The bad, the good, and the ugly about oxidative stress

Oxidative Medicine and Cellular Longevity

Volumn , Issue , 2012, Pages

  Jimenez Del Rio, Marlene ^a   Velez Pardo, Carlos ^a  

^a UNIVERSIDAD DE ANTIOQUIA   (Colombia)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMERS DISEASE; CANCER CELLS; DESIGN STRATEGIES; ETIOLOGIC FACTORS; INTRACELLULAR SIGNALING PATHWAYS; MOLECULAR BASIS; NEURODEGENERATION; PARKINSONS DISEASE; THERAPEUTIC TREATMENTS;

CELL DEATH; DISEASE CONTROL; OXIDATIVE STRESS; PATHOLOGY;

DISEASES;

4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; APOPTOSIS INDUCING FACTOR; CAFFEIC ACID; CASPASE 3; CASPASE ACTIVATED DEOXYRIBONUCLEASE; CATALASE; COUMARIC ACID; EPICATECHIN GALLATE; FERULIC ACID; GALLIC ACID; GALLIC ACID PROPYL ESTER; GLUTATHIONE PEROXIDASE; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INHIBITOR OF APOPTOSIS PROTEIN 1; INHIBITOR OF APOPTOSIS PROTEIN 2; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE 1; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN C JUN; PROTEIN P53; PROTEIN P62; PROTEIN SH2; REACTIVE OXYGEN METABOLITE; SOMATOMEDIN C; SUPEROXIDE DISMUTASE; UNINDEXED DRUG; OXYGEN;

ALZHEIMER DISEASE; APOPTOSIS; CANCER CELL; CELL DEATH; CELL SURVIVAL; DOPAMINERGIC NERVE CELL; HIPPOCAMPUS; HUMAN; LEUKEMIA; LOCOMOTION; MODEL; NEOPLASM; NERVE CELL NECROSIS; NERVE DEGENERATION; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PATHOGENESIS; PYRAMIDAL NERVE CELL; REVIEW; SENILE PLAQUE; SIGNAL TRANSDUCTION; SUBSTANTIA NIGRA; SYMPTOM; ANIMAL; METABOLISM; PATHOLOGY;

ALZHEIMER DISEASE; ANIMALS; CELL DEATH; HUMANS; NEOPLASMS; OXIDATIVE STRESS; OXYGEN; PARKINSON DISEASE;

EID: 84861057250     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.1155/2012/163913     Document Type: Review

References (214)

1. McCord J. M., Fridovich I., Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein) Journal of Biological Chemistry 1969 244 22 6049 6055
2. McCord J. M., Fridovich I., Superoxide dismutase: the first twenty years (19681988) Fre (Pubitemid 19024286)
3. Fridovich I., With the help of giants Annual Review of Biochemistry 2003 72 1 18 (Pubitemid 36930439)
4. Kresge N., Simoni R. D., Hill R. L., Forty years of superoxide dismutase research: the work of Irwin Fridovich The Journal of Biological Chemistry 2006 281 e17 e19
5. Goyal M. M., Basak A., Human catalase: looking for complete identity Protein and Cell 2010 1 10 888 897
6. Flohé L., Toppo S., Cozza G., Ursini F., A comparison of thiol peroxidase mechanisms Antioxidants and Redox Signaling 2011 15 3 763 780
7. Holmgren A., Lu J., Thioredoxin and thioredoxin reductase: current research with special reference to human disease Biochemical and Biophysical Research Communications 2010 396 1 120 124
8. Leto T. L., Geiszt M., Role of Nox family NADPH oxidases in host defense Antioxidants and Redox Signaling 2006 8 9-10 1549 1561 (Pubitemid 44726330)
9. D'alessandro A., Zolla L., The SODyssey: superoxide dismutases from biochemistry, through proteomics, to oxidative stress, aging and nutraceuticals Expert Review of Proteomics 2011 8 3 405 421
10. Batini-Haberle I., Rebouas J. S., Spasojevi I., Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potential Antioxidants and Redox Signaling 2010 13 6 877 918
11. Grace S. C., Phylogenetic distribution of superoxide dismutase supports an endosymbiotic origin for chloroplasts and mitochondria Life Sciences 1990 47 21 1875 1886
12. Aksoy H., Dean G., Elian M., Deng H. X., Deng G., Juneja T., Storey E., McKinlay Gardner R. J., Jacob R. L., Laing N. G., Siddique T., A4T mutation in the SOD1 gene causing familial amyotrophic lateral sclerosis Neuroepidemiology 2003 22 4 235 238 (Pubitemid 36693866)
13. Calabrese V., Sultana R., Scapagnini G., Guagliano E., Sapienza M., Bella R., Kanski J., Pennisi G., Mancuso C., Stella A. M. G., Butterfield D. A., Nitrosative stress, cellular stress response, and thiol homeostasis in patients with Alzheimer's disease Antioxidants and Redox Signaling 2006 8 11-12 1975 1986 (Pubitemid 46489625)
14. Martin H. L., Teismann P., Glutathione-A review on its role and significance in Parkinson's disease FASEB Journal 2009 23 10 3263 3272
15. Popov B., Gadjeva V., Valkanov P., Popova S., Tolekova A., Lipid peroxidation, superoxide dismutase and catalase activities in brain tumor tissues Archives of Physiology and Biochemistry 2003 111 5 455 459 (Pubitemid 40516336)
16. Kerr R. A., Earth science. The story of O 2 Science 2005 308 5729 1730 1732
17. Kerr R. A., Geochemistry. A shot of oxygen to unleash the evolution of animals Science 2006 314 5805 1529
18. Falkowski P. G., Isozaki Y., Geology: the story of O 2 Science 2008 322 5901 540 542
19. Fridovich I., Oxygen toxicity: a radical explanation Journal of Experimental Biology 1998 201 8 1203 1209 (Pubitemid 28278324)
20. Halliwel B., Gutteridge J. M. C., Free Radicals in Biology and Medicine 1985 New York, NY, USA Oxford University Press
21. Halliwell B., Tell me about free radicals, doctor: a review Journal of the Royal Society of Medicine 1989 82 12 747 752 (Pubitemid 20016945)
22. Halliwell B., Reactive species and antioxidants. Redox biology is a fundamental theme of aerobic life Plant Physiology 2006 141 2 312 322 (Pubitemid 43974521)
23. Halliwell B., Biochemistry of oxidative stress Biochemical Society Transactions 2007 35 5 1147 1150
24. Halliwell B., Whiteman M., Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean? British Journal of Pharmacology 2004 142 2 231 255 (Pubitemid 38746160)
25. Forman H. J., Maiorino M., Ursini F., Signaling functions of reactive oxygen species Biochemistry 2010 49 5 835 842
26. Brigelius-Flohé R., Flohé L., Basic principles and emerging concepts in the redox control of transcription factors Antioxidants and Redox Signaling 2011 15 8 2335 2381
27. Halliwell B., Oxidative stress and cancer: have we moved forward? Biochemical Journal 2007 401 1 1 11 (Pubitemid 46115897)
