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Volumn 139, Issue 18, 2012, Pages 3277-3299

Partitioning the heart: Mechanisms of cardiac septation and valve development

Author keywords

Cardiac septation; Congenital heart disease; Heart development; Signaling; Transcription; Valve development

Indexed keywords

BONE MORPHOGENETIC PROTEIN; CALCINEURIN; EPIDERMAL GROWTH FACTOR; MICRORNA; NOTCH RECEPTOR; SMAD PROTEIN; T BOX TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR PAX3; TRANSCRIPTION FACTOR PBX1; TRANSFORMING GROWTH FACTOR BETA; WNT PROTEIN;

EID: 84865236011     PISSN: 09501991     EISSN: 14779129     Source Type: Journal    
DOI: 10.1242/dev.063495     Document Type: Review
Times cited : (172)

References (298)
  • 1
    • 4944232950 scopus 로고    scopus 로고
    • Mesenchymal stem cells and the artery wall
    • Abedin, M., Tintut, Y. and Demer, L. L. (2004). Mesenchymal stem cells and the artery wall. Circ. Res. 95, 671-676.
    • (2004) Circ. Res. , vol.95 , pp. 671-676
    • Abedin, M.1    Tintut, Y.2    Demer, L.L.3
  • 2
    • 38149048031 scopus 로고    scopus 로고
    • Heart field: From mesoderm to heart tube
    • Abu-Issa, R. and Kirby, M. L. (2007). Heart field: from mesoderm to heart tube. Annu. Rev. Cell Dev. Biol. 23, 45-68.
    • (2007) Annu. Rev. Cell Dev. Biol. , vol.23 , pp. 45-68
    • Abu-Issa, R.1    Kirby, M.L.2
  • 4
    • 0025270339 scopus 로고
    • TGF beta in murine morphogenetic processes: The early embryo and cardiogenesis
    • Akhurst, R. J., Lehnert, S. A., Faissner, A. and Duffie, E. (1990). TGF beta in murine morphogenetic processes: the early embryo and cardiogenesis. Development 108, 645-656.
    • (1990) Development , vol.108 , pp. 645-656
    • Akhurst, R.J.1    Lehnert, S.A.2    Faissner, A.3    Duffie, E.4
  • 5
    • 0042354777 scopus 로고    scopus 로고
    • Development of the heart: (2) Septation of the atriums and ventricles
    • Anderson, R. H., Webb, S., Brown, N. A., Lamers, W. and Moorman, A. (2003a). Development of the heart: (2) Septation of the atriums and ventricles. Heart 89, 949-958.
    • (2003) Heart , vol.89 , pp. 949-958
    • Anderson, R.H.1    Webb, S.2    Brown, N.A.3    Lamers, W.4    Moorman, A.5
  • 6
    • 0041326750 scopus 로고    scopus 로고
    • Development of the heart: (3) formation of the ventricular outflow tracts, arterial valves, and intrapericardial arterial trunks
    • Anderson, R. H., Webb, S., Brown, N. A., Lamers, W. and Moorman, A. (2003b). Development of the heart: (3) formation of the ventricular outflow tracts, arterial valves, and intrapericardial arterial trunks. Heart 89, 1110-1118.
    • (2003) Heart , vol.89 , pp. 1110-1118
    • Anderson, R.H.1    Webb, S.2    Brown, N.A.3    Lamers, W.4    Moorman, A.5
  • 8
    • 63849250390 scopus 로고    scopus 로고
    • Noonan syndrome cardiac defects are caused by PTPN11 acting in endocardium to enhance endocardial-mesenchymal transformation
    • Araki, T., Chan, G., Newbigging, S., Morikawa, L., Bronson, R. T. and Neel, B. G. (2009). Noonan syndrome cardiac defects are caused by PTPN11 acting in endocardium to enhance endocardial-mesenchymal transformation. Proc. Natl. Acad. Sci. USA 106, 4736-4741.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 4736-4741
    • Araki, T.1    Chan, G.2    Newbigging, S.3    Morikawa, L.4    Bronson, R.T.5    Neel, B.G.6
  • 11
    • 78650047563 scopus 로고    scopus 로고
    • Myocardial deletion of Smad4 using a novel (skeletal muscle actin Cre recombinase transgenic mouse causes misalignment of the cardiac outflow tract
    • Azhar, M., Wang, P. Y., Frugier, T., Koishi, K., Deng, C., Noakes, P. G. and McLennan, I. S. (2010). Myocardial deletion of Smad4 using a novel (skeletal muscle actin Cre recombinase transgenic mouse causes misalignment of the cardiac outflow tract. Int. J. Biol. Sci. 6, 546-555.
    • (2010) Int. J. Biol. Sci. , vol.6 , pp. 546-555
    • Azhar, M.1    Wang, P.Y.2    Frugier, T.3    Koishi, K.4    Deng, C.5    Noakes, P.G.6    McLennan, I.S.7
  • 16
    • 0035810984 scopus 로고    scopus 로고
    • Double-outlet right ventricle and overriding tricuspid valve reflect disturbances of looping, myocardialization, endocardial cushion differentiation, and apoptosis in TGF-beta(2)-knockout mice
    • Bartram, U., Molin, D. G., Wisse, L. J., Mohamad, A., Sanford, L. P., Doetschman, T., Speer, C. P., Poelmann, R. E. and Gittenberger-de Groot, A. C. (2001). Double-outlet right ventricle and overriding tricuspid valve reflect disturbances of looping, myocardialization, endocardial cushion differentiation, and apoptosis in TGF-beta(2)-knockout mice. Circulation 103, 2745-2752.
    • (2001) Circulation , vol.103 , pp. 2745-2752
    • Bartram, U.1    Molin, D.G.2    Wisse, L.J.3    Mohamad, A.4    Sanford, L.P.5    Doetschman, T.6    Speer, C.P.7    Poelmann, R.E.8    Gittenberger-de Groot, A.C.9
  • 18
    • 67549128823 scopus 로고    scopus 로고
    • BMP type II receptor regulates positioning of outflow tract and remodeling of atrioventricular cushion during cardiogenesis
    • Beppu, H., Malhotra, R., Beppu, Y., Lepore, J. J., Parmacek, M. S. and Bloch, K. D. (2009). BMP type II receptor regulates positioning of outflow tract and remodeling of atrioventricular cushion during cardiogenesis. Dev. Biol. 331, 167-175.
    • (2009) Dev. Biol. , vol.331 , pp. 167-175
    • Beppu, H.1    Malhotra, R.2    Beppu, Y.3    Lepore, J.J.4    Parmacek, M.S.5    Bloch, K.D.6
  • 21
    • 0034743198 scopus 로고    scopus 로고
    • TGFbeta Type III and TGFbeta Type II receptors have distinct activities during epithelial-mesenchymal cell transformation in the embryonic heart
    • Boyer, A. S. and Runyan, R. B. (2001). TGFbeta Type III and TGFbeta Type II receptors have distinct activities during epithelial-mesenchymal cell transformation in the embryonic heart. Dev. Dyn. 221, 454-459.
    • (2001) Dev. Dyn. , vol.221 , pp. 454-459
    • Boyer, A.S.1    Runyan, R.B.2
  • 22
    • 0033560169 scopus 로고    scopus 로고
    • TGFbeta2 and TGFbeta3 have separate and sequential activities during epithelial-mesenchymal cell transformation in the embryonic heart
    • Boyer, A. S., Ayerinskas, I. I., Vincent, E. B., McKinney, L. A., Weeks, D. L. and Runyan, R. B. (1999). TGFbeta2 and TGFbeta3 have separate and sequential activities during epithelial-mesenchymal cell transformation in the embryonic heart. Dev. Biol. 208, 530-545.
    • (1999) Dev. Biol. , vol.208 , pp. 530-545
    • Boyer, A.S.1    Ayerinskas, I.I.2    Vincent, E.B.3    McKinney, L.A.4    Weeks, D.L.5    Runyan, R.B.6
  • 24
    • 0036134616 scopus 로고    scopus 로고
    • Requirement for AP-2alpha in cardiac outflow tract morphogenesis
    • Brewer, S., Jiang, X., Donaldson, S., Williams, T. and Sucov, H. M. (2002). Requirement for AP-2alpha in cardiac outflow tract morphogenesis. Mech. Dev. 110, 139-149.
    • (2002) Mech. Dev. , vol.110 , pp. 139-149
    • Brewer, S.1    Jiang, X.2    Donaldson, S.3    Williams, T.4    Sucov, H.M.5
  • 27
    • 0029966491 scopus 로고    scopus 로고
    • Antibodies to the Type II TGFbeta receptor block cell activation and migration during atrioventricular cushion transformation in the heart
    • Brown, C. B., Boyer, A. S., Runyan, R. B. and Barnett, J. V. (1996). Antibodies to the Type II TGFbeta receptor block cell activation and migration during atrioventricular cushion transformation in the heart. Dev. Biol. 174, 248-257.
    • (1996) Dev. Biol. , vol.174 , pp. 248-257
    • Brown, C.B.1    Boyer, A.S.2    Runyan, R.B.3    Barnett, J.V.4
  • 28
    • 0033605704 scopus 로고    scopus 로고
    • Requirement of type III TGF-beta receptor for endocardial cell transformation in the heart
    • Brown, C. B., Boyer, A. S., Runyan, R. B. and Barnett, J. V. (1999). Requirement of type III TGF-beta receptor for endocardial cell transformation in the heart. Science 283, 2080-2082.
    • (1999) Science , vol.283 , pp. 2080-2082
    • Brown, C.B.1    Boyer, A.S.2    Runyan, R.B.3    Barnett, J.V.4
  • 30
    • 0033168070 scopus 로고    scopus 로고
    • Chamber-specific cardiac expression of Tbx5 and heart defects in Holt-Oram syndrome
    • Bruneau, B. G., Logan, M., Davis, N., Levi, T., Tabin, C. J., Seidman, J. G. and Seidman, C. E. (1999). Chamber-specific cardiac expression of Tbx5 and heart defects in Holt-Oram syndrome. Dev. Biol. 211, 100-108.
    • (1999) Dev. Biol. , vol.211 , pp. 100-108
    • Bruneau, B.G.1    Logan, M.2    Davis, N.3    Levi, T.4    Tabin, C.J.5    Seidman, J.G.6    Seidman, C.E.7
  • 32
    • 33644680809 scopus 로고    scopus 로고
    • Building the mammalian heart from two sources of myocardial cells
    • Buckingham, M., Meilhac, S. and Zaffran, S. (2005). Building the mammalian heart from two sources of myocardial cells. Nat. Rev. Genet. 6, 826-837.
    • (2005) Nat. Rev. Genet. , vol.6 , pp. 826-837
    • Buckingham, M.1    Meilhac, S.2    Zaffran, S.3
  • 33
    • 0346783332 scopus 로고    scopus 로고
    • Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart
    • Cai, C. L., Liang, X., Shi, Y., Chu, P. H., Pfaff, S. L., Chen, J. and Evans, S. (2003). Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart. Dev. Cell 5, 877-889.
    • (2003) Dev. Cell , vol.5 , pp. 877-889
    • Cai, C.L.1    Liang, X.2    Shi, Y.3    Chu, P.H.4    Pfaff, S.L.5    Chen, J.6    Evans, S.7
  • 34
    • 84863149111 scopus 로고    scopus 로고
    • Epigenetics and cardiovascular development
    • Chang, C. P. and Bruneau, B. (2012). Epigenetics and cardiovascular development. Annu. Rev. Physiol. 74, 41-68.
    • (2012) Annu. Rev. Physiol. , vol.74 , pp. 41-68
    • Chang, C.P.1    Bruneau, B.2
  • 35
    • 0028947525 scopus 로고
    • Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins
    • Chang, C. P., Shen, W. F., Rozenfeld, S., Lawrence, H. J., Largman, C. and Cleary, M. L. (1995). Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins. Genes Dev. 9, 663-674.
    • (1995) Genes Dev. , vol.9 , pp. 663-674
    • Chang, C.P.1    Shen, W.F.2    Rozenfeld, S.3    Lawrence, H.J.4    Largman, C.5    Cleary, M.L.6
  • 36
    • 0030813558 scopus 로고    scopus 로고
    • Meis proteins are major in vivo DNA binding partners for wild-type but not chimeric Pbx proteins
    • Chang, C. P., Jacobs, Y., Nakamura, T., Jenkins, N. A., Copeland, N. G. and Cleary, M. L. (1997). Meis proteins are major in vivo DNA binding partners for wild-type but not chimeric Pbx proteins. Mol. Cell. Biol. 17, 5679-5687.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 5679-5687
    • Chang, C.P.1    Jacobs, Y.2    Nakamura, T.3    Jenkins, N.A.4    Copeland, N.G.5    Cleary, M.L.6
  • 38
    • 58149346044 scopus 로고    scopus 로고
    • Pbx1 functions in distinct regulatory networks to pattern the great arteries and cardiac outflow tract
    • Chang, C. P., Stankunas, K., Shang, C., Kao, S. C., Twu, K. Y. and Cleary, M. L. (2008). Pbx1 functions in distinct regulatory networks to pattern the great arteries and cardiac outflow tract. Development 135, 3577-3586.
