Hydrogen peroxide as a cell-survival signaling molecule

Antioxidants and Redox Signaling

Volumn 11, Issue 11, 2009, Pages 2655-2671

  Groeger, Gillian ^a   Quiney, Claire ^a   Cotter, Thomas G ^a  

^a UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CYSTEINE; HYDROGEN PEROXIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHOTRANSFERASE; PROTEIN P53; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TRANSCRIPTION FACTOR AP 1;

CELL DEATH; CELL SURVIVAL; CELLULAR STRESS RESPONSE; HUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN PROCESSING; REVIEW; SIGNAL TRANSDUCTION; ANIMAL; BIOLOGICAL MODEL; CHEMISTRY; GENETICS; METABOLISM; OXIDATION REDUCTION REACTION; PHYSIOLOGY;

ANIMALS; CELL SURVIVAL; HUMANS; HYDROGEN PEROXIDE; MODELS, BIOLOGICAL; NADPH OXIDASE; OXIDATION-REDUCTION; SIGNAL TRANSDUCTION;

EID: 73449129394     PISSN: 15230864     EISSN: None     Source Type: Journal    
DOI: 10.1089/ars.2009.2728     Document Type: Review

References (169)

1. Abo A, Pick E, Hall A, Totty N, Teahan CG, and Segal AW. Activation of the NADPH Gtp-binding protein P21rac1. Nature 353: 668-670, 1991.
2. Aebischer CP, Pasche I, and Jorg A. nanomolar arachidonicacid influences the respiratory burst in eosinophils and neutrophils induced by Gtp-binding protein: a comparative study of the respiratory burst in bovine eosinophils and neutrophils. Eur J Biochem 218: 669-677, 1993.
3. Alonso A, Sasin J, Bottini N, Friedberg I, Friedberg I Osterman A, Godzik A, Hunter T, Dixon J, and Mustelin T. Protein tyrosine phosphatases in the human genome. Cell 117: 699-711, 2004. (Pubitemid 38748887)
4. Ambasta RK, Kumar P, Griendling KK, Schmidt H, Busse R, and Brandes RP. Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase. J Biol Chem 279: 45935-45941, 2004.
5. Ameziane-El-Hassani R, Morand S, Boucher JL, Frapart YM, Apostolou D, Agnandji D, Gnidehou S, Ohayon R, Noel-Hudson MS, Francon J, Lalaoui K, Virion A, and Dupuy C. Dual oxidase-2 has an intrinsic Ca2α-dependent H2O2-generating activity. J Biol Chem 280: 30046-30054, 2005.
6. Angel P and Karin M. The role of Jun, Fos and the AP-1 complex in cell proliferation and transformation. Biochim Biophys Acta 1072: 129-157, 1991.
7. Banfi B, Molnar G, Maturana A, Steger K, Hegedus B, Demaurex N, and Krause KH. A Ca2α-activated NADPH oxidase in testis, spleen, and lymph nodes. J Biol Chem 276: 37594-37601, 2001.
8. Banfi B, Clark RA, Steger K, and Krause KH. Two novel proteins activate superoxide generation by the NADPH oxidase NOX1. J Biol Chem 278: 3510-3513, 2003.
9. Banfi B, Malgrange B, Knisz J, Steger K, Dubois-Dauphin M, and Krause KH. NOX3, a superoxide-generating NADPH oxidase of the inner ear. J Biol Chem 279: 46065-46072, 2004.
10. Banfi B, Tirone F, Durussel I, Knisz J, Moskwa P, Molnar GZ, Krause KH, and Cox JA. Mechanism of Ca2α activation of the NADPH oxidase 5 (NOX5). J Biol Chem 279: 18583-18591, 2004. (Pubitemid 38623279)
11. Barnett ME, Madgwick DK, and Takemoto DH. Protein kinase C as a stress sensor. Cell Signal 19: 1820-1829, 2007.
12. Barrett WC, DeGnore JP, Konig S, Fales HM, Keng YF, Zhang ZY, Yim MB, and Chock PB. Regulation of PTP1B via glutathionylation of the active site cysteine 215. Biochemistry 38: 6699-6705, 1999.
13. Bedard K and Krause KH. The NOX family of ROSgenerating NADPH oxidases: physiology and pathophysiology. Physiol Rev 87: 245-313, 2007.
14. Bengisgarber C and Gruener N. Involvement of proteinkinase-c and of protein phosphatase-1 and=or phosphatase-2a in p47 phox phosphorylation in formylmet-Leu-phe stimulated neutrophils: studies with selective inhibitors ro-31-8220 and alyculin-A. Cell Signal 7: 721-732, 1995.
15. Bouin AP, Grandvaux N. Vignais PV, and Fuchs A. p40(phox) is phosphorylated on threonine 154 and serine 315 during activation of the phagocyte NADPH oxidase: implication of a protein kinase C type kinase in the phosphorylation process. J Biol Chem 273: 30097-30103, 1998.
16. Brar SS, Corbin Z, Kennedy TP, Hemendinger R, Thornton L, Bommarius B, Arnold RS, Whorton AR, Sturrock AB, Huecksteadt TP, Quinn MT, Krenitsky K, Ardie KG, Lambeth JD, and Hoidal JR, NOX5 NAD(P)H oxidase regulates growth and apoptosis in DU 145 prostate cancer cells. Am J Physiol Cell Physiol 285: C353-C369, 2003.
