Conditional inactivation of TGF-β type II receptor in smooth muscle cells and epicardium causes lethal aortic and cardiac defects

Transgenic Research

Volumn 19, Issue 6, 2010, Pages 1069-1082

  Langlois, Dominique ^a   Hneino, Mohammad ^a   Bouazza, Lamia ^a   Parlakian, Ara ^b   Sasaki, Takako ^c   Bricca, Giampiero ^a   Li, Jacques Yuan ^a  

^a UNIVERSITÉ LYON 1   (France)

^b Unité de recherche 4   (France)

^c SHRINERS HOSPITAL FOR CHILDREN   (United States)

Author keywords

Cardiovascular development; Elastic fibers; Fibulin 5; Transforming growth factor beta; Vascular smooth muscle cell (VSMC)

Indexed keywords

ACTIN BINDING PROTEIN; ELASTIN; FBLN5 PROTEIN, MOUSE; MUSCLE PROTEIN; PROTEIN SERINE THREONINE KINASE; RECOMBINANT PROTEIN; SCLEROPROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA TYPE II RECEPTOR; TRANSFORMING GROWTH FACTOR-BETA TYPE II RECEPTOR; TRANSGELIN;

ANIMAL; ARTICLE; CELL DIFFERENTIATION; CONGENITAL HEART MALFORMATION; CONGENITAL MALFORMATION; DRUG ANTAGONISM; ELASTIC TISSUE; FEMALE; GENE SILENCING; GENETICS; MALE; METABOLISM; MOUSE; PATHOLOGY; PERICARDIUM; PREGNANCY; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; THORACIC AORTA; TRANSGENIC MOUSE;

ANIMALS; AORTA, THORACIC; CELL DIFFERENTIATION; ELASTIC TISSUE; ELASTIN; EXTRACELLULAR MATRIX PROTEINS; FEMALE; GENE KNOCKDOWN TECHNIQUES; HEART DEFECTS, CONGENITAL; MALE; MICE; MICE, TRANSGENIC; MICROFILAMENT PROTEINS; MUSCLE PROTEINS; MYOCYTES, SMOOTH MUSCLE; PERICARDIUM; PREGNANCY; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA;

MUS;

EID: 78149464338     PISSN: 09628819     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11248-010-9379-4     Document Type: Article

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