    • (2008) Development , vol.135 , pp. 3577-3586
    • Chang, C.P.1    Stankunas, K.2    Shang, C.3    Kao, S.C.4    Twu, K.Y.5    Cleary, M.L.6
  • 39
    • 4544358659 scopus 로고    scopus 로고
    • Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development
    • Chang, S., McKinsey, T. A., Zhang, C. L., Richardson, J. A., Hill, J. A. and Olson, E. N. (2004). Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development. Mol. Cell. Biol. 24, 8467-8476.
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 8467-8476
    • Chang, S.1    McKinsey, T.A.2    Zhang, C.L.3    Richardson, J.A.4    Hill, J.A.5    Olson, E.N.6
  • 42
    • 34547665471 scopus 로고    scopus 로고
    • Msx1 and Msx2 regulate survival of secondary heart field precursors and postmigratory proliferation of cardiac neural crest in the outflow tract
    • Chen, Y. H., Ishii, M., Sun, J., Sucov, H. M. and Maxson, R. E., Jr (2007). Msx1 and Msx2 regulate survival of secondary heart field precursors and postmigratory proliferation of cardiac neural crest in the outflow tract. Dev. Biol. 308, 421-437.
    • (2007) Dev. Biol. , vol.308 , pp. 421-437
    • Chen, Y.H.1    Ishii, M.2    Sun, J.3    Sucov, H.M.4    Maxson Jr., R.E.5
  • 44
    • 0025797513 scopus 로고
    • Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5
    • Chisaka, O. and Capecchi, M. R. (1991). Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5. Nature 350, 473-479.
    • (1991) Nature , vol.350 , pp. 473-479
    • Chisaka, O.1    Capecchi, M.R.2
  • 45
    • 30044443609 scopus 로고    scopus 로고
    • Cardiovascular malformations with normal smooth muscle differentiation in neural crest-specific type II TGFbeta receptor (Tgfbr2) mutant mice
    • Choudhary, B., Ito, Y., Makita, T., Sasaki, T., Chai, Y. and Sucov, H. M. (2006). Cardiovascular malformations with normal smooth muscle differentiation in neural crest-specific type II TGFbeta receptor (Tgfbr2) mutant mice. Dev. Biol. 289, 420-429.
    • (2006) Dev. Biol. , vol.289 , pp. 420-429
    • Choudhary, B.1    Ito, Y.2    Makita, T.3    Sasaki, T.4    Chai, Y.5    Sucov, H.M.6
  • 46
    • 1842561719 scopus 로고    scopus 로고
    • T-box transcription factor Tbx2 represses differentiation and formation of the cardiac chambers
    • Christoffels, V. M., Hoogaars, W. M., Tessari, A., Clout, D. E., Moorman, A. F. and Campione, M. (2004). T-box transcription factor Tbx2 represses differentiation and formation of the cardiac chambers. Dev. Dyn. 229, 763-770.
    • (2004) Dev. Dyn. , vol.229 , pp. 763-770
    • Christoffels, V.M.1    Hoogaars, W.M.2    Tessari, A.3    Clout, D.E.4    Moorman, A.F.5    Campione, M.6
  • 48
    • 70149088960 scopus 로고    scopus 로고
    • Heart valve development: Regulatory networks in development and disease
    • Combs, M. D. and Yutzey, K. E. (2009). Heart valve development: regulatory networks in development and disease. Circ. Res. 105, 408-421.
    • (2009) Circ. Res. , vol.105 , pp. 408-421
    • Combs, M.D.1    Yutzey, K.E.2
  • 49
    • 0031040876 scopus 로고    scopus 로고
    • Pax3 is required for cardiac neural crest migration in the mouse: Evidence from the splotch (Sp2H) mutant
    • Conway, S. J., Henderson, D. J. and Copp, A. J. (1997). Pax3 is required for cardiac neural crest migration in the mouse: evidence from the splotch (Sp2H) mutant. Development 124, 505-514.
    • (1997) Development , vol.124 , pp. 505-514
    • Conway, S.J.1    Henderson, D.J.2    Copp, A.J.3
  • 51
  • 52
    • 0035312839 scopus 로고    scopus 로고
    • Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactors
    • Crispino, J. D., Lodish, M. B., Thurberg, B. L., Litovsky, S. H., Collins, T., Molkentin, J. D. and Orkin, S. H. (2001). Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactors. Genes Dev. 15, 839-844.
    • (2001) Genes Dev. , vol.15 , pp. 839-844
    • Crispino, J.D.1    Lodish, M.B.2    Thurberg, B.L.3    Litovsky, S.H.4    Collins, T.5    Molkentin, J.D.6    Orkin, S.H.7
  • 55
    • 0037235556 scopus 로고    scopus 로고
    • BMP signaling is required for septation of the outflow tract of the mammalian heart
    • Délot, E. C., Bahamonde, M. E., Zhao, M. and Lyons, K. M. (2003). BMP signaling is required for septation of the outflow tract of the mammalian heart. Development 130, 209-220.
    • (2003) Development , vol.130 , pp. 209-220
    • Délot, E.C.1    Bahamonde, M.E.2    Zhao, M.3    Lyons, K.M.4
  • 56
    • 0037125957 scopus 로고    scopus 로고
    • Tetralogy of fallot and other congenital heart defects in Hey2 mutant mice
    • Donovan, J., Kordylewska, A., Jan, Y. N. and Utset, M. F. (2002). Tetralogy of fallot and other congenital heart defects in Hey2 mutant mice. Curr. Biol. 12, 1605-1610.
    • (2002) Curr. Biol. , vol.12 , pp. 1605-1610
    • Donovan, J.1    Kordylewska, A.2    Jan, Y.N.3    Utset, M.F.4
  • 57
    • 0034985151 scopus 로고    scopus 로고
    • A novel role for VEGF in endocardial cushion formation and its potential contribution to congenital heart defects
    • Dor, Y., Camenisch, T. D., Itin, A., Fishman, G. I., McDonald, J. A., Carmeliet, P. and Keshet, E. (2001). A novel role for VEGF in endocardial cushion formation and its potential contribution to congenital heart defects. Development 128, 1531-1538.
    • (2001) Development , vol.128 , pp. 1531-1538
    • Dor, Y.1    Camenisch, T.D.2    Itin, A.3    Fishman, G.I.4    McDonald, J.A.5    Carmeliet, P.6    Keshet, E.7
  • 59
    • 0036459994 scopus 로고    scopus 로고
    • Tgfbeta2-/-Tgfbeta3-/-double knockout mice display severe midline fusion defects and early embryonic lethality
    • Dünker, N. and Krieglstein, K. (2002). Tgfbeta2-/-Tgfbeta3-/-double knockout mice display severe midline fusion defects and early embryonic lethality. Anat. Embryol. (Berl.) 206, 73-83.
    • (2002) Anat. Embryol. (Berl.) , vol.206 , pp. 73-83
    • Dünker, N.1    Krieglstein, K.2
  • 60
    • 0029061401 scopus 로고
    • Molecular regulation of atrioventricular valvuloseptal morphogenesis
    • Eisenberg, L. M. and Markwald, R. R. (1995). Molecular regulation of atrioventricular valvuloseptal morphogenesis. Circ. Res. 77, 1-6.
    • (1995) Circ. Res. , vol.77 , pp. 1-6
    • Eisenberg, L.M.1    Markwald, R.R.2
  • 62
    • 0025925068 scopus 로고
    • Splotch (Sp2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3
    • Epstein, D. J., Vekemans, M. and Gros, P. (1991). Splotch (Sp2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3. Cell 67, 767-774.
    • (1991) Cell , vol.67 , pp. 767-774
    • Epstein, D.J.1    Vekemans, M.2    Gros, P.3
  • 63
    • 0030475661 scopus 로고    scopus 로고
    • Pax3, neural crest and cardiovascular development
    • Epstein, J. A. (1996). Pax3, neural crest and cardiovascular development. Trends Cardiovasc. Med. 6, 255-260.
    • (1996) Trends Cardiovasc. Med. , vol.6 , pp. 255-260
    • Epstein, J.A.1
  • 65
    • 0031454062 scopus 로고    scopus 로고
    • ErbB3 is required for normal cerebellar and cardiac development: A comparison with ErbB2-and heregulin-deficient mice
    • Erickson, S. L., O'Shea, K. S., Ghaboosi, N., Loverro, L., Frantz, G., Bauer, M., Lu, L. H. and Moore, M. W. (1997). ErbB3 is required for normal cerebellar and cardiac development: a comparison with ErbB2-and heregulin-deficient mice. Development 124, 4999-5011.
    • (1997) Development , vol.124 , pp. 4999-5011
    • Erickson, S.L.1    O'Shea, K.S.2    Ghaboosi, N.3    Loverro, L.4    Frantz, G.5    Bauer, M.6    Lu, L.H.7    Moore, M.W.8
  • 66
    • 57149114315 scopus 로고    scopus 로고
    • Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development
    • Etheridge, S. L., Ray, S., Li, S., Hamblet, N. S., Lijam, N., Tsang, M., Greer, J., Kardos, N., Wang, J., Sussman, D. J. et al. (2008). Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development. PLoS Genet. 4, e1000259.
    • (2008) PLoS Genet. , vol.4
    • Etheridge, S.L.1    Ray, S.2    Li, S.3    Hamblet, N.S.4    Lijam, N.5    Tsang, M.6    Greer, J.7    Kardos, N.8    Wang, J.9    Sussman, D.J.10
  • 68
    • 4344673276 scopus 로고    scopus 로고
    • Phenotypic variability in Hey2-/-mice and absence of HEY2 mutations in patients with congenital heart defects or Alagille syndrome
    • Fischer, A., Klamt, B., Schumacher, N., Glaeser, C., Hansmann, I., Fenge, H. and Gessler, M. (2004). Phenotypic variability in Hey2-/-mice and absence of HEY2 mutations in patients with congenital heart defects or Alagille syndrome. Mamm. Genome 15, 711-716.
    • (2004) Mamm. Genome , vol.15 , pp. 711-716
    • Fischer, A.1    Klamt, B.2    Schumacher, N.3    Glaeser, C.4    Hansmann, I.5    Fenge, H.6    Gessler, M.7
  • 70
    • 0029021660 scopus 로고
    • Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
    • Fong, G. H., Rossant, J., Gertsenstein, M. and Breitman, M. L. (1995). Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 376, 66-70.
    • (1995) Nature , vol.376 , pp. 66-70
    • Fong, G.H.1    Rossant, J.2    Gertsenstein, M.3    Breitman, M.L.4
  • 73
    • 42049107565 scopus 로고    scopus 로고
    • Atrial myocardium derives from the posterior region of the second heart field, which acquires left-right identity as Pitx2c is expressed
    • Galli, D., Domínguez, J. N., Zaffran, S., Munk, A., Brown, N. A. and Buckingham, M. E. (2008). Atrial myocardium derives from the posterior region of the second heart field, which acquires left-right identity as Pitx2c is expressed. Development 135, 1157-1167.
    • (2008) Development , vol.135 , pp. 1157-1167
    • Galli, D.1    Domínguez, J.N.2    Zaffran, S.3    Munk, A.4    Brown, N.A.5    Buckingham, M.E.6
  • 75
    • 77951236294 scopus 로고    scopus 로고
    • Ets1 is required for proper migration and differentiation of the cardiac neural crest
    • Gao, Z., Kim, G. H., Mackinnon, A. C., Flagg, A. E., Bassett, B., Earley, J. U. and Svensson, E. C. (2010). Ets1 is required for proper migration and differentiation of the cardiac neural crest. Development 137, 1543-1551.
    • (2010) Development , vol.137 , pp. 1543-1551
    • Gao, Z.1    Kim, G.H.2    Mackinnon, A.C.3    Flagg, A.E.4    Bassett, B.5    Earley, J.U.6    Svensson, E.C.7
  • 76
    • 33748196362 scopus 로고    scopus 로고
    • Molecular genetics of aortic valve disease
    • Garg, V. (2006). Molecular genetics of aortic valve disease. Curr. Opin. Cardiol. 21, 180-184.
    • (2006) Curr. Opin. Cardiol. , vol.21 , pp. 180-184
    • Garg, V.1
  • 79
    • 0028785406 scopus 로고
    • Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor
    • Gassmann, M., Casagranda, F., Orioli, D., Simon, H., Lai, C., Klein, R. and Lemke, G. (1995). Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor. Nature 378, 390-394.
    • (1995) Nature , vol.378 , pp. 390-394
    • Gassmann, M.1    Casagranda, F.2    Orioli, D.3    Simon, H.4    Lai, C.5    Klein, R.6    Lemke, G.7
  • 81
    • 4344594556 scopus 로고    scopus 로고
    • PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development
    • Gitler, A. D., Lu, M. M. and Epstein, J. A. (2004). PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development. Dev. Cell 7, 107-116.