17. Brune B and Zhou J. The role of nitric oxide (NO) in stability regulation of hypoxia inducible factor-1alpha (HIF-1alpha). Curr Med Chem 10: 845-855, 2003.
18. Caselli A, Marzocchini R, Camici R, Manao G, Moneti G, Pieraccini G, and Ramponi G. The inactivation mechanism of low molecular weight phosphotyrosine-protein phosphatase by H2O2. J Biol Chem 273: 32554-32560, 1998. (Pubitemid 28557633)
19. Chen K, Kirber MT, Xiao H, Yang Y, and Keaney JF. Regulation of ROS signal transduction by NADPH oxidase 4 localization. J Cell Biol 181: 1129-1139, 2008.
20. Cheng G, Diebold BA, Hughes Y, and Lambeth JD. Nox1-dependent reactive oxygen generation is regulated by Rac1. J Biol Chem 281: 17718-17726, 2006.
21. Cheng GJ, Cao ZH, Xu XX,Van Meir EG, and Lambeth JD. Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5. Gene 269: 131-140, 2001.
22. Cheng GJ and Lambeth JD. NOXO1, regulation of lipid binding, localization, and activation of Nox1 by the phox homology (PX) domain. J Biol Chem 279: 4737-4742, 2004.
23. Chiarugi P, Fiaschi T, Taddei ML, Talini D, Giannoni E, Raugei G, and Ramponi G. Two vicinal cysteines confer a peculiar redox regulation to low molecular weight protein tyrosine phosphatase in response to platelet-derived growth factor receptor stimulation. J Biol Chem 276: 33478-33487, 2001.
24. Chiarugi P and Giannoni E. Anoikis: a necessary death program for anchorage-dependent cells. Biochem Pharmacol 76: 1352-1364, 2008.
25. Chung HY, Baek BS, Song SH, Kim MS, Huh JI, Shim KH, Kim KW, and Lee KH. Xanthine dehydrogenase xanthine oxidase and oxidative stress. Age 20: 127-140, 1997.
26. Clark RA, Volpp BD, Leidal KG, and Nauseef WM. Cytosolic components of the human neutrophil respiratory burst oxidase translocate to the plasma-membrane during cell activation. J Clin Invest 85: 714-721, 1990.
27. Curnutte JT, Erickson RW, Ding JB, and Badwey JA. Reciprocal interactions between protein-kinase-c and components of the NADPH oxidase complex may regulate superoxide production by neutrophils stimulated with a phorbol ester. J Biol Chem 269: 10813-10819, 1994.
28. De Deken X, Wang DT, Many MC, Costagliola S, Libert F, Vassart G, Dumont JE, and Miot F. Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family. J Biol Chem 275: 23227-23233, 2000.
29. DeCoursey TE and Ligeti E. Regulation and termination of NADPH oxidase activity. Cell Mol Life Sci 62: 2173-2193, 2005.
30. Denu JM and Dixon JE. Protein tyrosine phosphatases: mechanisms of catalysis and regulation. Curr Opin Chem Biol 2: 633-641, 1998.
31. Doerries C, Grote K, Hilfiker-Kleiner D, Luchtefeld M, Schaefer A, Holland SM, Sorrentino S, Manes C, Schieffer B, Drexler H, and Landmesser U. Critical role of the NAD(P)H oxidase subunit p47(phox) for left ventricular remodeling=dysfunction and survival after myocardial infarction. Circ Res 100: 894-903, 2007.
32. Donko A, Peterfi Z, Sum A, Leto T, and Geiszt M. Dual oxidases. Phil Trans R Soc Lond B Biol Sci 360: 2301-2308, 2005.
33. Dupuy C, Ohayon R, Valent A, Noel-Hudson MS, Deme D, and Virion A. Purification of a novel flavoprotein involved in the thyroid NADPH oxidase: cloning of the porcine and human cDNAs. J Biol Chem 274: 37265-37269, 1999.
34. Dusi S and Rossi F. Activation of NADPH oxidase of human neutrophils involves the phosphorylation and the translocation of cytosolic p67phox. Biochem J 296: 367-371, 1993.
35. Edderkaoui M, Hong P, Vaquero EC, Lee JK, Fischer L, Friess H, Buchler MW, Lerch MM, Pandol SL, and Gukovskaya AS. Extracellular matrix stimulates reactive oxygen species production and increases pancreatic cancer cell survival through 5-lipoxygenase and NADPH oxidase. Am J Physiol Gastrointest Liver Physiol 289: G1137-G1147, 2005.
36. Edens WA, Sharling L, Cheng GJ, Shapira R, Kinkade JM, Lee T, Edens HA, Tang XX, Sullards C, Flaherty DB, Benian GM, and Lambeth JD. Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase= peroxidase with homology to the phagocyte oxidase subunit gp91phox. J Cell Biol 154: 879-891, 2001.
37. El Jamali A, Valente AJ, Lechleiter JD, Gamez MJ, Pearson DW, Nauseef WM, and Clark RA. Novel redox-dependent regulation of NOX5 by the tyrosine kinase c-Abl. Free Radic Biol Med 44: 868-881, 2008.
38. El Benna J, Dang PMC, Gaudry M, Fay M, Morel F, Hakim J, and Gougerot Pocidalo M.A. Phosphorylation of the respiratory burst oxidase subunit p67(phox) during human neutrophil activation: regulation by protein kinase Cdependent and independent pathways. J Biol Chem 272: 17204-17208, 1997.