28. Visconti R., Grieco D., New insights on oxidative stress in cancer Current Opinion in Drug Discovery and Development 2009 12 2 240 245
29. Halliwell B., Oxidative stress and neurodegeneration: where are we now? Journal of Neurochemistry 2006 97 6 1634 1658 (Pubitemid 43873658)
30. Reynolds A., Laurie C., Lee Mosley R., Gendelman H. E., Oxidative stress and the pathogenesis of neurodegenerative disorders International Review of Neurobiology 2007 82 297 325
31. Ikawa M., Okazawa H., Kudo T., Kuriyama M., Fujibayashi Y., Yoneda M., Evaluation of striatal oxidative stress in patients with Parkinson's disease using [ 62 Cu]ATSM PET Nuclear Medicine and Biology 2011 38 7 945 951
32. Golde T. E., The therapeutic importance of understanding mechanisms of neuronal cell death in neurodegenerative disease Molecular Neurodegeneration 2009 4 1, article no. 8
33. Golde T. E., Petrucelli L., "What kills neurons in neurodegenerative diseases?", A review series in an open access journal Molecular Neurodegeneration 2009 4 1, article no. 7
34. Surmeier D. J., Guzman J. N., Sanchez-Padilla J., Goldberg J. A., What causes the death of dopaminergic neurons in Parkinson's disease? Progress in Brain Research 2010 183 C 59 77
35. Olanow C. W., Kieburtz K., Schapira A. H. V., Why have we failed to achieve neuroprotection in Parkinson's disease? Annals of Neurology 2008 64, supplement 2 S101 S110
36. Rafii M. S., Aisen P. S., Recent developments in Alzheimer's disease therapeutics BMC Medicine 2009 7, article no. 7
37. Lhle M., Reichmann H., Clinical neuroprotection in Parkinson's diseasestill waiting for the breakthrough Journal of the Neurological Sciences 2010 289 1-2 104 114
38. Lauterbach E. C., Victoroff J., Coburn K. L., Shillcutt S. D., Doonan S. M., Mendez M. F., Psychopharmacological neuroprotection in neurodegenerative disease: assessing the preclinical data Journal of Neuropsychiatry and Clinical Neurosciences 2010 22 1 8 18
39. Frankel E. N., Finley J. W., How to standardize the multiplicity of methods to evaluate natural antioxidants Journal of Agricultural and Food Chemistry 2008 56 13 4901 4908 (Pubitemid 352039082)
40. Knebl J. A., Patki D., Recruitment of subjects into clinical trials for Alzheimer disease Journal of the American Osteopathic Association 2010 110 9, supplement 8 S43 S49
41. Singh M., Arseneault M., Sanderson T., Murthy V., Ramassamy C., Challenges for research on polyphenols from foods in Alzheimer's disease: bioavailability, metabolism, and cellular and molecular mechanisms Journal of Agricultural and Food Chemistry 2008 56 13 4855 4873 (Pubitemid 352039080)
42. D'Archivio M., Filesi C., Var R., Scazzocchio B., Masella R., Bioavailability of the polyphenols: status and controversies International Journal of Molecular Sciences 2010 11 4 1321 1342
43. Stevenson D. E., Hurst R. D., Polyphenolic phytochemicals-Just antioxidants or much more? Cellular and Molecular Life Sciences 2007 64 22 2900 2916 (Pubitemid 351152245)
44. Standaert D. G., Yacoubian T. A., Target validation: the Parkinson disease perspective DMM Disease Models and Mechanisms 2010 3 5-6 259 262
45. Liu Y., Schubert D. R., The specificity of neuroprotection by antioxidants Journal of Biomedical Science 2009 16 1, article no. 98
46. Alzheimer's Association, Thies W., Bleiler L., 2011 Alzheimer's disease facts and figures Alzheimer's and Dementia 2011 7 2 208 244
47. Wirdefeldt K., Adami H. -O., Cole P., Trichopoulos D., Mandel J., Epidemiology and etiology of Parkinson's disease: a review of the evidence European Journal of Epidemiology 2011 26, supplement 1 S1 S58
48. Lopera F., Ardilla A., Martnez A., Madrigal L., Arango-Viana J. C., Lemere C. A., Arango-Lasprilla J. C., Hincapié L., Arcos-Burgos M., Ossa J. E., Behrens I. M., Norton J., Lendon C., Goate A. M., Ruiz-Linares A., Rosselli M., Kosik K. S., Clinical features of early-onset Alzheimer disease in a large kindred with an E280A presenilin-1 mutation Journal of the American Medical Association 1997 277 10 793 799 (Pubitemid 27111314)
49. Pineda-Trujillo N., Carvajal-Carmona L. G., Buritic O., Moreno S., Uribe C., Pineda D., Toro M., Garca F., Arias W., Bedoya G., Lopera F., Ruiz-Linares A., A novel Cys212Tyr founder mutation in parkin and allelic heterogeneity of juvenile Parkinsonism in a population from North West Colombia Neuroscience Letters 2001 298 2 87 90 (Pubitemid 32037063)
50. Pineda-Trujillo N., Apergi M., Moreno S., Arias W., Lesage S., Franco A., Sepulveda-Falla D., Cano D., Buritica O., Pineda D., Santiago Uribe C., Garcia De Yebenes J., Lees A. J., Brice A., Bedoya G., Lopera F., Ruiz-Linares A., A genetic cluster of early onset Parkinson's disease in a Colombian population American Journal of Medical Genetics, Part B 2006 141 8 885 889 (Pubitemid 44905442)
51. Pineda-Trujillo N., Cepeda A. D., Pérez W. A., Masmela S. M., Henao A. S., Falla D. S., Berro G. B., Restrepo F. L., Ruiz-Linares A., Una mutacin en el gen PARK2 causa enfermedad de Parkinson juvenil en una extensa familia colombiana Iatreia 2009 22 2 122 131
52. Barral F., Doctors explain battle to beat Alzheimer's. CNN, January, 2011, http://articles.cnn.com/2011-01-27/world/alzheimer.qa1alzheimer-colombian- link-disease?s=PM:WORLD
53. Esiri M. M., Dawbarn D., Allen S. J., The neuropathology of Alzheimers disease Neurobiology of Alzheimers disease 2007 Oxford, UK Oxford University Press 37 58
54. Forno L. S., Neuropathology of Parkinson's disease Journal of Neuropathology and Experimental Neurology 1996 55 3 259 272 (Pubitemid 26085575)
55. Smith M. A., Harris P. L. R., Sayre L. M., Perry G., Iron accumulation in Alzheimer disease is a source of redox-generated free radicals Proceedings of the National Academy of Sciences of the United States of America 1997 94 18 9866 9868 (Pubitemid 27408156)