    • (2004) Dev. Cell , vol.7 , pp. 107-116
    • Gitler, A.D.1    Lu, M.M.2    Epstein, J.A.3
  • 82
    • 34248588104 scopus 로고    scopus 로고
    • Independent requirements for Hedgehog signaling by both the anterior heart field and neural crest cells for outflow tract development
    • Goddeeris, M. M., Schwartz, R., Klingensmith, J. and Meyers, E. N. (2007). Independent requirements for Hedgehog signaling by both the anterior heart field and neural crest cells for outflow tract development. Development 134, 1593-1604.
    • (2007) Development , vol.134 , pp. 1593-1604
    • Goddeeris, M.M.1    Schwartz, R.2    Klingensmith, J.3    Meyers, E.N.4
  • 85
    • 79959949912 scopus 로고    scopus 로고
    • Mechanisms of T-box gene function in the developing heart
    • Greulich, F., Rudat, C. and Kispert, A. (2011). Mechanisms of T-box gene function in the developing heart. Cardiovasc. Res. 91, 212-222.
    • (2011) Cardiovasc. Res. , vol.91 , pp. 212-222
    • Greulich, F.1    Rudat, C.2    Kispert, A.3
  • 86
    • 0029780320 scopus 로고    scopus 로고
    • RXR alpha deficiency confers genetic susceptibility for aortic sac, conotruncal, atrioventricular cushion, and ventricular muscle defects in mice
    • Gruber, P. J., Kubalak, S. W., Pexieder, T., Sucov, H. M., Evans, R. M. and Chien, K. R. (1996). RXR alpha deficiency confers genetic susceptibility for aortic sac, conotruncal, atrioventricular cushion, and ventricular muscle defects in mice. J. Clin. Invest. 98, 1332-1343.
    • (1996) J. Clin. Invest. , vol.98 , pp. 1332-1343
    • Gruber, P.J.1    Kubalak, S.W.2    Pexieder, T.3    Sucov, H.M.4    Evans, R.M.5    Chien, K.R.6
  • 87
    • 0037093383 scopus 로고    scopus 로고
    • Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: Implications for cardiac chamber formation
    • Habets, P. E., Moorman, A. F., Clout, D. E., van Roon, M. A., Lingbeek, M., van Lohuizen, M., Campione, M. and Christoffels, V. M. (2002). Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation. Genes Dev. 16, 1234-1246.
    • (2002) Genes Dev. , vol.16 , pp. 1234-1246
    • Habets, P.E.1    Moorman, A.F.2    Clout, D.E.3    van Roon, M.A.4    Lingbeek, M.5    van Lohuizen, M.6    Campione, M.7    Christoffels, V.M.8
  • 89
    • 79751473406 scopus 로고    scopus 로고
    • Chromatin remodeling in cardiovascular development and physiology
    • Han, P., Hang, C. T., Yang, J. and Chang, C. P. (2011). Chromatin remodeling in cardiovascular development and physiology. Circ. Res. 108, 378-396.
    • (2011) Circ. Res. , vol.108 , pp. 378-396
    • Han, P.1    Hang, C.T.2    Yang, J.3    Chang, C.P.4
  • 90
    • 77954222814 scopus 로고    scopus 로고
    • Chromatin regulation by Brg1 underlies heart muscle development and disease
    • Hang, C. T., Yang, J., Han, P., Cheng, H. L., Shang, C., Ashley, E., Zhou, B. and Chang, C. P. (2010). Chromatin regulation by Brg1 underlies heart muscle development and disease. Nature 466, 62-67.
    • (2010) Nature , vol.466 , pp. 62-67
    • Hang, C.T.1    Yang, J.2    Han, P.3    Cheng, H.L.4    Shang, C.5    Ashley, E.6    Zhou, B.7    Chang, C.P.8
  • 91
    • 8444252934 scopus 로고    scopus 로고
    • Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outflow tract during heart development
    • Harrelson, Z., Kelly, R. G., Goldin, S. N., Gibson-Brown, J. J., Bollag, R. J., Silver, L. M. and Papaioannou, V. E. (2004). Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outflow tract during heart development. Development 131, 5041-5052.
    • (2004) Development , vol.131 , pp. 5041-5052
    • Harrelson, Z.1    Kelly, R.G.2    Goldin, S.N.3    Gibson-Brown, J.J.4    Bollag, R.J.5    Silver, L.M.6    Papaioannou, V.E.7
  • 92
    • 77954762643 scopus 로고    scopus 로고
    • Development of the endocardium
    • Harris, I. S. and Black, B. L. (2010). Development of the endocardium. Pediatr. Cardiol. 31, 391-399.
    • (2010) Pediatr. Cardiol. , vol.31 , pp. 391-399
    • Harris, I.S.1    Black, B.L.2
  • 93
    • 40949131393 scopus 로고    scopus 로고
    • Signalling pathways regulating cardiac neural crest migration and differentiation
    • High, F. and Epstein, J. A. (2007). Signalling pathways regulating cardiac neural crest migration and differentiation. Novartis Found. Symp. 283, 238-241.
    • (2007) Novartis Found. Symp. , vol.283 , pp. 238-241
    • High, F.1    Epstein, J.A.2
  • 94
    • 33846839628 scopus 로고    scopus 로고
    • An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation
    • High, F. A., Zhang, M., Proweller, A., Tu, L., Parmacek, M. S., Pear, W. S. and Epstein, J. A. (2007). An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation. J. Clin. Invest. 117, 353-363.
    • (2007) J. Clin. Invest. , vol.117 , pp. 353-363
    • High, F.A.1    Zhang, M.2    Proweller, A.3    Tu, L.4    Parmacek, M.S.5    Pear, W.S.6    Epstein, J.A.7
  • 95
    • 68849128613 scopus 로고    scopus 로고
    • Murine Jagged1/Notch signaling in the second heart field orchestrates Fgf8 expression and tissue-tissue interactions during outflow tract development
    • High, F. A., Jain, R., Stoller, J. Z., Antonucci, N. B., Lu, M. M., Loomes, K. M., Kaestner, K. H., Pear, W. S. and Epstein, J. A. (2009). Murine Jagged1/Notch signaling in the second heart field orchestrates Fgf8 expression and tissue-tissue interactions during outflow tract development. J. Clin. Invest. 119, 1986-1996.
    • (2009) J. Clin. Invest. , vol.119 , pp. 1986-1996
    • High, F.A.1    Jain, R.2    Stoller, J.Z.3    Antonucci, N.B.4    Lu, M.M.5    Loomes, K.M.6    Kaestner, K.H.7    Pear, W.S.8    Epstein, J.A.9
  • 97
    • 0037134945 scopus 로고    scopus 로고
    • The incidence of congenital heart disease
    • Hoffman, J. I. and Kaplan, S. (2002). The incidence of congenital heart disease. J. Am. Coll. Cardiol. 39, 1890-1900.
    • (2002) J. Am. Coll. Cardiol. , vol.39 , pp. 1890-1900
    • Hoffman, J.I.1    Kaplan, S.2
  • 98
    • 0033366516 scopus 로고    scopus 로고
    • A loss-of-function mutation in the endothelin-converting enzyme 1 (ECE-1) associated with Hirschsprung disease, cardiac defects, and autonomic dysfunction
    • Hofstra, R. M., Valdenaire, O., Arch, E., Osinga, J., Kroes, H., Löffler, B. M., Hamosh, A., Meijers, C. and Buys, C. H. (1999). A loss-of-function mutation in the endothelin-converting enzyme 1 (ECE-1) associated with Hirschsprung disease, cardiac defects, and autonomic dysfunction. Am. J. Hum. Genet. 64, 304-307.
    • (1999) Am. J. Hum. Genet. , vol.64 , pp. 304-307
    • Hofstra, R.M.1    Valdenaire, O.2    Arch, E.3    Osinga, J.4    Kroes, H.5    Löffler, B.M.6    Hamosh, A.7    Meijers, C.8    Buys, C.H.9
  • 100
    • 77950470497 scopus 로고    scopus 로고
    • Beta-catenin deficiency causes DiGeorge syndrome-like phenotypes through regulation of Tbx1
    • Huh, S. H. and Ornitz, D. M. (2010). Beta-catenin deficiency causes DiGeorge syndrome-like phenotypes through regulation of Tbx1. Development 137, 1137-1147.
    • (2010) Development , vol.137 , pp. 1137-1147
    • Huh, S.H.1    Ornitz, D.M.2
  • 103
    • 0037507267 scopus 로고    scopus 로고
    • Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling
    • Jackson, L. F., Qiu, T. H., Sunnarborg, S. W., Chang, A., Zhang, C., Patterson, C. and Lee, D. C. (2003). Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling. EMBO J. 22, 2704-2716.
    • (2003) EMBO J. , vol.22 , pp. 2704-2716
    • Jackson, L.F.1    Qiu, T.H.2    Sunnarborg, S.W.3    Chang, A.4    Zhang, C.5    Patterson, C.6    Lee, D.C.7
  • 104
  • 105
    • 0035098557 scopus 로고    scopus 로고
    • DiGeorge syndrome phenotype in mice mutant for the T-box gene, Tbx1
    • Jerome, L. A. and Papaioannou, V. E. (2001). DiGeorge syndrome phenotype in mice mutant for the T-box gene, Tbx1. Nat. Genet. 27, 286-291.
    • (2001) Nat. Genet. , vol.27 , pp. 286-291
    • Jerome, L.A.1    Papaioannou, V.E.2
  • 106
    • 35348917234 scopus 로고    scopus 로고
    • Smad signaling in the neural crest regulates cardiac outflow tract remodeling through cell autonomous and non-cell autonomous effects
    • Jia, Q., McDill, B. W., Li, S. Z., Deng, C., Chang, C. P. and Chen, F. (2007). Smad signaling in the neural crest regulates cardiac outflow tract remodeling through cell autonomous and non-cell autonomous effects. Dev. Biol. 311, 172-184.
    • (2007) Dev. Biol. , vol.311 , pp. 172-184
    • Jia, Q.1    McDill, B.W.2    Li, S.Z.3    Deng, C.4    Chang, C.P.5    Chen, F.6
  • 108
    • 0036768806 scopus 로고    scopus 로고
    • Normal fate and altered function of the cardiac neural crest cell lineage in retinoic acid receptor mutant embryos
    • Jiang, X., Choudhary, B., Merki, E., Chien, K. R., Maxson, R. E. and Sucov, H. M. (2002). Normal fate and altered function of the cardiac neural crest cell lineage in retinoic acid receptor mutant embryos. Mech. Dev. 117, 115-122.
    • (2002) Mech. Dev. , vol.117 , pp. 115-122
    • Jiang, X.1    Choudhary, B.2    Merki, E.3    Chien, K.R.4    Maxson, R.E.5    Sucov, H.M.6
  • 109
    • 0141445966 scopus 로고    scopus 로고
    • An essential role of Bmp4 in the atrioventricular septation of the mouse heart
    • Jiao, K., Kulessa, H., Tompkins, K., Zhou, Y., Batts, L., Baldwin, H. S. and Hogan, B. L. (2003). An essential role of Bmp4 in the atrioventricular septation of the mouse heart. Genes Dev. 17, 2362-2367.
    • (2003) Genes Dev. , vol.17 , pp. 2362-2367
    • Jiao, K.1    Kulessa, H.2    Tompkins, K.3    Zhou, Y.4    Batts, L.5    Baldwin, H.S.6    Hogan, B.L.7
  • 110
    • 33845878509 scopus 로고    scopus 로고
    • Tgfbeta signaling is required for atrioventricular cushion mesenchyme remodeling during in vivo cardiac development
    • Jiao, K., Langworthy, M., Batts, L., Brown, C. B., Moses, H. L. and Baldwin, H. S. (2006). Tgfbeta signaling is required for atrioventricular cushion mesenchyme remodeling during in vivo cardiac development. Development 133, 4585-4593.
    • (2006) Development , vol.133 , pp. 4585-4593
    • Jiao, K.1    Langworthy, M.2    Batts, L.3    Brown, C.B.4    Moses, H.L.5    Baldwin, H.S.6
  • 111
    • 0028806184 scopus 로고
    • Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelialmesenchymal interaction
    • Kaartinen, V., Voncken, J. W., Shuler, C., Warburton, D., Bu, D., Heisterkamp, N. and Groffen, J. (1995). Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelialmesenchymal interaction. Nat. Genet. 11, 415-421.
    • (1995) Nat. Genet. , vol.11 , pp. 415-421
    • Kaartinen, V.1    Voncken, J.W.2    Shuler, C.3    Warburton, D.4    Bu, D.5    Heisterkamp, N.6    Groffen, J.7
  • 112
    • 4243182734 scopus 로고    scopus 로고
    • Cardiac outflow tract defects in mice lacking ALK2 in neural crest cells
    • Kaartinen, V., Dudas, M., Nagy, A., Sridurongrit, S., Lu, M. M. and Epstein, J. A. (2004). Cardiac outflow tract defects in mice lacking ALK2 in neural crest cells. Development 131, 3481-3490.
