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Volumn 292, Issue 3, 2007, Pages

Role of Rho kinases in PKG-mediated relaxation of pulmonary arteries of fetal lambs exposed to chronic high altitude hypoxia

Author keywords

cGMP; cGMP dependent protein kinase; Myosin light chain phosphatases; Rho kinase; Vascular smooth muscle

Indexed keywords

CYCLIC GMP DEPENDENT PROTEIN KINASE; ENDOTHELIN 1; MYOSIN LIGHT CHAIN PHOSPHATASE; RHO KINASE; THREONINE;

EID: 33847713292     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00178.2006     Document Type: Article
Times cited : (65)

References (51)
  • 2
    • 0034099755 scopus 로고    scopus 로고
    • Decreased synthesis and vasodilation to nitric oxide in piglets with hypoxia-induced pulmonary hypertension
    • Berkenbosch JW, Baribeau J, Perreault T. Decreased synthesis and vasodilation to nitric oxide in piglets with hypoxia-induced pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 278: L276-L283, 2000.
    • (2000) Am J Physiol Lung Cell Mol Physiol , vol.278
    • Berkenbosch, J.W.1    Baribeau, J.2    Perreault, T.3
  • 3
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254, 1976.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 4
    • 0029615463 scopus 로고
    • Inhibition of cyclic GMP-dependent protein kinase-mediated effects by (Rp)-8-bromo-PET-cyclic GMPS
    • Butt E, Pohler D, Genieser HG, Huggins JP, Bucher B. Inhibition of cyclic GMP-dependent protein kinase-mediated effects by (Rp)-8-bromo-PET-cyclic GMPS. Br J Pharmacol 116: 3110-3116, 1995.
    • (1995) Br J Pharmacol , vol.116 , pp. 3110-3116
    • Butt, E.1    Pohler, D.2    Genieser, H.G.3    Huggins, J.P.4    Bucher, B.5
  • 6
    • 0034036218 scopus 로고    scopus 로고
    • Involvement of cGMP-dependent protein kinase in the relaxation of ovine pulmonary arteries to cGMP and cAMP
    • Dhanakoti SR, Gao Y, Nguyen MQ, Raj JU. Involvement of cGMP-dependent protein kinase in the relaxation of ovine pulmonary arteries to cGMP and cAMP. J Appl Physiol 88: 1637-1642, 2000.
    • (2000) J Appl Physiol , vol.88 , pp. 1637-1642
    • Dhanakoti, S.R.1    Gao, Y.2    Nguyen, M.Q.3    Raj, J.U.4
  • 8
    • 0033601250 scopus 로고    scopus 로고
    • Inhibitory phosphorylation site for Rho associated kinase on smooth muscle myosin phosphatase
    • Feng J, Ito M, Ichikawa K, Isaka N, Nishikawa M, Hartshorne DJ, Nakano T. Inhibitory phosphorylation site for Rho associated kinase on smooth muscle myosin phosphatase. J Biol Chem 274: 37385-37390, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 37385-37390
    • Feng, J.1    Ito, M.2    Ichikawa, K.3    Isaka, N.4    Nishikawa, M.5    Hartshorne, D.J.6    Nakano, T.7
  • 9
    • 0028323256 scopus 로고
    • Structure and function of cyclic nucleotide-dependent protein kinases
    • Francis SH, Corbin JD. Structure and function of cyclic nucleotide-dependent protein kinases. Annu Rev Physiol 56: 237-272, 1994.
    • (1994) Annu Rev Physiol , vol.56 , pp. 237-272
    • Francis, S.H.1    Corbin, J.D.2
  • 12
    • 0032880669 scopus 로고    scopus 로고
    • Role of protein kinase G in nitric oxide- and cGMP-induced relaxation of newborn ovine pulmonary veins
    • Gao Y, Dhanakoti SR, Tolsa JF, Raj JU. Role of protein kinase G in nitric oxide- and cGMP-induced relaxation of newborn ovine pulmonary veins. J Appl Physiol 87: 993-998, 1999.
    • (1999) J Appl Physiol , vol.87 , pp. 993-998
    • Gao, Y.1    Dhanakoti, S.R.2    Tolsa, J.F.3    Raj, J.U.4
  • 14
    • 28444461454 scopus 로고    scopus 로고
    • Inhibition of RhoA/Rho kinase pathway is involved in the beneficial effect of sildenafil on pulmonary hypertension