39. Fetrow JS, Siew N, and Skolnick J. Structure-based functional motif identifies a potential disulfide oxidoreductase active site in the serine=threonine protein phosphatase-1 subfamily. FASEB J 13: 1866-1874, 1999.
40. Fortemaison N, Miot F, Dumont JE, and Dremier S. Regulation of H2O2 generation in thyroid cells does not involve Rac1 activation. Eur J Endocrinol 152: 127-133, 2005.
41. Freeman JL and Lambeth JD. NADPH oxidase activity is independent of p47(phox) in vitro (vol 271, pg 22578, 1996). J Biol Chem 272: 7566-7566, 1997.
42. Fuchs A, Bouin AP, Rabilloud T, and Vignais PV. The 40-kDa component of the phagocyte NADPH oxidase (p40phox) is phosphorylated during activation in differentiated HL60 cells. Eur J Biochem 249: 531-539, 1997.
43. Fukuyama M, Rokutan K, Sano T, Miyake H, Shimada M, and Tashiro S. Overexpression of a novel superoxideproducing enzyme, NADPH oxidase 1, in adenoma and well differentiated adenocarcinoma of the human colon. Cancer Lett 221: 97-104, 2005.
44. Gao T, Furnari F, and Newton AC. PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol Cell 18: 13-24, 2005.
45. Garcia-Mata R and Burridge K. Catching a GEF by its tail. Trends Cell Biol 17: 36-43, 2007.
46. Gauss KA, Bunger PL, and Quinn MT. AP-1 is essential for p67(phox) promoter activity. J Leukoc Biol 71: 163-172, 2002.
47. Geiszt M, Kopp JB, Varnai P, and Leto TL. Identification of renox, an NAD(P)H oxidase in kidney. Proc Natl Acad Sci U S A 97: 8010-8014, 2000.
48. Geiszt M, Witta J, Baffi J, Lekstrom K, and Leto TL. Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense. FASEB J 17: 1502-1504, 2003.
49. Giannoni E, Buricchi F, Grimaldi G, Parri M, Cialdai F, Taddei ML, Raugei G, Ramponi G, and Chiarugi P. Redox regulation of anoikis: reactive oxygen species as essential mediators of cell survival. Cell Death Differ 15: 867-878, 2008.
50. Go YM, Gipp JJ, Mulcahy RT, and Jones DP. H2O2-dependent activation of GCLC-ARE4 reporter occurs by mitogen-activated protein kinase pathways without oxidation of cellular glutathione or thioredoxin-1. J Biol Chem 279: 5837-5845, 2004.
51. Gorin Y, Ricono JM, Kim NH, Bhandari B, Choudhury GG, and Abboud HE. Nox4 mediates angiotensin II-induced mesangial cell hypertrophy via activation of Akt=protein kinase B. J Am Soc Nephrol 14: 91A-91A, 2003.
52. Gorlach A, Diebold I, Schini-Kerth VB, Berchner-Pfannschmidt U, Roth U, Brandes RP, Kietzmann T, and Busse R. Thrombin activates the hypoxia-inducible factor-1 signaling pathway in vascular smooth muscle cells: role of the p22(phox)-containing NADPH oxidase. Circ Res 89: 47-54, 2001.
53. Grasberger H and Refetoff S. Identification of the maturation factor for dual oxidase: evolution of a eukaryotic operon equivalent. J Biol Chem 281: 18269-18272, 2006.
54. Groemping Y, Lapouge K, Smerdon SJ, and Rittinger K. Molecular basis of phosphorylation-induced activation of the NADPH oxidase. Cell 113: 343-355, 2003.
55. Guy GR, Philp R, and Tan YH. Activation of protein kinases and the inactivation of protein phosphatase 2A in tumour necrosis factor and interleukin-1 signaltransduction pathways. Eur J Biochem 229: 503-511, 1995.
56. Ha H and Lee HB. Reactive oxygen species amplify glucose signaling in renal cells cultured under high glucose and in diabetic kidney. Nephrology (Carlton) 10(suppl): S7-S10, 2005. (Pubitemid 41743468)
57. Hampton MB, Kettle AJ, and Winterbourn CC. Involvement of superoxide and myeloperoxidase in oxygendependent killing of Staphylococcus aureus by neutrophils. Infect Immun 64: 3512-3517, 1996.
58. Hampton MB and Orrenius S. Dual regulation of caspase activity by hydrogen peroxide: implications for apoptosis. FEBS Lett 414: 552-556, 1997.
59. Heyworth PG, Knaus UG, Settleman J, Curnutte JT, and Bokoch GM. Regulation of NADPH oxidase activity by rac GTPase-activating protein(S). Mol Biol Cell 4: 1217-1223, 1993.
60. Inanami O, Johnson JL, McAdara JK, El Benna J, Faust LRP, Newburger PE, and Babior BM, Activation of the leukocyte NADPH oxidase by phorbol ester requires the phosphorylation of p47(phox) on serine 303 or 304. J Biol Chem 273: 9539-9543, 1998.
61. Iyer GY, Islam MF, and Quastel JH. Biochemical aspects of phagocytosis. Nature 192: 535-542, 1961.
62. Iyer SS, Pearson DW, Nauseef WM, and Clark RA. Evidence for a readily dissociable complex of p47phox and p67phox in cytosol of unstimulated human neutrophils. J Biol Chem 269: 22405-22411, 1994.
