Hydrogen peroxide induces nuclear translocation of p53 and apoptosis in cells of oligodendroglia origin

Molecular Brain Research

Volumn 65, Issue 2, 1999, Pages 167-175

  Uberti, Daniela ^a   Yavin, Ephraim ^a   Gil, Shosh ^a   Ayasola, Kameshwar Rao ^a   Goldfinger, Naomi ^a   Rotter, Varda ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

H2O2; Oligodendrocyte; Oligodendroglia; Oxidative stress; p53; Stress; Subcellular localization; Suppressor gene

Indexed keywords

HYDROGEN PEROXIDE; PROTEIN P53;

ANIMAL CELL; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL NUCLEUS; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN TRANSPORT; RAT;

ANIMALS; APOPTOSIS; BIOLOGICAL TRANSPORT; CELL COMPARTMENTATION; CELL NUCLEUS; CYTOSOL; G0 PHASE; G1 PHASE; HYDROGEN PEROXIDE; OLIGODENDROGLIA; OXIDANTS; OXIDATIVE STRESS; RATS; SUBCELLULAR FRACTIONS; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA;

EID: 0033525375     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(98)00339-8     Document Type: Article

References (54)

1. N. Almog, V. Rotter, An insight into the life of p53: a protein coping with many functions!, BBA, in press, 1998.
2. Almog N., Rotter V. Involvement of p53 in cell differentiation and development. Biochimica and Biopysica Acta. 1333:1997;F1-F27.
3. Armstrong J.F., Kaufman M.H., Harrison D.J., Clarke A.R. High-frequency developmental abnormalities in p53-deficient mice. Curr. Biol. 5(8):1995;931-936.
4. Bailly E., Pines J., Hunter T., Bornens M. Cytoplasmatic accumulation of cyclin B1 in human cells: association with a detergent-resistant compartment and with the centrosome. J. Cell Science. 101:1992;529-545.
5. Barak Y., Juven T., Haffner R., Oren M. mdm2 expression is induced by wild type-p53 activity. EMBO J. 12(2):1993;461-468.
6. Bates S., Vousden K.H. p53 in signaling checkpoint arrest or apoptosis. Curr. Opin. Genet. and Dev. 6:1996;12-19.
7. Breder J., Ruller S., Ruller E., Schlaak M., Ven Der Bosch J. Induction of cell death by cytokines in cell cycle-synchronous tumor cell populations restricted to G1 and G2. Exp. Cell Res. 223:1996;259-267.
8. Bredesen D.E. Genetic control of neural cell apoptosis. Perspect. Dev. Neurobiol. 3:1996;101-109.
9. Brugarolas J., Chandrasekaran C., Gordon I.J., Beach D., Jacks T., Hannon J.G. Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature. 377:1995;552-557.
10. waf1/cip1 mediated by STAT1. Science. 272:1996;719-722.
11. Cross S.M., Sanchez C.A., Morgan C.A., Schimke M.K., Ramel S., Idzerda R.L., Raskind W.H., Reid B.J. A p53-dependent mouse spindle checkpoint. Science. 267:1995;1353-1356.
12. Datto M.B., Li Y., Panus J.F., Howe D.J., Xiong Y., Wang X.-F. Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism. Proc. Natl. Acad. Sci. USA. 92:1995;5545-5549.
13. 1 arrest. Cell. 76:1994;1013-1023.
14. Eizenberg O., Faber-Elman A., Gotlieb E., Oren M., Rotter V., Schwartz M. Direct involvement of p53 in programmed cell death of oligodendrocytes. The EMBO J. 14(66):1995;1136-1144.
15. Eizenberg O., Faber-Elman A., Gottlieb E., Oren M., Rotter V., Schwartz M. p53 plays a regulatory role in differentiation and apoptosis of central nervous system-associated cells. Mol. Cell. Biol. 16:1996;5178-5185.
16. El-Deiry W.S., Harper J.W., O'Connor P.M., Velculescu V.E., Canman C.E., Jackman J., Pietenpol J.A., Burrell M., Hill D.E., Wang Y. WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res. 54:1994;1169-1174.
17. Gottlieb M.T., Oren M. p53 in growth control and neoplasia. BBA. 1287:1996;77-102.
18. Halevy O. p53 gene is up-regulated during skeletal muscle cell differentiation. Biochem. Biophy. Res. Comm. 192(2):1993;714-719.
19. B. Halliwell, J.M.C. Gutteridge, Free Radicals in Biology and Medicine, Clarendon Press, Oxford, 1989.
20. Harlow E., Crawford L.V., Pim D.C., Williamson N.M. Monoclonal antibodies specific for simian virus 40 tumor antigen. J. Virol. 39:1981;861-869.
21. waf1 expression and enhances apoptotic cell death in G1-arrested cells of oligodendroglia origin, submitted.
22. Kastan M. Signaling to p53 - where does it all start? Bioessays. 18:1996;617-619.
23. Kim Y.S., Kim S.U. Oligodendroglial cell death induced by oxygen radicals and its protation by catalase. J. Neurosci. Res. 29:1991;100-106.
24. Ko J.L., Prives C. p53: puzzle and paradigm. Genes Dev. 10:1996;1054-1072.
25. Komarova E.A., Zelnick C.R., Chin D., Zeremski M., Gleiberman A.S., Bacus S., Gudkov A.V. Intracellular localization of p53 tumor suppressor protein in gamma-irradiated cells is cell cycle regulated and determined by the nucleus. Cancer Res. 57:1997;5217-5220.