56. Takanashi M., Mochizuki H., Yokomizo K., Hattori N., Mori H., Yamamura Y., Mizuno Y., Iron accumulation in the substantia nigra of autosomal recessive juvenile parkinsonism (ARJP) Parkinsonism and Related Disorders 2001 7 4 311 314 (Pubitemid 32409973)
57. Schneider S. A., Paisan-Ruiz C., Quinn N. P., Lees A. J., Houlden H., Hardy J., Bhatia K. P., ATP13A2 mutations (PARK9) cause neurodegeneration with brain iron accumulation Movement Disorders 2010 25 8 979 984
58. Wang X., Michaelis E. K., Selective neuronal vulnerability to oxidative stress in the brain Front Aging Neurosci 2010 2, article 12
59. Shinde S., Pasupathy K., Respiratory-chain enzyme activities in isolated mitochondria of lymphocytes from patients with Parkinson's disease: preliminary study Neurology India 2006 54 4 390 393 (Pubitemid 44870691)
60. MacIver N. J., Jacobs S. R., Wieman H. L., Wofford J. A., Coloff J. L., Rathmell J. C., Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival Journal of Leukocyte Biology 2008 84 4 949 957
61. Calopa M., Bas J., Callén A., Mestre M., Apoptosis of peripheral blood lymphocytes in Parkinson patients Neurobiology of Disease 2010 38 1 1 7
62. Marazziti D., Consoli G., Masala I., Catena Dell'Osso M., Baroni S., Latest advancements on serotonin and dopamine transporters in lymphocytes Mini-Reviews in Medicinal Chemistry 2010 10 1 32 40
63. Feldhaus P., Fraga D. B., Ghedim F. V., De Luca R. D., Bruna T. D., Heluany M., Matos M. P., Ferreira G. K., Jeremias I. C., Heluany C., Streck E. L., Zugno A. I., Evaluation of respiratory chain activity in lymphocytes of patients with Alzheimer disease Metabolic Brain Disease 2011 26 3 229 236
64. Kroemer G., Galluzzi L., Vandenabeele P., Abrams J., Alnemri E. S., Baehrecke E. H., Blagosklonny M. V., El-Deiry W. S., Golstein P., Green D. R., Hengartner M., Knight R. A., Kumar S., Lipton S. A., Malorni W., Nuez G., Peter M. E., Tschopp J., Yuan J., Piacentini M., Zhivotovsky B., Melino G., Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009 Cell Death and Differentiation 2009 16 1 3 11
65. Reed J. C., Mechanisms of apoptosis American Journal of Pathology 2000 157 5 1415 1430
66. KEGG, The (Kyoto Encyclopedia of Genes and Genomes) PATHWAY Database. (Apoptosis). http://www.genome.jp/kegg/pathway/hsa/hsa04210.html
67. Galluzzi L., Vitale I., Abrams J. M., Alnemri E. S., Baehrecke E. H., Blagosklonny M. V., Dawson T. M., Dawson V. L., El-Deiry W. S., Fulda S., Gottlieb E., Green D. R., Hengartner M. O., Kepp O., Knight R. A., Kumar S., Lipton S. A., Lu X., Madeo F., Malorni W., Mehlen P., Nez G., Peter M. E., Piacentini M., Rubinsztein D. C., Shi Y., Simon H. -U., Vandenabeele P., White E., Yuan J., Zhivotovsky B., Melino G., Kroemer G., Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012 Cell Death and Differentiation 2012 19 1 107 120
68. Groeger G., Quiney C., Cotter T. G., Hydrogen peroxide as a cell-survival signaling molecule Antioxidants and Redox Signaling 2009 11 11 2655 2671
69. Velez-Pardo C., Garcia-Ospina G., Del Rio J. M., A [2535] peptide and iron promote apoptosis in lymphocytes by a common oxidative mechanism: involvement of hydrogen peroxide (H 2 O 2), caspase-3, NF-kappa B, p53 and c-Jun NeuroToxicol 2002 23 3 351 365
70. Del Rio M. J., Moreno S., Garcia-Ospina G., Buritica O., Uribe C. S., Lopera F., Velez-Pardo C., Autosomal recessive juvenile Parkinsonism Cys212Tyr mutation in parkin renders lymphocytes susceptible to dopamine- and iron-mediated apoptosis Movement Disorders 2004 19 3 324 330 (Pubitemid 38961088)
71. Del Rio M. J., Velez-Pardo C., Monoamine neurotoxins-induced apoptosis in lymphocytes by a common oxidative stress mechanism: Involvement of hydrogen peroxide (H 2 O 2), caspase-3, and nuclear factor kappa-B (NF- B), p53, c-Jun transcription factors Biochemical Pharmacology 2002 63 4 677 688 (Pubitemid 34464085)
72. Jimenez Del Rio M., Velez-Pardo C., Paraquat induces apoptosis in human lymphocytes: protective and rescue effects of glucose, cannabinoids and insulin-like growth factor-1 Growth Factors 2008 26 1 49 60 (Pubitemid 351448014)
73. Avila-Gomez I. C., Velez-Pardo C., Jimenez-Del-Rio M., Effects of insulin-like growth factor-1 on rotenone-induced apoptosis in human lymphocyte cells Basic and Clinical Pharmacology and Toxicology 2010 106 1 53 61
74. Jimenez Del Rio M., Velez-Pardo C., 17 -Estradiol protects lymphocytes against dopamine and iron-induced apoptosis by a genomic-independent mechanism-Implication in Parkinson's disease General Pharmacology: The Vascular System 2001 35 1 1 9 (Pubitemid 33009317)
75. Velez-Pardo C., Jimenez Del Rio M., Avoidance of A [25-35]/(H2O2)-induced apoptosis in lymphocytes by the cannabinoid agonists CP55,940 and JWH-015 via receptor-independent and PI3K-dependent mechanism: role of NF- B and p53 Medicinal Chemistry 2006 2 5 471 479 (Pubitemid 44389012)
76. Velez-Pardo C., Jimenez-Del-Rio M., Lores-Arnaiz S., Bustamante J., Protective effects of the synthetic cannabinoids CP55,940 and JWH-015 on rat brain mitochondria upon paraquat exposure Neurochemical Research 2010 35 9 1323 1332
77. Jimenez Del Rio M., Velez-Pardo C., Insulin-like growth factor-1 prevents A [ 2535 ]/ (H 2 O 2)- induced apoptosis in lymphocytes by reciprocal NF- B activation and p53 inhibition via PI3K-dependent pathway Growth Factors 2006 24 1 67 78 (Pubitemid 43108777)
78. Schoonbroodt S., Ferreira V., Best-Belpomme M., Boelaert J. R., Legrand-Poels S., Korner M., Korner M., Piette J., Crucial role of the amino-terminal tyrosine residue 42 and the carboxylterminal PEST domain of I kappa B alpha in NF-kappa B activation by an oxidative stress J Immunol 2000 164 8 4292 4300 (Pubitemid 30215091)
79. Takada Y., Mukhopadhyay A., Kundu G. C., Mahabeleshwar G. H., Singh S., Aggarwal B. B., Hydrogen peroxide activates NF- B through tyrosine phosphorylation of I B and serine phosphorylation of p65. Evidence for the involvement of I B kinase and Syk protein-tyrosine kinase Journal of Biological Chemistry 2003 278 26 24233 24241 (Pubitemid 36830260)
