Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH2-terminal kinase activation, and defects in AP-1 transcriptional activity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 7, 1997, Pages 3004-3009

  Yang, Di ^a,b   Tournier, Cathy ^a   Wysk, Mark ^a   Lu, Hong Tao ^a,b   Xu, Jie ^b   Davis, Roger J ^a   Flavell, Richard A ^a,b  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANISOMYCIN; DNA; ENZYME ACTIVATOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOTRANSFERASE; PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; CROSS BREEDING; EMBRYO; EMBRYO DEATH; ENZYME ACTIVATION; ENZYME INHIBITION; GENE DISRUPTION; GENE TARGETING; GENETIC COMPLEMENTATION; HEAT SHOCK; HETEROZYGOTE; HOMOZYGOTE; MOUSE; NONHUMAN; ONCOGENE C JUN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; EMBRYONIC AND FETAL DEVELOPMENT; ENZYME ACTIVATION; GENES, LETHAL; HETEROZYGOTE; HOMOZYGOTE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE 4; MICE; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; TRANSCRIPTION FACTOR AP-1;

ANIMALIA;

EID: 0030908341     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.7.3004     Document Type: Article

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