Excitation-contraction coupling in pulmonary vascular smooth muscle involves tyrosine kinase and Rho kinase

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 280, Issue 4 24-4, 2001, Pages

  Janssen, Luke J ^a   Lu Chao, Hwa ^a,b   Netherton, Stuart ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b ST JOSEPH S HOSPITAL   (Canada)

Author keywords

Intracellular calcium; Mitogen activated protein kinase; Myosin light chain kinase; Myosin light chain phosphatase; Norepinephrine; Protein kinase C; Thromboxane A2

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CAFFEINE; CALCIUM; CYCLOPIAZONIC ACID; GENISTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MYOSIN LIGHT CHAIN KINASE; NORADRENALIN; POTASSIUM CHLORIDE; PROTEIN KINASE C; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; RHO KINASE; THROMBOXANE A2;

ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CALCIUM TRANSPORT; CONTROLLED STUDY; DEPOLARIZATION; DOG; ELECTRIC POTENTIAL; ENZYME ACTIVATION; EXCITATION CONTRACTION COUPLING; LUNG BLOOD VESSEL; MICROELECTRODE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; SMOOTH MUSCLE;

EID: 0035006955     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.2001.280.4.l666     Document Type: Article

References (16)

1. Bradley AB and Morgan KG. Alterations in cytoplasmic calcium sensitivity during porcine coronary artery contractions as detected by aequorin. J Physiol (Lond) 385: 437-448, 1987.
2. Goff CD, Corbin RS, Theiss SD, Frierson HF, Cephas GA, Tribble CG, Kron IL, and Young JS. Postinjury thromboxane receptor blockade ameliorates acute lung injury. Ann Thorac Surg 64: 826-829, 1997.
3. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 260: 3440-3450, 1985.
4. Hedges JC, Oxhorn BC, Carty M, Adam LP, Yamboliev IA, and Gerthoffer WT. Phosphorylation of caldesmon by ERK MAP kinases in smooth muscle. Am J Physiol Cell Physiol 278: C718-C726, 2000.
5. 2+-sensitivity in rabbit pulmonary artery smooth muscle. Pflügers Arch 417: 21-28, 1990.
6. 2+ release in hypoxic vasoconstriction of canine pulmonary artery. Br J Pharmacol 122: 21-30, 1997.
7. Janssen LJ, Mardi K, Netherton SJ, and Betti AP. Nitric oxide inhibits human and canine pulmonary vascular tone via a postjunctional, nonelectromechanical, cGMP-dependent pathway. Can J Physiol Pharmacol 77: 320-329, 1999.
8. Kadowitz PG, Joiner PD, and Hyman AL. Influence of sympathetic stimulation and vasoactive substances on the canine pulmonary artery. J Clin Invest 56: 354-365, 1975.
9. Kong S-K and Stephens NL. Pharmacological properties of canine intrapulmonary blood vessels. Can J Physiol Pharmacol 62: 1198-1202, 1984.
10. Norel X, Labat C, Gardiner PJ, and Brink C. Inhibitory effects of BAY u3405 on prostanoid-induced contractions in human isolated bronchial and pulmonary arterial muscle preparations. Br J Pharmacol 104: 591-595, 1991.
11. Okabe K, Kitamura K, and Kuriyama H. Features of 4-aminopyridine-sensitive outward current observed in single smooth muscle cells from the rabbit main pulmonary artery. Pflügers Arch 409: 561-568, 1987.
12. Palevsky HI and Fishman AP. The management of primary pulmonary hypertension. JAMA 265: 1014-1020, 1991.
13. Somlyo AP and Somlyo AV. Signal transduction and regulation in smooth muscle. Nature 372: 231-236, 1995.
14. Somlyo AP and Somlyo AV. Signal transduction by G-proteins, Rho-kinase and protein phosphatase to smooth muscle and nonmuscle myosin II. J Physiol (Lond) 522: 177-185, 2000.
15. Wagner RS, Weare C, Jin N, Mohler ER, and Rhoades RA. Characterization of signal transduction events stimulated by 8-epi-prostaglandin(PG)F2 alpha in rat aortic rings. Prostaglandins 54: 581-599, 1997.
16. Zamora CA, Baron DA, and Heffner JE. Thromboxane contributes to pulmonary hypertension in ischemia-reperfusion lung injury. J Appl Physiol 74: 224-229, 1993.