80. Gloire G., Charlier E., Rahmouni S., Volanti C., Chariot A., Erneux C., Piette J., Restoration of SHIP-1 activity in human leukemic cells modifies NF- B activation pathway and cellular survival upon oxidative stress Oncogene 2006 25 40 5485 5494 (Pubitemid 44344099)
81. Lee F. S., Hagler J., Chen Z. J., Maniatis T., Activation of the I B kinase complex by MEKK1, a kinase of the JNK pathway Cell 1997 88 2 213 222 (Pubitemid 28015870)
82. Wu H., Lozano G., NF- B activation of p53. A potential mechanism for suppressing cell growth in response to stress Journal of Biological Chemistry 1994 269 31 20067 20074
83. Olovnikov I. A., Kravchenko J. E., Chumakov P. M., Homeostatic functions of the p53 tumor suppressor: regulation of energy metabolism and antioxidant defense Seminars in Cancer Biology 2009 19 1 32 41
84. Borutaite V., Mitochondria as decision-makers in cell death Environmental and Molecular Mutagenesis 2010 51 5 406 416
85. Ricchelli F., ileikyte J., Bernardi P., Shedding light on the mitochondrial permeability transition Biochimica et Biophysica Acta 2011 1807 5 482 490
86. Norberg E., Orrenius S., Zhivotovsky B., Mitochondrial regulation of cell death: processing of apoptosis-inducing factor (AIF) Biochemical and Biophysical Research Communications 2010 396 1 95 100
87. Zou H., Li Y., Liu X., Wang X., An APAf-1 cytochrome C multimeric complex is a functional apoptosome that activates procaspase-9 Journal of Biological Chemistry 1999 274 17 11549 11556
88. Jnicke R. U., Sprengart M. L., Wati M. R., Porter A. G., Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis Journal of Biological Chemistry 1998 273 16 9357 9360 (Pubitemid 28183012)
89. Enari M., Sakahira H., Yokoyama H., Okawa K., Iwamatsu A., Nagata S., A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD Nature 1998 391 6662 43 50 (Pubitemid 28079208)
90. Yuste V. J., Snchez-Lpez I., Solé C., Moubarak R. S., Bayascas J. R., Dolcet X., Encinas M., Susin S. A., Comella J. X., The contribution of apoptosis-inducing factor, caspase-activated DNase, and inhibitor of caspase-activated DNase to the nuclear phenotype and DNA degradation during apoptosis Journal of Biological Chemistry 2005 280 42 35670 35683 (Pubitemid 41532760)
91. Ichijo H., Nishida E., Irie K., Ten Dijke P., Saitoh M., Moriguchi T., Takagi M., Matsumoto K., Miyazono K., Gotoh Y., Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways Science 1997 275 5296 90 94 (Pubitemid 27020316)
92. Yan M., Dai T., Deak J. C., Kyriakis J. M., Zon L. I., Woodgett J. R., Templeton D. J., Activation of stress activated protein kinase by MEKK1 phosphorylation of its activator SEK1 Nature 1994 372 6508 798 800
93. Yang D., Tournier C., Wysk M., Lu H. T., Xu J., Davis R. J., Flavell R. A., Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH2-terminal kinase activation, and defects in AP-1 transcriptional activity Proceedings of the National Academy of Sciences of the United States of America 1997 94 7 3004 3009 (Pubitemid 27157254)
94. Minden A., Lin A., Smeal T., Derijard B., Cobb M., Davis R., Karin M., c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases Molecular and Cellular Biology 1994 14 10 6683 6688 (Pubitemid 24299737)
95. Dhanasekaran D. N., Reddy E. P., JNK signaling in apoptosis Oncogene 2008 27 48 6245 6251
96. Oleinik N. V., Krupenko N. I., Krupenko S. A., Cooperation between JNK1 and JNK2 in activation of p53 apoptotic pathway Oncogene 2007 26 51 7222 7230 (Pubitemid 350085318)
97. Jiménez Del Ro M., Vélez-Pardo C., Transition metal-induced apoptosis in lymphocytes via hydroxyl radical generation, mitochondria dysfunction, and caspase-3 activation: an in vitro model for neurodegeneration Archives of Medical Research 2004 35 3 185 193 (Pubitemid 38648986)
98. Bales K. R., Du Y., Dodel R. C., Yan G. M., Hamilton-Byrd E., Paul S. M., The NF- B/Rel family of proteins mediates A -induced neurotoxicity and glial activation Molecular Brain Research 1998 57 1 63 72 (Pubitemid 28279561)
99. Uberti D., Yavin E., Gil S., Ayasola K. R., Goldfinger N., Rotter V., Hydrogen peroxide induces nuclear translocation of p53 and apoptosis in cells of oligodendroglia origin Molecular Brain Research 1999 65 2 167 175 (Pubitemid 29113266)
100. Marn N., Romero B., Bosch-Morell F., Llansola M., Felipo V., Rom J., Romero F. J., -Amyloid-induced activation of Caspase-3 in primary cultures of rat neurons Mechanisms of Ageing and Development 2000 119 1-2 63 67
101. Panet H., Barzilai A., Daily D., Melamed E., Offen D., Activation of nuclear transcription factor kappa B (NF- B) is essential for dopamine-induced apoptosis in PC12 cells Journal of Neurochemistry 2001 77 2 391 398 (Pubitemid 32298733)
102. Troy C. M., Rabacchi S. A., Xu Z., Maroney A. C., Connors T. J., Shelanski M. L., Greene L. A., -Amyloid-induced neuronal apoptosis requires c-Jun N-terminal kinase activation Journal of Neurochemistry 2001 77 1 157 164 (Pubitemid 32245089)
103. Aleyasin H., Cregan S. P., Iyirhiaro G., O'Hare M. J., Callaghan S. M., Slack R. S., Park D. S., Nuclear factor- B modulates the p53 response in neurons exposed to DNA damage Journal of Neuroscience 2004 24 12 2963 2973 (Pubitemid 38405744)
104. Ohyagi Y., Asahara H., Chui D. H., Tsuruta Y., Sakae N., Miyoshi K., Yamada T., Kikuchi H., Taniwaki T., Murai H., Ikezoe K., Furuya H., Kawarabayashi T., Shoji M., Checler F., Iwaki T., Makifuchi T., Takeda K., Kira J. I., Tabira T., Intracellular A 42 activates p53 promoter: a pathway to neurodegeneration in Alzheimer's disease FASEB Journal 2005 19 2 255 257 (Pubitemid 40189273)
105. Son Y.-O., Jang Y. S., Shi X., Lee J. C., Activation of JNK and c-Jun is involved in glucose oxidase-mediated cell death of human lymphoma cells Molecules and Cells 2009 28 6 545 551
106. Choi W. S., Klintworth H. M., Xia Z., JNK3-mediated apoptotic cell death in primary dopaminergic neurons Methods in Molecular Biology 2011 758 279 292
