Disruption of ECE-1 and ECE-2 reveals a role for endothelin-converting enzyme-2 in murine cardiac development

Journal of Clinical Investigation

Volumn 105, Issue 10, 2000, Pages 1373-1382

  Yanagisawa, Hiromi ^a,b   Hammer, Robert E ^a,b   Richardson, James A ^a,b   Emoto, Noriaki ^a,b,d   Clay Williams, S ^a,b   Takeda, Shin Ichi ^a,b,c   Clouthier, David E ^a,b   Yanagisawa, Masashi ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^d KOBE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIN 1; ENDOTHELIN 2; ENDOTHELIN CONVERTING ENZYME; ENDOTHELIN CONVERTING ENZYME 2; METALLOPROTEINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; ENDOCARDIUM; ENZYME ACTIVITY; FEMALE; GENOTYPE; HEART ATRIOVENTRICULAR VALVE; HEART DEVELOPMENT; HEART OUTFLOW TRACT OBSTRUCTION; HOMOZYGOSITY; LIFESPAN; MALE; MESENCHYME; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

EID: 0034086055     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI7447     Document Type: Article

References (32)

1. Yanagisawa, M., et al. 1988. A novel vasoconstrictor peptide produced by vascular endothelial cells. Nature. 332:411-415.
2. Inone, A., et al. 1989. The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proc. Natl. Acad. Sci. USA. 86:2863-2867.
3. Arai, H., Hori, S., Aramori, I., Ohkubo, H., and Nakanishi, S. 1990. Cloning and expression of a cDNA encoding an endothelin receptor. Nature. 348:730-732.
4. Sakurai, T., et al. 1990. Cloning of a cDNA encoding a non-isopeptide selective subtype of the endothelin receptor. Nature. 349:732-735.
5. Kurihara, Y., et al. 1994. Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1. Nature. 368:703-710.
6. Kurihara, Y., et al. 1995. Aortic arch malformations and ventricular septal defect in mice deficient in endothelin-1. J. Clin. Invest. 96:293-300.
7. Clouthier, D.H., et al. 1998. Cranial and cardiac neural crest defects in endothelin-A receptor deficient mice. Development. 125:813-824.
8. Baynash, A.G., et al. 1994. Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons. Cell. 79:1277-1285.
9. Hosoda, K., et al. 1994. Targeted and natural (piebald-lethal) mutations ot endothelin-B receptor gene produce megacolon associated with spotted coat color in mice. Cell. 79:1267-1276.
10. Xu, D., et al. 1994. ECE-1: a membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1. Cell. 78:473-485.
11. Emoto, N., and Yanagisawa, M. 1995. Endothelin-converting enzyme-2 is a membrane-bound, phosphoramidon-sensitive metalloprotease with acidic pH optimum. J. Biol. Chem. 270:15262-15268.
12. Yanagisawa, H., et al. 1998. Dual genetic pathways of endothelin-mediated intercellular signaling revealed by targeted disruption of endothelin converting enzyme-1 gene. Development. 125:825-836.
13. Yanagisawa, H., et al. 1998. Role of endothelin-1/endothelin-A receptor-mediated signaling pathway in the aortic arch patterning in mice. J. Clin. Invest. 102:22-33.
14. Taurog, J.D., Maika, S.D., Simmons, W.A., Breban, M., and Hammer, R.E. 1993. Susceptibility to inflammatory disease in HLA-B27 transgenic rat lines correlates with the level of B27 expression. J. Immunol. 150:4168-4178.
15. Suzuki, N., et al. 1990. A sandwich-type enzyme immunoassay to detect immunoreactive big-endothelin-1 in plasma. J. Immunol. Methods. 127:165-170.
16. Eisenberg, L.M., and Markwald, R.R. 1995. Molecular regulation of atrioventricular valvuloseptal morphogenesis. Circ. Res. 77:1-6.
17. Kirby, M.L., and Waldo, K.L. 1995. Neural crest and cardiovascular patterning. Circ. Res. 77:211-215.
18. Noden, D.M., Poelmann, R.E., and Gittenberger-de Groot, A.C. 1995. Cell origins and tissue boundaries during outflow tract development. Trends Cardiovasc. Med. 5:69-75.
19. Noden, D.M. 1991. Origins and patterning of avian outflow tract endothelium. Development. 111:867-876.
20. Gassmann, M., et al. 1995. Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor. Nature. 378:390-394.
21. Lee, K.-F., et al. 1995. Requirement for neuregulin receptor erbB2 in neural and cardiac development. Nature. 378:394-398.
22. d) alleles: differential phenotypic effects on neural crest and limb musculature. Anat. Embryol. (Berl.) 187:371-377.
23. Brannan, C.I., et al. 1994. Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues. Genes Dev. 8:1019-1029.
24. Schilham, M.W., et al. 1996. Defects in cardiac outflow tract formation and pro-B-lymphocyte expansion in mice lacking Sox-4. Nature. 380:711-714.
25. Oh, S.P., and Li, E. 1997. The signaling pathway mediated by the type IIB activin receptor controls axial patterning and lateral asymmetry in the mouse. Genes Dev. 11:1812-1826.
26. Donovan, M.J., Halm, R., Tessarollo, L., and Hempstead, B.L. 1996. Identification of an essential nonneuronal function of neurotrophin 3 in mammalian cardiac development. Nat. Genet. 14:210-213.
27. Sanford, L.P., et al. 1997. TGFβ2 knockout mice have multiple developmental defects that are non-overlapping with other TGFβ knockout phenotypes. Development. 124:2659-2670.
28. Chisaka, O., and Capecchi, M.R. 1991. Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene box-1.5. Nature. 350:473-479.
29. Huang, G., et al. 1998. Alteration in connexin 43 gap junction gene dosage impairs conotruncal heart development. Dev. Biol. 198:32-44.
30. Mendelsohn, C., et al. 1994. Function of the retinoic acid receptors (RARs) during development (II). Multiple abnormalities at various stages of organogenesis in RAR double mutants. Development. 120:2749-2771.
31. Gruber, P.J., et al. 1996. RXRα deficiency confers genetic susceptibility for aortic sac, conotruncal, atrioventricular cushion, and ventricular muscle defecrs in mice. J. Clin. Invest. 98:1332-1343.
32. Valdenaire, O., Rohrbacher, E., and Mattei, M.-G. 1995. Organization of the gene encoding the human endothelin-converting enzyme (ECE-1). J. Biol. Chem. 270:29794-29798.