63. Jagnandan D, Church JE, Banfi B, Stuehr DJ, Marrero MB, and Fulton DJR. Novel mechanism of activation of NADPH oxidase 5: calcium sensitization via phosphorylation. J Biol Chem 282: 6494-6507, 2007.
64. Kamata H, Manabe T, Oka S, Kamata K, and Hirata H. Hydrogen peroxide activates IkappaB kinases through phosphorylation of serine residues in the activation loops. FEBS Lett 519: 231-237, 2002.
65. Kambayashi Y, Takekoshi S, Tanino Y, Watanabe K, Nakano M, Hitomi Y, Takigawa T, Ogino K, and Yamamoto Y. Various molecular species of diacylglycerol hydroperoxide activate human neutrophils via PKC activation. J Clin Biochem Nutr 41: 68-75, 2007.
66. Kamiguti AS, Serrander L, Lin K, Harris RJ, Cawley JC, Allsup DJ, Slupsky JR, Krause KH, and Zuzel M. Expression and activity of NOX5 in the circulating malignant B cells of hairy cell leukemia. J Immunol 175: 8424-8430, 2005.
67. Kao YY, Gianni D, Bohl B, Taylor RM, and Bokoch GM. Identification of a conserved Rac-binding site on NADPH oxidases supports a direct GTPase regulatory mechanism. J Biol Chem 283: 12736-12746, 2008.
68. Karin M. The regulation of AP-1 activity by mitogenactivated protein kinases. J Biol Chem 270: 16483-16486, 1995.
69. Katsuyama M, Fan C, and Yabe-Nishimura C. NADPH oxidase is involved in prostaglandin F2alpha-induced hypertrophy of vascular smooth muscle cells: induction of NOX1 by PGF2alpha. J Biol Chem 277: 13438-13442, 2002.
70. Kawahara T, Ritsick D, Cheng GJ, and Lambeth JD. Point mutations in the proline-rich region of p22(phox) are dominant inhibitors of Nox1-and Nox2-dependent reactive oxygen generation. J Biol Chem 280: 31859-31869, 2005.
71. Kawahara T, Quinn MT, and Lambeth JD. Molecular evolution of the reactive oxygen-generating NADPH oxidase (Nox=Duox) family of enzymes. BMC Evol Biol 7: 104, 2007.
72. Khan WA, Blob E, and Hannun YA. Arachidonic-acid and free fatty-acids as 2nd-messengers and the role of proteinkinase-C. Cell Signal 7: 171-184, 1995.
73. Kim JS, Diebold BA, Babior BM, Knaus UG, and Bokoch UG. Regulation of Nox1 activity via protein kinase Amediated phosphorylation of NoxA1 and 14-3-3 binding. J Biol Chem 282: 34787-34800, 2007.
74. Kiss PJ, Knisz J, Zhang YZ, Baltrusaitis J, Sigmund CD, Thalmann R, Smith RJH, Verpy E, and Banfi B. Inactivation of NADPH oxidase organizer 1 results in severe imbalance. Curr Biol 16: 208-213, 2006.
75. Klebanoff SJ. Myeloperoxidase: friend and foe. J Leukoc Biol 77: 598-625, 2005.
76. Klumpp S, Maurer A, Zhu Y, Aichele D, Pinna LA, and Krieglstein J. Protein kinase CK2 phosphorylates BAD at threonine-117. Neurochem Int 45: 747-752, 2004.
77. Knowles HJ, Raval RR, Harris AL, and Ratcliffe PJ. Effect of ascorbate on the activity of hypoxia-inducible factor in cancer cells. Cancer Res 63: 1764-1768, 2003.
78. Koga H, Terasawa H, Nunoi H, Takeshige K, Inagaki F, and Sumimoto H. Tetratricopeptide repeat (TPR) motifs of p67(phox) participate in interaction with the small GTPase Rac and activation of the phagocyte NADPH oxidase. J Biol Chem 274: 25051-25060, 1999.
79. Koshkin V, Lotan O, and Pick E. The cytosolic component p47(phox) is not a sine qua non participant in the activation of NADPH oxidase but is required for optimal superoxide production. J Biol Chem 271: 30326-30329, 1996.
80. Kuhn H and Thiele BJ. The diversity of the lipoxygenase family: many sequence data but little information on biological significance. FEBS Lett 449: 7-11, 1999.
81. Kuroda J, Nakagawa K, Yamasaki T, Nakamura K, Takeya R, Kuribayashi F, Imajoh-Ohmi S, Igarashi K, Shibata Y, Sueishi K, and Sumimoto H. The superoxide-producing NAD(P)H oxidase Nox4 in the nucleus of human vascular endothelial cells. Genes Cells 10: 1139-1151, 2005.
82. Kuwano Y, Kawahara T, Yamamoto H, Teshima-Kondo S, Tominaga K, Masuda K, Kishi K, Morita K, and Rokutan K. Interferon-gamma activates transcription of NADPH oxidase 1 gene and upregulates production of superoxide anion by human large intestinal epithelial cells. Am J Physiol Cell Physiol 290: C433-C443, 2006.
