The secondary heart field is a new site of calcineurin/Nfatc1 signaling for semilunar valve development

Journal of Molecular and Cellular Cardiology

Volumn 52, Issue 5, 2012, Pages 1096-1102

  Lin, Chieh Yu ^a   Lin, Chien Jung ^a   Chen, Chen Hao ^a   Chen, Richard M ^a   Zhou, Bin ^b   Chang, Ching Pin ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Calcineurin; Endocardial cushion; Nfatc1; Secondary heart field; Semilunar valve

Indexed keywords

CALCINEURIN; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR NFATC1; UNCLASSIFIED DRUG;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ECHOCARDIOGRAPHY; EMBRYO; FEMALE; HEART; HEART DEVELOPMENT; HISTOPATHOLOGY; KNOCKOUT MOUSE; LETHALITY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REGULATORY MECHANISM; SECONDARY HEART FIELD; SEMILUNAR VALVE DEVELOPMENT; SIGNAL TRANSDUCTION;

ANIMALS; ANIMALS, OUTBRED STRAINS; CALCINEURIN; EMBRYO, MAMMALIAN; EMBRYONIC STEM CELLS; ENDOCARDIAL CUSHIONS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEART; MICE; MICE, KNOCKOUT; NFATC TRANSCRIPTION FACTORS; ORGAN SPECIFICITY; PULMONARY VALVE; SIGNAL TRANSDUCTION;

MUS;

EID: 84862798575     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2012.01.013     Document Type: Article

References (33)