    • (2004) Development , vol.131 , pp. 3481-3490
    • Kaartinen, V.1    Dudas, M.2    Nagy, A.3    Sridurongrit, S.4    Lu, M.M.5    Epstein, J.A.6
  • 115
    • 0035461911 scopus 로고    scopus 로고
    • The arterial pole of the mouse heart forms from Fgf10-expressing cells in pharyngeal mesoderm
    • Kelly, R. G., Brown, N. A. and Buckingham, M. E. (2001). The arterial pole of the mouse heart forms from Fgf10-expressing cells in pharyngeal mesoderm. Dev. Cell 1, 435-440.
    • (2001) Dev. Cell , vol.1 , pp. 435-440
    • Kelly, R.G.1    Brown, N.A.2    Buckingham, M.E.3
  • 116
    • 0035879140 scopus 로고    scopus 로고
    • Bmp6 and Bmp7 are required for cushion formation and septation in the developing mouse heart
    • Kim, R. Y., Robertson, E. J. and Solloway, M. J. (2001). Bmp6 and Bmp7 are required for cushion formation and septation in the developing mouse heart. Dev. Biol. 235, 449-466.
    • (2001) Dev. Biol. , vol.235 , pp. 449-466
    • Kim, R.Y.1    Robertson, E.J.2    Solloway, M.J.3
  • 117
    • 18744369031 scopus 로고    scopus 로고
    • Identification of a Wnt/Dvl/beta-Catenin r Pitx2 pathway mediating cell-type-specific proliferation during development
    • Kioussi, C., Briata, P., Baek, S. H., Rose, D. W., Hamblet, N. S., Herman, T., Ohgi, K. A., Lin, C., Gleiberman, A., Wang, J. et al. (2002). Identification of a Wnt/Dvl/beta-Catenin r Pitx2 pathway mediating cell-type-specific proliferation during development. Cell 111, 673-685.
    • (2002) Cell , vol.111 , pp. 673-685
    • Kioussi, C.1    Briata, P.2    Baek, S.H.3    Rose, D.W.4    Hamblet, N.S.5    Herman, T.6    Ohgi, K.A.7    Lin, C.8    Gleiberman, A.9    Wang, J.10
  • 118
    • 0020640517 scopus 로고
    • Neural crest cells contribute to normal aorticopulmonary septation
    • Kirby, M. L., Gale, T. F. and Stewart, D. E. (1983). Neural crest cells contribute to normal aorticopulmonary septation. Science 220, 1059-1061.
    • (1983) Science , vol.220 , pp. 1059-1061
    • Kirby, M.L.1    Gale, T.F.2    Stewart, D.E.3
  • 119
    • 34547738523 scopus 로고    scopus 로고
    • Mutations in cardiac T-box factor gene TBX20 are associated with diverse cardiac pathologies, including defects of septation and valvulogenesis and cardiomyopathy
    • Kirk, E. P., Sunde, M., Costa, M. W., Rankin, S. A., Wolstein, O., Castro, M. L., Butler, T. L., Hyun, C., Guo, G., Otway, R. et al. (2007). Mutations in cardiac T-box factor gene TBX20 are associated with diverse cardiac pathologies, including defects of septation and valvulogenesis and cardiomyopathy. Am. J. Hum. Genet. 81, 280-291.
    • (2007) Am. J. Hum. Genet. , vol.81 , pp. 280-291
    • Kirk, E.P.1    Sunde, M.2    Costa, M.W.3    Rankin, S.A.4    Wolstein, O.5    Castro, M.L.6    Butler, T.L.7    Hyun, C.8    Guo, G.9    Otway, R.10
  • 123
  • 125
    • 79959913398 scopus 로고    scopus 로고
    • Loss of Gata5 in mice leads to bicuspid aortic valve
    • Laforest, B., Andelfinger, G. and Nemer, M. (2011). Loss of Gata5 in mice leads to bicuspid aortic valve. J. Clin. Invest. 121, 2876-2887.
    • (2011) J. Clin. Invest. , vol.121 , pp. 2876-2887
    • Laforest, B.1    Andelfinger, G.2    Nemer, M.3
  • 126
    • 0031647555 scopus 로고    scopus 로고
    • Neurofibromin modulation of ras activity is required for normal endocardial-mesenchymal transformation in the developing heart
    • Lakkis, M. M. and Epstein, J. A. (1998). Neurofibromin modulation of ras activity is required for normal endocardial-mesenchymal transformation in the developing heart. Development 125, 4359-4367.
    • (1998) Development , vol.125 , pp. 4359-4367
    • Lakkis, M.M.1    Epstein, J.A.2
  • 127
    • 0347193003 scopus 로고    scopus 로고
    • DSCR1 gene expression is dependent on NFATc1 during cardiac valve formation and colocalizes with anomalous organ development in trisomy 16 mice
    • Lange, A. W., Molkentin, J. D. and Yutzey, K. E. (2004). DSCR1 gene expression is dependent on NFATc1 during cardiac valve formation and colocalizes with anomalous organ development in trisomy 16 mice. Dev. Biol. 266, 346-360.
    • (2004) Dev. Biol. , vol.266 , pp. 346-360
    • Lange, A.W.1    Molkentin, J.D.2    Yutzey, K.E.3
  • 128
    • 78149464338 scopus 로고    scopus 로고
    • Conditional inactivation of TGF-(type II receptor in smooth muscle cells and epicardium causes lethal aortic and cardiac defects
    • Langlois, D., Hneino, M., Bouazza, L., Parlakian, A., Sasaki, T., Bricca, G. and Li, J. Y. (2010). Conditional inactivation of TGF-(type II receptor in smooth muscle cells and epicardium causes lethal aortic and cardiac defects. Transgenic Res. 19, 1069-1082.
    • (2010) Transgenic Res. , vol.19 , pp. 1069-1082
    • Langlois, D.1    Hneino, M.2    Bouazza, L.3    Parlakian, A.4    Sasaki, T.5    Bricca, G.6    Li, J.Y.7
  • 129
    • 0025942116 scopus 로고
    • Clonal analysis of epiblast fate during germ layer formation in the mouse embryo
    • Lawson, K. A., Meneses, J. J. and Pedersen, R. A. (1991). Clonal analysis of epiblast fate during germ layer formation in the mouse embryo. Development 113, 891-911.
    • (1991) Development , vol.113 , pp. 891-911
    • Lawson, K.A.1    Meneses, J.J.2    Pedersen, R.A.3
  • 130
    • 0028884413 scopus 로고
    • Requirement for neuregulin receptor erbB2 in neural and cardiac development
    • Lee, K. F., Simon, H., Chen, H., Bates, B., Hung, M. C. and Hauser, C. (1995). Requirement for neuregulin receptor erbB2 in neural and cardiac development. Nature 378, 394-398.
    • (1995) Nature , vol.378 , pp. 394-398
    • Lee, K.F.1    Simon, H.2    Chen, H.3    Bates, B.4    Hung, M.C.5    Hauser, C.6
  • 131
    • 0030906262 scopus 로고    scopus 로고
    • Compartment-selective sensitivity of cardiovascular morphogenesis to combinations of retinoic acid receptor gene mutations
    • Lee, R. Y., Luo, J., Evans, R. M., Giguere, V. and Sucov, H. M. (1997). Compartment-selective sensitivity of cardiovascular morphogenesis to combinations of retinoic acid receptor gene mutations. Circ. Res. 80, 757-764.
    • (1997) Circ. Res. , vol.80 , pp. 757-764
    • Lee, R.Y.1    Luo, J.2    Evans, R.M.3    Giguere, V.4    Sucov, H.M.5
  • 132
    • 0034704998 scopus 로고    scopus 로고
    • Abnormal aortic valve development in mice lacking endothelial nitric oxide synthase
    • Lee, T. C., Zhao, Y. D., Courtman, D. W. and Stewart, D. J. (2000). Abnormal aortic valve development in mice lacking endothelial nitric oxide synthase. Circulation 101, 2345-2348.
    • (2000) Circulation , vol.101 , pp. 2345-2348
    • Lee, T.C.1    Zhao, Y.D.2    Courtman, D.W.3    Stewart, D.J.4
  • 133
    • 0034640295 scopus 로고    scopus 로고
    • Jumonji, a nuclear protein that is necessary for normal heart development
    • Lee, Y., Song, A. J., Baker, R., Micales, B., Conway, S. J. and Lyons, G. E. (2000). Jumonji, a nuclear protein that is necessary for normal heart development. Circ. Res. 86, 932-938.
    • (2000) Circ. Res. , vol.86 , pp. 932-938
    • Lee, Y.1    Song, A.J.2    Baker, R.3    Micales, B.4    Conway, S.J.5    Lyons, G.E.6
  • 134
    • 33645503504 scopus 로고    scopus 로고
    • GATA-6 regulates semaphorin 3C and is required in cardiac neural crest for cardiovascular morphogenesis
    • Lepore, J. J., Mericko, P. A., Cheng, L., Lu, M. M., Morrisey, E. E. and Parmacek, M. S. (2006). GATA-6 regulates semaphorin 3C and is required in cardiac neural crest for cardiovascular morphogenesis. J. Clin. Invest. 116, 929-939.
    • (2006) J. Clin. Invest. , vol.116 , pp. 929-939
    • Lepore, J.J.1    Mericko, P.A.2    Cheng, L.3    Lu, M.M.4    Morrisey, E.E.5    Parmacek, M.S.6
  • 136
    • 0034063281 scopus 로고    scopus 로고
    • Neural crest expression of Cre recombinase directed by the proximal Pax3 promoter in transgenic mice
    • Li, J., Chen, F. and Epstein, J. A. (2000). Neural crest expression of Cre recombinase directed by the proximal Pax3 promoter in transgenic mice. Genesis 26, 162-164.
    • (2000) Genesis , vol.26 , pp. 162-164
    • Li, J.1    Chen, F.2    Epstein, J.A.3
  • 137
    • 77950592658 scopus 로고    scopus 로고
    • Retinoic acid regulates differentiation of the secondary heart field and TGFbeta-mediated outflow tract septation
    • Li, P., Pashmforoush, M. and Sucov, H. M. (2010). Retinoic acid regulates differentiation of the secondary heart field and TGFbeta-mediated outflow tract septation. Dev. Cell 18, 480-485.
    • (2010) Dev. Cell , vol.18 , pp. 480-485
    • Li, P.1    Pashmforoush, M.2    Sucov, H.M.3
  • 139
    • 3543095147 scopus 로고    scopus 로고
    • Beta-catenin is required for endothelial-mesenchymal transformation during heart cushion development in the mouse
    • Liebner, S., Cattelino, A., Gallini, R., Rudini, N., Iurlaro, M., Piccolo, S. and Dejana, E. (2004). Beta-catenin is required for endothelial-mesenchymal transformation during heart cushion development in the mouse. J. Cell Biol. 166, 359-367.
    • (2004) J. Cell Biol. , vol.166 , pp. 359-367
    • Liebner, S.1    Cattelino, A.2    Gallini, R.3    Rudini, N.4    Iurlaro, M.5    Piccolo, S.6    Dejana, E.7
  • 140
    • 84862798575 scopus 로고    scopus 로고
    • The secondary heart field is a new site of calcineurin/Nfatc1 signaling for semilunar valve development
    • Lin, C. Y., Lin, C. J., Chen, C. H., Chen, R. M., Zhou, B. and Chang, C. P. (2012). The secondary heart field is a new site of calcineurin/Nfatc1 signaling for semilunar valve development. J. Mol. Cell. Cardiol. 52, 1096-1102.
    • (2012) J. Mol. Cell. Cardiol. , vol.52 , pp. 1096-1102
    • Lin, C.Y.1    Lin, C.J.2    Chen, C.H.3    Chen, R.M.4    Zhou, B.5    Chang, C.P.6
  • 141
    • 33745267057 scopus 로고    scopus 로고
    • Isl1 is upstream of sonic hedgehog in a pathway required for cardiac morphogenesis
    • Lin, L., Bu, L., Cai, C. L., Zhang, X. and Evans, S. (2006). Isl1 is upstream of sonic hedgehog in a pathway required for cardiac morphogenesis. Dev. Biol. 295, 756-763.
