Linking a serotonin transporter polymorphism to vascular smooth muscle proliferation in patients with primary pulmonary hypertension

Journal of Clinical Investigation

Volumn 108, Issue 8, 2001, Pages 1109-1111

  Rabinovitch, M ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN RECEPTOR; MESSENGER RNA; SEROTONIN; SEROTONIN RECEPTOR; TRANSFORMING GROWTH FACTOR BETA;

CELL PROLIFERATION; CONTROLLED STUDY; GENE MUTATION; HUMAN; NOTE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PULMONARY HYPERTENSION; SEROTONINERGIC SYSTEM; SIGNAL TRANSDUCTION; VASCULAR SMOOTH MUSCLE;

BONE MORPHOGENETIC PROTEIN RECEPTORS, TYPE II; CARRIER PROTEINS; HUMANS; HYPERTENSION, PULMONARY; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MODELS, BIOLOGICAL; MUSCLE, SMOOTH, VASCULAR; NERVE TISSUE PROTEINS; POLYMORPHISM, GENETIC; PROTEIN-SERINE-THREONINE KINASES; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 0034778907     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200114205     Document Type: Note

References (24)

1. Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-Ii gene
2. Heterozygous germline mutations in BMPR2, encoding a TGFβ receptor, cause familial primary pulmonary hypertension
3. Mutation in the gene for bone morphogenetic protein receptor II as a cause of primary pulmonary hypertension in a large kindred
4. Clinical and molecular genetic features in pulmonary hypertension in patients with hereditary hemorrhagic telangiectasia
5. Serotonin transporter overexpression in primary pulmonary hypertension contributes to arterial smooth muscle hyperplasia
6. Treatment with 5-HT potentiates development of pulmonary hypertension in chronically hypoxic rats
7. Induction of serotonin transporter by hypoxia in pulmonary vascular smooth muscle cell. Relationship with the mitogenic action of serotonin
8. Attenuated hypoxic pulmonary hypertension in mice lacking the 5-hydroxytryptamine transporter gene
9. Appetite-suppressant drugs and the risk of primary pulmonary hypertension
10. Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor beta(1) and bone morphogenetic proteins
11. Bone morphogenetic protein -7 (osteogenic protein -1) inhibits smooth muscle cell proliferation and stimulates the expression of markers that are characteristic of SMC phenotype
12. Progressive pulmonary vascular disease is characterized by a proliferative response related to deposition of tenascin-C and is preceded by subendothdial accumulation of fibronectin
13. Monoclonal endothelial cell profileration is present in primary but not secondary hypertension
14. Active collagen synthesis by pulmonary arteries in human primary pulmonary hypertension
15. Expression of transforming growth factor β mRNA and proteins in pulmonary vascular remodeling in the sheep with chronic pulmonary hypertension induced by air embolization
16. Inhibition of elastolysis by SC-37698 reduces development and progression of monocrotaline pulmonary hypertension
17. Exogenous leukocyte elastase and endogenous elastases can mediate mitogenic activity in pulmonary artery smooth muscle cells by release of extracellular matrix bound fibroblast growth factor
18. Tenascin-C is induced with progressive pulmonary vascular disease in rats and is functionally related to increased smooth muscle cell proliferation
19. Regulation of tenascin-C, a vascular smooth muscle cell survival factor that interacts with the αvβ3 integrin to promote epidermal growth factor receptor phosphorylation and growth
20. Factors influencing the idiopathic development of pulmonary hypertension in the fawn hooded rat
21. Mild hypoxia causes severe pulmonary hypertension in fawn-hooded but not in Tester Moriyama rats
22. Smooth muscle cells isolated from discrete compartments of the mature vascular media exhibit unique phenotypes and distinct growth capabilities
23. Elastase and matrix metalloproteinase inhibitors induce regression and renascin-C anti-sense prevents progression of vascular disease
24. Long term continuous prostacyclin reduces pulmonary vascular resistance in severe primary pulmonary hypertension