83. Kuwano Y, Tominaga K, Kawahara T, Sasaki H, Takeo K, Nishida K, Masuda K, Kawai T, Teshima-Kondo S, and Rokutan K. Tumor necrosis factor alpha activates transcription of the NADPH oxidase organizer 1 (NOXO1) gene and upregulates superoxide production in colon epithelial cells. Free Radic Biol Med 45: 1642-1652, 2008.
84. Lambeth JD, Kawahara T, and Diebold B. Regulation of Nox and Duox enzymatic activity and expression. Free Radic Biol Med 43: 319-331, 2007.
85. Lapouge K, Smith SJM, Walker PA, Gamblin SJ, Smerdon SJ, and Rittinger K. Structure of the TPR domain of p67(phox) in complex with Rac center dot GTP. Mol Cell 6: 899-907, 2000.
86. Le Gall M, Chambard JC, Breittmayer JP, Grall D, Pouyssegur J, and Van Obberghen-Schilling E. The p42=p44 MAP kinase pathway prevents apoptosis induced by anchorage and serum removal. Mol Biol Cell 11: 1103-1112, 2000.
87. Lee SR, Kwon KS, Kim SR, and Rhee SG. Reversible inactivation of protein-tyrosine phosphatase 1B in A431 cells stimulated with epidermal growth factor. J Biol Chem 273: 15366-15372, 1998.
88. Lee YI, Seo M, Kim Y, Kim SY, Kang UG, Kim YS, and Juhnn YS. Membrane depolarization induces the undulating phosphorylation=dephosphorylation of glycogen synthase kinase 3beta, and this dephosphorylation involves protein phosphatases 2A and 2B in SH-SY5Y human neuroblastoma cells. J Biol Chem 280: 22044-22252, 2005.
89. Lemarie A, Bourdonnay E, Morzadec C, Fardel O, and Lernhet L. Inorganic arsenic activates reduced NADPH oxidase in human primary macrophages through a Rho kinase=p38 kinase pathway. J Immunol 180: 6010-6017, 2008.
90. Leto TL, Adams AG, and Demendez I. Assembly of the phagocyte NADPH oxidase: binding of Src homology-3 domains to proline-rich targets. Proc Natl Acad Sci U S A 91: 10650-10654, 1994.
91. Li JM, Fan LM, George VT, and Brooks G. Nox2 regulates endothelial cell cycle arrest and apoptosis via p21cip1 and p53. Free Radic Biol Med 43: 976-986, 2007.
92. Li SL, Valente AJ, Wang L, Gamez MJ, and Clark RA. Transcriptional regulation of the p67phox gene: role of AP-1 in concert with myeloid-specific transcription factors. J Biol Chem 276: 39368-39378, 2001.
93. Lim SD, Sun C, Lambeth JD, Marshall F, Amin M, Chung L, Petros JA, and Arnold RS. Increased NOX1 and hydrogen peroxide in prostate cancer. Prostate 62: 200-207, 2005.
94. Liu Q, Kang JH, and Zheng RL. NADPH oxidase produces reactive oxygen species and maintains survival of rat astrocytes. Cell Biochem Funct 23: 93-100, 2005.
95. Lomax KJ, Leto TL, Nunoi H, Gallin JI, and Malech HL. Recombinant 47-kilodalton cytosol factor restores NADPH oxidase in chronic granulomatous disease. Science 245: 409-412, 1989.
96. Mackey AM, Sanvicens N, Groeger G, Doonan F, Wallace D, and Cotter TG. Redox survival signaling in retinaderived 661W cells. Cell Death Differ 15: 1291-1303, 2008.
97. Mahadev K, Zilbering A, Zhu L, and Goldstein BJ. Insulinstimulated hydrogen peroxide reversibly inhibits proteintyrosine phosphatase 1b in vivo and enhances the early insulin action cascade. J Biol Chem 276: 21938-21942, 2001.
98. Malle E, Furtmuller PG, Sattler W, and Obinger C. Myeloperoxidase: a target for new drug development? Br J Pharmacol 152: 838-854, 2007.
99. Martyn KD, Frederick LM, von Loehneysen K, Dinauer MC, and Knaus UG. Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases. Cell Signal 18: 69-82, 2006.
100. Meng TC, Fukada T, and Tonks NK. Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo. Mol Cell 9: 387-399, 2002.
101. Mochizuki T, Furuta S, Mitsushita J, Shang Ito, Yokoo M, Yamaura M, Ishizone S, Nakayama J, Konagai A, Hirose K, Kiyosawa K, and Kamata T. Inhibition of NADPH oxidase 4 activates apoptosis via the AKT=apoptosis signalregulating kinase 1 pathway in pancreatic cancer PANC-1 cells. Oncogene 25: 3699-3707, 2006.
102. Monks TJ, Xie R, Tikoo K, and Lau SS. ROS-induced histone modifications and their role in cell survival and cell death. Drug Metab Rev 38: 755-767, 2006.
103. Murillo MM, Carmona-Cuenca I, Del Castillo G, Ortiz C, Roncero C, Sanchez A, Fernandez M, and Fabregat I. Activation of NADPH oxidase by transforming growth factorbeta in hepatocytes mediates up-regulation of epidermal growth factor receptor ligands through a nuclear factorkappa B-dependent mechanism. Biochem J 405: 251-259, 2007.
104. Murry CE, Jennings RB, and Reimer KA. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 74: 1124-1136, 1986.
105. Nakamura Y, Ogihara S, and Ohtaki S. Activation by Atp of calcium-dependent NADPH-oxidase generating hydrogenperoxide in thyroid plasma-membranes. J Biochem (Tokyo) 102: 1121-1132, 1987.
