The alkaloid sanguinarine is effective against multidrug resistance in human cervical cells via bimodal cell death

Biochemical Pharmacology

Volumn 63, Issue 8, 2002, Pages 1415-1421

  Ding, Zhihu ^a   Tang, Shou Ching ^a,b   Weerasinghe, Priya ^a   Yang, Xiaolong ^a   Pater, Alan ^a   Liepins, Andrejs ^a  

^a MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

^b Newfoundland Cancer Treatment and Research Foundation   (Canada)

Author keywords

Alkaloid sanguinarine; Apoptosis; Caspase 3; Multidrug resistant cervical cells; Oncosis

Indexed keywords

ALKALOID; CASPASE 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; SANGUINARINE;

APOPTOSIS; ARTICLE; BIOASSAY; CELL DEATH; CELL IMMORTALIZATION; CELL SURFACE; CELL TYPE; CLONOGENIC ASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG SENSITIVITY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MULTIDRUG RESISTANCE; PAPILLOMA VIRUS; PRIORITY JOURNAL; PROTEIN DEGRADATION; SCANNING ELECTRON MICROSCOPY; SURVIVAL; UTERINE CERVIX; UTERINE CERVIX CYTOLOGY;

ALKALOIDS; APOPTOSIS; BENZOPHENANTHRIDINES; CASPASE 3; CASPASES; CELL SURVIVAL; CELLS, CULTURED; CERVIX UTERI; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, MULTIPLE; ENZYME ACTIVATION; FEMALE; HUMANS; INTERCALATING AGENTS; ISOQUINOLINES;

EID: 0037090858     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)00902-4     Document Type: Article

References (58)

1. Aporphinoid alkaloids
2. Sanguinaria toothpaste and oral rinse regimen clinical efficacy in short- and long-term trials
3. New perspectives on Sanguinaria clinicals: Individual toothpaste and oral rinse testing
4. Whole mouth microbiota effects following subgingival delivery of sanguinarium
5. Pharmacological activities of Chelidonium majus L. (Papaveraceae)
6. Sanguinarine and ellipticine cytotoxic alkaloids isolated from well-known antitumor plants. Intracellular targets of their action
7. Differential antiproliferative and apoptotic response of sanguinarine for cancer cells versus normal cells
8. Benzo[c]phenanthridine alkaloids sanguinarine and chelerythrine: Biological activities and dental care applications
9. Binding of sanguinarine to deoxyribonucleic acids of differing base composition
10. 1H NMR investigation of the interaction of berberine and sanguinarine with DNA
11. Antimicrotubule properties of benzophenanthridine alkaloids
12. Cytotoxicity of sanguinarine chloride to cultured human cells from oral tissue
13. Biochemical activities of berberine, palmatine and sanguinarine mediating chemical defence against microorganisms and herbivores
14. Clinicoepidemiological, toxicological, and safety evaluation studies on argemone oil
15. Inhibition of eukaryote protein kinases by isoquinoline and oxazine alkaloids
16. Sanguinarine (pseudochelerythrine) is a potent inhibitor of NF-κB activation, IκB-α phosphorylation, and degradation
17. Apoptosis: Molecular mechanisms and implications for human disease
18. Apoptosis in the pathogenesis and treatment of disease
19. Life, death, and the pursuit of apoptosis
20. Morphological, physiological and biochemical parameters associated with cell injury: A review
21. Induction of bimodal programmed cell death in malignant cells by the derivative Ukrain (NSC-631570)
22. The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death
23. Tumor necrosis factor's cytotoxic activity is signaled by the p55 TNF receptor
24. Monoclonal antibody-mediated tumor regression by induction of apoptosis
25. Apoptosis and drug response
26. Estimates of the worldwide mortality from 25 cancers in 1990
27. Estimates of the worldwide incidence of 25 major cancers in 1990
28. Phosphorylation of the multidrug resistance associated protein gene encoded protein P190
29. Human papillomavirus type 16-immortalized endocervical cells selected for resistance to cisplatin are malignantly transformed and have a multidrug resistance phenotype
30. Human papillomavirus 16 DNA immortalizes two types of normal human epithelial cells of the uterine cervix
31. Malignant transformation of HPV 16-immortalized human endocervical cells by cigarette smoke condensate and characterization of multistage carcinogenesis
32. BAG-1 promotes apoptosis induced by N-(4-hydroxyphenyl)retinamide in human cervical carcinoma cells
33. Sensitive method for measuring apoptosis and cell surface phenotype in human thymocytes by flow cytometry
34. Cisplatin, camptothecin, and taxol sensitivities of cells with p53-associated multidrug resistance
35. + channels in tumor cell injury. Membrane vesicle shedding and nuclear DNA fragmentation
36. Enhanced expression of anti-apoptotic proteins in human papillomavirus-immortalized and cigarette smoke condensate-transformed human endocervical cells: Correlation with resistance to apoptosis induced by DNA damage
37. Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis
38. Proteases to die for
39. Resistance to apoptosis is correlated with the reduced caspase-3 activation and enhanced expression of antiapoptotic proteins in human cervical multidrug-resistant cells
40. Caspases: The proteases of the apoptotic pathway
41. Major DNA fragmentation is a late event in apoptosis
42. Bax, bcl-2, and NF-κB expression in sanguinarine induced bimodal cell death
43. The pathways of cell death: Oncosis, apoptosis, and necrosis
44. Apoptosis, oncosis and necrosis. An overview of cell death
45. Human monocyte-derived macrophages infected with virulent Shigella flexneri in vitro undergo a rapid cytolytic event similar to oncosis but not apoptosis
46. Cytomorphology of murine B16 melanoma in vivo after treatment with cyclophosphamide: Evidence of "oncotic" cell death
47. Novel path to apoptosis: Small transmembrane pores created by staphylococcal alpha-toxin in T lymphocytes evoke internucleosomal DNA degradation
48. A novel type of cell death of lymphocytes induced by a monoclonal antibody without participation of complement
49. 2s in cell injury and death
50. Molecular cloning of Porimin, a novel cell surface receptor mediating oncotic cell death
51. Intracellular ATP levels determine cell death fate by apoptosis or necrosis
52. 2 as defined by gene knockouts
53. Death of tumor cells after intracellular acidification is dependent on stress-activated protein kinases (SAPK/JNK) pathway activation and cannot be inhibited by Bcl-2 expression or interleukin 1β-converting enzyme inhibition
54. Cisplatin-induced apoptosis proceeds by caspase-3-dependent and -independent pathways in cisplatin-resistant and -sensitive human ovarian cancer cell lines
55. Caspase-dependent and -independent death of camptothecin-treated embryonic cortical neurons
56. Oncogenic Ras triggers cell suicide through the activation of a caspase-independent cell death program in human cancer cells
57. Caspase-independent programmed cell death with necrotic morphology
58. Autophagy is activated by apoptotic signalling in sympathetic neurons: An alternative mechanism of death execution