Nf1 has an essential role in endothelial cells

Nature Genetics

Volumn 33, Issue 1, 2003, Pages 75-79

  Gitler, Aaron D ^a   Zhu, Yuan ^b   Ismat, Fraz A ^a,c   Lu, Min Min ^a   Yamauchi, Yasutaka ^d   Parada, Luis F ^b   Epstein, Jonathan A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^d KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROFIBROMIN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME DEFICIENCY; GENE ACTIVATION; GENE INACTIVATION; GENETIC DISORDER; GENETIC TRANSCRIPTION; HEART MUSCLE; MOUSE; NEURAL CREST; NEUROFIBROMATOSIS; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; NULL ALLELE; ONCOGENE RAS; PHENOTYPE; PHENOTYPIC VARIATION; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TISSUE SPECIFICITY;

ANIMALS; CELL LINEAGE; CELLS, CULTURED; ENDOTHELIUM; GENE DELETION; GENES, ESSENTIAL; HEART; HUMANS; INTEGRASES; MICE; MICE, KNOCKOUT; MYOCARDIUM; NEURAL CREST; NEUROFIBROMATOSIS 1; NEUROFIBROMIN 1; NFATC TRANSCRIPTION FACTORS; PHENOTYPE; PROTO-ONCOGENE PROTEINS P21(RAS); SIGNAL TRANSDUCTION; VIRAL PROTEINS;

ANIMALIA;

EID: 0037229065     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng1059     Document Type: Article

References (30)

1. Friedman, J.M. et al. Cardiovascular disease in neurofibromatosis 1: Report of the NF1 Cardiovascular Task Force. Genet. Med. 4, 105-111 (2002).
2. Lin, A.E. et al. Cardiovascular malformations and other cardiovascular abnormalities in neurofibromatosis 1. Am. J. Med. Genet. 95, 108-117 (2000).
3. Jacks, T. et al. Tumour predisposition in mice heterozygous for a targeted mutation in Nf1. Nat. Genet. 7, 353-361 (1994).
4. Brannan, C.I. et al. Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues. Genes Dev. 8, 1019-1029 (1994).
5. Lakkis, M.M. & Epstein, J.A. Neurofibromin modulation of ras activity is required for normal endocardial-mesenchymal transformation in the developing heart. Development 125, 4359-4367 (1998).
6. Kirby, M.L., Gale, T.F. & Stewart, D.E. Neural crest cells contribute to normal aorticopulmonary septation. Science 220, 1059-1061 (1983).
7. Zhu, Y. et al. Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain. Genes Dev. 15, 859-876 (2001).
8. Kisanuki, Y.Y. et al. Tie2-Cre transgenic mice: A new model for endothelial celllineage analysis in vivo. Dev. Biol. 230, 230-242 (2001).
9. Meyer, D. & Birchmeier, C. Multiple essential functions of neuregulin in development. Nature 378, 386-390 (1995).
10. Erickson, S.L. et al. ErbB3 is required for normal cerebellar and cardiac development: a comparison with ErbB2- and heregulin-deficient mice. Development 124, 4999-5011 (1997).
11. Morrison-Graham, K., Schatteman, G., Bork, T., Bowen-Pope, D. & Weston, J. A PDGF receptor mutation in the mouse (Patch) perturbs the development of a non-neuronal subset of neural crest-derived cells. Development 115, 133-142 (1992).
12. Epstein, J. Pax3, neural crest and cardiovascular development. Trends Cardiovasc. Med. 6, 255-261 (1996).
13. Feiner, L. et al. Targeted disruption of semaphorin 3C leads to persistent truncus arteriosus and aortic arch interruption. Development 128, 3061-3070 (2001).
14. Galvin, K.M. et al. A role for smad6 in development and homeostasis of the cardiovascular system. Nat. Genet. 24, 171-174 (2000).
15. Ya, J. et al. Sox4-deficiency syndrome in mice is an animal model for common trunk. Circ. Res. 83, 986-994 (1998).
16. Yang, J.T., Rayburn, H. & Hynes, R.O. Cell adhesion events mediated by alpha 4 integrins are essential in placental and cardiac development. Development 121, 549-560 (1995).
17. de la Pompa, J.L. et al. Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum. Nature 392, 182-186 (1998).
18. Camenisch, T.D. et al. Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme. J. Clin. Invest. 106, 349-360 (2000).
19. Chen, B. et al. Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis. Nat. Genet. 24, 296-299 (2000).
20. Ranger, A.M. et al. The transcription factor NF-ATc is essential for cardiac valve formation. Nature 392, 186-190 (1998).
21. Ichida, M. & Finkel, T. Ras regulates NFAT3 activity in cardiac myocytes. J. Biol. Chem. 276, 3524-3530 (2001).
22. Woodrow, M.A., Rayter, S., Downward, J. & Cantrell, D.A. p21ras function is important for T-cell antigen receptor and protein kinase C regulation of nuclear factor of activated T cells. J. Immunol. 150, 3853-3861 (1993).
23. Vogel, K.S. et al. Mouse tumor model for neurofibromatosis type 1. Science 286, 2176-2179 (1999).
24. Cichowski, K. et al. Mouse models of tumor development in neurofibromatosis type 1. Science 286, 2172-2176 (1999).
25. Jiang, X., Rowitch, D.H., Soriano, P., McMahon, A.P. & Sucov, H.M. Fate of the mammalian cardiac neural crest. Development 127, 1607-1616 (2000).
26. Li, J., Chen, F. & Epstein, J.A. Neural crest expression of Cre recombinase directed by the proximal Pax3 promoter in transgenic mice. Genesis 26, 162-164 (2000).
27. Yamauchi, Y. et al. A novel transgenic technique that allows specific marking of the neural crest cell lineage in mice. Dev. Biol. 212, 191-203 (1999).
28. Ricci, A. Jr. et al. Malignant peripheral nerve sheath tumors arising from ganglioneuromas. Am. J. Surg. Pathol. 8, 19-29 (1984).
29. Novak, A., Guo, C., Yang, W., Nagy, A. & Lobe, C.G. Z/EG, a double reporter mouse line that expresses enhanced green fluorescent protein upon Cre-mediated excision. Genesis 28, 147-155 (2000).
30. Soriano, P. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat. Genet. 21, 70-71 (1999).