106. Nakamura Y, Makino R, Tanaka T, Ishimura I, and Ohtaki S, Mechanism of H2O2 production in porcine thyroid-cells: evidence for intermediary formation of superoxide anion by NADPH-dependent H2O2-generating machinery. Biochemistry 30: 4880-4886, 1991.
107. Nawata R, Yujiri T, Nakamura Y, Ariyoshi K, Takahashi T, Sato Y, Oka Y, and Tanizawa Y. MEK kinase 1 mediates the antiapoptotic effect of the Bcr-Abl oncogene through NFkappaB activation. Oncogene 22: 7774-7780, 2003.
108. Nobes CD and Hall A. Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 81: 53-62, 1995.
109. O'Connor JC, Wallace DM, O'Brien CJ, and Cotter TJ. A novel antioxidant function for the tumor-suppressor gene p53 in the retinal ganglion cell. Invest Ophthalmol Vis Sci 49: 4237-4244, 2008.
110. O'Loghlen A, Perez-Morgado MI, Salinas M, and Martin ME. Reversible inhibition of the protein phosphatase 1 by hydrogen peroxide: potential regulation of eIF2 alpha phosphorylation in differentiated PC12 cells. Arch Biochem Biophys 417: 194-202, 2003.
111. Pacquelet S, Lehmann M, Luxen S, Regazzoni K, Frausto M, Noack D, and Knaus UG. Inhibitory action of NoxA1 on dual oxidase activity in airway cells. J Biol Chem 283: 24649-24658, 2008.
112. Park HS, Jung HY, Park EY, Kim J, Lee WJ, and Bae YS. Cutting edge: direct interaction of TLR4 with NAD(P)H oxidase 4 isozyme is essential for lipopolysaccharideinduced production of reactive oxygen species and activation of NF-kappa B. J Immunol 173: 3589-3593, 2004.
113. Park HS, Lee SH, Park D, Lee JS, Ryu HS, Lee WJ, Rhee SG, and Bae YS. Sequential activation of phosphatidylinositol 3-kinase, beta Pix, Rac1, and Nox1 in growth factor-induced production of H2O2. Mol Cell Biol 24: 4384-4394, 2004.
114. Park HS, Park D, and Bae YS. Molecular interaction of NADPH oxidase 1 with beta Pix and Nox organizer 1. Biochem Biophys Res Commun 339: 985-990, 2006.
115. Park JW and Babior BM. Activation of the leukocyte NADPH oxidase subunit p47(phox) by protein kinase C: a phosphorylation-dependent change in the conformation of the C-terminal end of p47(phox). Biochemistry 36: 11292-11292, 1997.
116. Peshavariya H, Dusting GJ, Jiang F, Halmos LR, Sobey CG, Drummond GR, and Selemidis S. NADPH oxidase isoform selective regulation of endothelial cell proliferation and survival. Naunyn Schmiedebergs Arch Pharmacol 380: 193-204, 2009.
117. Puddu P, Puddu GM, Cravero E, Rosati M, and Muscari A. The molecular sources of reactive oxygen species in hypertension. Blood Press 17: 70-77, 2008.
118. Qin L, Liu Y, Qian X, Hong JS, and Block ML. Microglial NADPH oxidase mediates leucine enkephalin dopaminergic neuroprotection. Ann N Y Acad Sci 1053: 107-120, 2005. (Pubitemid 43031088)
119. Quadros MR, Peruzzi F, Kari C, and Rodeck U. Complex regulation of signal transducers and activators of transcription 3 activation in normal and malignant keratinocytes. Cancer Res 64: 3934-3939, 2004.
120. Rahman I, Gilmour PS, Jimenez LA, and MacNee W. Oxidative stress and TNF-alpha induce histone acetylation and NF-kappaB=AP-1 activation in alveolar epithelial cells: potential mechanism in gene transcription in lung inflammation. Mol Cell Biochem 234-235: 239-248, 2002.
121. Rahman I, Marwick J, and Kirkham P. Redox modulation of chromatin remodeling: impact on histone acetylation and deacetylation, NF-kappaB and pro-inflammatory gene expression. Biochem Pharmacol 68: 1255-1267, 2004.
122. Rao RK and Clayton LW. Regulation of protein phosphatase 2A by hydrogen peroxide and glutathionylation. Biochem Biophys Res Commun 293: 610-616, 2002.
123. Reeves EP, Dekker LV, Forbes LV, Wientjes FB, Grogan A, Pappin DJC, and Segal AW. Direct interaction between p47(phox) and protein kinase C: evidence for targeting of protein kinase C by p47(phox) in neutrophils. Biochem J 344: 859-866, 1999.
124. Regier DS, Waite KA, Wallin R, and McPhail LC. A phosphatidic acid-activated protein kinase and conventional protein kinase C isoforms phosphorylate p22(phox) NADPH oxidase component. J Biol Chem 274: 36601-36608, 1999.
125. Regier DS, Greene DG, Sergeant S, Jesaitis AJ, and McPhail LC. Phosphorylation of p22phox is mediated by phospholipase D-dependent and -independent mechanisms: correlation of NADPH oxidase activity and p22phox phosphorylation. J Biol Chem 275: 28406-28412, 2000.
