메뉴 건너뛰기




Volumn 44, Issue 4, 2011, Pages 524-530

Heparin inhibits pulmonary artery smooth muscle cell proliferation through guanine nucleotide exchange factor-H1/RhoA/Rho kinase/p27

Author keywords

Guanine nucleotide exchange factor H1; Heparin; Proliferation; Pulmonary artery smooth muscle cell; Rho kinase

Indexed keywords

COMPLEMENTARY DNA; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANINE NUCLEOTIDE EXCHANGE FACTOR H1; HEPARIN; PROTEIN P27; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

EID: 79953746692     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2010-0145OC     Document Type: Article
Times cited : (26)

References (47)
  • 1
    • 27944479854 scopus 로고    scopus 로고
    • Rho GTPases: Biochemistry and biology
    • Jaffe AB, Hall A. Rho GTPases: biochemistry and biology. Annu Rev Cell Dev Biol 2005;21:247-269.
    • (2005) Annu Rev Cell Dev Biol , vol.21 , pp. 247-269
    • Jaffe, A.B.1    Hall, A.2
  • 2
    • 4544298268 scopus 로고    scopus 로고
    • The tone of pulmonary smooth muscle: ROK and Rho music?
    • Sylvester JT. The tone of pulmonary smooth muscle: ROK and Rho music? Am J Physiol Lung Cell Mol Physiol 2004;287:L624-L630.
    • (2004) Am J Physiol Lung Cell Mol Physiol , vol.287
    • Sylvester, J.T.1
  • 3
    • 10944244704 scopus 로고    scopus 로고
    • Rho signaling at a glance
    • Schwartz M. Rho signaling at a glance. J Cell Sci 2004;117:5457-5458.
    • (2004) J Cell Sci , vol.117 , pp. 5457-5458
    • Schwartz, M.1
  • 4
    • 33745055712 scopus 로고    scopus 로고
    • Kip1 levels by distinct mechanisms
    • Kip1 levels by distinct mechanisms. Mol Cell Biol 2006;26:4612-4627.
    • (2006) Mol Cell Biol , vol.26 , pp. 4612-4627
    • Croft, D.R.1    Olson, M.F.2
  • 7
    • 28444461454 scopus 로고    scopus 로고
    • Inhibition of RhoA/Rho kinase pathway is involved in the beneficial effect of sildenafil on pulmonary hypertension
    • DOI 10.1038/sj.bjp.0706408, PII 0706408
    • Guilluy C, Sauzeau V, Rolli-Derkinderen M, Guerin P, Sagan C, Pacaud P, Loirand G. Inhibition of RhoA/Rho kinase pathway is involved in the beneficial effect of sildenafil on pulmonary hypertension. Br J Pharmacol 2005;146:1010-1018. (Pubitemid 41722174)
    • (2005) British Journal of Pharmacology , vol.146 , Issue.7 , pp. 1010-1018
    • Guilluy, C.1    Sauzeau, V.2    Rolli-Derkinderen, M.3    Guerin, P.4    Sagan, C.5    Pacaud, P.6    Loirand, G.7
  • 8
    • 22744455284 scopus 로고    scopus 로고
    • Inhibition of Rho-kinase attenuates hypoxia-induced angiogenesis in the pulmonary circulation
    • DOI 10.1161/01.RES.0000174287.17953.83
    • Hyvelin JM, Howell K, Nichol A, Costello CM, Preston RJ, McLoughlin P. Inhibition of Rho-kinase attenuates hypoxia-induced angiogenesis in the pulmonary circulation. Circ Res 2005;97:185-191. (Pubitemid 41033475)
    • (2005) Circulation Research , vol.97 , Issue.2 , pp. 185-191
    • Hyvelin, J.-M.1    Howell, K.2    Nichol, A.3    Costello, C.M.4    Preston, R.J.5    McLoughlin, P.6
  • 12
    • 0037042177 scopus 로고    scopus 로고
    • Waf1/Cip1/Sdi1: Association with cell senescence and tumour-promoting activities of stromal fibroblasts
    • DOI 10.1016/S0304-3835(01)00847-3, PII S0304383501008473
    • Roninson IB. Oncogenic functions of tumor suppressor p21 (Waf1/Cip1/Sdi1): association with cell senescence and tumor-promoting activities of stromal fibroblasts. Cancer Lett 2002;179:1-14. (Pubitemid 34195647)
    • (2002) Cancer Letters , vol.179 , Issue.1 , pp. 1-14
    • Roninson, I.B.1
  • 13
    • 0036180120 scopus 로고    scopus 로고
    • Molecular aspects of the mammalian cell cycle and cancer
    • DOI 10.1634/theoncologist.7-1-73
