Sildenafil prevents change in RhoA expression induced by chronic hypoxia in rat pulmonary artery

Circulation Research

Volumn 93, Issue 7, 2003, Pages 630-637

  Sauzeau, Vincent ^a   Rolli Derkinderen, Malvyne ^a   Lehoux, Stéphanie ^b   Loirand, Gervaise ^a   Pacaud, Pierre ^a  

^a UNIVERSITÉ DE NANTES   (France)

^b HÔPITAL LARIBOISIÈRE   (France)

Author keywords

Contraction; G proteins; Pulmonary hypertension; Smooth muscle

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; CALCIUM ION; CYCLIC GMP; ENDOTHELIN 1; MESSENGER RNA; NORADRENALIN; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SILDENAFIL; THROMBOXANE A2 RECEPTOR STIMULATING AGENT; CALCIUM; PIPERAZINE DERIVATIVE; POTASSIUM CHLORIDE; PROTEIN SERINE THREONINE KINASE; RHO-ASSOCIATED KINASE; SIGNAL PEPTIDE; VASOCONSTRICTOR AGENT; VASODILATOR AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY CONSTRICTION; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVITY; HYPOXIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY ARTERY; PULMONARY HYPERTENSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; VASOCONSTRICTION; WESTERN BLOTTING; ANIMAL; DOSE RESPONSE; GENE EXPRESSION REGULATION; GENETICS; IN VITRO STUDY; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ANIMALS; BLOTTING, WESTERN; CALCIUM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIN-1; GENE EXPRESSION REGULATION; HYPERTENSION, PULMONARY; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NOREPINEPHRINE; PIPERAZINES; POTASSIUM CHLORIDE; PROTEIN-SERINE-THREONINE KINASES; PULMONARY ARTERY; RATS; RHOA GTP-BINDING PROTEIN; RNA, MESSENGER; VASOCONSTRICTION; VASOCONSTRICTOR AGENTS; VASODILATOR AGENTS;

EID: 0141529785     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000093220.90027.D9     Document Type: Article

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