    • (2006) Dev. Biol. , vol.295 , pp. 756-763
    • Lin, L.1    Bu, L.2    Cai, C.L.3    Zhang, X.4    Evans, S.5
  • 142
    • 34250888462 scopus 로고    scopus 로고
    • Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis
    • Lin, L., Cui, L., Zhou, W., Dufort, D., Zhang, X., Cai, C. L., Bu, L., Yang, L., Martin, J., Kemler, R. et al. (2007). Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis. Proc. Natl. Acad. Sci. USA 104, 9313-9318.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 9313-9318
    • Lin, L.1    Cui, L.2    Zhou, W.3    Dufort, D.4    Zhang, X.5    Cai, C.L.6    Bu, L.7    Yang, L.8    Martin, J.9    Kemler, R.10
  • 144
    • 0037092595 scopus 로고    scopus 로고
    • Molecular genetics of Axenfeld-Rieger malformations
    • Lines, M. A., Kozlowski, K. and Walter, M. A. (2002). Molecular genetics of Axenfeld-Rieger malformations. Hum. Mol. Genet. 11, 1177-1187.
    • (2002) Hum. Mol. Genet. , vol.11 , pp. 1177-1187
    • Lines, M.A.1    Kozlowski, K.2    Walter, M.A.3
  • 145
    • 56649091211 scopus 로고    scopus 로고
    • T-box transcription factor TBX20 mutations in Chinese patients with congenital heart disease
    • Liu, C., Shen, A., Li, X., Jiao, W., Zhang, X. and Li, Z. (2008). T-box transcription factor TBX20 mutations in Chinese patients with congenital heart disease. Eur. J. Med. Genet. 51, 580-587.
    • (2008) Eur. J. Med. Genet. , vol.51 , pp. 580-587
    • Liu, C.1    Shen, A.2    Li, X.3    Jiao, W.4    Zhang, X.5    Li, Z.6
  • 146
    • 57749121689 scopus 로고    scopus 로고
    • microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart
    • Liu, N., Bezprozvannaya, S., Williams, A. H., Qi, X., Richardson, J. A., Bassel-Duby, R. and Olson, E. N. (2008). microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart. Genes Dev. 22, 3242-3254.
    • (2008) Genes Dev. , vol.22 , pp. 3242-3254
    • Liu, N.1    Bezprozvannaya, S.2    Williams, A.H.3    Qi, X.4    Richardson, J.A.5    Bassel-Duby, R.6    Olson, E.N.7
  • 149
    • 33750404816 scopus 로고    scopus 로고
    • N-cadherin is required for neural crest remodeling of the cardiac outflow tract
    • Luo, Y., High, F. A., Epstein, J. A. and Radice, G. L. (2006). N-cadherin is required for neural crest remodeling of the cardiac outflow tract. Dev. Biol. 299, 517-528.
    • (2006) Dev. Biol. , vol.299 , pp. 517-528
    • Luo, Y.1    High, F.A.2    Epstein, J.A.3    Radice, G.L.4
  • 150
    • 31144440253 scopus 로고    scopus 로고
    • Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning
    • Ma, L., Lu, M. F., Schwartz, R. J. and Martin, J. F. (2005). Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning. Development 132, 5601-5611.
    • (2005) Development , vol.132 , pp. 5601-5611
    • Ma, L.1    Lu, M.F.2    Schwartz, R.J.3    Martin, J.F.4
  • 151
    • 77956332837 scopus 로고    scopus 로고
    • Notch signaling in cardiac development and disease
    • MacGrogan, D., Nus, M. and de la Pompa, J. L. (2010). Notch signaling in cardiac development and disease. Curr. Top. Dev. Biol. 92, 333-365.
    • (2010) Curr. Top. Dev. Biol. , vol.92 , pp. 333-365
    • MacGrogan, D.1    Nus, M.2    de la Pompa, J.L.3
  • 154
    • 50849104527 scopus 로고    scopus 로고
    • NOTCH1 mutations in individuals with left ventricular outflow tract malformations reduce ligand-induced signaling
    • McBride, K. L., Riley, M. F., Zender, G. A., Fitzgerald-Butt, S. M., Towbin, J. A., Belmont, J. W. and Cole, S. E. (2008). NOTCH1 mutations in individuals with left ventricular outflow tract malformations reduce ligand-induced signaling. Hum. Mol. Genet. 17, 2886-2893.
    • (2008) Hum. Mol. Genet. , vol.17 , pp. 2886-2893
    • McBride, K.L.1    Riley, M.F.2    Zender, G.A.3    Fitzgerald-Butt, S.M.4    Towbin, J.A.5    Belmont, J.W.6    Cole, S.E.7
  • 155
    • 0036339631 scopus 로고    scopus 로고
    • A mouse model of Alagille syndrome: Notch2 as a genetic modifier of Jag1 haploinsufficiency
    • McCright, B., Lozier, J. and Gridley, T. (2002). A mouse model of Alagille syndrome: Notch2 as a genetic modifier of Jag1 haploinsufficiency. Development 129, 1075-1082.
    • (2002) Development , vol.129 , pp. 1075-1082
    • McCright, B.1    Lozier, J.2    Gridley, T.3
  • 156
    • 55549092471 scopus 로고    scopus 로고
    • BMP4 is required in the anterior heart field and its derivatives for endocardial cushion remodeling, outflow tract septation, and semilunar valve development
    • McCulley, D. J., Kang, J. O., Martin, J. F. and Black, B. L. (2008). BMP4 is required in the anterior heart field and its derivatives for endocardial cushion remodeling, outflow tract septation, and semilunar valve development. Dev. Dyn. 237, 3200-3209.
    • (2008) Dev. Dyn. , vol.237 , pp. 3200-3209
    • McCulley, D.J.1    Kang, J.O.2    Martin, J.F.3    Black, B.L.4
  • 159
    • 33644852924 scopus 로고    scopus 로고
    • Novel TBX3 mutation data in families with ulnar-mammary syndrome indicate a genotype-phenotype relationship: Mutations that do not disrupt the T-domain are associated with less severe limb defects
    • Meneghini, V., Odent, S., Platonova, N., Egeo, A. and Merlo, G. R. (2006). Novel TBX3 mutation data in families with ulnar-mammary syndrome indicate a genotype-phenotype relationship: mutations that do not disrupt the T-domain are associated with less severe limb defects. Eur. J. Med. Genet. 49, 151-158.
    • (2006) Eur. J. Med. Genet. , vol.49 , pp. 151-158
    • Meneghini, V.1    Odent, S.2    Platonova, N.3    Egeo, A.4    Merlo, G.R.5
  • 163
    • 0028827104 scopus 로고
    • Multiple essential functions of neuregulin in development
    • Meyer, D. and Birchmeier, C. (1995). Multiple essential functions of neuregulin in development. Nature 378, 386-390.
    • (1995) Nature , vol.378 , pp. 386-390
    • Meyer, D.1    Birchmeier, C.2
  • 165
    • 0025977578 scopus 로고
    • Embryonic gene expression patterns of TGF beta 1, beta 2 and beta 3 suggest different developmental functions in vivo
    • Millan, F. A., Denhez, F., Kondaiah, P. and Akhurst, R. J. (1991). Embryonic gene expression patterns of TGF beta 1, beta 2 and beta 3 suggest different developmental functions in vivo. Development 111, 131-143.
    • (1991) Development , vol.111 , pp. 131-143
    • Millan, F.A.1    Denhez, F.2    Kondaiah, P.3    Akhurst, R.J.4
  • 168
    • 0037869525 scopus 로고    scopus 로고
    • Development of the heart: (1) formation of the cardiac chambers and arterial trunks
    • Moorman, A., Webb, S., Brown, N. A., Lamers, W. and Anderson, R. H. (2003). Development of the heart: (1) formation of the cardiac chambers and arterial trunks. Heart 89, 806-814.
    • (2003) Heart , vol.89 , pp. 806-814
    • Moorman, A.1    Webb, S.2    Brown, N.A.3    Lamers, W.4    Anderson, R.H.5
  • 169
    • 58149394175 scopus 로고    scopus 로고
    • Cardiac neural crest expression of Hand2 regulates outflow and second heart field development
    • Morikawa, Y. and Cserjesi, P. (2008). Cardiac neural crest expression of Hand2 regulates outflow and second heart field development. Circ. Res. 103, 1422-1429.
    • (2008) Circ. Res. , vol.103 , pp. 1422-1429
    • Morikawa, Y.1    Cserjesi, P.2
  • 170
    • 73849134811 scopus 로고    scopus 로고
    • Canonical Notch signaling in the developing lung is required for determination of arterial smooth muscle cells and selection of Clara versus ciliated cell fate
    • Morimoto, M., Liu, Z., Cheng, H. T., Winters, N., Bader, D. and Kopan, R. (2010). Canonical Notch signaling in the developing lung is required for determination of arterial smooth muscle cells and selection of Clara versus ciliated cell fate. J. Cell Sci. 123, 213-224.
    • (2010) J. Cell Sci. , vol.123 , pp. 213-224
    • Morimoto, M.1    Liu, Z.2    Cheng, H.T.3    Winters, N.4    Bader, D.5    Kopan, R.6
  • 174
    • 72049100179 scopus 로고    scopus 로고
    • Wnt-11 signalling controls ventricular myocardium development by patterning N-cadherin and beta-catenin expression
    • Nagy, I. I., Railo, A., Rapila, R., Hast, T., Sormunen, R., Tavi, P., Räsänen, J. and Vainio, S. J. (2010). Wnt-11 signalling controls ventricular myocardium development by patterning N-cadherin and beta-catenin expression. Cardiovasc. Res. 85, 100-109.
    • (2010) Cardiovasc. Res. , vol.85 , pp. 100-109
    • Nagy, I.I.1    Railo, A.2    Rapila, R.3    Hast, T.4    Sormunen, R.5    Tavi, P.6    Räsänen, J.7    Vainio, S.J.8
  • 175
    • 3342889548 scopus 로고    scopus 로고
    • Presenilin 1 is essential for cardiac morphogenesis
    • Nakajima, M., Moriizumi, E., Koseki, H. and Shirasawa, T. (2004). Presenilin 1 is essential for cardiac morphogenesis. Dev. Dyn. 230, 795-799.
    • (2004) Dev. Dyn. , vol.230 , pp. 795-799
    • Nakajima, M.1    Moriizumi, E.2    Koseki, H.3    Shirasawa, T.4
  • 176
    • 67650495042 scopus 로고    scopus 로고
    • Protein tyrosine phosphatase activity in the neural crest is essential for normal heart and skull development
    • Nakamura, T., Gulick, J., Colbert, M. C. and Robbins, J. (2009). Protein tyrosine phosphatase activity in the neural crest is essential for normal heart and skull development. Proc. Natl. Acad. Sci. USA 106, 11270-11275.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 11270-11275
    • Nakamura, T.1    Gulick, J.2    Colbert, M.C.3    Robbins, J.4
  • 177
    • 0038771965 scopus 로고    scopus 로고
    • The 'Shp'ing news: SH2 domaincontaining tyrosine phosphatases in cell signaling
    • Neel, B. G., Gu, H. and Pao, L. (2003). The 'Shp'ing news: SH2 domaincontaining tyrosine phosphatases in cell signaling. Trends Biochem. Sci. 28, 284-293.
    • (2003) Trends Biochem. Sci. , vol.28 , pp. 284-293
    • Neel, B.G.1    Gu, H.2    Pao, L.3
  • 178
    • 78751641054 scopus 로고    scopus 로고
    • Functional interaction between Foxd3 and Pax3 in cardiac neural crest development
    • Nelms, B. L., Pfaltzgraff, E. R. and Labosky, P. A. (2011). Functional interaction between Foxd3 and Pax3 in cardiac neural crest development. Genesis 49, 10-23.
    • (2011) Genesis , vol.49 , pp. 10-23
    • Nelms, B.L.1    Pfaltzgraff, E.R.2    Labosky, P.A.3
  • 179
    • 70349786507 scopus 로고    scopus 로고
    • Loss of glypican-3 function causes growth factordependent defects in cardiac and coronary vascular development
    • Ng, A., Wong, M., Viviano, B., Erlich, J. M., Alba, G., Pflederer, C., Jay, P. Y. and Saunders, S. (2009). Loss of glypican-3 function causes growth factordependent defects in cardiac and coronary vascular development. Dev. Biol. 335, 208-215.
    • (2009) Dev. Biol. , vol.335 , pp. 208-215
    • Ng, A.1    Wong, M.2    Viviano, B.3    Erlich, J.M.4    Alba, G.5    Pflederer, C.6    Jay, P.Y.7    Saunders, S.8
  • 181
    • 45149102678 scopus 로고    scopus 로고
    • Notch signaling in cardiac development
    • Niessen, K. and Karsan, A. (2008). Notch signaling in cardiac development. Circ. Res. 102, 1169-1181.
    • (2008) Circ. Res. , vol.102 , pp. 1169-1181
    • Niessen, K.1    Karsan, A.2
  • 182
    • 67650461956 scopus 로고    scopus 로고
    • A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf-Hirschhorn syndrome
    • Nimura, K., Ura, K., Shiratori, H., Ikawa, M., Okabe, M., Schwartz, R. J. and Kaneda, Y. (2009). A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf-Hirschhorn syndrome. Nature 460, 287-291.