    • Sandal T. Molecular aspects of the mammalian cell cycle and cancer. Oncologist 2002;7:73-81. (Pubitemid 34151110)
    • (2002) Oncologist , vol.7 , Issue.1 , pp. 73-81
    • Sandal, T.1
  • 14
    • 33744510570 scopus 로고    scopus 로고
    • Gene expression of cyclin-dependent kinase inhibitors and effect of heparin on their expression in mice with hypoxia-induced pulmonary hypertension
    • DOI 10.1016/j.bbrc.2006.05.060, PII S0006291X06011053
    • Yu L, Quinn DA, Garg HG, Hales CA. Gene expression of cyclin-dependent kinase inhibitors and effect of heparin on their expression in mice with hypoxia-induced pulmonary hypertension. Biochem Biophys Res Commun 2006;345:1565-1572. (Pubitemid 43817908)
    • (2006) Biochemical and Biophysical Research Communications , vol.345 , Issue.4 , pp. 1565-1572
    • Yu, L.1    Quinn, D.A.2    Garg, H.G.3    Hales, C.A.4
  • 15
    • 0037053407 scopus 로고    scopus 로고
    • V12-induced transformation in a manner dependent on p27 status
    • DOI 10.1074/jbc.M112090200
    • Vidal A, Millard SS, Miller JP, Koff A. Rho activity can alter the translation of p27 mRNA and is important for RasV12-induced transformation in a manner dependent on p27 status. J Biol Chem 2002;277:16433-16440. (Pubitemid 34967655)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.19 , pp. 16433-16440
    • Vidal, A.1    Sean, M.S.2    Miller, J.P.3    Koff, A.4
  • 16
    • 2942707853 scopus 로고    scopus 로고
    • 1/S transition
    • DOI 10.1074/jbc.M402725200
    • Mammoto A, Huang S, Moore K, Oh P, Ingber DE. Role of RhoA, mDia, and ROCK in cell shape-dependent control of the Skp2-p27kip1 pathway and the G1/S transition. J Biol Chem 2004;279:26323-26330. (Pubitemid 38798782)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.25 , pp. 26323-26330
    • Mammoto, A.1    Huang, S.2    Moore, K.3    Oh, P.4    Ingber, D.E.5
  • 17
    • 1942466518 scopus 로고    scopus 로고
    • Kip1 modulates cell migration through the regulation of RhoA activation
    • DOI 10.1101/gad.1185504
    • Besson A, Gurian-West M, Schmidt A, Hall A, Roberts JM. p27Kip1 modulates cell migration through the regulation of RhoA activation. Genes Dev 2004;18:862-876. (Pubitemid 38529656)
    • (2004) Genes and Development , vol.18 , Issue.8 , pp. 862-876
    • Besson, A.1    Gurian-West, M.2    Schmidt, A.3    Hall, A.4    Roberts, J.M.5
  • 19
    • 33646763902 scopus 로고    scopus 로고
    • Rho kinases in cardiovascular physiology and pathophysiology
    • Loirand G, Guerin P, Pacaud P. Rho kinases in cardiovascular physiology and pathophysiology. Circ Res 2006;98:322-334.
    • (2006) Circ Res , vol.98 , pp. 322-334
    • Loirand, G.1    Guerin, P.2    Pacaud, P.3
  • 21
    • 0024537365 scopus 로고
    • Effect of heparin and warfarin on chronic hypoxic pulmonary hypertension and vascular remodeling in the guinea pig
    • Hassoun PM, Thompson BT, Steigman D, Hales CA. Effect of heparin and warfarin on chronic hypoxic pulmonary hypertension and vascular remodeling in the guinea pig. Am Rev Respir Dis 1989;139:763-768. (Pubitemid 19084403)
    • (1989) American Review of Respiratory Disease , vol.139 , Issue.3 , pp. 763-768
    • Hassoun, P.M.1    Thompson, B.T.2    Steigman, D.3    Hales, C.A.4
  • 22
  • 23
    • 0026567472 scopus 로고
    • Partial reversal of hypoxic pulmonary hypertension by heparin
    • Hassoun PM, Thompson BT, Hales CA. Partial reversal of hypoxic pulmonary hypertension by heparin. Am Rev Respir Dis 1992;145:193-196.
    • (1992) Am Rev Respir Dis , vol.145 , pp. 193-196
    • Hassoun, P.M.1    Thompson, B.T.2    Hales, C.A.3
  • 24
    • 0031560415 scopus 로고    scopus 로고