107. Maheshwari A., Misro M. M., Aggarwal A., Sharma R. K., Nandan D., N-acetyl-L-cysteine counteracts oxidative stress and prevents H 2 O 2 induced germ cell apoptosis through down-regulation of caspase-9 and JNK/c-Jun Molecular Reproduction and Development 2011 78 2 69 79
108. Hunot S., Brugg B., Ricard D., Michel P. P., Muriel M. P., Ruberg M., Faucheux B. A., Agid Y., Hirsch E. C., Nuclear translocation of NF- b is increased in dopaminergic neurons of patients with Parkinson disease Proceedings of the National Academy of Sciences of the United States of America 1997 94 14 7531 7536 (Pubitemid 27345350)
109. He Y., Lee T., Leong S. K., 6-Hydroxydopamine induced apoptosis of dopaminergic cells in the rat substantia nigra Brain Research 2000 858 1 163 166 (Pubitemid 30105794)
110. Hartmann A., Hunot S., Michel P. P., Muriel M. P., Vyas S., Faucheux B. A., Mouatt-Prigent A., Turmel H., Srinivasan A., Ruberg M., Evan G. I., Agid Y., Hirsch E. C., Caspase-3: a vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease Proceedings of the National Academy of Sciences of the United States of America 2000 97 6 2875 2880 (Pubitemid 30159265)
111. Velez-Pardo C., Lopera F., Jimenez Del Rio M., DNA damage does not correlate with amyloid- -plaques and neurofibrillary tangles in familial Alzheimer's disease presenilin-1 [E280A] mutation Journal of Alzheimer's Disease 2000 2 1 47 57 (Pubitemid 30353517)
112. Su J. H., Zhao M., Anderson A. J., Srinivasan A., Cotman C. W., Activated caspase-3 expression in Alzheimer's and aged control brain: correlation with Alzheimer pathology Brain Research 2001 898 2 350 357 (Pubitemid 32299965)
113. Garcia-Ospina G., Del Rio J. M., Lopera F., Velez-Pardo C., Neuronal DNA damage correlates with a positive detection of c-Jun, nuclear factor B, p53 and Par-4 transcription factors in Alzheimers disease Rev Neurol 2003 36 11 1004 1010 (Pubitemid 36899381)
114. Thakur A., Wang X., Siedlak S. L., Perry G., Smith M. A., Zhu X., c-Jun phosphorylation in Alzheimer disease Journal of Neuroscience Research 2007 85 8 1668 1673 (Pubitemid 46849614)
115. Ferrer I., Blanco R., Carmona M., Puig B., Barrachina M., Gmez C., Ambrosio S., Active, phosphorylation-dependent mitogen-activated protein kinase (MAPK/ERK), stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK), and p38 kinase expression in Parkinson's disease and Dementia with Lewy bodies Journal of Neural Transmission 2001 108 12 1383 1396 (Pubitemid 34020444)
116. McLellan M. E., Kajdasz S. T., Hyman B. T., Bacskai B. J., In vivo imaging of reactive oxygen species specifically associated with thioflavine S-positive amyloid plaques by multiphoton microscopy Journal of Neuroscience 2003 23 6 2212 2217 (Pubitemid 36368909)
117. Wang C., Li J., Liu Q., Yang R., Zhang J. H., Cao Y. -P., Sun X. -J., Hydrogen-rich saline reduces oxidative stress and inflammation by inhibit of JNK and NF- B activation in a rat model of amyloid-beta-induced Alzheimer's disease Neuroscience Letters 2011 491 2 127 132
118. Mogi M., Togari A., Kondo T., Mizuno Y., Komure O., Kuno S., Ichinose H., Nagatsu T., Caspase activities and tumor necrosis factor receptor R1 (p55) level are elevated in the substantia nigra from Parkinsonian brain Journal of Neural Transmission 2000 107 3 335 341 (Pubitemid 30162695)
119. Mogi M., Kondo T., Mizuno Y., Nagatsu T., p53 protein, interferon-, and NF- B levels are elevated in the parkinsonian brain Neuroscience Letters 2007 414 1 94 97 (Pubitemid 46241643)
120. Liang Z. Q., Li Y. L., Zhao X. L., Han R., Wang X. X., Wang Y., Chase T. N., Bennett M. C., Qin Z. H., NF- B contributes to 6-hydroxydopamine-induced apoptosis of nigral dopaminergic neurons through p53 Brain Research 2007 1145 1 190 203 (Pubitemid 46497982)
121. Li L. Y., Zhao X. L., Fei X. F., Gu Z. L., Qin Z. H., Liang Z. Q., Bilobalide inhibits 6-OHDA-induced activation of NF- B and loss of dopaminergic neurons in rat substantia nigra Acta Pharmacologica Sinica 2008 29 5 539 547
122. Muoz A. M., Rey P., Soto-Otero R., Guerra M. J., Labandeira-Garcia J. L., Systemic Administration of N-Acetylcysteine Protects Dopaminergic Neurons Against 6-Hydroxydopamine-Induced Degeneration Journal of Neuroscience Research 2004 76 4 551 562 (Pubitemid 38580470)
123. Braithwaite S. P., Schmid R. S., He D. N., Sung M. L. A., Cho S., Resnick L., Monaghan M. M., Hirst W. D., Essrich C., Reinhart P. H., Lo D. C., Inhibition of c-Jun kinase provides neuroprotection in a model of Alzheimer's disease Neurobiology of Disease 2010 39 3 311 317
124. Jimenez-Del-Rio M., Daza-Restrepo A., Velez-Pardo C., The cannabinoid CP55,940 prolongs survival and improves locomotor activity in Drosophila melanogaster against paraquat: implications in Parkinson's disease Neuroscience Research 2008 61 4 404 411
125. Botella J. A., Bayersdorfer F., Gmeiner F., Schneuwly S., Modelling Parkinson's Disease in Drosophila NeuroMolecular Medicine 2009 11 4 268 280
126. Guo M., What have we learned from Drosophila models of Parkinson's disease? Progress in Brain Research 2010 184 C 1 16
127. Chaudhuri A., Bowling K., Funderburk C., Lawal H., Inamdar A., Wang Z., O'Donnell J. M., Interaction of genetic and environmental factors in a Drosophila parkinsonism model Journal of Neuroscience 2007 27 10 2457 2467 (Pubitemid 46393605)
128. Jimenez-Del-Rio M., Guzman-Martinez C., Velez-Pardo C., The effects of polyphenols on survival and locomotor activity in Drosophila melanogaster exposed to iron and paraquat Neurochemical Research 2010 35 2 227 238
129. Ortega-Arellano H. F., Jimenez-Del-Rio M., Velez-Pardo C., Life span and locomotor activity modification by glucose and polyphenols in Drosophila melanogaster chronically exposed to oxidative stress-stimuli: implications in Parkinson's disease Neurochemical Research 2011 36 6 1073 1086
130. Zhao B., Natural antioxidants protect neurons in Alzheimer's disease and parkinson's disease Neurochemical Research 2009 34 4 630 638
