Modulation of multidrug resistance and apoptosis of cancer cells by selected carotenoids

In Vivo

Volumn 18, Issue 2, 2004, Pages 237-244

  Molnár, Joseph ^a   Gyémánt, Nóra ^a   Mucsi, Ilona ^a   Molnár, Annamária ^a   Szabó, Margaret ^a   Körtvélyesi, Tamás ^a   Varga, András ^b   Molnár, Peter ^c   Tóth, Gyula ^c  

^a UNIVERSITY OF SZEGED   (Hungary)

^b HUMBOLDT UNIVERSITY   (Germany)

^c UNIVERSITY OF PÉCS   (Hungary)

Author keywords

Apoptosis; Carotenoids; Multidrug resistance

Indexed keywords

ALPHA CAROTENE; ANTHREXANTHINE; BETA CAROTENE; CAPSANTHIN; CAPSORUBIN; CAROTENOID; CRYPTOXANTHIN; LYCOPENE; LYCOPHYLL; MULTIDRUG RESISTANCE PROTEIN 1; RHODAMINE 123; UNCLASSIFIED DRUG; VERAPAMIL; VIOLAXANTHIN; VITAMIN; XANTHOPHYLL; ZEAXANTHINE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CANCER CHEMOTHERAPY; CANCER PREVENTION; CANCER RESISTANCE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG EFFICACY; DRUG ISOLATION; GENE CONTROL; GENETIC CODE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; ION TRANSPORT; LYMPHOMA CELL; MULTIDRUG RESISTANCE; NONHUMAN; PEPPER; VEGETABLE;