    • (2009) Nature , vol.460 , pp. 287-291
    • Nimura, K.1    Ura, K.2    Shiratori, H.3    Ikawa, M.4    Okabe, M.5    Schwartz, R.J.6    Kaneda, Y.7
  • 183
    • 0035192873 scopus 로고    scopus 로고
    • Loss of mRor1 enhances the heart and skeletal abnormalities in mRor2-deficient mice: Redundant and pleiotropic functions of mRor1 and mRor2 receptor tyrosine kinases
    • Nomi, M., Oishi, I., Kani, S., Suzuki, H., Matsuda, T., Yoda, A., Kitamura, M., Itoh, K., Takeuchi, S., Takeda, K. et al. (2001). Loss of mRor1 enhances the heart and skeletal abnormalities in mRor2-deficient mice: redundant and pleiotropic functions of mRor1 and mRor2 receptor tyrosine kinases. Mol. Cell. Biol. 21, 8329-8335.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 8329-8335
    • Nomi, M.1    Oishi, I.2    Kani, S.3    Suzuki, H.4    Matsuda, T.5    Yoda, A.6    Kitamura, M.7    Itoh, K.8    Takeuchi, S.9    Takeda, K.10
  • 185
    • 77956026082 scopus 로고    scopus 로고
    • Formal genesis of the outflow tracts of the heart revisited: Previous works in the light of recent observations
    • Okamoto, N., Akimoto, N., Hidaka, N., Shoji, S. and Sumida, H. (2010). Formal genesis of the outflow tracts of the heart revisited: previous works in the light of recent observations. Congenit. Anom. (Kyoto) 50, 141-158.
    • (2010) Congenit. Anom. (Kyoto) , vol.50 , pp. 141-158
    • Okamoto, N.1    Akimoto, N.2    Hidaka, N.3    Shoji, S.4    Sumida, H.5
  • 187
    • 79960561999 scopus 로고    scopus 로고
    • Pax3 is essential for normal cardiac neural crest morphogenesis but is not required during migration nor outflow tract septation
    • Olaopa, M., Zhou, H. M., Snider, P., Wang, J., Schwartz, R. J., Moon, A. M. and Conway, S. J. (2011). Pax3 is essential for normal cardiac neural crest morphogenesis but is not required during migration nor outflow tract septation. Dev. Biol. 356, 308-322.
    • (2011) Dev. Biol. , vol.356 , pp. 308-322
    • Olaopa, M.1    Zhou, H.M.2    Snider, P.3    Wang, J.4    Schwartz, R.J.5    Moon, A.M.6    Conway, S.J.7
  • 190
    • 78751474118 scopus 로고    scopus 로고
    • Non-coding RNAs as regulators of embryogenesis
    • Pauli, A., Rinn, J. L. and Schier, A. F. (2011). Non-coding RNAs as regulators of embryogenesis. Nat. Rev. Genet. 12, 136-149.
    • (2011) Nat. Rev. Genet. , vol.12 , pp. 136-149
    • Pauli, A.1    Rinn, J.L.2    Schier, A.F.3
  • 193
    • 4644358238 scopus 로고    scopus 로고
    • GATA4 is a dosage-sensitive regulator of cardiac morphogenesis
    • Pu, W. T., Ishiwata, T., Juraszek, A. L., Ma, Q. and Izumo, S. (2004). GATA4 is a dosage-sensitive regulator of cardiac morphogenesis. Dev. Biol. 275, 235-244.
    • (2004) Dev. Biol. , vol.275 , pp. 235-244
    • Pu, W.T.1    Ishiwata, T.2    Juraszek, A.L.3    Ma, Q.4    Izumo, S.5
  • 195
    • 0031214212 scopus 로고    scopus 로고
    • Induction of endocardial cushion tissue in the avian heart is regulated, in part, by TGFbeta-3-mediated autocrine signaling
    • Ramsdell, A. F. and Markwald, R. R. (1997). Induction of endocardial cushion tissue in the avian heart is regulated, in part, by TGFbeta-3-mediated autocrine signaling. Dev. Biol. 188, 64-74.
    • (1997) Dev. Biol. , vol.188 , pp. 64-74
    • Ramsdell, A.F.1    Markwald, R.R.2
  • 199
    • 33745266407 scopus 로고    scopus 로고
    • Bmp2 instructs cardiac progenitors to form the heart-valve-inducing field
    • Rivera-Feliciano, J. and Tabin, C. J. (2006). Bmp2 instructs cardiac progenitors to form the heart-valve-inducing field. Dev. Biol. 295, 580-588.
    • (2006) Dev. Biol. , vol.295 , pp. 580-588
    • Rivera-Feliciano, J.1    Tabin, C.J.2
  • 201
    • 77956276917 scopus 로고    scopus 로고
    • The TGF(type II receptor plays a critical role in the endothelial cells during cardiac development
    • Robson, A., Allinson, K. R., Anderson, R. H., Henderson, D. J. and Arthur, H. M. (2010). The TGF(type II receptor plays a critical role in the endothelial cells during cardiac development. Dev. Dyn. 239, 2435-2442.
    • (2010) Dev. Dyn. , vol.239 , pp. 2435-2442
    • Robson, A.1    Allinson, K.R.2    Anderson, R.H.3    Henderson, D.J.4    Arthur, H.M.5
  • 202
    • 67650927632 scopus 로고    scopus 로고
    • Hes1 is expressed in the second heart field and is required for outflow tract development
    • Rochais, F., Dandonneau, M., Mesbah, K., Jarry, T., Mattei, M. G. and Kelly, R. G. (2009). Hes1 is expressed in the second heart field and is required for outflow tract development. PLoS ONE 4, e6267.
    • (2009) PLoS ONE , vol.4
    • Rochais, F.1    Dandonneau, M.2    Mesbah, K.3    Jarry, T.4    Mattei, M.G.5    Kelly, R.G.6
  • 205
    • 0034235433 scopus 로고    scopus 로고
    • Slug is an essential target of TGFbeta2 signaling in the developing chicken heart
    • Romano, L. A. and Runyan, R. B. (2000). Slug is an essential target of TGFbeta2 signaling in the developing chicken heart. Dev. Biol. 223, 91-102.
    • (2000) Dev. Biol. , vol.223 , pp. 91-102
    • Romano, L.A.1    Runyan, R.B.2
  • 206
    • 54749138371 scopus 로고    scopus 로고
    • Notch signaling in cardiovascular disease and calcification
    • Rusanescu, G., Weissleder, R. and Aikawa, E. (2008). Notch signaling in cardiovascular disease and calcification. Curr. Cardiol. Rev. 4, 148-156.
    • (2008) Curr. Cardiol. Rev. , vol.4 , pp. 148-156
    • Rusanescu, G.1    Weissleder, R.2    Aikawa, E.3
  • 210
    • 76249093896 scopus 로고    scopus 로고
    • miRNA-processing enzyme Dicer is necessary for cardiac outflow tract alignment and chamber septation
    • Saxena, A. and Tabin, C. J. (2010). miRNA-processing enzyme Dicer is necessary for cardiac outflow tract alignment and chamber septation. Proc. Natl. Acad. Sci. USA 107, 87-91.
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 87-91
    • Saxena, A.1    Tabin, C.J.2
  • 211
    • 0029134975 scopus 로고
    • Platelet-derived growth factor receptor alpha subunit deleted Patch mouse exhibits severe cardiovascular dysmorphogenesis
    • Schatteman, G. C., Motley, S. T., Effmann, E. L. and Bowen-Pope, D. F. (1995). Platelet-derived growth factor receptor alpha subunit deleted Patch mouse exhibits severe cardiovascular dysmorphogenesis. Teratology 51, 351-366.
    • (1995) Teratology , vol.51 , pp. 351-366
    • Schatteman, G.C.1    Motley, S.T.2    Effmann, E.L.3    Bowen-Pope, D.F.4
  • 215
    • 0042368795 scopus 로고    scopus 로고
    • Form and function of developing heart valves: Coordination by extracellular matrix and growth factor signaling
    • Schroeder, J. A., Jackson, L. F., Lee, D. C. and Camenisch, T. D. (2003). Form and function of developing heart valves: coordination by extracellular matrix and growth factor signaling. J. Mol. Med. 81, 392-403.
    • (2003) J. Mol. Med. , vol.81 , pp. 392-403
    • Schroeder, J.A.1    Jackson, L.F.2    Lee, D.C.3    Camenisch, T.D.4
  • 216
  • 217
    • 33746926015 scopus 로고    scopus 로고
    • Forkhead transcription factors, Foxc1 and Foxc2, are required for the morphogenesis of the cardiac outflow tract
    • Seo, S. and Kume, T. (2006). Forkhead transcription factors, Foxc1 and Foxc2, are required for the morphogenesis of the cardiac outflow tract. Dev. Biol. 296, 421-436.
    • (2006) Dev. Biol. , vol.296 , pp. 421-436
    • Seo, S.1    Kume, T.2
  • 219
    • 78650212442 scopus 로고    scopus 로고
    • The neural crest-enriched microRNA miR-452 regulates epithelialmesenchymal signaling in the first pharyngeal arch
    • Sheehy, N. T., Cordes, K. R., White, M. P., Ivey, K. N. and Srivastava, D. (2010). The neural crest-enriched microRNA miR-452 regulates epithelialmesenchymal signaling in the first pharyngeal arch. Development 137, 4307-4316.
    • (2010) Development , vol.137 , pp. 4307-4316
    • Sheehy, N.T.1    Cordes, K.R.2    White, M.P.3    Ivey, K.N.4    Srivastava, D.5
  • 221
    • 73249139527 scopus 로고    scopus 로고
    • T-box 2, a mediator of Bmp-Smad signaling, induced hyaluronan synthase 2 and Tgfbeta2 expression and endocardial cushion formation
    • Shirai, M., Imanaka-Yoshida, K., Schneider, M. D., Schwartz, R. J. and Morisaki, T. (2009). T-box 2, a mediator of Bmp-Smad signaling, induced hyaluronan synthase 2 and Tgfbeta2 expression and endocardial cushion formation. Proc. Natl. Acad. Sci. USA 106, 18604-18609.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 18604-18609
    • Shirai, M.1    Imanaka-Yoshida, K.2    Schneider, M.D.3    Schwartz, R.J.4    Morisaki, T.5
  • 222
    • 0026799402 scopus 로고
    • Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease
    • Shull, M. M., Ormsby, I., Kier, A. B., Pawlowski, S., Diebold, R. J., Yin, M., Allen, R., Sidman, C., Proetzel, G., Calvin, D. et al. (1992). Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature 359, 693-699.
    • (1992) Nature , vol.359 , pp. 693-699
    • Shull, M.M.1    Ormsby, I.2    Kier, A.B.3    Pawlowski, S.4    Diebold, R.J.5    Yin, M.6    Allen, R.7    Sidman, C.8    Proetzel, G.9    Calvin, D.10
  • 223
    • 0142042546 scopus 로고    scopus 로고
    • Mice humanised for the EGF receptor display hypomorphic phenotypes in skin, bone and heart
    • Sibilia, M., Wagner, B., Hoebertz, A., Elliott, C., Marino, S., Jochum, W. and Wagner, E. F. (2003). Mice humanised for the EGF receptor display hypomorphic phenotypes in skin, bone and heart. Development 130, 4515-4525.
    • (2003) Development , vol.130 , pp. 4515-4525
    • Sibilia, M.1    Wagner, B.2    Hoebertz, A.3    Elliott, C.4    Marino, S.5    Jochum, W.6    Wagner, E.F.7
  • 224
    • 81355127622 scopus 로고    scopus 로고
    • Histone deacetylase 3 regulates smooth muscle differentiation in neural crest cells and development of the cardiac outflow tract
    • Singh, N., Trivedi, C. M., Lu, M., Mullican, S. E., Lazar, M. A. and Epstein, J. A. (2011). Histone deacetylase 3 regulates smooth muscle differentiation in neural crest cells and development of the cardiac outflow tract. Circ. Res. 109, 1240-1249.
    • (2011) Circ. Res. , vol.109 , pp. 1240-1249
    • Singh, N.1    Trivedi, C.M.2    Lu, M.3    Mullican, S.E.4    Lazar, M.A.5    Epstein, J.A.6
  • 225
    • 36048929457 scopus 로고    scopus 로고
    • Isl1 expression at the venous pole identifies a novel role for the second heart field in cardiac development
    • Snarr, B. S., O'Neal, J. L., Chintalapudi, M. R., Wirrig, E. E., Phelps, A. L., Kubalak, S. W. and Wessels, A. (2007a). Isl1 expression at the venous pole identifies a novel role for the second heart field in cardiac development. Circ. Res. 101, 971-974.
