Retinoic Acid Regulates Differentiation of the Secondary Heart Field and TGFβ-Mediated Outflow Tract Septation

Developmental Cell

Volumn 18, Issue 3, 2010, Pages 480-485

  Li, Peng ^a   Pashmforoush, Mohammad ^a   Sucov, Henry M ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

DEVBIO; HUMDISEASE

Indexed keywords

RETINOIC ACID; RETINOIC ACID RECEPTOR; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA2; TGFB2 PROTEIN, MOUSE;

ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL RENEWAL; CELL SPECIFICITY; CELL TRANSFORMATION; CONTROLLED STUDY; EMBRYO; ENDOCARDIUM; GENE DOSAGE; GENE EXPRESSION; HEART DEVELOPMENT; MARKER GENE; MESENCHYME CELL; MESODERM; MESODERMAL CELL; MORPHOGENESIS; MOUSE; NONHUMAN; OUTFLOW TRACT SEPTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SECONDARY HEART FIELD; SIGNAL TRANSDUCTION; ANIMAL; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HEART; HEART MUSCLE; METABOLISM; MOUSE MUTANT; PHYSIOLOGY; PREGNANCY; PRENATAL DEVELOPMENT; TRANSGENIC MOUSE;

ANIMALS; BODY PATTERNING; FEMALE; GENE DOSAGE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEART; MICE; MICE, KNOCKOUT; MICE, MUTANT STRAINS; MICE, TRANSGENIC; MYOCARDIUM; PREGNANCY; RECEPTORS, RETINOIC ACID; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA2; TRETINOIN;

EID: 77950592658     PISSN: 15345807     EISSN: 18781551     Source Type: Journal    
DOI: 10.1016/j.devcel.2009.12.019     Document Type: Article

References (30)

