Rescue of morphogenetic defects and of retinoic acid signaling in retinaldehyde dehydrogenase 2 (Raldh2) mouse mutants by chimerism with wild-type cells

Differentiation

Volumn 74, Issue 9-10, 2006, Pages 661-668

  Vermot, Julien ^a,c   Messaddeq, Nadia ^c   Niederreither, Karen ^b,c   Dierich, Andrée ^c   Dollé, Pascal ^c  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

Aldehyde dehydrogenases; Embryonic stem (ES) cells; Heart; Lung; Mouse chimeras; Mouse development; Myocardium; Retinoids

Indexed keywords

RETINAL DEHYDROGENASE; RETINAL DEHYDROGENASE 2; RETINOIC ACID; RETINOL;

ANIMAL CELL; AORTOPULMONARY SEPTAL DEFECT; ARTICLE; CELLULAR DISTRIBUTION; CHIMERA; CONTROLLED STUDY; DEVELOPMENTAL SCREENING; EMBRYO; EMBRYO DEVELOPMENT; GENE; GENE MUTATION; HEART DEVELOPMENT; HOMOZYGOSITY; LUNG DISEASE; MORPHOGENESIS; MOUSE; MUSCLE DEVELOPMENT; NONHUMAN; NULL ALLELE; PHENOTYPE; PRIORITY JOURNAL; RALDH2 GENE; TRANSGENE; VITAMIN METABOLISM; WILD TYPE;

VERTEBRATA;

EID: 33845527678     PISSN: 03014681     EISSN: 14320436     Source Type: Journal    
DOI: 10.1111/j.1432-0436.2006.00094.x     Document Type: Article

References (31)