131. Williams R. J., Spencer J. P.E., Flavonoids, cognition, and dementia: actions, mechanisms, and potential therapeutic utility for Alzheimer disease Free Radical Biology and Medicine 2012 52 1 35 45
132. Bonilla-Ramirez L., Jimenez-Del-Rio M., Velez-Pardo C., Acute and chronic metal exposure impairs locomotion activity in Drosophila melanogaster: a model to study Parkinsonism BioMetals 2011 24 6 1045 1057
133. Clark J., Clore E. L., Zheng K., Adame A., Masliah E., Simon D. K., Oral N-Acetyl-cysteine attenuates loss of dopaminergic terminals in -synuclein overexpressing mice PLoS One 2010 5 8
134. Badrick A. C., Jones C. E., Reorganizing metals: the use of chelating compounds as potential therapies for metal-related neurodegenerative disease Current Topics in Medicinal Chemistry 2011 11 5 543 552
135. Manczak M., Mao P., Calkins M. J., Cornea A., Reddy A. P., Murphy M. P., Szeto H. H., Park B., Reddy P. H., Mitochondria-targeted antioxidants protect against amyloid- toxicity in Alzheimer's disease neurons Journal of Alzheimer's Disease 2010 20, supplement 2 S609 S631
136. Szeto H. H., Schiller P. W., Novel therapies targeting inner mitochondrial membrane-from discovery to clinical development Pharmaceutical Research 2011 28 11 2669 2679
137. Orange J. S., May M. J., Cell penetrating peptide inhibitors of nuclear factor-kappa B Cellular and Molecular Life Sciences 2008 65 22 3564 3591
138. Flood P. M., Qian L., Peterson L. J., Zhang F., Shi J. -S., Gao H. -M., Hong J. -S., Transcriptional factor NF- b as a target for therapy in Parkinson's disease Parkinson's Disease 2011 2011 8
139. Zhu X., Yu Q. S., Cutler R. G., Culmsee C. W., Holloway H. W., Lahiri D. K., Mattson M. P., Greig N. H., Novel p53 inactivators with neuroprotective action: syntheses and pharmacological evaluation of 2-imino-2,3,4,5,6,7- hexahydrobenzothiazole and 2-imino-2,3,4,5,6,7-hexahydrobenzoxazole derivatives Journal of Medicinal Chemistry 2002 45 23 5090 5097 (Pubitemid 35278705)
140. Hu C., Li X., Wang W., Zhang L., Tao L., Dong X., Sheng R., Yang B., Hu Y., Design, synthesis, and biological evaluation of imidazoline derivatives as p53-MDM2 binding inhibitors Bioorganic and Medicinal Chemistry 2011 19 18 5454 5461
141. Mehan S., Meena H., Sharma D., Sankhla R., JNK: a stress-activated protein kinase therapeutic strategies and involvement in Alzheimer's and various neurodegenerative abnormalities Journal of Molecular Neuroscience 2010 43 3 376 390
142. Polytarchou C., Hatziapostolou M., Papadimitriou E., Hydrogen peroxide stimulates proliferation and migration of human prostate cancer cells through activation of activator protein-1 and up-regulation of the heparin affin regulatory peptide gene Journal of Biological Chemistry 2005 280 49 40428 40435 (Pubitemid 41780529)
143. Payne S. L., Fogelgren B., Hess A. R., Seftor E. A., Wiley E. L., Fong S. F. T., Csiszar K., Hendrix M. J. C., Kirschmann D. A., Lysyl oxidase regulates breast cancer cell migration and adhesion through a hydrogen peroxide-mediated mechanism Cancer Research 2005 65 24 11429 11436 (Pubitemid 41821700)
144. Heirman I., Ginneberge D., Brigelius-Flohé R., Hendrickx N., Agostinis P., Brouckaert P., Rottiers P., Grooten J., Blocking tumor cell eicosanoid synthesis by GPx4 impedes tumor growth and malignancy Free Radical Biology and Medicine 2006 40 2 285 294 (Pubitemid 43069352)
145. Wang J., Yi J., Cancer cell killing via ROS: to increase or decrease, that is a question Cancer Biology and Therapy 2008 7 12 1875 1884
146. Chen J., Song M., Yu S., Gao P., Yu Y., Wang H., Huang L., Advanced
147. Maek R., Borowicz K. K., Jargieo M., Czuczwar S. J., Role of nuclear factor kappaB in the central nervous system Pharmacological Reports 2007 59 1 25 33 (Pubitemid 46522699)
148. Qin Z. H., Tao L. Y., Chen X., Dual roles of NF- B in cell survival and implications of NF- B inhibitors in neuroprotective therapy Acta Pharmacologica Sinica 2007 28 12 1859 1872 (Pubitemid 350198354)
149. Bazan N. G., Is NF- B from astrocytes a decision maker of neuronal life or death? (Commentary on Dvoriantchikova et al.): commentary European Journal of Neuroscience 2009 30 2 173 174
150. Bednarski B. K., Baldwin A. S., Kim H. J., Addressing reported pro-apoptotic functions of NF- B: targeted inhibition of canonical NF- B enhances the apoptotic effects of doxorubicin PLoS One 2009 4 9
151. Wang F., Li H., Shi H., Sun B., Pro-apoptotic role of nuclear factor- B in adriamycin-induced acute myocardial injury in rats Molecular Medicine Reports 2012 5 2 400 404
152. Isaac M. G. E. K. N., Quinn R., Tabet N., Vitamin E for Alzheimer's disease and mild cognitive impairment Cochrane Database of Systematic Reviews 2008 3
153. Brewer G. J., Why vitamin e therapy fails for treatment of Alzheimer's disease Journal of Alzheimer's Disease 2010 19 1 27 30
154. Snow B. J., Rolfe F. L., Lockhart M. M., Frampton C. M., O'Sullivan J. D., Fung V., Smith R. A.J., Murphy M. P., Taylor K. M., A double-blind, placebo-controlled study to assess the mitochondria- targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease Movement Disorders 2010 25 11 1670 1674
155. Pui C. H., Relling M. V., Downing J. R., Mechanisms of disease: acute lymphoblastic leukemia New England Journal of Medicine 2004 350 15 1535 1548 (Pubitemid 38477778)
156. Bonilla-Porras A. R., Jimenez-Del-Rio M., Velez-Pardo C., Vitamin K3 and vitamin C alone or in combination induced apoptosis in leukemia cells by a similar oxidative stress signalling mechanism Cancer Cell International 2011 11, article 19
157. Jomova K., Jenisova Z., Feszterova M., Baros S., Liska J., Hudecova D., Rhodes C. J., Valko M., Arsenic: toxicity, oxidative stress and human disease Journal of Applied Toxicology 2011 31 2 95 107
158. Meshkini A., Yazdanparast R., Involvement of oxidative stress in taxol-induced apoptosis in chronic myelogenous leukemia K562 cells. Experimental and Toxicologic Pathology. In press
