Mouse Pitx2 deficiency leads to anomalies of the ventral body wall, heart, extra- and periocular mesoderm and right pulmonary isomerism

Development

Volumn 126, Issue 24, 1999, Pages 5749-5758

  Kitamura, Kunio ^a   Miura, Hirohito ^a,d   Miyagawa Tomita, Sachiko ^b   Yanazawa, Masako ^a   Katoh Fukui, Yuko ^a   Suzuki, Rika ^a   Ohuchi, Hideyo ^c   Suehiro, Atuko ^a   Motegi, Yoshiko ^a   Nakahara, Yoko ^a   Kondo, Shunzo ^a   Yokoyama, Minesuke ^a  

^a MITSUBISHI KASEI INST OF LIFE SCI   (Japan)

^b TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d NATIONAL FOOD RESEARCH INSTITUTE   (Japan)

Author keywords

Gene targeting; Isoforms; Mouse; Pitx2; Rieger's syndrome; Symmetric asymmetric expression

Indexed keywords

AMNION; ANIMAL EXPERIMENT; ARTICLE; CONGENITAL HEART MALFORMATION; CORNEA; ENOPHTHALMOS; EXON; EXTRAOCULAR MUSCLE; FEMALE; HEART ATRIOVENTRICULAR VALVE; HOMEOBOX; MESODERM; MITRAL VALVE; MORPHOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRICUSPID VALVE;

ANIMALS; CORNEA; EPITHELIUM; FEMALE; GENE EXPRESSION; HEART; HEART DEFECTS, CONGENITAL; HOMEODOMAIN PROTEINS; LUNG; MALE; MESODERM; MICE; MICE, INBRED C57BL; NUCLEAR PROTEINS; PAIRED BOX TRANSCRIPTION FACTORS; PROTEIN ISOFORMS; SYNDROME; TRANSCRIPTION FACTORS;