    • (2007) Circ. Res. , vol.101 , pp. 971-974
    • Snarr, B.S.1    O'Neal, J.L.2    Chintalapudi, M.R.3    Wirrig, E.E.4    Phelps, A.L.5    Kubalak, S.W.6    Wessels, A.7
  • 226
    • 34248589631 scopus 로고    scopus 로고
    • A spatiotemporal evaluation of the contribution of the dorsal mesenchymal protrusion to cardiac development
    • Snarr, B. S., Wirrig, E. E., Phelps, A. L., Trusk, T. C. and Wessels, A. (2007b). A spatiotemporal evaluation of the contribution of the dorsal mesenchymal protrusion to cardiac development. Dev. Dyn. 236, 1287-1294.
    • (2007) Dev. Dyn. , vol.236 , pp. 1287-1294
    • Snarr, B.S.1    Wirrig, E.E.2    Phelps, A.L.3    Trusk, T.C.4    Wessels, A.5
  • 227
    • 54549116935 scopus 로고    scopus 로고
    • Origin and fate of cardiac mesenchyme
    • Snarr, B. S., Kern, C. B. and Wessels, A. (2008). Origin and fate of cardiac mesenchyme. Dev. Dyn. 237, 2804-2819.
    • (2008) Dev. Dyn. , vol.237 , pp. 2804-2819
    • Snarr, B.S.1    Kern, C.B.2    Wessels, A.3
  • 228
    • 78650364001 scopus 로고    scopus 로고
    • Cell autonomous requirement of endocardial Smad4 during atrioventricular cushion development in mouse embryos
    • Song, L., Zhao, M., Wu, B., Zhou, B., Wang, Q. and Jiao, K. (2011). Cell autonomous requirement of endocardial Smad4 during atrioventricular cushion development in mouse embryos. Dev. Dyn. 240, 211-220.
    • (2011) Dev. Dyn. , vol.240 , pp. 211-220
    • Song, L.1    Zhao, M.2    Wu, B.3    Zhou, B.4    Wang, Q.5    Jiao, K.6
  • 231
    • 33748621746 scopus 로고    scopus 로고
    • Making or breaking the heart: From lineage determination to morphogenesis
    • Srivastava, D. (2006). Making or breaking the heart: from lineage determination to morphogenesis. Cell 126, 1037-1048.
    • (2006) Cell , vol.126 , pp. 1037-1048
    • Srivastava, D.1
  • 234
    • 77957906102 scopus 로고    scopus 로고
    • VEGF signaling has distinct spatiotemporal roles during heart valve development
    • Stankunas, K., Ma, G. K., Kuhnert, F. J., Kuo, C. J. and Chang, C. P. (2010). VEGF signaling has distinct spatiotemporal roles during heart valve development. Dev. Biol. 347, 325-336.
    • (2010) Dev. Biol. , vol.347 , pp. 325-336
    • Stankunas, K.1    Ma, G.K.2    Kuhnert, F.J.3    Kuo, C.J.4    Chang, C.P.5
  • 235
    • 0036362978 scopus 로고    scopus 로고
    • Efficient Cre-mediated deletion in cardiac progenitor cells conferred by a 3_UTR-ires-Cre allele of the homeobox gene Nkx2-5
    • Stanley, E. G., Biben, C., Elefanty, A., Barnett, L., Koentgen, F., Robb, L. and Harvey, R. P. (2002). Efficient Cre-mediated deletion in cardiac progenitor cells conferred by a 3_UTR-ires-Cre allele of the homeobox gene Nkx2-5. Int. J. Dev. Biol. 46, 431-439.
    • (2002) Int. J. Dev. Biol. , vol.46 , pp. 431-439
    • Stanley, E.G.1    Biben, C.2    Elefanty, A.3    Barnett, L.4    Koentgen, F.5    Robb, L.6    Harvey, R.P.7
  • 236
    • 21044446280 scopus 로고    scopus 로고
    • Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation
    • Stennard, F. A., Costa, M. W., Lai, D., Biben, C., Furtado, M. B., Solloway, M. J., McCulley, D. J., Leimena, C., Preis, J. I., Dunwoodie, S. L. et al. (2005). Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation. Development 132, 2451-2462.
    • (2005) Development , vol.132 , pp. 2451-2462
    • Stennard, F.A.1    Costa, M.W.2    Lai, D.3    Biben, C.4    Furtado, M.B.5    Solloway, M.J.6    McCulley, D.J.7    Leimena, C.8    Preis, J.I.9    Dunwoodie, S.L.10
  • 241
    • 0030729636 scopus 로고    scopus 로고
    • Targeted disruption of the mouse homologue of the Drosophila polyhomeotic gene leads to altered anteroposterior patterning and neural crest defects
    • Takihara, Y., Tomotsune, D., Shirai, M., Katoh-Fukui, Y., Nishii, K., Motaleb, M. A., Nomura, M., Tsuchiya, R., Fujita, Y., Shibata, Y. et al. (1997). Targeted disruption of the mouse homologue of the Drosophila polyhomeotic gene leads to altered anteroposterior patterning and neural crest defects. Development 124, 3673-3682.
    • (1997) Development , vol.124 , pp. 3673-3682
    • Takihara, Y.1    Tomotsune, D.2    Shirai, M.3    Katoh-Fukui, Y.4    Nishii, K.5    Motaleb, M.A.6    Nomura, M.7    Tsuchiya, R.8    Fujita, Y.9    Shibata, Y.10
  • 242
    • 0037323832 scopus 로고    scopus 로고
    • Cell autonomous requirement for PDGFRalpha in populations of cranial and cardiac neural crest cells
    • Tallquist, M. D. and Soriano, P. (2003). Cell autonomous requirement for PDGFRalpha in populations of cranial and cardiac neural crest cells. Development 130, 507-518.
    • (2003) Development , vol.130 , pp. 507-518
    • Tallquist, M.D.1    Soriano, P.2
  • 243
    • 0030926093 scopus 로고    scopus 로고
    • The allocation of epiblast cells to the embryonic heart and other mesodermal lineages: The role of ingression and tissue movement during gastrulation
    • Tam, P. P., Parameswaran, M., Kinder, S. J. and Weinberger, R. P. (1997). The allocation of epiblast cells to the embryonic heart and other mesodermal lineages: the role of ingression and tissue movement during gastrulation. Development 124, 1631-1642.
    • (1997) Development , vol.124 , pp. 1631-1642
    • Tam, P.P.1    Parameswaran, M.2    Kinder, S.J.3    Weinberger, R.P.4
  • 245
    • 46049099580 scopus 로고    scopus 로고
    • Requirement for Foxd3 in the maintenance of neural crest progenitors
    • Teng, L., Mundell, N. A., Frist, A. Y., Wang, Q. and Labosky, P. A. (2008). Requirement for Foxd3 in the maintenance of neural crest progenitors. Development 135, 1615-1624.
    • (2008) Development , vol.135 , pp. 1615-1624
    • Teng, L.1    Mundell, N.A.2    Frist, A.Y.3    Wang, Q.4    Labosky, P.A.5
  • 246
    • 42049098616 scopus 로고    scopus 로고
    • Myocardial Pitx2 differentially regulates the left atrial identity and ventricular asymmetric remodeling programs
    • Tessari, A., Pietrobon, M., Notte, A., Cifelli, G., Gage, P. J., Schneider, M. D., Lembo, G. and Campione, M. (2008). Myocardial Pitx2 differentially regulates the left atrial identity and ventricular asymmetric remodeling programs. Circ. Res. 102, 813-822.
    • (2008) Circ. Res. , vol.102 , pp. 813-822
    • Tessari, A.1    Pietrobon, M.2    Notte, A.3    Cifelli, G.4    Gage, P.J.5    Schneider, M.D.6    Lembo, G.7    Campione, M.8
  • 247
    • 0034705318 scopus 로고    scopus 로고
    • FOG-2, a cofactor for GATA transcription factors, is essential for heart morphogenesis and development of coronary vessels from epicardium
    • Tevosian, S. G., Deconinck, A. E., Tanaka, M., Schinke, M., Litovsky, S. H., Izumo, S., Fujiwara, Y. and Orkin, S. H. (2000). FOG-2, a cofactor for GATA transcription factors, is essential for heart morphogenesis and development of coronary vessels from epicardium. Cell 101, 729-739.
    • (2000) Cell , vol.101 , pp. 729-739
    • Tevosian, S.G.1    Deconinck, A.E.2    Tanaka, M.3    Schinke, M.4    Litovsky, S.H.5    Izumo, S.6    Fujiwara, Y.7    Orkin, S.H.8
  • 248
    • 77951205663 scopus 로고    scopus 로고
    • Neural crest cell-specific deletion of Rac1 results in defective cell-matrix interactions and severe craniofacial and cardiovascular malformations
    • Thomas, P. S., Kim, J., Nunez, S., Glogauer, M. and Kaartinen, V. (2010). Neural crest cell-specific deletion of Rac1 results in defective cell-matrix interactions and severe craniofacial and cardiovascular malformations. Dev. Biol. 340, 613-625.
    • (2010) Dev. Biol. , vol.340 , pp. 613-625
    • Thomas, P.S.1    Kim, J.2    Nunez, S.3    Glogauer, M.4    Kaartinen, V.5
  • 249
    • 76549113391 scopus 로고    scopus 로고
    • Characterization and in vivo pharmacological rescue of a Wnt2-Gata6 pathway required for cardiac inflow tract development
    • Tian, Y., Yuan, L., Goss, A. M., Wang, T., Yang, J., Lepore, J. J., Zhou, D., Schwartz, R. J., Patel, V., Cohen, E. D. et al. (2010). Characterization and in vivo pharmacological rescue of a Wnt2-Gata6 pathway required for cardiac inflow tract development. Dev. Cell 18, 275-287.
    • (2010) Dev. Cell , vol.18 , pp. 275-287
    • Tian, Y.1    Yuan, L.2    Goss, A.M.3    Wang, T.4    Yang, J.5    Lepore, J.J.6    Zhou, D.7    Schwartz, R.J.8    Patel, V.9    Cohen, E.D.10
  • 251
    • 78650365007 scopus 로고    scopus 로고
    • Long form of latent TGF-(binding protein 1 (Ltbp1L) regulates cardiac valve development
    • Todorovic, V., Finnegan, E., Freyer, L., Zilberberg, L., Ota, M. and Rifkin, D. B. (2011). Long form of latent TGF-(binding protein 1 (Ltbp1L) regulates cardiac valve development. Dev. Dyn. 240, 176-187.
    • (2011) Dev. Dyn. , vol.240 , pp. 176-187
    • Todorovic, V.1    Finnegan, E.2    Freyer, L.3    Zilberberg, L.4    Ota, M.5    Rifkin, D.B.6
  • 253
    • 68849129918 scopus 로고    scopus 로고
    • Focal adhesion kinase is required for neural crest cell morphogenesis during mouse cardiovascular development
    • Vallejo-Illarramendi, A., Zang, K. and Reichardt, L. F. (2009). Focal adhesion kinase is required for neural crest cell morphogenesis during mouse cardiovascular development. J. Clin. Invest. 119, 2218-2230.
    • (2009) J. Clin. Invest. , vol.119 , pp. 2218-2230
    • Vallejo-Illarramendi, A.1    Zang, K.2    Reichardt, L.F.3
  • 257
    • 33845527678 scopus 로고    scopus 로고
    • Rescue of morphogenetic defects and of retinoic acid signaling in retinaldehyde dehydrogenase 2 (Raldh2) mouse mutants by chimerism with wild-type cells
    • Vermot, J., Messaddeq, N., Niederreither, K., Dierich, A. and Dollé, P. (2006). Rescue of morphogenetic defects and of retinoic acid signaling in retinaldehyde dehydrogenase 2 (Raldh2) mouse mutants by chimerism with wild-type cells. Differentiation 74, 661-668.
    • (2006) Differentiation , vol.74 , pp. 661-668
    • Vermot, J.1    Messaddeq, N.2    Niederreither, K.3    Dierich, A.4    Dollé, P.5
  • 258
    • 27744507847 scopus 로고    scopus 로고
    • The right ventricle, outflow tract, and ventricular septum comprise a restricted expression domain within the secondary/anterior heart field
    • Verzi, M. P., McCulley, D. J., De Val, S., Dodou, E. and Black, B. L. (2005). The right ventricle, outflow tract, and ventricular septum comprise a restricted expression domain within the secondary/anterior heart field. Dev. Biol. 287, 134-145.
    • (2005) Dev. Biol. , vol.287 , pp. 134-145
    • Verzi, M.P.1    McCulley, D.J.2    de Val, S.3    Dodou, E.4    Black, B.L.5
  • 259
    • 77955334500 scopus 로고    scopus 로고
    • How to make a heart: The origin and regulation of cardiac progenitor cells
    • Vincent, S. D. and Buckingham, M. E. (2010). How to make a heart: the origin and regulation of cardiac progenitor cells. Curr. Top. Dev. Biol. 90, 1-41.
