The transcription factor NF-ATc is essential for cardiac valve formation

Nature

Volumn 392, Issue 6672, 1998, Pages 186-190

  Ranger, Ann M ^a,b   Grusby, Michael J ^a,b   Hodge, Martin R ^a,b,e   Gravallese, Ellen M ^a,b   De La Brousse, Fabienne Charles ^c   Hoey, Tim ^c   Mickanin, Craig ^d   Baldwin, H Scott ^d   Glimcher, Laurie H ^a,b  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c AMGEN INC   (United States)

^d CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^e MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; CYCLOSPORIN A; NUCLEAR FACTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NF ATC; UNCLASSIFIED DRUG;

ALLELE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONGENITAL HEART DISEASE; CONGESTIVE HEART FAILURE; EMBRYO; GENE EXPRESSION; HEART DEVELOPMENT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; VALVULAR HEART DISEASE;

ANIMALS; CALCINEURIN; DNA-BINDING PROTEINS; ENDOTHELIUM, VASCULAR; GENE TARGETING; HEART VALVES; MICE; MORPHOGENESIS; NFATC TRANSCRIPTION FACTORS; NUCLEAR PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

ANIMALIA; MAMMALIA;

EID: 0032510581     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/32426     Document Type: Article

References (31)

1. McCaffrey, P. G. et al. Isolation of the cyclosporin-sensitive T cell transcription factor NFATp. Science 262, 750-754 (1993).
2. Rao, A., Luo, C. & Hogan, P. G. Transcription factors of the NFAT family: regulation and function. Annu. Rev. Immunol. 15, 707-747 (1997).
3. Hoey, T., Sun, Y.-L., Wiliiamson, K. & Xu, X. Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins. Immunity 2, 461-472 (1995).
4. Northrop, J. P. et al. NF-AT components define a family of transcription factors targeted in T-cell activation. Nature 369, 497-502 (1994).
5. Emmel, E. A. et al. Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation. Science 246, 1617-1620 (1989).
6. 2+ signals and immunosuppression. Nature 383, 837-840 (1996).
7. Rossant, J. Mouse mutants and cardiac development. Circ. Res. 78, 349-353 (1996).
8. Eisenburg, L. M. & Markwald, R. R. Molecular regulation of atrioventricular valvuloseptal morphogenesis. Circ. Res. 77, 106 (1995).
9. Kwee, L. et al. Defective development of the embryonic and extraembryonic circulatory systems in vascular cell adhesion molecule (VCAM-1) deficient mice. Development 121, 489-503 (1995).
10. Baldwin, H. S., Jensen, K. L. & Solursh, M. Myogenic cytodifferentiation of the precardiac mesoderm in the rat. Differentiation 47, 163-172 (1991).
11. Copp, A. J. Death before birth: clues from gene knockouts and mutations. Trends Genet. 11, 87-93 (1995).
12. Olson, E. N. & Srivastava, D. Molecular pathways controlling heart development. Science 272, 671-676 (1996).
13. Fishman, M. C. & Chien, K. R. Fashioning the vertebrate heart: earliest embryonic decisions. Development 124, 2099-2177 (1997).
14. Ferencz, C. et al. Congenital heart disease: prevalence at live birth. Am. J. Epidemiol. 121, 31-36 (1985).
15. Kwee, L. et al. Defective development of the embryonic and extraembryonic circulatory systems in vascular cell adhesion molecule (VCAM-1) deficient mice. Development 121, 489-503 (1995).
16. Moens, C. B., Stanton, B. R., Parada, L. F. & Rossant, J. Defects in heart and lung development in compound heterozygotes for two different targeted mutations of the N-myc locus. Development 119, 485-499 (1993).
17. Meyer, D. & Birchmeier, C. Multiple essential functions of neuregulin in development. Nature 23, 386-390 (1995).
18. Gassmann, M. et al. Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor. Nature 378, 390-394 (1995).
19. Lee, K. F. et al. Requirement for neuregulin receptor erbB2 in neural and cardiac development. Nature 378, 394-398 (1995).
20. Yang, J. T., Rayburn, H. & Hynes, R. O. Cell adhesion events mediated by α4 integrins are essential in placental and cardiac development. Development 121, 549-560 (1995).
21. Schilham, M. W. et al. Defects in cardiac outflow tract formation and pro-B-lymphocyte expansion in mice lacking Sox-4. Nature 380, 711-714 (1996).
22. Miyabawa, S. et al. Absent aortic and pulmonary valves: investigation of three fetal cases with cystic hygroma and review of the literature. Heart Vessels 9, 49-55 (1994).
23. Brown, P. A. J., Gray, E. S., Whiting, P. H., Simpson, J. G. & Thomson, A. W. Effects of cyclosporin A on fetal development in the rat. Biol. Neonate 48, 172-180 (1985).
24. Lyons, K. M., Hogan, B. L. & Robertson, E. J. Colocalization of BMP-7 and BMP2 RNAs suggest that these factors cooperatively mediate tissue interactions during murine development. Mech. Dev. 50, 71-83 (1995).
25. Yamamura, H., Zhang, M., Markwald, R. R. & Mjaatvedt, C. H. A heart segmental defect in the anterior-posterior axis of a transgenic mutant mouse. Dev. Biol. 186, 58-72 (1997).
26. Clark, E. B. in Genetics of Cardiovascular Diseases (eds Pierpont, M. E. & Moller, J. H.) 3-11 (Martinus-Nijhoff, Boston, Massachusetts, 1987).
27. Tian, H., McKnight, S. L. & Russell, D. W. Endothelial PAS domain protein l (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev. 11, 72-82 (1997).
28. Hurle, J. M., Colveé, E. & Blanco, A. M. Development of mouse semilunar valves. Anat. Embryol. 160, 83-91 (1980).
29. Markwald, R. R. et al. in The Role of Extracellular Matrix in Development (ed. Treistead, R. L.) 323-350 (Allan R, Liss Inc, New York, 1994).
30. Runyan, R. B. et al. Signal transduction of a tissue interaction during embryonic heart development. Cell Regulation 1, 301-313 (1990).
31. Sturm, K. & Tam, P. P. L. Methods Enzymol 225, 164-190 (1993).