1. Abu-Abed, S., Dolle, P., Metzger, D., Beckett, B., Chambon, P. and Petkovich, M. (2001) The retinoic acid-metabolizing enzyme, CYP26A1, is essential for normal hindbrain patterning, vertebral identity, and development of posterior structures. Genes Dev 15:226-240.
2. Bohnsack, B.L., Lai, L., Dolle, P. and Hirschi, K.K. (2004) Signaling hierarchy downstream of retinoic acid that independently regulates vascular remodeling and endothelial cell proliferation. Genes Dev 18:1345-1358.
3. Chazaud, C., Chambon, P. and Dolle, P. (1999) Retinoic acid is required in the mouse embryo for left-right asymmetry determination and heart morphogenesis. Development 126:2589-2596.
4. Desai, T.J., Malpel, S., Flentke, G.R., Smith, S.M. and Cardoso, W.V. (2004) Retinoic acid selectively regulates Fgf10 expression and maintains cell identity in the prospective lung field of the developing foregut. Dev Biol 273:402-415.
5. Dierich, A. and Dollé, P. (1997) Gene targeting in embryonic stem cells. In: Klug, S. and Thiel, R. eds. Methods in developmental toxicology and biology. Blackwell Science, Oxford, UK, pp. 111-123.
6. Friedrich, G. and Soriano, P. (1991) Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Genes Dev 5:1513-1523.
7. Hochgreb, T., Linhares, V.L., Menezes, D.C., Sampaio, A.C., Yan, C.Y., Cardoso, W.V., Rosenthal, N. and Xavier-Neto, J. (2003) A caudorostral wave of RALDH2 conveys anteroposterior information to the cardiac field. Development 130:5363-5374.
8. Kastner, P., Messaddeq, N., Mark, M., Wendling, O., Grondona, J.M., Ward, S., Ghyselinck, N. and Chambon, P. (1997) Vitamin A deficiency and mutations of RXRalpha, RXRbeta and RAR-alpha lead to early differentiation of embryonic ventricular cardiomyocytes. Development 124:4749-4758.
9. Lu, H.C., Revelli, J.P., Goering, L., Thaller, C. and Eichele, G. (1997) Retinoid signaling is required for the establishment of a ZPA and for the expression of Hoxb-8, a mediator of ZPA formation. Development 124:1643-1651.
10. Maden, M., Sonneveld, E., van der Saag, P.T. and Gale, E. (1998) The distribution of endogenous retinoic acid in the chick embryo: implications for developmental mechanisms. Development 125:4133-4144.
11. Martin, M., Gallego-Llamas, J., Ribes, V., Kedinger, M., Niederreither, K., Chambon, P., Dolle, P. and Gradwohl, G. (2005) Dorsal pancreas agenesis in retinoic acid-deficient Raldh2 mutant mice. Dev Biol 284:399-411.
12. Maskos, U. and McKay, R.D. (2003) Neural cells without functional N-Methyl-D-Aspartate (NMDA) receptors contribute extensively to normal postnatal brain development in efficiently generated chimaeric NMDA R1 -/- ↔ +/+ mice. Dev Biol 262:119-136.
13. Mic, F.A., Haselbeck, R.J., Cuenca, A.E. and Duester, G. (2002) Novel retinoic acid generating activities in the neural tube and heart identified by conditional rescue of Raldh2 null mutant mice. Development 129:2271-2282.
14. Molotkov, A., Molotkova, N. and Duester, G. (2005) Retinoic acid generated by Raldh2 in mesoderm is required for mouse dorsal endodermal pancreas development. Dev Dyn 232:950-957.
15. Niederreither, K., McCaffery, P., Drager, U.C., Chambon, P. and Dolle, P. (1997) Restricted expression and retinoic acid-induced down-regulation of the retinaldehyde dehydrogenase type 2 (RALDH-2) gene during mouse development. Mech Dev 62:67-78.
16. Niederreither, K., Subbarayan, V., Dolle, P. and Chambon, P. (1999) Embryonic retinoic acid synthesis is essential for early mouse post-implantation development. Nat Genet 21:444-448.
17. Niederreither, K., Vermot, J., Le Roux, I., Schuhbaur, B., Chambon, P. and Dolle, P. (2003) The regional pattern of retinoic acid synthesis by RALDH2 is essential for the development of posterior pharyngeal arches and the enteric nervous system. Development 130:2525-2534.
18. Niederreither, K., Vermot, J., Messaddeq, N., Schuhbaur, B., Chambon, P. and Dolle, P. (2001) Embryonic retinoic acid synthesis is essential for heart morphogenesis in the mouse. Development 128:1019-1031.
19. Niederreither, K., Vermot, J., Schuhbaur, B., Chambon, P. and Dolle, P. (2000) Retinoic acid synthesis and hindbrain patterning in the mouse embryo. Development 127:75-85.
20. Niederreither, K., Vermot, J., Schuhbaur, B., Chambon, P. and Dollé, P. (2002) Embryonic retinoic acid synthesis is required for forelimb growth and anteroposterior patterning in the mouse. Development 129:3563-3574.
21. Reijntjes, S., Blentic, A., Gale, E. and Maden, M. (2005) The control of morphogen signalling: regulation of the synthesis and catabolism of retinoic acid in the developing embryo. Dev Biol 285:224-237.
22. Rossant, J., Zirngibl, R., Cado, D., Shago, M. and Giguere, V. (1991) Expression of a retinoic acid response element-hsplacZ transgene defines specific domains of transcriptional activity during mouse embryogenesis. Genes Dev 5:1333-1344.
23. Sakai, Y., Meno, C., Fujii, H., Nishino, J., Shiratori, H., Saijoh, Y., Rossant, J. and Hamada, H. (2001) The retinoic acid-inactivating enzyme CYP26 is essential for establishing an uneven distribution of retinoic acid along the anterio-posterior axis within the mouse embryo. Genes Dev 15:213-225.
24. Schneider, R.A., Hu, D., Rubenstein, J.L., Maden, M. and Helms, J.A. (2001) Local retinoid signaling coordinates forebrain and facial morphogenesis by maintaining FGF8 and SHH. Development 128:2755-2767.
25. Sirbu, I.O., Gresh, L., Barra, J. and Duester, G. (2005) Shifting boundaries of retinoic acid activity control hindbrain segmental gene expression. Development 132:2611-2622.
26. Swindell, E.C., Thaller, C., Sockanathan, S., Petkovich, M., Jessell, T.M. and Eichele, G. (1999) Complementary domains of retinoic acid production and degradation in the early chick embryo. Dev Biol 216:282-296.
27. Varlet, I., Collignon, J. and Robertson, E.J. (1997) Nodal expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulation. Development 124:1033-1044.
28. Vermot, J., Niederreither, K., Garnier, J.M., Chambon, P. and Dolle, P. (2003) Decreased embryonic retinoic acid synthesis results in a DiGeorge syndrome phenotype in newborn mice. Proc Natl Acad Sci USA 100:1763-1768.
29. Vermot, J., Schuhbaur, B., Le Mouellic, H., McCaffery, P., Garnier, J.M., Hentsch, D., Brulet, P., Niederreither, K., Chambon, P., Dolle, P. and Le Roux, I. (2005) Retinaldehyde dehydrogenase 2 and Hoxc8 are required in the murine brachial spinal cord for the specification of Lim1+ motoneurons and the correct distribution of Islet1+ motoneurons. Development 132:1611-1621.
30. Wendling, O., Dennefeld, C., Chambon, P. and Mark, M. (2000) Retinoid signaling is essential for patterning the endoderm of the third and fourth pharyngeal arches. Development 127:1553-1562.
31. Yashiro, K., Zhao, X., Uehara, M., Yamashita, K., Nishijima, M., Nishino, J., Saijoh, Y., Sakai, Y. and Hamada, H. (2004) Regulation of retinoic acid distribution is required for proximodistal patterning and outgrowth of the developing mouse limb. Dev Cell 6:411-422.