Inhibition of human P-glycoprotein transport and substrate binding using a galantamine dimer

Biochemical and Biophysical Research Communications

Volumn 388, Issue 4, 2009, Pages 672-676

  Namanja, Hilda A ^a   Emmert, Dana ^a   Pires, Marcos M ^a   Hrycyna, Christine A ^a   Chmielewski, Jean ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

ATP Binding Cassette transporter; Blood brain barrier; Dimer; Galantamine; Inhibition; P glycoprotein

Indexed keywords

ADENOSINE TRIPHOSPHATASE; DAUNORUBICIN; DIMER; DOXORUBICIN; ELACRIDAR; GALANTAMINE; GALANTAMINE 2; GLYCOPROTEIN P; GLYCOPROTEIN P INHIBITOR; PRAZOSIN; RHODAMINE 123; SEBACIC ACID; UNCLASSIFIED DRUG; VERAPAMIL;

ANIMAL CELL; ARTICLE; BLOOD BRAIN BARRIER; CANCER CELL CULTURE; CELL STRAIN MCF 7; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIMERIZATION; DRUG ACCUMULATION; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG SYNTHESIS; DRUG TRANSPORT; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; NONHUMAN; PHOTOAFFINITY LABELING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; STRUCTURE ACTIVITY RELATION;

ANTIBIOTICS, ANTINEOPLASTIC; BLOOD-BRAIN BARRIER; DAUNORUBICIN; DIMERIZATION; DOXORUBICIN; GALANTAMINE; HUMANS; INHIBITORY CONCENTRATION 50; P-GLYCOPROTEIN; VERAPAMIL;

EID: 69949156876     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.08.056     Document Type: Article

References (28)

