Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, suppresses 5-hydroxytryptamine-induced pulmonary artery smooth muscle cell proliferation via JNK and ERK1/2 pathway

Pharmacology

Volumn 83, Issue 2, 2009, Pages 67-79

  Chen, Xue Yan ^a   Dun, Jie Ning ^a   Miao, Qing Feng ^a   Zhang, Yong Jian ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

Author keywords

c jun NH2 terminal kinase; Cell cycle; Extracellular signal regulated kinase 1 2; Fasudil; Pulmonary artery smooth muscle cell proliferation; Rho kinase

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CELL NUCLEUS ANTIGEN; ENZYME; FASUDIL; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MYOSIN PHOSPHATASE 1; PROTEIN C FOS; PROTEIN C JUN; RHO KINASE; RHO KINASE INHIBITOR; SEROTONIN; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG INHIBITION; DRUG MECHANISM; DRUG TARGETING; ENZYME ACTIVATION; ENZYME INACTIVATION; FLOW CYTOMETRY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; PULMONARY ARTERY; PULMONARY HYPERTENSION; RAT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; WISTAR RAT;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ANIMALS; CELL CYCLE; CELL PROLIFERATION; CELLS, CULTURED; HYPERTENSION, PULMONARY; MALE; MAP KINASE KINASE 4; MITOGEN-ACTIVATED PROTEIN KINASE 3; MYOCYTES, SMOOTH MUSCLE; PROTEIN KINASE INHIBITORS; PROTEIN PHOSPHATASE 1; PULMONARY ARTERY; RATS; RATS, WISTAR; RHO-ASSOCIATED KINASES; RHOA GTP-BINDING PROTEIN; SEROTONIN; SIGNAL TRANSDUCTION;

EID: 57049169732     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000178814     Document Type: Article

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