    • (2010) Curr. Top. Dev. Biol. , vol.90 , pp. 1-41
    • Vincent, S.D.1    Buckingham, M.E.2
  • 260
    • 18544374140 scopus 로고    scopus 로고
    • Fgf15 is required for proper morphogenesis of the mouse cardiac outflow tract
    • Vincentz, J. W., McWhirter, J. R., Murre, C., Baldini, A. and Furuta, Y. (2005). Fgf15 is required for proper morphogenesis of the mouse cardiac outflow tract. Genesis 41, 192-201.
    • (2005) Genesis , vol.41 , pp. 192-201
    • Vincentz, J.W.1    McWhirter, J.R.2    Murre, C.3    Baldini, A.4    Furuta, Y.5
  • 261
    • 0037091009 scopus 로고    scopus 로고
    • Tbx1 mutation causes multiple cardiovascular defects and disrupts neural crest and cranial nerve migratory pathways
    • Vitelli, F., Morishima, M., Taddei, I., Lindsay, E. A. and Baldini, A. (2002). Tbx1 mutation causes multiple cardiovascular defects and disrupts neural crest and cranial nerve migratory pathways. Hum. Mol. Genet. 11, 915-922.
    • (2002) Hum. Mol. Genet. , vol.11 , pp. 915-922
    • Vitelli, F.1    Morishima, M.2    Taddei, I.3    Lindsay, E.A.4    Baldini, A.5
  • 262
    • 67049173938 scopus 로고    scopus 로고
    • Gain of function of Tbx1 affects pharyngeal and heart development in the mouse
    • Vitelli, F., Huynh, T. and Baldini, A. (2009). Gain of function of Tbx1 affects pharyngeal and heart development in the mouse. Genesis 47, 188-195.
    • (2009) Genesis , vol.47 , pp. 188-195
    • Vitelli, F.1    Huynh, T.2    Baldini, A.3
  • 266
    • 33750825092 scopus 로고    scopus 로고
    • Defective ALK5 signaling in the neural crest leads to increased postmigratory neural crest cell apoptosis and severe outflow tract defects
    • Wang, J., Nagy, A., Larsson, J., Dudas, M., Sucov, H. M. and Kaartinen, V. (2006). Defective ALK5 signaling in the neural crest leads to increased postmigratory neural crest cell apoptosis and severe outflow tract defects. BMC Dev. Biol. 6, 51.
    • (2006) BMC Dev. Biol. , vol.6 , pp. 51
    • Wang, J.1    Nagy, A.2    Larsson, J.3    Dudas, M.4    Sucov, H.M.5    Kaartinen, V.6
  • 271
    • 77649172161 scopus 로고    scopus 로고
    • Role of mesodermal FGF8 and FGF10 overlaps in the development of the arterial pole of the heart and pharyngeal arch arteries
    • Watanabe, Y., Miyagawa-Tomita, S., Vincent, S. D., Kelly, R. G., Moon, A. M. and Buckingham, M. E. (2010). Role of mesodermal FGF8 and FGF10 overlaps in the development of the arterial pole of the heart and pharyngeal arch arteries. Circ. Res. 106, 495-503.
    • (2010) Circ. Res. , vol.106 , pp. 495-503
    • Watanabe, Y.1    Miyagawa-Tomita, S.2    Vincent, S.D.3    Kelly, R.G.4    Moon, A.M.5    Buckingham, M.E.6
  • 272
    • 0032489848 scopus 로고    scopus 로고
    • Formation of the atrioventricular septal structures in the normal mouse
    • Webb, S., Brown, N. A. and Anderson, R. H. (1998). Formation of the atrioventricular septal structures in the normal mouse. Circ. Res. 82, 645-656.
    • (1998) Circ. Res. , vol.82 , pp. 645-656
    • Webb, S.1    Brown, N.A.2    Anderson, R.H.3
  • 273
    • 0347132690 scopus 로고    scopus 로고
    • Developmental anatomy of the heart: A tale of mice and man
    • Wessels, A. and Sedmera, D. (2003). Developmental anatomy of the heart: a tale of mice and man. Physiol. Genomics 15, 165-176.
    • (2003) Physiol. Genomics , vol.15 , pp. 165-176
    • Wessels, A.1    Sedmera, D.2
  • 275
    • 77957601615 scopus 로고    scopus 로고
    • Genetic factors in non-syndromic congenital heart malformations
    • Wessels, M. W. and Willems, P. J. (2010). Genetic factors in non-syndromic congenital heart malformations. Clin. Genet. 78, 103-123.
    • (2010) Clin. Genet. , vol.78 , pp. 103-123
    • Wessels, M.W.1    Willems, P.J.2
  • 279
    • 79960374172 scopus 로고    scopus 로고
    • Nfatc1 coordinates valve endocardial cell lineage development required for heart valve formation
    • Wu, B., Wang, Y., Lui, W., Langworthy, M., Tompkins, K. L., Hatzopoulos, A. K., Baldwin, H. S. and Zhou, B. (2011). Nfatc1 coordinates valve endocardial cell lineage development required for heart valve formation. Circ. Res. 109, 183-192.
    • (2011) Circ. Res. , vol.109 , pp. 183-192
    • Wu, B.1    Wang, Y.2    Lui, W.3    Langworthy, M.4    Tompkins, K.L.5    Hatzopoulos, A.K.6    Baldwin, H.S.7    Zhou, B.8
  • 280
    • 35648949357 scopus 로고    scopus 로고
    • Down syndrome critical region-1 is a transcriptional target of nuclear factor of activated T cells-c1 within the endocardium during heart development
    • Wu, H., Kao, S. C., Barrientos, T., Baldwin, S. H., Olson, E. N., Crabtree, G. R., Zhou, B. and Chang, C. P. (2007). Down syndrome critical region-1 is a transcriptional target of nuclear factor of activated T cells-c1 within the endocardium during heart development. J. Biol. Chem. 282, 30673-30679.
    • (2007) J. Biol. Chem. , vol.282 , pp. 30673-30679
    • Wu, H.1    Kao, S.C.2    Barrientos, T.3    Baldwin, S.H.4    Olson, E.N.5    Crabtree, G.R.6    Zhou, B.7    Chang, C.P.8
  • 281
    • 14644418529 scopus 로고    scopus 로고
    • Inactivation of TGFbeta signaling in neural crest stem cells leads to multiple defects reminiscent of DiGeorge syndrome
    • Wurdak, H., Ittner, L. M., Lang, K. S., Leveen, P., Suter, U., Fischer, J. A., Karlsson, S., Born, W. and Sommer, L. (2005). Inactivation of TGFbeta signaling in neural crest stem cells leads to multiple defects reminiscent of DiGeorge syndrome. Genes Dev. 19, 530-535.
    • (2005) Genes Dev. , vol.19 , pp. 530-535
    • Wurdak, H.1    Ittner, L.M.2    Lang, K.S.3    Leveen, P.4    Suter, U.5    Fischer, J.A.6    Karlsson, S.7    Born, W.8    Sommer, L.9
  • 284
  • 285
    • 0031940499 scopus 로고    scopus 로고
    • Dual genetic pathways of endothelin-mediated intercellular signaling revealed by targeted disruption of endothelin converting enzyme-1 gene
    • Yanagisawa, H., Yanagisawa, M., Kapur, R. P., Richardson, J. A., Williams, S. C., Clouthier, D. E., de Wit, D., Emoto, N. and Hammer, R. E. (1998b). Dual genetic pathways of endothelin-mediated intercellular signaling revealed by targeted disruption of endothelin converting enzyme-1 gene. Development 125, 825-836.
    • (1998) Development , vol.125 , pp. 825-836
    • Yanagisawa, H.1    Yanagisawa, M.2    Kapur, R.P.3    Richardson, J.A.4    Williams, S.C.5    Clouthier, D.E.6    de Wit, D.7    Emoto, N.8    Hammer, R.E.9
  • 288
  • 290
    • 4043059202 scopus 로고    scopus 로고
    • Right ventricular myocardium derives from the anterior heart field
    • Zaffran, S., Kelly, R. G., Meilhac, S. M., Buckingham, M. E. and Brown, N. A. (2004). Right ventricular myocardium derives from the anterior heart field. Circ. Res. 95, 261-268.
    • (2004) Circ. Res. , vol.95 , pp. 261-268
    • Zaffran, S.1    Kelly, R.G.2    Meilhac, S.M.3    Buckingham, M.E.4    Brown, N.A.5
  • 291
    • 70349914321 scopus 로고    scopus 로고
    • Spatial and temporal regulation of coronary vessel formation by calcineurin-NFAT signaling
    • Zeini, M., Hang, C. T., Lehrer-Graiwer, J., Dao, T., Zhou, B. and Chang, C. P. (2009). Spatial and temporal regulation of coronary vessel formation by calcineurin-NFAT signaling. Development 136, 3335-3345.
    • (2009) Development , vol.136 , pp. 3335-3345
    • Zeini, M.1    Hang, C.T.2    Lehrer-Graiwer, J.3    Dao, T.4    Zhou, B.5    Chang, C.P.6
  • 292
    • 33947729462 scopus 로고    scopus 로고
    • Conditioning effect of blood flow on resistance artery smooth muscle myosin phosphatase
    • Zhang, H. and Fisher, S. A. (2007). Conditioning effect of blood flow on resistance artery smooth muscle myosin phosphatase. Circ. Res. 100, 730-737.
    • (2007) Circ. Res. , vol.100 , pp. 730-737
    • Zhang, H.1    Fisher, S.A.2
  • 293
    • 57349186277 scopus 로고    scopus 로고
    • Frs2alpha-deficiency in cardiac progenitors disrupts a subset of FGF signals required for outflow tract morphogenesis
    • Zhang, J., Lin, Y., Zhang, Y., Lan, Y., Lin, C., Moon, A. M., Schwartz, R. J., Martin, J. F. and Wang, F. (2008). Frs2alpha-deficiency in cardiac progenitors disrupts a subset of FGF signals required for outflow tract morphogenesis. Development 135, 3611-3622.
    • (2008) Development , vol.135 , pp. 3611-3622
    • Zhang, J.1    Lin, Y.2    Zhang, Y.3    Lan, Y.4    Lin, C.5    Moon, A.M.6    Schwartz, R.J.7    Martin, J.F.8    Wang, F.9
  • 294
    • 57849120401 scopus 로고    scopus 로고
    • Tie2Cre-mediated inactivation of plexinD1 results in congenital heart, vascular and skeletal defects
    • Zhang, Y., Singh, M. K., Degenhardt, K. R., Lu, M. M., Bennett, J., Yoshida, Y. and Epstein, J. A. (2009). Tie2Cre-mediated inactivation of plexinD1 results in congenital heart, vascular and skeletal defects. Dev. Biol. 325, 82-93.
    • (2009) Dev. Biol. , vol.325 , pp. 82-93
    • Zhang, Y.1    Singh, M.K.2    Degenhardt, K.R.3    Lu, M.M.4    Bennett, J.5    Yoshida, Y.6    Epstein, J.A.7
  • 295
    • 33750282189 scopus 로고    scopus 로고
    • Mesodermal expression of Tbx1 is necessary and sufficient for pharyngeal arch and cardiac outflow tract development
    • Zhang, Z., Huynh, T. and Baldini, A. (2006). Mesodermal expression of Tbx1 is necessary and sufficient for pharyngeal arch and cardiac outflow tract development. Development 133, 3587-3595.
    • (2006) Development , vol.133 , pp. 3587-3595
    • Zhang, Z.1    Huynh, T.2    Baldini, A.3
  • 297
    • 16844380032 scopus 로고    scopus 로고
    • Characterization of Nfatc1 regulation identifies an enhancer required for gene expression that is specific to pro-valve endocardial cells in the developing heart
    • Zhou, B., Wu, B., Tompkins, K. L., Boyer, K. L., Grindley, J. C. and Baldwin, H. S. (2005). Characterization of Nfatc1 regulation identifies an enhancer required for gene expression that is specific to pro-valve endocardial cells in the developing heart. Development 132, 1137-1146.
    • (2005) Development , vol.132 , pp. 1137-1146
    • Zhou, B.1    Wu, B.2    Tompkins, K.L.3    Boyer, K.L.4    Grindley, J.C.5    Baldwin, H.S.6
  • 298
    • 34748911728 scopus 로고    scopus 로고
    • Modulation of morphogenesis by noncanonical Wnt signaling requires ATF/CREB family-mediated transcriptional activation of TGFbeta2
    • Zhou, W., Lin, L., Majumdar, A., Li, X., Zhang, X., Liu, W., Etheridge, L., Shi, Y., Martin, J., Van de Ven, W. et al. (2007). Modulation of morphogenesis by noncanonical Wnt signaling requires ATF/CREB family-mediated transcriptional activation of TGFbeta2. Nat. Genet. 39, 1225-1234.
    • (2007) Nat. Genet. , vol.39 , pp. 1225-1234
    • Zhou, W.1    Lin, L.2    Majumdar, A.3    Li, X.4    Zhang, X.5    Liu, W.6    Etheridge, L.7    Shi, Y.8    Martin, J.9    van de Ven, W.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.