Modulation of multidrug resistance by three bisbenzyl-isoquinolines in comparison with verapamil

Acta Pharmacologica Sinica

Volumn 18, Issue 5, 1997, Pages 455-458

  Tian, Hui ^a   Pan, Qi Chao ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Cultured tumor cells; Cycleanine; Doxorubivin; Insulanoline; Insularine; Isoquinolines; Multiple drug resistance; Vincristine

Indexed keywords

CYCLEANINE; DOXORUBICIN; INSULANOLINE; INSULARINE; ISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG; VERAPAMIL; VINCRISTINE;

ARTICLE; CELL LINE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; MODULATION; MULTIDRUG RESISTANCE;

ALKALOIDS; ANTIHYPERTENSIVE AGENTS; BREAST NEOPLASMS; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; DRUGS, CHINESE HERBAL; HUMANS; ISOQUINOLINES; KB CELLS; TUMOR CELLS, CULTURED; VERAPAMIL;

EID: 0030825773     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Ling V. P-glycoprotein and resistance to anticancer drugs. Cancer 1992; 69: 2603-9.
2. Georges E, Sharom HI, Ling V. Multidrug resistance and chemosensitization: therapeutic implications for cancer chemotherapy. Adv Pharmacol 1990; 21: 185-220.
3. Ford JM, Hait WN. Pharmacology of drugs that alter multidrug resistance in cancer. Pharmacol Rev 1990; 42: 155-199.
4. Yusa K, Tsuruo T. Reversal mechanism of multidrug resistance by verapamil: direct binding of verapamil to P-glycoprotein on specific sites and transport of verapamil outward across the plasma membrane of K562/ADM cells. Cancer Res 1989; 49: 5002-6.
5. Pan QC, Tian H. Reversal of multidrug resistance by various principles from Chinese herbal medicine. Chin Sci Bull 1996; 41: 410-4.
6. Shiraishi N, AkiyamaS, Nakagawa M, Kobayashi M, Kuwano M. Effect of bisbenzylisoquinoline (biscoclaurine) alkaloids on multidrug resistance in KB human cancer cells. Cancer Res 1987; 47: 2413-6.
7. Akiyama S, Cornwell MM, Kuwano M, Pastan I, Gottesman MM. Most drugs that reverse multidrag resistance also inhibit photoaffinity labeling of P-glycoprotein by a vinblastine analog. Mol Pharmacol 1988; 33: 144-7.
8. Chen G, Ramachandran C, Krishan A. Thaliblastine, a plant alkaloid, circumvents multidrug resistance by direct binding to P-glycoprotein. Cancer Res 1993; 53: 2544-7.
9. Lai S, Zhao TF, Wang XK. Studies on the bisbenzylisoquinoline alkaloids of Cyclea racemosa Oliv. West China J Pharm Sci 1988; 3: 6-11.
10. Ford JM, Bruggemaan EP, Pastan I, Gottesman MM, Hait WN. Cellular and biochemical characterization of thioxanthenes for reversal of multidrag resistance in human and murine cell lines. Cancer Res 1990; 50: 1748-56.
11. Zhang XH, Zhang FY, Ji XJ, Li ZY. Vincristine-resistant human KB cell line and mechanism of multidrag resistance. Acta Pharm Sin 1994; 29: 246-51.