126. Rhee SG. H2O2, a necessary evil for cell signaling. Science 312: 1882-1883, 2006.
127. Roepstorff K, Rasmussen I, Sawada M, Cudre-Maroux C, Salmon P, Bokoch G, van Deurs B, and Vilhardt F. Stimulus-dependent regulation of the phagocyte NADPH oxidase by a VAV1, Rac1, and PAK1 signaling axis. J Biol Chem 283: 7983-7993, 2008.
128. Royerpokora B, Kunkel LM, Monaco AP, Goff SC, Newburger PE, Baehner RL, Cole FS, Curnutte JT, and Orkin SH. Cloning the gene for an inherited human disorder-chronic granulomatous disease-on the basis of its chromosomal location. Nature 322: 32-38, 1986.
129. Rygiel TP, Mertens AE, Strumane K, van der Kammen R, and Collard JG. The Rac activator Tiam1 prevents keratinocyte apoptosis by controlling ROS-mediated ERK phosphorylation. J Cell Sci 121: 1183-1192, 2008.
130. Sablina AA, Budanov AV, Ilyinskaya GV, Agapova LS, Kravchenko JE, and Chumakov PM. The antioxidant function of the p53 tumor suppressor. Nat Med 11: 1306-1313, 2005.
131. Salmeen A and Barford D. Functions and mechanisms of redox regulation of cysteine-based phosphatases. Antioxid Redox Signal 7: 560-577, 2005.
132. San Jose G, Bidegain J, Robador PA, Diez J, Fortuno A, and Zalba G. Insulin-induced NADPH oxidase activation promotes proliferation and matrix metalloproteinase activation in monocytes=macrophages. Free Radic Biol Med 46: 1058-1067, 2009.
133. Sanchez G, Escobar M, Pedrozo Z, Macho P, Domenech R, Hartel S, Hidalgo C, and Donoso P. Exercise and tachycardia increase NADPH oxidase and ryanodine receptor-2 activity: possible robe in cardioprotection. Cardiovasc Res 77: 380-386, 2008.
134. Savitsky PA and Finkel T. Redox regulation of Cdc25C. J Biol Chem 277: 20535-20540, 2002.
135. Serrander L, Jaquet V, Bedard K, Plastre O, Hartley O, Arnaudeau S, Demaurex N, Schlegel W, and Krause KH. NOX5 is expressed at the plasma membrane and generates superoxide in response to protein kinase C activation. Biochimie 89: 1159-1167, 2007.
136. Sharma P, Chakraborty R, Wang L, Min B, Tremblay ML, Kawahara T, Lambeth JD, and Haque SH. Redox regulation of interleukin-4 signaling. Immunity 29: 551-564, 2008.
137. Shatrov VA, Sumbayev VV, Zhou J, and Brune B. Oxidized low-density lipoprotein (oxLDL) triggers hypoxia-inducible factor-1alpha (HIF-1alpha) accumulation via redox-dependent mechanisms. Blood 101: 4847-4849, 2003.
138. Shiose A, Kuroda J, Tsuruya K, Hirai M, Hirakata H, Naito S, Hattori M, Sakaki Y, and Sumimoto H. A novel superoxide-producing NAD(P)H oxidase in kidney. J Biol Chem 276: 1417-1423, 2001.
139. Shono T, Yokoyama N, Uesaka T, Kuroda J, Takeya R, Yamasaki T, Amano T, Mizoguchi M, Suzuki SO, Niiro H, Miyamoto K, Akashi K, Iwaki T, Sumimoto H, and Sasaki T. Enhanced expression of NADPH oxidase Nox4 in human gliomas and its roles in cell proliferation and survival. Int J Cancer 123: 787-792, 2008.
140. Silverman ES and Drazen JM. The biology of 5-lipoxygenase: function, structure, and regulatory mechanisms. Proc Assoc Am Physicians 111: 525-536, 1999.
141. St-Pierre J, Buckingham JA, Roebuck SJ, and Brand MD. Topology of superoxide production from different sites in the mitochondrial electron transport chain. J Biol Chem 277: 44784-44790, 2002.
142. Sugawara M, Sugawara Y, Wen K, and Giulivi C. Generation of oxygen free radicals in thyroid cells and inhibition of thyroid peroxidase. Exp Biol Med 227: 141-146, 2002.
143. Suh YA, Arnold RS, Lassegue B, Shi J, Xu XX, Sorescu D, Chung AB, Griendling KK, and Lambeth JD. Cell transformation by the superoxide-generating oxidase Mox1. Nature 401: 79-82, 1999.
144. Suleyman, H, Demircan B, and Karagoz Y. Antiinflammatory and side effects of cyclooxygenase inhibitors. Pharmacol Rep 59: 247-258, 2007.
145. Sumimoto H, Miyano K, and Takeya R. Molecular composition and regulation of the Nox family NAD(P)H oxidases. Biochem Biophys Res Commun 338: 677-686, 2005.
146. Sumimoto H. Structure, regulation and evolution of Noxfamily NADPH oxidases that produce reactive oxygen species. FEBS J 275: 3249-3277, 2008.
147. Sun Y and Oberley LW. Redox regulation of transcriptional activators. Free Radic Biol Med 21: 335-348, 1996.
148. Szaszi K, Korda A, Wolfl J, Paclet MH, Morel F, and Ligeti E. Possible role of Rac-GTPase-activating protein in the termination of superoxide production in phagocytic cells. Free Radic Biol Med 27: 764-772, 1999.
