Loss of mRor1 enhances the heart and skeletal abnormalities in mRor2-deficient mice: Redundant and pleiotropic functions of mRor1 and mRor2 receptor tyrosine kinases

Molecular and Cellular Biology

Volumn 21, Issue 24, 2001, Pages 8329-8335

  Nomi, M ^a   Oishi, I ^a   Kani, S ^a   Suzuki, H ^a   Matsuda, T ^a   Yoda, A ^a   Kitamura, M ^a   Itoh, K ^a   Takeuchi, S ^a   Takeda, K ^a   Akira, S ^a   Ikeya, M ^a   Takada, S ^a   Minami, Y ^a  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN TYROSINE KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DYSPLASIA; CONGENITAL HEART MALFORMATION; CONTROLLED STUDY; HEART VENTRICLE SEPTUM DEFECT; MOUSE; NONHUMAN; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RESPIRATORY FAILURE; SKELETON MALFORMATION;

ANIMALS; ANIMALS, NEWBORN; BONE AND BONES; HEART DEFECTS, CONGENITAL; IN SITU HYBRIDIZATION; LUNG; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MODELS, GENETIC; MUTATION; PHENOTYPE; PROTEIN STRUCTURE, TERTIARY; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, CELL SURFACE; TIME FACTORS;

ANIMALIA; MAMMALIA; UEDA;

EID: 0035192873     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.24.8329-8335.2001     Document Type: Article

References (35)

1. Recessive Robinow syndrome, allelic to dominant brachydactyly type B, is caused by mutation of Ror2
2. Cranial and cardiac neural crest defects in endothelin-A receptor-deficient mice
3. Cardiac pathology
4. Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11
5. Ror2, encoding a receptor-like tyrosine kinase, is required for cartilage and growth plate development
6. The cardiovascular system
7. C. elegans Ror receptor tyrosine kinase regulates cell motility and asymmetric cell division
8. Lateral plate mesoderm and endoderm
9. Pulmonary surfactant: Functions and molecular composition
10. Neural crest and cardiovascular patterning
11. Hoxd-12 differentially affects preaxial and postaxial chondrogenic branches in the limb and regulates Sonic hedgehog in a positive feedback loop
12. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
13. Pulmonary surfactant proteins
14. A novel family of cell surface receptors with tyrosine kinase-like domain
15. The Wnt receptor CRD domain is also found in MuSK and related orphan receptor tyrosine kinases
16. Expression of the receptor tyrosine kinase genes, Ror1 and Ror2, during mouse development
17. Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
18. The signaling pathway mediated by the type IIB activin receptor controls axial patterning and lateral asymmetry in the mouse
19. A novel Drosophila receptor tyrosine kinase expressed specifically in the nervous system: Unique structural features and implication in developmental signaling
20. Spatio-temporally regulated expression of receptor tyrosine kinases, mRor1, mRor2, during mouse development: Implications in development and function of the nervous system
21. Dominant mutations in Ror2, encoding an orphan receptor tyrosine kinase, cause brachydactyly type B
22. Molecular pathways controlling heart development
23. Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development
24. Kringles: Modules specialized for protein binding
25. The frizzled motif: In how many different protein families does it occur?
26. The protein tyrosine kinase family of the human genome
27. Mouse mutants and cardiac development
28. Cardiovascular system
29. Identification of a Frizzled-like cysteine rich domain in the extracellular region of developmental receptor tyrosine kinases
30. Cell signaling by receptor tyrosine kinases
31. Distinct mutations in the receptor tyrosine kinase gene Ror2 cause brachydactyly type B
32. Mouse Ror2 receptor tyrosine kinase is required for the heart development and limb formation
33. Mutation of the gene encoding the Ror2 tyrosine kinase causes autosomal recessive Robinow syndrome
34. Dror, a potential neurotrophic receptor gene, encodes a Drosophila homolog of the vertebrate Ror family of Trk-related receptor kinases
35. Evidence that absence of Wnt-3a signaling promotes neuralization instead of paraxial mesoderm development in the mouse