    • Influence of molecular weight, protein core and charge of native heparin fractions on pulmonary artery smooth muscle cell proliferation
    • DOI 10.1006/bbrc.1997.7687
    • Joseph PAM, Garg HG, Thompson BT, Liu X, Hales CA. Influence of molecular weight, protein core and charge of native heparin fractions on pulmonary artery smooth muscle cells proliferation. Biochem Biophys Res Commun 1997;241:18-23. (Pubitemid 28033532)
    • (1997) Biochemical and Biophysical Research Communications , vol.241 , Issue.1 , pp. 18-23
    • Joseph, P.A.M.1    Garg, H.G.2    Thompson, T.B.3    Liu, X.4    Hales, C.A.5
  • 27
    • 0033844456 scopus 로고    scopus 로고
    • Heparin like molecules inhibit pulmonary vascular pericyte proliferation in vitro
    • Khoury J, Langleben D. Heparin like molecules inhibit pulmonary vascular pericyte proliferation in vitro. Am J Physiol Lung Cell Mol Physiol 2000;279:L252-L261.
    • (2000) Am J Physiol Lung Cell Mol Physiol , vol.279
    • Khoury, J.1    Langleben, D.2
  • 29
    • 27644564685 scopus 로고    scopus 로고
    • WAF1/Cip1, is required for inhibition of hypoxia-induced pulmonary hypertension and remodeling by heparin in mice
    • DOI 10.1161/01.RES.0000188211.83193.1a
    • Yu L, Quinn DA, Garg HG, Hales CA. Cyclin-dependent kinase inhibitor p27Kip1, but not p21WAF1/Cip1, is required for inhibition of hypoxia-induced pulmonary hypertension and remodeling by heparin in mice. Circ Res 2005;97:937-945. (Pubitemid 41552680)
    • (2005) Circulation Research , vol.97 , Issue.9 , pp. 937-945
    • Yu, L.1    Quinn, D.A.2    Garg, H.G.3    Hales, C.A.4
  • 30
    • 18144403761 scopus 로고    scopus 로고
    • kip1
    • DOI 10.1074/jbc.M411458200
    • Fasciano S, Patel RC, Handy I, Patel CV. Regulation of vascular smooth muscle proliferation by heparin: inhibition of cyclin-dependent kinase 2 activity by p27(kip1). J Biol Chem 2005;280:15682-15689. (Pubitemid 40616687)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.16 , pp. 15682-15689
    • Fasciano, S.1    Patel, R.C.2    Handy, I.3    Patel, C.V.4
  • 31
    • 44449095608 scopus 로고    scopus 로고
    • Deficiency of the NHE1 gene prevents hypoxia-induced pulmonary hypertension and vascular remodeling
    • DOI 10.1164/rccm.200710-1522OC
    • Yu L, Quinn DA, Garg HG, Hales CA. Deficiency of the NHE1 gene prevents hypoxia-induced pulmonary hypertension and vascular remodeling. Am J Respir Crit Care Med 2008;177:1276-1284. (Pubitemid 351860938)
    • (2008) American Journal of Respiratory and Critical Care Medicine , vol.177 , Issue.11 , pp. 1276-1284
    • Yu, L.1    Quinn, D.A.2    Garg, H.G.3    Hales, C.A.4
  • 32
    • 13444252631 scopus 로고    scopus 로고
    • GEF means go: Turning on Rho GTPases with guanine nucleotide-exchange factors
    • DOI 10.1038/nrm1587
    • Rossman KL, Der CJ, Sondek J. GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors. Nat Rev Mol Cell Biol 2005;6:167-180. (Pubitemid 40215811)
    • (2005) Nature Reviews Molecular Cell Biology , vol.6 , Issue.2 , pp. 167-180
    • Rossman, K.L.1    Der, C.J.2    Sondek, J.3
  • 33
    • 0036644975 scopus 로고    scopus 로고
    • Guanine nucleotide exchange factors for Rho GTPases: Turning on the switch
    • DOI 10.1101/gad.1003302
    • Schmidt A, Hall A. Guanine nucleotide exchange factors for Rho GTPases: turning on the switch. Genes Dev 2002;16:1587-1609. (Pubitemid 34743321)
    • (2002) Genes and Development , vol.16 , Issue.13 , pp. 1587-1609
    • Schmidt, A.1    Hall, A.2
  • 34
    • 17844402719 scopus 로고    scopus 로고
    • Binding of GEF-H1 to the tight junction-associated adaptor cingulin results in inhibition of Rho signaling and G1/S phase transition
    • DOI 10.1016/j.devcel.2005.03.003, PII S1534580705000869