1. Arceci, R.J., King, A.A., Simon, M.C., Orkin, S.H., Wilson, D.B., Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart. Mol. Cell. Biol. 13 (1993), 2235–2246.
2. Bajolle, F., Zaffran, S., Kelly, R.G., Hadchouel, J., Bonnet, D., Brown, N.A., Buckingham, M.E., Rotation of the myocardial wall of the outflow tract is implicated in the normal positioning of the great arteries. Circ. Res. 98 (2006), 421–428.
3. Bajolle, F., Zaffran, S., Meilhac, S.M., Dandonneau, M., Chang, T., Kelly, R.G., Buckingham, M.E., Myocardium at the base of the aorta and pulmonary trunk is prefigured in the outflow tract of the heart and in subdomains of the second heart field. Dev. Biol. 313 (2008), 25–34.
4. Buckingham, M., Meilhac, S., Zaffran, S., Building the mammalian heart from two sources of myocardial cells. Nat. Rev. Genet. 6 (2005), 826–835.
5. Chen, F., Desai, T.J., Qian, J., Niederreither, K., Lu, J., Cardoso, W.V., Inhibition of Tgf beta signaling by endogenous retinoic acid is essential for primary lung bud induction. Development 134 (2007), 2969–2979.
6. Choudhary, B., Ito, Y., Makita, T., Sasaki, T., Chai, Y., Sucov, H.M., Cardiovascular malformations with normal smooth muscle differentiation in neural crest-specific type II TGFbeta receptor (Tgfbr2) mutant mice. Dev. Biol. 289 (2006), 420–429.
7. Choudhary, B., Zhou, J., Li, P., Thomas, S., Kaartinen, V., Sucov, H.M., Absence of TGFbeta signaling in embryonic vascular smooth muscle leads to reduced lysyl oxidase expression, impaired elastogenesis, and aneurysm. Genesis 47 (2009), 115–121.
8. Crispino, J.D., Lodish, M.B., Thurberg, B.L., Litovsky, S.H., Collins, T., Molkentin, J.D., Orkin, S.H., Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactors. Genes Dev. 15 (2001), 839–844.
9. Dodou, E., Verzi, M.P., Anderson, J.P., Xu, S.M., Black, B.L., Mef2c is a direct transcriptional target of ISL1 and GATA factors in the anterior heart field during mouse embryonic development. Development 131 (2004), 3931–3942.
10. Dyer, L.A., Kirby, M.L., The role of secondary heart field in cardiac development. Dev. Biol. 336 (2009), 137–144.
11. Eisenberg, L.M., Markwald, R.R., Molecular regulation of atrioventricular valvuloseptal morphogenesis. Circ. Res. 77 (1995), 1–6.
12. Ghatpande, S., Ghatpande, A., Zile, M., Evans, T., Anterior endoderm is sufficient to rescue foregut apoptosis and heart tube morphogenesis in an embryo lacking retinoic acid. Dev. Biol. 219 (2000), 59–70.
13. Gu, C., Rodriguez, E.R., Reimert, D.V., Shu, T., Fritzsch, B., Richards, L.J., Kolodkin, A.L., Ginty, D.D., Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development. Dev. Cell 5 (2003), 45–57.
14. Hayashi, S., McMahon, A.P., Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse. Dev. Biol. 244 (2002), 305–318.
15. Horsthuis, T., Christoffels, V.M., Anderson, R.H., Moorman, A.F., Can recent insights into cardiac development improve our understanding of congenitally malformed hearts?. Clin. Anat. 22 (2009), 4–20.
16. Jiang, X., Choudhary, B., Merki, E., Chien, K.R., Maxson, R.E., Sucov, H.M., Normal fate and altered function of the cardiac neural crest cell lineage in retinoic acid receptor mutant embryos. Mech. Dev. 117 (2002), 115–122.
17. Kirby, M.L., Pulmonary atresia or persistent truncus arteriosus: is it important to make the distinction and how do we do it?. Circ. Res. 103 (2008), 337–339.
18. Kubalak, S.W., Hutson, D.R., Scott, K.K., Shannon, R.A., Elevated transforming growth factor beta2 enhances apoptosis and contributes to abnormal outflow tract and aortic sac development in retinoic X receptor alpha knockout embryos. Development 129 (2002), 733–746.
19. Lee, R.Y., Luo, J., Evans, R.M., Giguere, V., Sucov, H.M., Compartment-selective sensitivity of cardiovascular morphogenesis to combinations of retinoic acid receptor gene mutations. Circ. Res. 80 (1997), 757–764.
20. McCulley, D.J., Kang, J.O., Martin, J.F., Black, B.L., BMP4 is required in the anterior heart field and its derivatives for endocardial cushion remodeling, outflow tract septation, and semilunar valve development. Dev. Dyn. 237 (2008), 3200–3209.
21. Moss, J.B., Xavier-Neto, J., Shapiro, M.D., Nayeem, S.M., McCaffery, P., Drager, U.C., Rosenthal, N., Dynamic patterns of retinoic acid synthesis and response in the developing mammalian heart. Dev. Biol. 199 (1998), 55–71.
22. Pu, W.T., Ishiwata, T., Juraszek, A.L., Ma, Q., Izumo, S., GATA4 is a dosage-sensitive regulator of cardiac morphogenesis. Dev. Biol. 275 (2004), 235–244.
23. Ryckebusch, L., Wang, Z., Bertrand, N., Lin, S.C., Chi, X., Schwartz, R., Zaffran, S., Niederreither, K., Retinoic acid deficiency alters second heart field formation. Proc. Natl. Acad. Sci. USA 105 (2008), 2913–2918.
24. Sanford, L.P., Ormsby, I., Gittenberger-de Groot, A.C., Sariola, H., Friedman, R., Boivin, G.P., Cardell, E.L., Doetschman, T., TGFb2 knockout mice have multiple developmental defects that are nonoverlapping with other TGFb knockout phenotypes. Development 124 (1997), 2659–2670.
25. Sirbu, I.O., Zhao, X., Duester, G., Retinoic acid controls heart anteroposterior patterning by down-regulating Isl1 through the Fgf8 pathway. Dev. Dyn. 237 (2008), 1627–1635.
26. Tanaka, M., Chen, Z., Bartunkova, S., Yamasaki, N., Izumo, S., The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development. Development 126 (1999), 1269–1280.
27. Verzi, M.P., McCulley, D.J., De Val, S., Dodou, E., Black, B.L., The right ventricle, outflow tract, and ventricular septum comprise a restricted expression domain within the secondary/anterior heart field. Dev. Biol. 287 (2005), 134–145.
28. Xin, M., Davis, C.A., Molkentin, J.D., Lien, C.L., Duncan, S.A., Richardson, J.A., Olson, E.N., A threshold of GATA4 and GATA6 expression is required for cardiovascular development. Proc. Natl. Acad. Sci. USA 103 (2006), 11189–11194.
29. Xu, H., Cerrato, F., Baldini, A., Timed mutation and cell-fate mapping reveal reiterated roles of Tbx1 during embryogenesis, and a crucial function during segmentation of the pharyngeal system via regulation of endoderm expansion. Development 132 (2005), 4387–4395.
30. Zhao, R., Watt, A.J., Battle, M.A., Li, J., Bondow, B.J., Duncan, S.A., Loss of both GATA4 and GATA6 blocks cardiac myocyte differentiation and results in acardia in mice. Dev. Biol. 317 (2008), 614–619.