multidrug transporter
3. Prevention of drug access to bacterial targets: Permeability barriers and active efflux
4. Bacteria lacking a multidrug pump: A sensitive tool for drug discovery
5. Fluoroquinolone resistance protein NorA of Staphylococcus aureus is a multidrug efflux transporter
6. Multiple novel inhibitors of the NorA multidrug transporter of Staphylococcus aureus
7. Molecular requirements for the inhibition of the tetracycline antiport protein and the effect of potent inhibitors on the growth of tetracycline-resistant bacteria
8. Inhibitors of efflux pumps in Pseudomonas aeruginosa potentiate the activity of the fluoroquinolone antibacterial levofloxacin
9. Synergy in a medicinal plant: Antimicrobial action of berberine potentiated by 5′-methoxyhydnocarpin, a multidrug pump inhibitor
10. 5′-Methoxyhydnocarpin-D and pheophorbide a: Berberis species components that potentiate berberine growth inhibition of resistant Staphylococcus aureus
11. Synthesis and structures of regioisomeric hydnocarpin-type flavonolignans
12. A convenient synthesis of (±)-3-methoxybenzodioxane-4,9,9′-triol neolignan, and methyl ethers of isoamericanol A and isoamericanin A
13. Benzodioxans by oxidative phenol coupling. Synthesis of silybin
14. Flavonoids, flavonolignans and a phenylpropenoid from Onopordon corymbosum
15. Die endgültige struktur von americanin-A und hydnocarpin
16. Cytotoxic flavonolignans and flavones from Verbascum sinaiticum leaves
17. Total synthesis of (±)-sinaiticin
18. Studies on Nepalese crude drugs XIV. New flavonoids from the root of Scutellaria prostrata Jacq. ex Benth
19. Total synthesis of rac-silandrin, an antihepatotoxic flavanolignan
20. The biochemistry of P-glycoprotein mediated multidrug resistance
21. Novel multidrug resistance reversal agents
22. Tolyporphins J and K, two further porphinoid metabolites from the cyanobacterium Tolypothrix nodosa
23. Binding of steroid modulators to recombinant cytosolic domain from mouse P-glycoprotein in close proximity to the ATP site
24. Structure of the multidrug resistance P-glycoprotein to 2.5 nm resolution determined by electron microscopy and image analysis
25. Multidrug resistance efflux
26. A bacterial antibiotic-resistance gene that complements the human multidrug-resistance P-glycoprotein gene
27. Flavonoids: A class of modulators with bifunctional interaction at vicinal ATP- and steroid-binding sites on mouse P-glycoprotein
28. Flavonoid-related modulators of multidrug resistance: Synthesis, pharmacological activity, and structure-activity relationships
29. Halogenated chalcones with high-affinity binding to P-glycoprotein: Potential modulators of multidrug resistance
30. Physical-chemical properties shared by compounds that modulate multidrug resistance in human leukemia cells
31. Design, synthesis, and in vitro activity of catamphilic reverters of multidrug resistance: Discovery of a selective, highly efficacious chemosensitizer with potency in the nanomolar range
32. Synthesis and in vitro resistance modulating activity of a series of dihydrobenzopyrans and tetrahydroquinolines
33. Total synthesis of ningalin B utilizing a heterocycylic azadiene Diels-Alder reaction and discovery of a new class of potent multidrug resistant (MDR) reversal agents
34. Resisting resistance: New chemical strategies for battling superbugs