1. Schinkel A.H., and Borst P. Multidrug resistance mediated by P-glycoproteins. Semin. Cancer Biol. 2 (1991) 213-226
2. Hrycyna C.A. Molecular genetic analysis and biochemical characterization of mammalian P-glycoproteins involved in multidrug resistance. Semin. Cell Dev. Biol. 12 (2001) 247-256
3. Higgins C.F. ABC transporters: from microorganisms to man. Annu. Rev. Cell Biol. 8 (1992) 67-113
4. Gottesman M.M., and Pastan I. Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu. Rev. Biochem. 62 (1993) 385-427
5. Lazarowski A., Czornyj L., Lubienieki F., Girardi E., Vazquez S., and D'Giano C. ABC transporters during epilepsy and mechanisms underlying multidrug resistance in refractory epilepsy. Epilepsia 48 Suppl. 5 (2007) 140-149
6. Boulton D.W., DeVane C.L., Liston H.L., and Markowitz J.S. In vitro P-glycoprotein affinity for atypical and conventional antipsychotics. Life Sci. 71 (2002) 163-169
7. Uhr M., Grauer M.T., and Holsboer F. Differential enhancement of antidepressant penetration into the brain in mice with abcb1ab (mdr1ab) P-glycoprotein gene disruption. Biol. Psychiatry 54 (2003) 840-846
8. Uhr M., Grauer M.T., Yassouridis A., and Ebinger M. Blood-brain barrier penetration and pharmacokinetics of amitriptyline and its metabolites in p-glycoprotein (abcb1ab) knock-out mice and controls. J. Psychiatry. Res. 41 (2007) 179-188
9. Zhou S.F. Structure. Function and regulation of P-glycoprotein and its clinical relevance in drug disposition, xenobiotica 38 (2008) 802-832
10. Dey S., Ramachandra M., Pastan I., Gottesman M.M., and Ambudkar S.V. Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein. Proc. Natl. Acad. Sci. USA 94 (1997) 10594-10599
11. Shapiro A.B., and Ling V. Positively cooperative sites for drug transport by P-glycoprotein with distinct drug specificities. Eur. J. Biochem. 250 (1997) 130-137
12. Loo T.W., Bartlett M.C., and Clarke D.M. Simultaneous binding of two different drugs in the binding pocket of the human multidrug resistance P-glycoprotein. J. Biol. Chem. 278 (2003) 39706-39710
13. Pires M.M., Emmert D., Hrycyna C.A., and Chmielewski J. Inhibition of P-glycoprotein-mediated paclitaxel resistance by reversibly linked quinine homodimers. Mol. Pharmacol. 75 (2009) 92-100
14. Pires M.M., Hrycyna C.A., and Chmielewski J. Bivalent probes of the human multidrug transporter P-glycoprotein. Biochemistry 45 (2006) 11695-11702
15. Mealey K.L., Barhoumi R., Burghardt R.C., Safe S., and Kochevar D.T. Doxycycline induces expression of P glycoprotein in MCF-7 breast carcinoma cells. Antimicrob. Agents Chemother. 46 (2002) 755-761
16. Dey S., Ramachandra M., Pastan I., Gottesman M.M., and Ambudkar S.V. Photoaffinity labeling of human P-glycoprotein: effect of modulator interaction and ATP hydrolysis on substrate binding. Methods Enzymol. 292 (1998) 318-328
17. Hrycyna C.A., Ramachandra M., Pastan I., and Gottesman M.M. Functional expression of human P-glycoprotein from plasmids using vaccinia virus-bacteriophage T 7 RNA polymerase system. Methods Enzymol. 292 (1998) 456-473
18. Homolya L., Hollo Z., Germann U.A., Pastan I., Gottesman M.M., and Sarkadi B. Fluorescent cellular indicators are extruded by the multidrug resistance protein. J. Biol. Chem. 268 (1993) 21493-21496
19. Tsuji A., Tamai I., Sakata A., Tenda Y., and Terasaki T. Restricted transport of cyclosporin A across the blood-brain barrier by a multidrug transporter, P-glycoprotein. Biochem. Pharmacol. 46 (1993) 1096-1099
20. Martin C., Berridge G., Higgins C.F., Mistry P., Charlton P., and Callaghan R. Communication between multiple drug binding sites on P-glycoprotein. Mol. Pharmacol. 58 (2000) 624-632
21. Bruggemann E.P., Germann U.A., Gottesman M.M., and Pastan I. Two different regions of P-glycoprotein [corrected] are photoaffinity-labeled by azidopine. J. Biol. Chem. 264 (1989) 15483-15488
22. Bruggemann E.P., Currier S.J., Gottesman M.M., and Pastan I. Characterization of the azidopine and vinblastine binding site of P-glycoprotein. J. Biol. Chem. 267 (1992) 21020-21026
23. Pearson V.E. Galantamine: a new alzheimer drug with a past life. Ann. Pharmacother. 35 (2001) 1406-1413
24. Hamabe W., Maeda T., Fukazawa Y., Kumamoto K., Shang L.Q., Yamamoto A., Yamamoto C., Tokuyama S., and Kishioka S. P-glycoprotein ATPase activating effect of opioid analgesics and their P-glycoprotein-dependent antinociception in mice. Pharmacol. Biochem. Behav. 85 (2006) 629-636
25. Hyafil F., Vergely C., Du Vignaud P., and Grand-Perret T. In vitro and in vivo reversal of multidrug resistance by GF120918, an acridonecarboxamide derivative. Cancer Res. 53 (1993) 4595-4602
26. Ambudkar S.V., Dey S., Hrycyna C.A., Ramachandra M., Pastan I., and Gottesman M.M. Biochemical, cellular, and pharmacological aspects of the multidrug transporter. Annu. Rev. Pharmacol. Toxicol. 39 (1999) 361-398
27. Shapiro A.B., Fox K., Lam P., and Ling V. Stimulation of P-glycoprotein-mediated drug transport by prazosin and progesterone. Evidence for a third drug-binding site. Eur. J. Biochem. 259 (1999) 841-850
28. Horio M., Gottesman M.M., and Pastan I. ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells. Proc. Natl. Acad. Sci. USA 85 (1988) 3580-3584