메뉴 건너뛰기




Volumn 30, Issue 3, 2009, Pages 363-366

Acute Inhibition of Rho-Kinase Attenuates Pulmonary Hypertension in Patients with Congenital Heart Disease

Author keywords

Congenital heart defects; Fasudil; Hemodynamics; Pulmonary hypertension; Rho kinase

Indexed keywords

FASUDIL; RHO KINASE; RHO KINASE INHIBITOR;

EID: 64249097973     PISSN: 01720643     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00246-008-9315-z     Document Type: Article
Times cited : (55)

References (24)
  • 1
    • 10744222390 scopus 로고    scopus 로고
    • Long-term treatment with a rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats
    • K Abe H Shimokawa K Morikawa 2004 Long-term treatment with a rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats Circ Res 94 385 393
    • (2004) Circ Res , vol.94 , pp. 385-393
    • Abe, K.1    Shimokawa, H.2    Morikawa, K.3
  • 2
    • 15444360813 scopus 로고    scopus 로고
    • Cytoskeletal rearrangements and transcriptional activation of c-fos serum response element by rho-kinase
    • K Chihara M Amano N Nakamura 1997 Cytoskeletal rearrangements and transcriptional activation of c-fos serum response element by rho-kinase J Biol Chem 272 25121 25127
    • (1997) J Biol Chem , vol.272 , pp. 25121-25127
    • Chihara, K.1    Amano, M.2    Nakamura, N.3
  • 4
    • 0037805583 scopus 로고    scopus 로고
    • Serine phosphorylation negatively regulates RhoA in vivo
    • SM Ellerbroek K Wennerberg K Burridge 2003 Serine phosphorylation negatively regulates RhoA in vivo J Biol Chem 278 19023 19031
    • (2003) J Biol Chem , vol.278 , pp. 19023-19031
    • Ellerbroek, S.M.1    Wennerberg, K.2    Burridge, K.3
  • 5
    • 4544388803 scopus 로고    scopus 로고
    • Attenuation of acute hypoxic pulmonary vasoconstriction and hypoxic pulmonary hypertension in mice by inhibition of rho-kinase
    • KA Fagan M Oka NR Bauer 2004 Attenuation of acute hypoxic pulmonary vasoconstriction and hypoxic pulmonary hypertension in mice by inhibition of rho-kinase Am J Physiol Lung Cell Mol Physiol 287 L656 L664
    • (2004) Am J Physiol Lung Cell Mol Physiol , vol.287
    • Fagan, K.A.1    Oka, M.2    Bauer, N.R.3
  • 6
    • 0033601250 scopus 로고    scopus 로고
    • Inhibitory phosphorylation site for rho-associated kinase on smooth muscle myosin phosphatase
    • J Feng M Ito K Ichikawa 1999 Inhibitory phosphorylation site for rho-associated kinase on smooth muscle myosin phosphatase J Biol Chem 274 37385 37390
    • (1999) J Biol Chem , vol.274 , pp. 37385-37390
    • Feng, J.1    Ito, M.2    Ichikawa, K.3
  • 7
    • 28444461454 scopus 로고    scopus 로고
    • Inhibition of RhoA/Rho-kinase pathway is involved in the beneficial effect of sildenafil on pulmonary hypertension
    • C Guilluy V Sauzeau M Rolli-Derkinderen 2005 Inhibition of RhoA/Rho-kinase pathway is involved in the beneficial effect of sildenafil on pulmonary hypertension Br J Pharmacol 146 1010 1018
    • (2005) Br J Pharmacol , vol.146 , pp. 1010-1018
    • Guilluy, C.1    Sauzeau, V.2    Rolli-Derkinderen, M.3
  • 8
    • 0032559362 scopus 로고    scopus 로고
    • Rho GTPases and the actin cytoskeleton
    • A Hall 1998 Rho GTPases and the actin cytoskeleton Science 279 509 514
    • (1998) Science , vol.279 , pp. 509-514
    • Hall, A.1
  • 9
    • 0142120102 scopus 로고    scopus 로고
    • Long-term inhibition of rho-kinase suppresses angiotensin II-induced cardiovascular hypertrophy in rats in vivo: Effect on endothelial NAD(P)H oxidase system
    • M Higashi H Shimokawa T Hattori 2003 Long-term inhibition of rho-kinase suppresses angiotensin II-induced cardiovascular hypertrophy in rats in vivo: effect on endothelial NAD(P)H oxidase system Circ Res 93 767 775
    • (2003) Circ Res , vol.93 , pp. 767-775
    • Higashi, M.1    Shimokawa, H.2    Hattori, T.3
  • 10
    • 31644431508 scopus 로고    scopus 로고
    • Beneficial acute effects of rho-kinase inhibitor in patients with pulmonary arterial hypertension
    • K Ishikura N Yamada M Ito 2006 Beneficial acute effects of rho-kinase inhibitor in patients with pulmonary arterial hypertension Circ J 70 174 178
    • (2006) Circ J , vol.70 , pp. 174-178
    • Ishikura, K.1    Yamada, N.2    Ito, M.3
  • 11
    • 0037043341 scopus 로고    scopus 로고
    • Effects of cell tension on the small GTPase rac
    • A Katsumi J Milanini WB Kiosses 2002 Effects of cell tension on the small GTPase rac J Cell Biol 158 153 164
    • (2002) J Cell Biol , vol.158 , pp. 153-164
    • Katsumi, A.1    Milanini, J.2    Kiosses, W.B.3
  • 12
    • 0036892061 scopus 로고    scopus 로고
    • Rho GTPase/Rho-kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase B/Akt in human endothelial cells
