Abnormal aortic valve development in mice lacking endothelial nitric oxide synthase

Circulation

Volumn 101, Issue 20, 2000, Pages 2345-2348

  Lee, Tony C ^a   Zhao, Yidan D ^a   Courtman, David W ^a   Stewart, Duncan J ^a  

^a ST MICHAEL'S HOSPITAL   (Canada)

Author keywords

Endothelium; Heart defects, congenital; Mice, knockout; Nitric oxide; Valves

Indexed keywords

NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA VALVE DISEASE; ARTICLE; CONGENITAL HEART MALFORMATION; CONTROLLED STUDY; EMBRYO DEVELOPMENT; ENZYME DEFICIENCY; HEART DEVELOPMENT; HEART MUSCLE; MALE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; VASCULAR ENDOTHELIUM;

EID: 0034704998     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.101.20.2345     Document Type: Article

References (13)

1. Moncada S, Higgs A. The L-arginine-nitric oxide pathway. N Engl J Med. 1993;329:2002-2012.
2. Nathan C, Xie QW. Nitric oxide synthases: roles, tolls, and controls. Cell. 1994;78:915-918.
3. Chang WJ, Iannaccone ST, Lau KS, et al. Neuronal nitric oxide synthase and dystrophin-deficient muscular dystrophy. Proc Natl Acad Sci U S A. 1996;93:9142-9147.
4. Rudic RD, Shesely EG, Maeda N, et al. Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling. J Clin Invest. 1998;101:731-736.
5. Murohara T, Asahara T, Silver M, et al. Nitric oxide synthase modulates angiogenesis in response to tissue ischemia. J Clin Invest. 1998;101: 2567-2578.
6. Gregg AR, Schauer A, Shi O, et al. Limb reduction defects in endothelial nitric oxide synthase-deficient mice. Am J Physiol. 1998;275: H2319-H2324.
7. Roberts WC. The congenitally bicuspid aortic valve: a study of 85 autopsy cases. Am J Cardiol. 1970;26:72-83.
8. Huntington K, Hunter AG, Chan KL. A prospective study to assess the frequency of familial clustering of congenital bicuspid aortic valve. J Am Coll Cardiol. 1997;30:1809-1812.
9. Olson LJ, Subramanian R, Edwards WD. Surgical pathology of pure aortic insufficiency: a study of 225 cases. Mayo Clin Proc. 1984;59: 835-841.
10. Bloch W, Fleischmann BK, Lorke DE, et al. Nitric oxide synthase expression and role during cardiomyogenesis. Cardiovasc Res. 1999;43: 675-684.
11. Basson CT, Cowley GS, Solomon SD, et al. The clinical and genetic spectrum of the Holt-Oram syndrome (heart-hand syndrome). N Engl J Med. 1994;330:885-891.
12. Gelb BD, Zhang J, Sommer RJ, et al. Familial patent ductus arteriosus and bicuspid aortic valve with hand anomalies: a novel heart-hand syndrome. Am J Med Genet. 1999;87:175-179.
13. Becker AE, Becker MJ, Edwards JE. Anomalies associated with coarctation of aorta: particular reference to infancy. Circulation. 1970;41: 1067-1075.