    • Guilluy C, Sauzeau V, Rolli-Derkinderen M, Guerin P, Sagan C, Pacaud P, Loirand G. Inhibition of RhoA/Rho kinase pathway is involved in the beneficial effect of sildenafil on pulmonary hypertension. Br J Pharmacol 146: 1010-1018, 2005.
    • (2005) Br J Pharmacol , vol.146 , pp. 1010-1018
    • Guilluy, C.1    Sauzeau, V.2    Rolli-Derkinderen, M.3    Guerin, P.4    Sagan, C.5    Pacaud, P.6    Loirand, G.7
  • 15
    • 33644834949 scopus 로고    scopus 로고
    • Function of cGMP-dependent protein kinases as revealed by gene deletion
    • Hofmann F, Feil R, Kleppisch T, Schlossmann J. Function of cGMP-dependent protein kinases as revealed by gene deletion. Physiol Rev 86: 1-23, 2006.
    • (2006) Physiol Rev , vol.86 , pp. 1-23
    • Hofmann, F.1    Feil, R.2    Kleppisch, T.3    Schlossmann, J.4
  • 16
    • 22744455284 scopus 로고    scopus 로고
    • Inhibition of Rho-kinase attenuates hypoxia-induced angiogenesis in the pulmonary circulation
    • Hyvelin JM, Howell K, Nichol A, Costello CM, Preston RJ, McLoughlin P. Inhibition of Rho-kinase attenuates hypoxia-induced angiogenesis in the pulmonary circulation. Circ Res 97: 185-191, 2005.
    • (2005) Circ Res , vol.97 , pp. 185-191
    • Hyvelin, J.M.1    Howell, K.2    Nichol, A.3    Costello, C.M.4    Preston, R.J.5    McLoughlin, P.6
  • 17
    • 0029976102 scopus 로고    scopus 로고
    • Phosphorylation of the large subunit of myosin phosphatase and inhibition of phosphatase activity
    • Ichikawa K, Ito M, Hartshorne DJ. Phosphorylation of the large subunit of myosin phosphatase and inhibition of phosphatase activity. J Biol Chem 271: 4733-4740, 1996.
    • (1996) J Biol Chem , vol.271 , pp. 4733-4740
    • Ichikawa, K.1    Ito, M.2    Hartshorne, D.J.3
  • 20
    • 0036084399 scopus 로고    scopus 로고
    • Chronic hypoxia attenuates cGMP-dependent pulmonary vasodilation
    • Jernigan NL, Resta TC. Chronic hypoxia attenuates cGMP-dependent pulmonary vasodilation. Am J Physiol Lung Cell Mol Physiol 282: L1366-L1375, 2002.
    • (2002) Am J Physiol Lung Cell Mol Physiol , vol.282
    • Jernigan, N.L.1    Resta, T.C.2
  • 22
    • 8644246786 scopus 로고    scopus 로고
    • 2+ desensitization in pulmonary vascular smooth muscle through inhibition of RhoA/Rho kinase signaling
    • 2+ desensitization in pulmonary vascular smooth muscle through inhibition of RhoA/Rho kinase signaling. Am J Physiol Lung Cell Mol Physiol 287: L1220-L1229, 2004.
    • (2004) Am J Physiol Lung Cell Mol Physiol , vol.287
    • Jernigan, N.L.1    Walker, B.R.2    Resta, T.C.3
  • 23
    • 4544302627 scopus 로고    scopus 로고
    • Endothelium-derived reactive oxygen species and endothelin-1 attenuate NO dependent pulmonary vasodilation following chronic hypoxia
    • Jernigan NL, Walker BR, Resta TC. Endothelium-derived reactive oxygen species and endothelin-1 attenuate NO dependent pulmonary vasodilation following chronic hypoxia. Am J Physiol Lung Cell Mol Physiol 287: L801-L808, 2004.
    • (2004) Am J Physiol Lung Cell Mol Physiol , vol.287
    • Jernigan, N.L.1    Walker, B.R.2    Resta, T.C.3
  • 25
    • 33746806784 scopus 로고    scopus 로고
    • Modulation of BK channel calcium affinity by differential phosphorylation in developing ovine basilar artery myocytes
    • Lin MT, Hessinger DA, Pearce WJ, Longo LD. Modulation of BK channel calcium affinity by differential phosphorylation in developing ovine basilar artery myocytes. Am J Physiol Heart Circ Physiol 291: H732-H740, 2006.
    • (2006) Am J Physiol Heart Circ Physiol , vol.291
    • Lin, M.T.1    Hessinger, D.A.2    Pearce, W.J.3    Longo, L.D.4
  • 27
    • 0034862256 scopus 로고    scopus 로고