    • XF Ming H Viswambharan C Barandier 2002 Rho GTPase/Rho-kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase B/Akt in human endothelial cells Mol Cell Biol 22 8467 8477
    • (2002) Mol Cell Biol , vol.22 , pp. 8467-8477
    • Ming, X.F.1    Viswambharan, H.2    Barandier, C.3
  • 13
    • 4544244944 scopus 로고    scopus 로고
    • Rho/Rho-kinase signaling mediates increased basal pulmonary vascular tone in chronically hypoxic rats
    • T Nagaoka Y Morio N Casanova 2004 Rho/Rho-kinase signaling mediates increased basal pulmonary vascular tone in chronically hypoxic rats Am J Physiol Lung Cell Mol Physiol 287 L665 L672
    • (2004) Am J Physiol Lung Cell Mol Physiol , vol.287
    • Nagaoka, T.1    Morio, Y.2    Casanova, N.3
  • 14
    • 0029791373 scopus 로고    scopus 로고
    • The small GTPase rho: Cellular functions and signal transduction
    • S Narumiya 1996 The small GTPase rho: cellular functions and signal transduction J Biochem (Tokyo) 120 215 228
    • (1996) J Biochem (Tokyo) , vol.120 , pp. 215-228
    • Narumiya, S.1
  • 15
    • 0033538615 scopus 로고    scopus 로고
    • Mechanotransduction of rat aortic vascular smooth muscle cells requires RhoA and intact actin filaments
    • K Numaguchi S Eguchi T Yamakawa 1999 Mechanotransduction of rat aortic vascular smooth muscle cells requires RhoA and intact actin filaments Circ Res 85 5 11
    • (1999) Circ Res , vol.85 , pp. 5-11
    • Numaguchi, K.1    Eguchi, S.2    Yamakawa, T.3
  • 16
    • 0037369208 scopus 로고    scopus 로고
    • External mechanical strain regulates membrane targeting of rho GTPases by controlling microtubule assembly
    • AJ Putnam JJ Cunningham BB Pillemer 2003 External mechanical strain regulates membrane targeting of rho GTPases by controlling microtubule assembly Am J Physiol Cell Physiol 284 C627 C639
    • (2003) Am J Physiol Cell Physiol , vol.284
    • Putnam, A.J.1    Cunningham, J.J.2    Pillemer, B.B.3
  • 18
    • 0032877847 scopus 로고    scopus 로고
    • Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm
    • H Shimokawa M Seto N Katsumata 1999 Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm Cardiovasc Res 43 1029 1039
    • (1999) Cardiovasc Res , vol.43 , pp. 1029-1039
    • Shimokawa, H.1    Seto, M.2    Katsumata, N.3
  • 19
    • 0141751697 scopus 로고    scopus 로고
    • 2+ sensitivity of smooth muscle and nonmuscle myosin II: Modulated by G proteins, kinases, and myosin phosphatase
    • 2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase Physiol Rev 83 1325 1358
    • (2003) Physiol Rev , vol.83 , pp. 1325-1358
    • Somlyo, A.P.1    Somlyo, A.V.2
  • 20
    • 0030656619 scopus 로고    scopus 로고
    • Calcium sensitization of smooth muscle mediated by a rho-associated protein kinase in hypertension
    • M Uehata T Ishizaki H Satoh 1997 Calcium sensitization of smooth muscle mediated by a rho-associated protein kinase in hypertension Nature 389 990 994
    • (1997) Nature , vol.389 , pp. 990-994
    • Uehata, M.1    Ishizaki, T.2    Satoh, H.3
  • 21
    • 0032422705 scopus 로고    scopus 로고
    • Mechanical influences on vascular smooth muscle cell function
    • B Williams 1998 Mechanical influences on vascular smooth muscle cell function J Hypertens 16 1921 1929
    • (1998) J Hypertens , vol.16 , pp. 1921-1929
    • Williams, B.1
  • 22
    • 0027358735 scopus 로고
    • Mechanical strain induces growth of vascular smooth muscle cells via autocrine action of PDGF
    • E Wilson Q Mai K Sudhir 1993 Mechanical strain induces growth of vascular smooth muscle cells via autocrine action of PDGF J Cell Biol 123 741 747
    • (1993) J Cell Biol , vol.123 , pp. 741-747
    • Wilson, E.1    Mai, Q.2    Sudhir, K.3
  • 23
    • 0028865580 scopus 로고
    • Mechanical strain of rat vascular smooth muscle cells is sensed by specific extracellular matrix/integrin interactions
    • E Wilson K Sudhir HE Ives 1995 Mechanical strain of rat vascular smooth muscle cells is sensed by specific extracellular matrix/integrin interactions J Clin Invest 96 2364 2372
    • (1995) J Clin Invest , vol.96 , pp. 2364-2372
    • Wilson, E.1    Sudhir, K.2    Ives, H.E.3
  • 24
    • 5344268785 scopus 로고    scopus 로고
    • Inhibition of rho-kinase leads to rapid activation of phosphatidylinositol 3-kinase/protein kinase Akt and cardiovascular protection
    • S Wolfrum A Dendorfer Y Rikitake 2004 Inhibition of rho-kinase leads to rapid activation of phosphatidylinositol 3-kinase/protein kinase Akt and cardiovascular protection Arterioscler Thromb Vasc Biol 24 1842 1847
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 1842-1847
    • Wolfrum, S.1    Dendorfer, A.2    Rikitake, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.