EID: 0033387975     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Bellusci, S., Grindley, J., Emoto, H., Itoh, N. and Hogan, B. L. M. (1997). Fibroblast growth factor 10 (FGF10) and branching morophogenesis in the embryonic mouse lung. Development 124, 4867-4878.
2. Boer, P. H., Potten, H., Adra, C. N., Jardine, K., Mullhofer, G. and McBurney. M. W. (1990). Polymorphisms in the coding and noncoding regions or murine Pgk-1 alles. Biochem. Genet. 28, 299-308.
3. Campione, M., Steinbeisser, H., Schweickert, A., Deissler, K., van Bebber, F., Lowe, L. A., Mowotschin, S., Viebahn, C., Haffter, P., Kuehn, M. R. and Blum, M. (1999). The homeobox gene Pitx2: mediator of asymmetric left-right signaling in vertebrate heart and gut looping. Development 126, 1225-1234.
4. Chiang, C., Litingtung, Y., Lee. E., Young, K. E., Corden, J. L., Westphal, H. and Beachy, P. A. (1996). Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature 383, 407-413.
5. Eisenberg, L. M. and Markwald, R. R. (1995). Molecular regulation of atrioventricular valvuloseptal morphogenesis. Cir. Res. 77,1-6.
6. Feldt, R. H., Porter, C. J., Edwards, W. D., Puga, F. J. and Seward, J. B. (1995). Atrioventricular septal defects. In Heart Disease In Infants, Children, and Adolescents 5th ed (ed. G. C. Emmanouilides et al.), pp. 704-710. Barlimore: Williams & Wilkins.
7. Gage, P. J. and Camper, S. A. (1997). Pituitary homeobox 2, a novel member of the bicoid-related famoly of homeobox genes, is a potential regulator of anterior structure formation. Hum. Mol. Genet. 6, 457-464.
8. Gage, P. J., Hookyo, S. and Camper, S. A. (1999). Dosage requirement of Pitx2 for development of multiple organs. Developmet 126, 4643-4651.
9. Hogan, B., Beddington, R., Costantini, F. and Lacy, E. (1994). Staining embryos for cartilage and hone. In Manipulating the Mouse Embryo. pp. 379-380. New York: Cold Spring Harbor Laboratory Press.
10. Hummel, K. P. and Chapman, D. B. (1959). Visceral inversion and assocoiated anomalies in the mouse. J. Hered. 50, 9-13.
11. Izraeli, S., Lowe, L. A., Bertness, V. L., Good, D. J., Dorward, D. W., Kirsch, I. R., and Kuehn, M. R. (1999). The SIL gene is required for mouse embryonic axial development and let-right specification. Nature 399, 691-694.
12. Jorgenson, R. J., Levin, L. S., Cross, H. E., Yoder, F. and Kelly, T. E. (1978). The Rieger syndrome. Am. J. Med. Gen. 2, 307-318.
13. Kaufman, M. H. (1998). The Atlas of Mouse Development. New York: Academic Press.
14. Kitamura, K., Miura, H., Yanazawa, M., Miyashita, T. and Kato, K. (1997). Expression patterns of Brx1 (Rieg gene), Sonic hedgehog, Nkx2.2, Dlx1 and Arx during zona limitans intrathalamica and embryonic ventral lateral geniculate nuclear foramation. Mech. Dev. 67, 83-96.
15. Kulharya, A. S., Mabbery, M., Kukolich, M. K., Day, D. W., Schneider, N, R., Wilson, G. N. and Tonk, V. (1995). Interstitial deletions 4q21.1q25 and 4q25q27:phenotypic variability and relation to Rieger anomaly. Am. J. Med. Genet. 55, 165-170.
16. Lamers, W. H., Wessels, A., Verbeek, F. J., Moorman, A. F. M., Viragh, S., Wenink, A. C. G., Gittenberger-de Groot, A. and Anderson, R. H. (1992). New findings concerning ventricular septation in the human heart. Circulation 86,1194-1205
17. Lin, C. R., Kioussi, C., O'Connell, S., Briata, P., Szeto, D., Liu, F., Izpisua-Belmonte, J, C. and Rosenfeld, M. G. (1999). Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis. Nature 401, 279-282.
18. Logan, M., Pagan-Westphal, S. M., Smith, D. M. Paganessi and Tabin, C. J. (1998). The transcription factor Pitx2 mediates situs-specific morphogenensis is response to left-right asymmteric signals. Cell 94, 307-317.
19. Lu, M-F., Pressman, C., Dyer, R., Johnson, R. L. and Martin, J. F. (1999). Function of Rieger syndrome gene in left-right asymmetry and carniofacial development. Nature 401, 276-278.
20. Meyers, E. N. and Martin, G. R. (1999). Difference in left-right axis pathways in mouse and chick: functions of FGF8 and Shh. Scince 285, 403-406.
21. Meno, C., Shimono, A., Saijoh, Y., Yashiro, K., Mochida, K., Ohishi, S., Noji, S., Kondoh, H. and Hamada, H. (1998). lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal. Cell 94, 287-297.
22. Miller, S. and White, R. D. (1998). Right-left asymmetry of cell proliferation predominates in mouse embryos undergoing clockwise axial rotation. Anat. Rec. 250, 103-108.
23. Mucchielli, M-L., Marinez, S., Pattyn, A., Goridis, C. and Brunet, J.-F. (1996). Otlx2, an Otx-related homeobox gene expressed in the pituitary gland and in the restricted pattern in the forebrain. Mol. Cell. Neurosci. 8, 258-271.
24. Oh, S. P. and Li, E. (1997). The signaling pathway mediated by the type IIB activin receptor controls axial patterning and lateral asymmetry in the mouse. Genes Dev. 11, 1812-1826.
25. Piedra, M. E., Icardo, J. M., Albajar, M., Rodoriguez-Rey, J. C. and Ros, M. A. (1998). Pitx2 participates in the late phase of the pathway controlling left-right asymmetry. Cell 94, 319-324.
26. Rieger, H. (1935). Dysgenesis mesodemalis corneal et iridis. Z. Augenheilk 86, 333.
27. Ryan, A. K., Blumberg, B., Rodriguez-Esteban, C., Yonetani-Tamura, S., Tamura, K., Tsukui, T., de la Pena, J., Sabbagh, W., Greenwald, J., Choe, S., Norris, D. P., Robertson, E, J., Evans, R. M., Rosenfeld, M. G. and Belmonte, J. C. I. (1998). Pitx2 determines left-right asymmetry of internal oragans in vertebrates. Nature 394, 545-551.
28. Semina, E. V., Reiter, R., Leysens, N. J., Alward, W. L. M., Small, K. W., Datson, N. A, Siegel-Batelt, J., Bierke-Nelson, D., Bitoun, P., Zabel, B. U., Carey, J. C. and Murray, J. C. (1996). Cloning and characterization of a novel bicoid-related homeobox transcription factor gene, RIEG, involved in Rieger syndrome. Nature Genet. 14, 392-399.
29. St. Amand, T, R., Ra, J., Zhang, Y., Hu, Y., Baber, S. I., Qiu, M. and Chen, Y. (1998). Cloning and expression pattern of chicken Pitx2: a new component in the Shh signaling pathway controlling embryonic heat looping. Biochem. Biophys. Rec. Comm. 347, 100-105.
30. Tajbakhsh, S., Rocancourt, D., Cossu, G. and Buckingham, M. (1997). Refinding the genetic hierarchies controlling skeletal myogenesis: Pax-3 and myf-5 act upstream of myoD. Cell 89, 127-138.
31. Takeuchi, T., Yamazaki, Y., Katoh-Fukui, Y., Tsuchiya, R., Kondo, S., Motoyama J. and Higashinakagawa T. (1995). Gene trap capture of a novel mouse gene, jumonji, required for neural tube formation. Genes Dev. 9, 1211-1222.
32. Yoshioka, H., Meno, C., Koshiba, K., Sugihara, M., Itoh, H., Ishimaru, Y., Inoue. T., Ohuchi, H., Semina, E. V., Murray, J. C., Hamada, H. and Noji, S. (1998). Pitx2, a bicoid-type homeobox gene, is involved in a lefty-signaling pathway in determination of left-right asymmetry. Cell 94, 299-305.