    • cGMP-dependent protein kinase signaling mechanisms in smooth muscle: From the regulation of tone to gene expression
    • Lincoln TM, Dey N, Sellak H. cGMP-dependent protein kinase signaling mechanisms in smooth muscle: from the regulation of tone to gene expression. J Appl Physiol 91: 1421-1430, 2001.
    • (2001) J Appl Physiol , vol.91 , pp. 1421-1430
    • Lincoln, T.M.1    Dey, N.2    Sellak, H.3
  • 28
    • 33646763902 scopus 로고    scopus 로고
    • Pacaud P. Rho kinases in cardiovascular physiology and pathophysiology
    • Loirand G, Guerin P, Pacaud P. Rho kinases in cardiovascular physiology and pathophysiology. Circ Res 98: 322-334, 2006.
    • (2006) Circ Res , vol.98 , pp. 322-334
    • Loirand, G.1    Guerin, P.2
  • 30
    • 11144325613 scopus 로고    scopus 로고
    • Fetal cerebrovascular acclimatization responses to high-altitude, long-term hypoxia: A model for prenatal programming of adult disease?
    • Longo LD, Pearce WJ. Fetal cerebrovascular acclimatization responses to high-altitude, long-term hypoxia: a model for prenatal programming of adult disease? Am J Physiol Regul Integr Comp Physiol 288: R16-R24, 2005.
    • (2005) Am J Physiol Regul Integr Comp Physiol , vol.288
    • Longo, L.D.1    Pearce, W.J.2
  • 32
    • 0016374484 scopus 로고
    • Analogs of cyclic AMP and cyclic GMP: General methods of synthesis and the relationship of structure to enzymic activity
    • Meyer RB Jr, Miller JP. Analogs of cyclic AMP and cyclic GMP: general methods of synthesis and the relationship of structure to enzymic activity. Life Sci 14: 1019-1040, 1974.
    • (1974) Life Sci , vol.14 , pp. 1019-1040
    • Meyer Jr, R.B.1    Miller, J.P.2
  • 33
    • 18944372230 scopus 로고    scopus 로고
    • Rho kinase, a promising drug target for neurological disorders
    • Mueller BK, Mack H, Teusch N. Rho kinase, a promising drug target for neurological disorders. Nature Rev 4: 387-398, 2005.
    • (2005) Nature Rev , vol.4 , pp. 387-398
    • Mueller, B.K.1    Mack, H.2    Teusch, N.3
  • 34
    • 0025194259 scopus 로고
    • 5-[imino(nitroamine)methyl]-L-ornithine} impairs endothelium-dependent dilations by inhibiting cytosolic nitric oxide synthesis from L-arginine
    • 5-[imino(nitroamine)methyl]-L-ornithine} impairs endothelium-dependent dilations by inhibiting cytosolic nitric oxide synthesis from L-arginine. Naunyn-Schmiedeberg Arch Pharmacol 341: 143-147, 1990.
    • (1990) Naunyn-Schmiedeberg Arch Pharmacol , vol.341 , pp. 143-147
    • Mülsch, A.1    Busse, R.2
  • 35
    • 27944458787 scopus 로고    scopus 로고
    • Phosphorylation of Thr695 and Thr850 on the myosin phosphatase target subunit: Inhibitory effects and occurrence in A7r5 cells
    • Muranyi A, Derkach D, Erdodi F, Kiss A, Ito M, Hartshorne DJ. Phosphorylation of Thr695 and Thr850 on the myosin phosphatase target subunit: inhibitory effects and occurrence in A7r5 cells. FEBS Lett 579: 6611-6615, 2005.
    • (2005) FEBS Lett , vol.579 , pp. 6611-6615
    • Muranyi, A.1    Derkach, D.2    Erdodi, F.3    Kiss, A.4    Ito, M.5    Hartshorne, D.J.6
  • 39
    • 33645457715 scopus 로고    scopus 로고
    • Physiological role of ROCKs in the cardiovascular system
    • Noma K, Oyama N, Liao JK. Physiological role of ROCKs in the cardiovascular system. Am J Physiol Cell Physiol 290: C661-C668, 2006.
    • (2006) Am J Physiol Cell Physiol , vol.290
    • Noma, K.1    Oyama, N.2    Liao, J.K.3
  • 40
    • 33751172972 scopus 로고    scopus 로고
    • Spontaneously tonic smooth muscle has characteristically higher levels of RhoA/ROK as compared with the phasic smooth muscle