159. Bekris L. M., Yu C. E., Bird T. D., Tsuang D. W., Review article: genetics of Alzheimer disease Journal of Geriatric Psychiatry and Neurology 2010 23 4 213 227
160. Bekris L. M., Mata I. F., Zabetian C. P., The genetics of Parkinson disease Journal of Geriatric Psychiatry and Neurology 2010 23 4 228 242
161. Schapira A. H., Gegg M., Mitochondrial contribution to Parkinsons disease pathogenesis Parkinson's Disease 2011 2011 7
162. McCoy M. K., Cookson M. R., Mitochondrial quality control and dynamics in parkinson's disease Antioxid Redox Signal 2012 16 9 869 882
163. Vinish M., Anand A., Prabhakar S., Altered oxidative stress levels in Indian Parkinson's disease patients with PARK2 mutations Acta Biochimica Polonica 2011 58 2 165 169
164. Ramsey C. P., Giasson B. I., The E163K DJ-1 mutant shows specific antioxidant deficiency Brain Research 2008 1239 C 1 11
165. Ren H., Fu K., Wang D., Mu C., Wang G., Oxidized DJ-1 interacts with the mitochondrial protein BCL- X L Journal of Biological Chemistry 2011 286 40 35308 35317
166. Heo H. Y., Park J. M., Kim C. H., Han B. S., Kim K. S., Seol W., LRRK2 enhances oxidative stress-induced neurotoxicity via its kinase activity Experimental cell research 2010 316 4 649 656
167. Mohmmad Abdul H., Wenk G. L., Gramling M., Hauss-Wegrzyniak B., Butterfield D. A., APP and PS-1 mutations induce brain oxidative stress independent of dietary cholesterol: implications for Alzheimer's disease Neuroscience Letters 2004 368 2 148 150 (Pubitemid 39194861)
168. Mohmmad A. H., Sultana R., Keller J. N., St Clair D. K., Markesbery W. R., Butterfield D. A., Mutations in amyloid precursor protein and presenilin-1 genes increase the basal oxidative stress in murine neuronal cells and lead to increased sensitivity to oxidative stress mediated by amyloid beta-peptide (1-42), HO and kainic acid: implications for Alzheimer's disease Journal of Neurochemistry 2006 96 5 1322 1335
169. Ghebranious N., Mukesh B., Giampietro P. F., Glurich I., Mickel S. F., Waring S. C., McCarty C. A., A pilot study of gene/gene and gene/environment interactions in Alzheimer disease Clinical Medicine and Research 2011 9 1 17 25
170. Burbulla L. F., Krger R., Converging environmental and genetic pathways in the pathogenesis of Parkinson's disease Journal of the Neurological Sciences 2011 306 1-2 1 8
171. Gao H. M., Hong J. -S., Gene-environment interactions: key to unraveling the mystery of Parkinson's disease Progress in Neurobiology 2011 94 1 1 19
172. Spivey A., Rotenone and paraquat linked to Parkinson's disease: human exposure study supports years of animal studies Environmental Health Perspectives 2011 119 6 A259
173. Sian-Hlsmann J., Mandel S., Youdim M. B.H., Riederer P., The relevance of iron in the pathogenesis of Parkinson's disease Journal of Neurochemistry 2011 118 6 939 957
174. Qin Y., Zhu W., Zhan C., Zhao L., Wang J., Tian Q., Wang W., Investigation on positive correlation of increased brain iron deposition with cognitive impairment in Alzheimer disease by using quantitative MR R2' mapping Journal of Huazhong University of Science and Technology-Medical Science 2011 31 4 578 585
175. Gille G., Reichmann H., Iron-dependent functions of mitochondriarelation to neurodegeneration Journal of Neural Transmission 2011 118 3 349 359
176. Levy O. A., Malagelada C., Greene L. A., Cell death pathways in Parkinson's disease: proximal triggers, distal effectors, and final steps Apoptosis 2009 14 4 478 500
177. Bertrand E., Lechowicz W., Szpak G. M., Lewandowska E., Dymecki J., Wierzba-Bobrowicz T., Limbic neuropathology in idiopathic Parkinson's disease with concomitant dementia Folia Neuropathologica 2004 42 3 141 150 (Pubitemid 39433399)
178. Ramirez A., Heimbach A., Grndemann J., Stiller B., Hampshire D., Cid L. P., Goebel I., Mubaidin A. F., Wriekat A. L., Roeper J., Al-Din A., Hillmer A. M., Karsak M., Liss B., Woods C. G., Behrens M. I., Kubisch C., Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase Nature Genetics 2006 38 10 1184 1191 (Pubitemid 44470365)
179. Compta Y., Parkkinen L., O'Sullivan S. S., Vandrovcova J., Holton J. L., Collins C., Lashley T., Kallis C., Williams D. R., De Silva R., Lees A. J., Revesz T., Lewy- and Alzheimer-type pathologies in Parkinson's disease dementia: which is more important? Brain 2011 134 5 1493 1505
180. Oda A., Tamaoka A., Araki W., Oxidative stress up-regulates presenilin 1 in lipid rafts in neuronal cells Journal of Neuroscience Research 2010 88 5 1137 1145
181. Jo D. -G., Arumugam T. V., Woo H. -N., Park J. -S., Tang S. -C., Mughal M., Hyun D. -H., Park J. -H., Choi Y. -H., Gwon A. -R., Camandola S., Cheng A., Cai H., Song W., Markesbery W. R., Mattson M. P., Evidence that -secretase mediates oxidative stress-induced -secretase expression in Alzheimer's disease Neurobiology of Aging 2010 31 6 917 925
182. Iijima-Ando K., Iijima K., Transgenic Drosophila models of Alzheimer's disease and tauopathies Brain Structure and Function 2010 214 2-3 245 262
183. Bonner J. M., Boulianne G. L., Drosophila as a model to study age-related neurodegenerative disorders: Alzheimer's disease Experimental Gerontology 2011 46 5 335 339
184. Park J., Kim Y., Chung J., Mitochondrial dysfunction and Parkinson's disease genes: insights from Drosophila DMM Disease Models and Mechanisms 2009 2 7-8 336 340
185. Whitworth A. J., Drosophila models of Parkinson's disease Advances in Genetics 2011 73 1 50
186. Sang T. K., Chang H. Y., Lawless G. M., Ratnaparkhi A., Mee L., Ackerson L. C., Maidment N. T., Krantz D. E., Jackson G. R., A Drosophila model of mutant human parkin-induced toxicity demonstrates selective loss of dopaminergic neurons and dependence on cellular dopamine Journal of Neuroscience 2007 27 5 981 992 (Pubitemid 46203305)
187. Wang C., Lu R., Ouyang X., Ho M. W. L., Chia W., Yu F., Lim K. L., Drosophila overexpressing parkin R275W mutant exhibits dopaminergic neuron degeneration and mitochondrial abnormalities Journal of Neuroscience 2007 27 32 8563 8570 (Pubitemid 47254271)
