The xanthine derivative KMUP-1 inhibits models of pulmonary artery hypertension via increased NO and cGMP-dependent inhibition of RhoA/Rho kinase

British Journal of Pharmacology

Volumn 160, Issue 4, 2010, Pages 971-986

  Chung, Hui Hsuan ^a   Dai, Zen Kong ^a   Wu, Bin Nan ^b   Yeh, Jwu Lai ^b   Chai, Chee Yin ^a   Chu, Koung Shing ^a   Liu, Chung Pin ^a,c   Chen, Ing Jun ^b  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^c Yuan's Hospital   (Taiwan)

Author keywords

cGMP; eNOS; KMUP 1; Pulmonary hypertension; Rho Kinase; RhoA

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ANGIOTENSIN II; CALCIUM ION; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GUANYLATE CYCLASE; KMUP 1; MONOCROTALINE; MYOSIN LIGHT CHAIN PHOSPHATASE; NITRIC OXIDE; PHENYLEPHRINE; PHOSPHODIESTERASE V; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SILDENAFIL; THROMBOXANE A2 RECEPTOR STIMULATING AGENT; UNCLASSIFIED DRUG; XANTHINE DERIVATIVE; ZAPRINAST; ANTIHYPERTENSIVE AGENT; CYCLIC NUCLEOTIDE; ENZYME INHIBITOR; NOS3 PROTEIN, RAT; PHOSPHOPROTEIN PHOSPHATASE 1; PIPERIDINE DERIVATIVE; PPP1R12A PROTEIN, RAT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD OXYGENATION; BLOOD VESSEL WALL; CALCIUM TRANSPORT; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HEART RIGHT VENTRICLE HYPERTROPHY; IMMUNOHISTOCHEMISTRY; LUNG BLOOD VESSEL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY ARTERY; PULMONARY HYPERTENSION; RAT; SMOOTH MUSCLE CONTRACTILITY; SMOOTH MUSCLE FIBER; VASCULAR RESISTANCE; VASCULAR SMOOTH MUSCLE; VASOCONSTRICTION; VASODILATATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD; CALCIUM SIGNALING; CELL CULTURE; CHEMICALLY INDUCED; CYTOLOGY; DRUG EFFECTS; HYPERTENSION, PULMONARY; HYPERTROPHY, RIGHT VENTRICULAR; IN VITRO STUDY; LUNG; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; VASCULAR ENDOTHELIUM; WISTAR RAT;

ANIMALS; ANTIHYPERTENSIVE AGENTS; CALCIUM SIGNALING; CELLS, CULTURED; CYCLIC GMP-DEPENDENT PROTEIN KINASES; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; HYPERTENSION, PULMONARY; HYPERTROPHY, RIGHT VENTRICULAR; IN VITRO TECHNIQUES; LUNG; MALE; MYOCYTES, SMOOTH MUSCLE; NITRIC OXIDE SYNTHASE TYPE III; NUCLEOTIDES, CYCLIC; PHOSPHORYLATION; PIPERIDINES; PROTEIN PHOSPHATASE 1; PULMONARY ARTERY; RATS; RATS, WISTAR; RHO-ASSOCIATED KINASES; RHOA GTP-BINDING PROTEIN; VASODILATION; XANTHINES;

EID: 77952836879     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.00740.x     Document Type: Article

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