Loss of MicroRNAs in neural crest leads to cardiovascular syndromes resembling human congenital heart defects

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 30, Issue 12, 2010, Pages 2575-2586

  Huang, Zhan Peng ^a,b   Chen, Jian Fu ^a   Regan, Jenna N ^a   Maguire, Colin T ^a   Tang, Ru Hang ^a   Rong Dong, Xiu ^a   Majesky, Mark W ^a   Wang, Da Zhi ^a,b,c  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

cardiovascular development; Dicer; microRNAs; neural crest cells; vascular biology

Indexed keywords

DICER; MICRORNA; MICRORNA 181A; MICRORNA 21; SPROUTY PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA ARCH INTERRUPTION; ARTICLE; CARDIOVASCULAR DISEASE; CELL DEATH; CELL SURVIVAL; CONGENITAL HEART MALFORMATION; CONTROLLED STUDY; CRANIOFACIAL MALFORMATION; EMBRYO; HEART RIGHT VENTRICLE DOUBLE OUTLET; HEART VENTRICLE SEPTUM DEFECT; KNOCKOUT MOUSE; MOUSE; NEURAL CREST CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION;

ABNORMALITIES, MULTIPLE; ANIMALS; CELL DEATH; CELL DIFFERENTIATION; CELL MOVEMENT; CELL SURVIVAL; CRANIOFACIAL ABNORMALITIES; EMBRYO, MAMMALIAN; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENOTYPE; HEART DEFECTS, CONGENITAL; HUMANS; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MICRORNAS; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; NEURAL CREST; PHENOTYPE; RIBONUCLEASE III; SEVERITY OF ILLNESS INDEX; SYNDROME;

EID: 78650414944     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/ATVBAHA.110.213306     Document Type: Article

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