188. Clark I. E., Dodson M. W., Jiang C., Cao J. H., Huh J. R., Seol J. H., Yoo S. J., Hay B. A., Guo M., Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin Nature 2006 441 7097 1162 1166 (Pubitemid 43990738)
189. Feany M. B., Bender W. W., A Drosophila model of Parkinson's disease Nature 2000 404 6776 394 398 (Pubitemid 30164341)
190. Liu Z., Wang X., Yu Y., Li X., Wang T., Jiang H., Ren Q., Jiao Y., Sawa A., Moran T., Ross C. A., Montell C., Smith W. W., A Drosophila model for LRRK2-linked parkinsonism Proceedings of the National Academy of Sciences of the United States of America 2008 105 7 2693 2698 (Pubitemid 351520575)
191. Lavara-Culebras E., Paricio N., Drosophila DJ-1 mutants are sensitive to oxidative stress and show reduced lifespan and motor deficits Gene 2007 400 1-2 158 165 (Pubitemid 47284741)
192. Moore D. J., Zhang L., Troncoso J., Lee M. K., Hattori N., Mizuno Y., Dawson T. M., Dawson V. L., Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress Human Molecular Genetics 2005 14 1 71 84 (Pubitemid 40123464)
193. Jendrach M., Gispert S., Ricciardi F., Klinkenberg M., Schemm R., Auburger G., The mitochondrial kinase PINK1, stress response and Parkinson's disease Journal of Bioenergetics and Biomembranes 2009 41 6 481 486
194. Angeles D. C., Gan B. -H., Onstead L., Zhao Y., Lim K. -L., Dachsel J., Melrose H., Farrer M., Wszolek Z. K., Dickson D. W., Tan E. -K., Mutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death Human Mutation 2011 32 12 1390 1397
195. Wang H. -L., Chou A. -H., Wu A. -S., Chen S. -Y., Weng Y. -H., Kao Y. -C., Yeh T. -H., Chu P. -J., Lu C. -S., PARK6 PINK1 mutants are defective in maintaining mitochondrial membrane potential and inhibiting ROS formation of substantia nigra dopaminergic neurons Biochimica et Biophysica Acta 2011 1812 6 674 684
196. Park J., Lee S. B., Lee S., Kim Y., Song S., Kim S., Bae E., Kim J., Shong M., Kim J. M., Chung J., Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin Nature 2006 441 7097 1157 1161 (Pubitemid 43990737)
197. Hao L. Y., Giasson B. I., Bonini N. M., DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function Proceedings of the National Academy of Sciences of the United States of America 2010 107 21 9747 9752
198. Korey C. A., We hold these truths to be self-evident, that all flies and men are created equal: recent progress on human disease models Fly 2007 1 2 118 122
199. Bertoni J. M., Arlette J. P., Fernandez H. H., Fitzer-Attas C., Frei K., Hassan M. N., Isaacson S. H., Lew M. F., Molho E., Ondo W. G., Phillips T. J., Singer C., Sutton J. P., Wolf J. E. Jr., North American Parkinson's and melanoma survey investigators. increased melanoma risk in Parkinson disease: a prospective clinicopathological study Archives of Neurology 2010 67 3 347 352
200. Liu R., Gao X., Lu Y., Chen H., Meta-analysis of the relationship between Parkinson disease and melanoma Neurology 2011 76 23 2002 2009
201. Pan T., Li X., Jankovic J., The association between Parkinson's disease and melanoma International Journal of Cancer 2011 128 10 2251 2260
202. Veeriah S., Taylor B. S., Meng S., Fang F., Yilmaz E., Vivanco I., Janakiraman M., Schultz N., Hanrahan A. J., Pao W., Ladanyi M., Sander C., Heguy A., Holland E. C., Paty P. B., Mischel P. S., Liau L., Cloughesy T. F., Mellinghoff I. K., Solit D. B., Chan T. A., Somatic mutations of the Parkinson's disease-associated gene PARK2 in glioblastoma and other human malignancies Nature Genetics 2010 42 1 77 82
203. Zhang C., Lin M., Wu R., Wang X., Yang B., Levine A. J., Hu W., Feng Z., Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect Proceedings of the National Academy of Sciences of the United States of America 2011 108 39 16259 16264
204. da Costa C. A., Sunyach C., Giaime E., West A., Corti O., Brice A., Safe S., Abou-Sleiman P. M., Wood N. W., Takahashi H., Goldberg M. S., Shen J., Checler F., Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease Nature Cell Biology 2009 11 11 1370 1375
205. Alves da Costa C., Checler F., Apoptosis in Parkinson's disease: is p53 the missing link between genetic and sporadic Parkinsonism? Cellular Signalling 2010 23 6 963 968
206. Schneider G., Kramer O. H., NF B/p53 crosstalk-a promising new therapeutic target Biochimica et Biophysica Acta 2011 1815 1 90 103
207. Pandey K. B., Rizvi S. I., Plant polyphenols as dietary antioxidants in human health and disease Oxidative Medicine and Cellular Longevity 2009 2 5 270 278
208. Darvesh A. S., Carroll R. T., Bishayee A., Geldenhuys W. J., Van Der Schyf C. J., Oxidative stress and Alzheimer's disease: dietary polyphenols as potential therapeutic agents Expert Review of Neurotherapeutics 2010 10 5 729 745
209. Ghosh N., Ghosh R., Mandal S. C., Antioxidant protection: a promising therapeutic intervention in neurodegenerative disease Free Radical Research 2011 45 8 888 905
210. Halliwell B., Dietary polyphenols: good, bad, or indifferent for your health? Cardiovascular Research 2007 73 2 341 347 (Pubitemid 44937697)
211. Halliwell B., Are polyphenols antioxidants or pro-oxidants? What do we learn from cell culture and in vivo studies? Archives of Biochemistry and Biophysics 2008 476 2 107 112
212. Schaffer S., Halliwell B., Do polyphenols enter the brain and does it matter? Some theoretical and practical considerations Genes Nutrition 2012 7 2 99 109
213. Visioli F., de la Lastra C. A., Andres-Lacueva C., Aviram M., Calhau C., Cassano A., D'Archivio M., Faria A., Favé G., Fogliano V., Llorach R., Vitaglione P., Zoratti M., Edeas M., Polyphenols and human health: a prospectus Critical Reviews in Food Science and Nutrition 2011 51 6 524 546
214. Kieburtz K., Ravina B., Why hasn't neuroprotection worked in Parkinson's disease? Nature Clinical Practice Neurology 2007 3 5 240 241 (Pubitemid 46745468)