EID: 1842841638     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Szent-Györgyi A: Identification of Vitamin C. Nature (Lond.) 131: 225-226, 1933.
2. Szent-Györgyi A: Hexuronic acid (ascorbic acid) as the antiscorbutic factor. Nature (Lond.) 131: 24, 1933.
3. Banga I and Szent-Györgyi A: The large scale preparation of ascorbic acid from Hungarian pepper (Capsicum annuum). Biochem J 28: 1625-1628, 1934.
4. Szent-Györgyi A: Geleitwort. Raunert M: Der Paprika, Verpflegungstechnisch und diätetisch gesehen. Leipzig, Barth, [III]. p. 1939.
5. Szent-Györgyi A: Process of preparing substances belonging to the flavone group. [Patent] U.S. 2, 152, 827, 4 Apr 1939.
6. Molnár J, Szabó D, Pusztai R, Mucsi I, Berek L, Ocsovszki I, Kawata E and Shoyama Y: Membrane associated antitumor crocine, ginsenoside and cannabinoid derivatives. Anticancer Res 20: 861-868, 2000.
7. Bollag W: Retinoids in oncology: experimental and clinical aspects. Pure Appl Chem 66: 995-1002, 1994.
8. Nishino H, Tokuda H, Satomi Y, Masuda M, Bu P, Onozuka M, Yamaguchi S, Ichiishi E, Murakoshi M, Kato T, Misawa N, Narisawa T, Takasuka N and Yano M: Cancer prevention by carotenoids. Pure Appl Chem 71: 2273-2278, 1999.
9. Mayne ST: Carotenoids and health: Critical evaluation of the evidence. Invited Lecture 10, 12th Int Carotenoid Symposium, Cairns, Australia, July 18-23, 1999, Abstracts p. 155.
10. Murakoshi M and Nishino H: Comparison of cancer preventive effect of five kinds of carotenoids on mouse lung carcinogenesis. Cancer Res 52: 6583-6587, 1992.
11. Smaller B, Isenberg I and Baird SL: Spin resonance and electrical conductivity of indole-iodine. Nature 191: 168-169, 1961.
12. Motohashi N, Kurihara T, Wakabayashi H, Yaji M, Mucsi I, Molnar J, Maruyama S, Sakagami H, Nakasima H, Tani S, Shirataki Y and Kawase M: Biological activity of a fruit vegetable "Anastasia green" species of sweet pepper. In Vivo 15: 437-442, 2001.
13. Deli J, Molnár P, Tóth G, Baumeler A and Eugster CH: Cycloviolaxanthin, ein neues Carotinoid aus Paprika (Capsicum annum). Helv Chim Acta 74: 819-824, 1991.
14. Deli J, Molnár P, Matus Z, Traber B and Pfander H: "Prenigroxanthin" (beta-carotene-3,3,6′-triol) a novel carotenoid from red paprika (Capsicum annum). Tetrahedron Letters 42: 1395-1397, 2001.
15. Deli J, Molnár P, Osz E and Toth G: Capsoneoxanthin, a new carotenoid isolated from the fruits of Asparagus falcatus. Tetrahedron Letters 41: 8153-8155, 2000.
16. Cornwell MM, Pastan I and Gottesmann MM: Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein. J Biol Chem 262: 2166-2170, 1987.
17. Motohashi N, Wakabayashi H, Kurihara T, Takada Y, Maruyama S, Sakagami H, Nakashima H, Tani S, Shiratakim Y, Kawase M, Wolfard K and Molnár J: Cytotoxic and MDR reversal activity of a vegetable "Anastasia red", a variety of sweet pepper. Phytotherapy Res 17: 348-352, 2003.
18. Khachik F, Nir Z and Ausich RL: Distribution of carotenoids in fruits and vegetables as a criterion for the selection of appropriate chemopreventive agents. Proceedings of the Second International Conference on Food Factors: Chemistry and Cancer Prevention: Ohigashi H, Ed, Springer-Verlag: Tokyo 1997. P. 204.
19. Rock CL: Carotenoids and cervical, breast, ovarian and colorectal cancer: epidemiology and trials. Abstract from 13th Int Carotenoid Symposium January 6-11, 2002, Honolulu. Hawaii. USA
20. Mayne ST: Carotenoids and cancer of the lung, mouth and throat, esophagus, and stomach: epidemiology and trials. Abstract from 13th International Carotenoid Symposium January 6-11, 2002, Honolulu. Hawaii. USA.
21. Van Breemen RB, Xu X, Wang Y, Constantinou A and Bowen PE: Solubilization, stabilization and delivery of cartonenoids to tissue culture using micelles: Investigation of the antiproliferative effect of lycopene on human prostate tumor cells. 12th Int. Carotenoid Symposium, Cairns, Australia, July 18-23, 1999, Abstracts, p. 160.
22. Nahum A, Amir H, Danilenko M, Karas M, Giat Y, Levy J and Sharoni Y: Modulation of cell cycle molecular components by lycopene and IGF-I in MCF-7 mammary cancer cells. 12th Int. Carotenoid Symposium, Cairns, Australia, July 18-23, 1999, Abstracts, p. 188.
23. Sharoni Y, Karas M, Amir H, Giat J, Danilenko M and Levy J: Lycopene inhibits cell proliferation and interferes with IGF-I signal transduction in endometrial and mammary cancer cells. 11th Int Symposium on Carotenoids, Leiden, The Netherlands, August 18-23, 1996. Abstracts of Oral Presentations, p. 92.
24. Kleinman D, Karas M, Roberts C T, LeRoith D, Phillip M, Segev Y, Levy J and Sharoni Y: Modulation of insulin-like growth factor I (IGF-I) receptors and membrane-associated IGF-binding proteins in endometrial cancer cells by estradiol. Endocrinol 136: 2531-2537, 1995.
25. Nishino H, Tokuda H, Murakoshi M, Satomi Y, Masuda M, Onozuka M, Yamaguchi S, Takayasu J, Tsuruta J, Okuda M, Khachik F, Narisawa T, Takasduka N and Yano M: Cancer prevention by natural carotenoids. Biofactors 131/1-4: 9-94, 2000.
26. Louvet C, Empereur S. Fagot D., Forgue-Lafitte E, Zimber A, Mester J and Gespach C: The aritonoid Ro 40-8757 has antiproliferative effects in drug resistant human colon and breast cancer cell lines in vitro. Cancer Lett 85: 83-86, 1994.
27. Gutmann F, Jonhson C, Keyzer H and Molnar J: Charge Transfer Complexes in Biological Systems, Marcel Dekker, Inc, New York, Basel, Honkong, 1997 p. 323
28. Huggins CM and Le Blanc OH: Electrical and magnetic properties of β-carotene triiodide. Nature 186: 552-553, 1960.
29. Eley DD and Snart RS: Conduction in chloroplast components. Biochim Biophys Acta 102: 379-385, 1965.
30. Utsun C, Beksac M, Dalva K, Koc H, Konuk N, Ilhan O, Ozcan M, Topcuoglu P, Sertkaya D and Hayran M: In vivo use of all-trans-retinoic acid prior to induction chemotherapy improves complete remission rate and increases rhodamine 123 uptake in patients with de novo acute myeloid leukemia. Med Oncol 19: 59-67, 2002.
31. Debal V, Breillout F and Manfait M: Concomitant decrease of resistance and modifications of the cytoskeleton after all-trans-retinoic acid and phorbol ester treatments in a navelbine-resistant bladder carcinoma cell line. Anticancer Res 17: 1147-54, 1997.
32. Su IJ, Cheng AL, Tsai FF and Lay JD: Retinoic acid-induced apoptosis and regression of a refractory Epstein-Barr virus-containing T cell lymphoma expressing multidrug-resistance phenotypes. Br J Haematol 85: 826-8 1993.
33. Kim HS, Christov K, Chen L, Ghosh L, Duncan C, Sharifi R and Bowen P: Modulation of apoptotic cell death in prostate tumors by tomato sauce supplementation. Abstract from 13th Int Carotenoid Symposium, January 6-11, 2002, Honolulu. Hawaii. USA.
34. Simoni D and Tolomeo M: Retinoids, apoptosis and cancer. Curr Pharm Des 17: 1823-37, 2001.