    • Aijaz S, D'Atri F, Citi S, BaldaMS, Matter K. Binding of GEF-H1 to the tight junction-associated adaptor cingulin results in inhibition of Rho signaling and G1/S phase transition. Dev Cell 2005;8:777-786. (Pubitemid 40585299)
    • (2005) Developmental Cell , vol.8 , Issue.5 , pp. 777-786
    • Aijaz, S.1    D'Atri, F.2    Citi, S.3    Balda, M.S.4    Matter, K.5
  • 36
    • 0036228955 scopus 로고    scopus 로고
    • Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton
    • DOI 10.1038/ncb773
    • Krendel M, Zenke FT, Bokoch GM. Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton. Nat Cell Biol 2002;4:294-301. (Pubitemid 34308855)
    • (2002) Nature Cell Biology , vol.4 , Issue.4 , pp. 294-301
    • Krendel, M.1    Zenke, F.T.2    Bokoch, G.M.3
  • 37
    • 33745700179 scopus 로고    scopus 로고
    • Mutant p53 induces the GEF-H1 oncogene, a guanine nucleotide exchange factor-H1 for RhoA, resulting in accelerated cell proliferation in tumor cells
    • Mizuarai S, Yamanaka K, Kotani H. Mutant p53 induces the GEF-H1 oncogene, a guanine nucleotide exchange factor-H1 for RhoA, resulting in accelerated cell proliferation in tumor cells. Cancer Res 2006;66:6319-6326.
    • (2006) Cancer Res , vol.66 , pp. 6319-6326
    • Mizuarai, S.1    Yamanaka, K.2    Kotani, H.3
  • 38
    • 2442483847 scopus 로고    scopus 로고
    • P21-activated Kinase 1 Phosphorylates and Regulates 14-3-3 Binding to GEF-H1, a Microtubule-localized Rho Exchange Factor
    • DOI 10.1074/jbc.M400084200
    • Zenke FT, Krendel M, DerMardirossian C, King CC, Bohl BP, Bokoch GM. p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor. J Biol Chem 2004;279:18392-18400. (Pubitemid 38623255)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.18 , pp. 18392-18400
    • Zenke, F.T.1    Krendel, M.2    DerMardirossian, C.3    King, C.C.4    Bohl, B.P.5    Bokoch, G.M.6
  • 39
    • 19444362954 scopus 로고    scopus 로고
    • PAK4 mediates morphological changes through the regulation of GEF-H1
    • DOI 10.1242/jcs.02313
    • Callow MG, Zozulya S, Gishizky ML, Jallal B, Smeal T. PAK4 mediates morphological changes through the regulation of GEF-H1. J Cell Sci 2005;118:1861-1872. (Pubitemid 40723831)
    • (2005) Journal of Cell Science , vol.118 , Issue.9 , pp. 1861-1872
    • Callow, M.G.1    Zozulya, S.2    Gishizky, M.L.3    Jallal, B.4    Smeal, T.5
  • 44
    • 33846194678 scopus 로고    scopus 로고
    • Long-term inhibition of Rho kinase with fasudil attenuates high flow induced pulmonary artery remodeling in rats
    • DOI 10.1016/j.phrs.2006.10.009, PII S1043661806001903
    • Li F, Xia W, Li A, Zhao C, Sun R. Long-term inhibition of Rho kinase with fasudil attenuates high flow induced pulmonary artery remodeling in rats. Pharmacol Res 2007;55:64-71. (Pubitemid 46108589)
    • (2007) Pharmacological Research , vol.55 , Issue.1 , pp. 64-71
    • Li, F.1    Xia, W.2    Li, A.3    Zhao, C.4    Sun, R.5
  • 47
    • 66449091744 scopus 로고    scopus 로고
    • GEF-H1 mediates tumor necrosis factor-alpha-induced Rho activation and myosin phosphorylation: Role in the regulation of tubular paracellular permeability
    • Kakiashvili E, Speight P, Waheed F, Seth R, Lodyga M, Tanimura S, Kohno M, Rotstein OD, Kapus A, Szászi K. GEF-H1 mediates tumor necrosis factor-alpha-induced Rho activation and myosin phosphorylation: role in the regulation of tubular paracellular permeability. J Biol Chem 2009;284:11454-11466.
    • (2009) J Biol Chem , vol.284 , pp. 11454-11466
    • Kakiashvili, E.1    Speight, P.2    Waheed, F.3    Seth, R.4    Lodyga, M.5    Tanimura, S.6    Kohno, M.7    Rotstein, O.D.8    Kapus, A.9    Szászi, K.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.