149. Takeya R, Ueno N, Kami K, Taura M, Kohjima M, Izaki T, Nunoi H, and Sumimoto H. Novel human homologues of p47(phox) and p67(phox) participate in activation of superoxide-producing NADPH oxidases. J Biol Chem 278: 25234-25246, 2003.
150. Teahan C, Rowe P, Parker P, Totty N, and Segal AW. The X-linked chronic granulomatous disease gene codes for the beta-chain of cytochrome-b-245. Nature 327: 720-721, 1987.
151. Tirone F and Cox JA. NADPH oxidase 5 (NOX5) interacts with and is regulated by calmodulin. FEBS Lett 581: 1202-1208, 2007.
152. Tithof PK, Peters-Golden M, and Ganey PE. Distinct phospholipases A(2) regulate the release of arachidonic acid for eicosanoid production and superoxide anion generation in neutrophils. J Immunol 160: 953-960, 1998.
153. Toledano MB and Leonard WJ. Modulation of transcription factor NF-kappa B binding activity by oxidation-reduction in vitro. Proc Natl Acad Sci U S A 88: 4328-4332, 1991.
154. Torres M. Mitogen-activated protein kinase pathways in redox signaling. Front Biosci 8: d369-d391, 2003.
155. Trachootham D, Lu W, Ogasawara MA, Nilsa RD, and Huang P. Redox regulation of cell survival. Antioxid Redox Signal 10: 1343-1374, 2008.
156. Ueno N, Takeya R, Miyano R, Kikuchi H, and Sumimoto H. The NADPH oxidase Nox3 constitutively produces superoxide in a p22(Phox)-dependent manner. J Biol Chem 280: 23328-23339, 2005.
157. Utomo A, Cullere X, Glogauer M, Swat W, and Mayadas TN. Vav proteins in neutrophils are required for Fc gamma R-mediated signaling to Rac GTPases and nicotinamide adenine dinucleotide phosphate oxidase component p40(phox). J Immunol 177: 6388-6397, 2006.
158. Vandermoere F, El Yazidi-Belkoura I, Adriaenssens E, Lemoine J, and Hondermarck H. The antiapoptotic effect of fibroblast growth factor-2 is mediated through nuclear factor-kappaB activation induced via interaction between Akt and IkappaB kinase-beta in breast cancer cells. Oncogene 24: 5482-5491, 2005.
159. Vaquero EC, Edderkaoui M, Pandol SJ, Gukovsky I, and Gukovskaya AS. Reactive oxygen species produced by NAD(P)H oxidase inhibit apoptosis in pancreatic cancer cells. J Biol Chem 279: 34643-34654, 2004.
160. Vasquez-Vivar J, Kalyanaraman B, Martasek P, Hogg N, Masters BSS, Karoui H, Tordo P, and Pritchard KA. Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors. Proc Natl Acad Sci U S A 95: 9220-9225, 1998. (Pubitemid 28506212)
161. Villalba M, Bi K, Hu JR, Altman Y, Bushway P, Reits E, Neefjes J, Beire G, Abraham RT, and Altman A. Translocation of PKC0 in T cells is mediated by a nonconventional, PI3-K-and Vav-dependent pathway, but does not absolutely
162. Wang YJ, Zeigler MM, Lam GK, Hunter MG, Eubank TD, Khramtsov VV, Tridandapani S, Sen CK, Sen K, and Marsh CB. The role of the NADPH oxidase complex, p38 MAPK, and Akt in regulating human monocyte=macrophage survival. Am J Respir Cell Mol Biol 36: 68-77, 2007.
163. Wientjes FB, Hsuan JJ, Totty NF, and Segal AW. P40(phox), a 3rd cytosolic component of the activation complex of the NADPH oxidase to contain src homology 3 domains. Biochem J 296: 557-561, 1993.
164. Wientjes FB, Reeves EP, Soskic MG, Furthmayr PW, and Segal AW. The NADPH oxidase components p47(phox) and p40(phox) bind to moesin through their PX domain. Biochem Biophys Res Commun 289: 382-388, 2001.
165. Wu Y, Zu K, Warren MA, Wallace PK, and Ip C. Delineating the mechanism by which selenium deactivates Akt in prostate cancer cells. Mol Cancer Ther 5: 246-252, 2006.
166. Xia Y, Wang J, Liu TL, Yung WK, Hunter T, and Lu Z. c-Jun downregulation by HDAC3-dependent transcriptional repression promotes osmotic stress-induced cell apoptosis. Mol Cell 25: 219-232, 2007.
167. Xia Y, Wang J, Xu S, Johnson GL, Hunter T, and Lu Z. MEKK1 mediates the ubiquitination and degradation of c-Jun in response to osmotic stress. Mol Cell Biol 27: 510-517, 2007.
168. Yoshida LS and Tsunawaki S. Expression of NADPH oxidases and enhanced H(2)O(2)-generating activity in human coronary artery endothelial cells upon induction with tumor necrosis factor-alpha. Int Immunopharmacol 8: 1377-1385, 2008.
169. Yu JH, Kim KH, Kim DG, and Kim H. Diphenyleneiodonium suppresses apoptosis in cerulein-stimulated pancreatic acinar cells. Int J Biochem Cell Biol 39: 2063-2075, 2007.