    • Patel CA, Rattan S. Spontaneously tonic smooth muscle has characteristically higher levels of RhoA/ROK as compared with the phasic smooth muscle. Am J Physiol Gastrointest Liver Physiol 291: G830-G837, 2006.
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.291
    • Patel, C.A.1    Rattan, S.2
  • 42
    • 24144498411 scopus 로고    scopus 로고
    • Rho-kinase is an important therapeutic target in cardiovascular medicine
    • Shimokawa H, Takeshita A. Rho-kinase is an important therapeutic target in cardiovascular medicine. Arterioscler Thromb Vasc Biol 25: 1767-1775, 2005.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 1767-1775
    • Shimokawa, H.1    Takeshita, A.2
  • 43
    • 0141751697 scopus 로고    scopus 로고
    • 2+ sensitivity of smooth muscle and non-muscle myosin II: Modulated by G proteins, kinases, and myosin phosphatase
    • 2+ sensitivity of smooth muscle and non-muscle myosin II: modulated by G proteins, kinases, and myosin phosphatase. Physiol Rev 83: 1325-1358, 2003.
    • (2003) Physiol Rev , vol.83 , pp. 1325-1358
    • Somlyo, A.P.1    Somlyo, A.V.2
  • 47
    • 8844220471 scopus 로고    scopus 로고
    • Protein kinases in vascular smooth muscle tone: Role in the pulmonary vasculature and hypoxic pulmonary vasoconstriction
    • Ward JP, Knock GA, Snetkov VA, Aaronson PI. Protein kinases in vascular smooth muscle tone: role in the pulmonary vasculature and hypoxic pulmonary vasoconstriction. Pharmacol Ther 104: 207-231, 2004.
    • (2004) Pharmacol Ther , vol.104 , pp. 207-231
    • Ward, J.P.1    Knock, G.A.2    Snetkov, V.A.3    Aaronson, P.I.4
  • 48
    • 33645297364 scopus 로고    scopus 로고
    • 2+-desensitizing hypoxic vasorelaxation: Pivotal role for the myosin binding subunit of myosin phosphatase (MYPT1) in porcine coronary artery
    • 2+-desensitizing hypoxic vasorelaxation: pivotal role for the myosin binding subunit of myosin phosphatase (MYPT1) in porcine coronary artery. J Physiol 572: 259-267, 2006.
    • (2006) J Physiol , vol.572 , pp. 259-267
    • Wardle, R.L.1    Gu, M.2    Ishida, Y.3    Paul, R.J.4
  • 49
    • 33644837177 scopus 로고    scopus 로고
    • Mechanisms of endothelin-1-induced contraction in pulmonary arteries from chronically hypoxic rats
    • Weigand L, Sylvester JT, Shimoda LA. Mechanisms of endothelin-1-induced contraction in pulmonary arteries from chronically hypoxic rats. Am J Physiol Lung Cell Mol Physiol 290: L284-L290, 2006.
    • (2006) Am J Physiol Lung Cell Mol Physiol , vol.290
    • Weigand, L.1    Sylvester, J.T.2    Shimoda, L.A.3
  • 50
    • 23744492968 scopus 로고    scopus 로고
    • 2+ sensitization: Rho-associated kinase-mediated phosphorylation of MYPT1 at Thr-855, but not Thr-697
    • 2+ sensitization: Rho-associated kinase-mediated phosphorylation of MYPT1 at Thr-855, but not Thr-697. Biochem J 389: 763-774, 2005.
    • (2005) Biochem J , vol.389 , pp. 763-774
    • Wilson, D.P.1    Susnjar, M.2    Kiss, E.3    Sutherland, C.4    Walsh, M.P.5
  • 51
    • 4544321243 scopus 로고    scopus 로고
    • Smooth muscle phosphatase is regulated in vivo by exclusion of phosphorylation of threonine 696 of MYPT1 by phosphorylation of serine 695 in response to cyclic nucleotides
    • Wooldridge AA, MacDonald JA, Erdodi F, Ma C, Borman MA, Hartshorne DJ, Haystead TAJ. Smooth muscle phosphatase is regulated in vivo by exclusion of phosphorylation of threonine 696 of MYPT1 by phosphorylation of serine 695 in response to cyclic nucleotides. J Biol Chem 279: 34496-34504, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 34496-34504
    • Wooldridge, A.A.1    MacDonald, J.A.2    Erdodi, F.3    Ma, C.4    Borman, M.A.5    Hartshorne, D.J.6    Haystead, T.A.J.7


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