1. Brickner M.E., Hillis L.D., Lange R.A. Congenital heart disease in adults. First of two parts. N Engl J Med 2000, 342:256-263.
2. Chang C.P., Neilson J.R., Bayle J.H., Gestwicki J.E., Kuo A., Stankunas K., et al. A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis. Cell 2004, 118:649-663.
3. Kirby M.L., Gale T.F., Stewart D.E. Neural crest cells contribute to normal aorticopulmonary septation. Science 1983, 220:1059-1061.
4. Kirby M.L. Cardiac Development 2007, 3500.
5. Markwald R.R., Fitzharris T.P., Manasek F.J. Structural development of endocardial cushions. Am J Anat 1977, 148:85-119.
6. Harvey R.P., Rosenthal N. Heart Development 1999, Academic Press.
7. Fisher S.A., Langille B.L., Srivastava D. Apoptosis during cardiovascular development. Circ Res 2000, 87:856-864.
8. Rentschler S., Jain R., Epstein J.A. Tissue-tissue interactions during morphogenesis of the outflow tract. Pediatr Cardiol 2010, 31:408-413.
9. Verzi M.P., McCulley D.J., De Val S., Dodou E., Black B.L. The right ventricle, outflow tract, and ventricular septum comprise a restricted expression domain within the secondary/anterior heart field. Dev Biol 2005, 287:134-145.
10. Yang L., Cai C.L., Lin L., Qyang Y., Chung C., Monteiro R.M., et al. Isl1Cre reveals a common Bmp pathway in heart and limb development. Development 2006, 133:1575-1585.
11. McCulley D.J., Kang J.O., Martin J.F., Black B.L. BMP4 is required in the anterior heart field and its derivatives for endocardial cushion remodeling, outflow tract septation, and semilunar valve development. Dev Dyn 2008, 237:3200-3209.
12. Park E.J., Ogden L.A., Talbot A., Evans S., Cai C.L., Black B.L., et al. Required, tissue-specific roles for Fgf8 in outflow tract formation and remodeling. Development 2006, 133:2419-2433.
13. Varadkar P.A., Kraman M., McCright B. Generation of mice that conditionally express the activation domain of Notch2. Genesis 2009, 47:573-578.
14. High F.A., Jain R., Stoller J.Z., Antonucci N.B., Lu M.M., Loomes K.M., et al. Murine Jagged1/Notch signaling in the second heart field orchestrates Fgf8 expression and tissue-tissue interactions during outflow tract development. J Clin Invest 2009, 119:1986-1996.
15. Jain R., Engleka K.A., Rentschler S.L., Manderfield L.J., Li L., Yuan L., et al. Cardiac neural crest orchestrates remodeling and functional maturation of mouse semilunar valves. J Clin Invest 2011, 121:422-430.
16. Wu B., Wang Y., Lui W., Langworthy M., Tompkins K.L., Hatzopoulos A.K., et al. Nfatc1 coordinates valve endocardial cell lineage development required for heart valve formation. Circ Res 2011.
17. Ranger A.M., Grusby M.J., Hodge M.R., Gravallese E.M., de la Brousse F.C., Hoey T., et al. The transcription factor NF-ATc is essential for cardiac valve formation. Nature 1998, 392:186-190.
18. de la Pompa J.L., Timmerman L.A., Takimoto H., Yoshida H., Elia A.J., Samper E., et al. Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum. Nature 1998, 392:182-186.
19. Neilson J.R., Winslow M.M., Hur E.M., Crabtree G.R. Calcineurin B1 is essential for positive but not negative selection during thymocyte development. Immunity 2004, 20:255-266.
20. Aliprantis A.O., Ueki Y., Sulyanto R., Park A., Sigrist K.S., Sharma S.M., et al. NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism. J Clin Invest 2008, 118:3775-3789.
21. Jiang X., Rowitch D.H., Soriano P., McMahon A.P., Sucov H.M. Fate of the mammalian cardiac neural crest. Development 2000, 127:1607-1616.
22. Hang C.T., Yang J., Han P., Cheng H.L., Shang C., Ashley E., et al. Chromatin regulation by Brg1 underlies heart muscle development and disease. Nature 2010, 466:62-67.
23. Zeini M., Hang C.T., Lehrer-Graiwer J., Dao T., Zhou B., Chang C.P. Spatial and temporal regulation of coronary vessel formation by calcineurin-NFAT signaling. Development 2009, 136:3335-3345.
24. Chang C.P., Chen L., Crabtree G.R. Sonographic staging of the developmental status of mouse embryos in utero. Genesis 2003, 36:7-11.
25. Brown C.B., Feiner L., Lu M.M., Li J., Ma X., Webber A.L., et al. PlexinA2 and semaphorin signaling during cardiac neural crest development. Development 2001, 128:3071-3080.
26. Stankunas K., Hang C.T., Tsun Z.Y., Chen H., Lee N.V., Wu J.I., et al. Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis. Dev Cell 2008, 14:298-311.
27. Chang C.P., Stankunas K., Shang C., Kao S.C., Twu K.Y., Cleary M.L. Pbx1 functions in distinct regulatory networks to pattern the great arteries and cardiac outflow tract. Development 2008, 135:3577-3586.
28. Hutson M.R., Kirby M.L. Model systems for the study of heart development and disease. Cardiac neural crest and conotruncal malformations. Semin Cell Dev Biol 2007, 18:101-110.
29. Waldo K., Zdanowicz M., Burch J., Kumiski D.H., Stadt H.A., Godt R.E., et al. A novel role for cardiac neural crest in heart development. J Clin Invest 1999, 103:1499-1507.
30. Hutson M.R., Kirby M.L. Neural crest and cardiovascular development: a 20-year perspective. Birth Defects Res C Embryo Today 2003, 69:2-13.
31. Wu H., Kao S.C., Barrientos T., Baldwin S.H., Olson E.N., Crabtree G.R., et al. Down syndrome critical region-1 is a transcriptional target of nuclear factor of activated T cells-c1 within the endocardium during heart development. J Biol Chem 2007, 282:30673-30679.
32. Jackson L.F., Qiu T.H., Sunnarborg S.W., Chang A., Zhang C., Patterson C., et al. Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling. EMBO J 2003, 22:2704-2716.
33. Araki T., Mohi M.G., Ismat F.A., Bronson R.T., Williams I.R., Kutok J.L., et al. Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation. Nat Med 2004, 10:849-857.