26. Lane D.P. p53, guardian of the genome. Nature. 358:1992;15-16.
27. Lee S., Elenbaas B., Levine A., Griffith J. p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches. Cell. 81:1995;1013-1020.
28. Levine J.A. p53, the cellular gatekeeper for growth and division. Cell. 88:1997;323-331.
29. Livingstone L.R., White A., Sprouse J., Livanos E., Jacks T., Tlsty T.D. Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53. Cell. 70:1992;923-935.
30. Macleod K.F., Sherry N., Hannon G., Beach D., Tokino T., Kinzler K., Vogelstein B., Jacks T. p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage. Genes Dev. 9(8):1995;935-944.
31. Mazarakis N.D., Edwards A.D., Mehmet H. Apoptosis in neural development and disease. Arch. Dis. Child Fetal Neonatal Ed. 77:1997;F165-F170.
32. Michieli P., Chedid M., Lin D., Pierce J.H., Mercer W.E., Givol D. Induction of WAF1/CIP1 by a p53-independent pathway. Cancer Res. 54:1994;3391-3395.
33. Momand J., Zambetti G.P., Olson D.C., George D., Levine A.J. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell. 69:1992;1237-1245.
34. Naruse I., Keino H. Apoptosis in the developing CNS. Prog. Neurobiol. 47:1995;135-155.
35. cip1/waf1 at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication. Mol. and Cell. Biology. 18(1):1998;629-643.
36. Olson D.C., Marechal V., Momand J., Chen J., Romocki C., Levine A.J. Identification and characterization of multiple mdm-2 proteins and mdm-2-p53 protein complexes. Oncogene. 8:1993;2353-2360.
37. Oppenheim R.W. Cell death during development of the nervous system. Ann. Rev. Neurosci. 14:1991;453-501.
38. Ostermeyer A.G., Runko E., Winkfield B., Ahn B., Moll U.M. Cytoplasmically sequestered wild-type p53 protein in neuroblastoma is relocated to the nucleus by a C-terminal peptide. Proc. Natl. Acad. Sci. USA. 93:1996;15190-15194.
39. Pines J., Hunter T. Human cyclin A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport. J. Cell Biology. 115(1):1991;1-17.
40. Raff M.C. Social controls on cell survival and cell death. Nature. 356:1992;397-400.
41. Richter-Landsberg C., Heinrich M. OLN-93: a new permanent oligodendroglia cell line derived from primary rat brain glial cultures. J. Neuroscience Res. 45:1996;161-173.
42. Roth J., Dobbelstein M., Freedman D.A., Shenk T., Levine A.J. Nuclear-cytoplasmatic shuttling of the hmd2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein. EMBO J. 17(2):1998;554-564.
43. Sah V.P., Attardi L.D., Mulligan G.J., Williams B.O., Bronson R.T., Jacks T. A subset of p53-deficient embryos exhibit exencephaly. Nat. Genetics. 10:1995;175-180.
44. Sanchez Y., Elledge J.S. Stopped for repairs. BioAssays. 17(6):1995;545-548.
45. Shaulsky G., Goldfinger N., Ben-Ze'ev A., Rotter V. Nuclear accumulation of p53 protein is mediated by several nuclear localization signals and plays a role in tumorigenesis. Mol. Cell. Biol. 10:1990;6565-6577.
46. Shaulsky G., Goldfinger N., Peled A., Rotter V. Involvement of wild type p53 in pre-B cell differentiation in vitro. Proc. Natl. Acad. Sci. USA. 88:1991;8982-8986.
47. Shaulsky G., Goldfinger N., Tosky M.S., Levine A.J., Rotter V. Nuclear localization is essential for the activity of p53 protein. Oncogene. 6:1991;2055-2065.
48. Soddu S., Blandino G., Scardigli R., Coen S., Marchetti A., Rizzo M.G., Bossi G., Cimino L., Crescenzi M., Sacchi A. Interference with p53 protein inhibits hematopoietic and muscle differentiation. J. Cell Biol. 134:1996;1-12.
49. Spandau D.F. Distinct conformations of p53 are observed in different stages of keratinocyte differentiation. Oncogene. 9:1994;1861-1868.
50. Stein G.S., Stein J.L., Lian J.B., Last T.J., Owen T.A., McCabe L. Synchronization of normal diploid and transformed mammalian cells. Cell Biology: a laboratory handbook. 1:1988;253-260.
51. Stewart N., Hicks G.G., Paraskevas F., Mowat M. Evidence for a second cell cycle block at G2/M by p53. Oncogene. 10:1994;109-115.
52. Uberti D., Belloni M., Grilli M., Spano P., Memo M. Induction of the tumor suppressor phosphoprotein p53 in the apoptosis of cultured rat cerebellar granule neurones triggered by excitatory amino acid. Eur. J. Neurosci. 10:1998;246-254.
53. Wu X.W., Bayle J.H., Olson D., Levine A.J. The p53 mdm-2 autoregulatory feedback loop. Genes Dev. 7(7A):1993;1126-1132.
54. Zhu Y., Bradbury D., Russel N. Wild type p53 is required for apoptosis induced by growth factor deprivation in factor-dependent leukaemic cells. Br. J. Cancer. 69:1994;468-472.