메뉴 건너뛰기




Volumn 11, Issue 4, 2009, Pages 268-280

Modelling Parkinson's Disease in Drosophila

Author keywords

Synuclein; Drosophila; Oxidative stress; Parkin; Parkinson's disease; PINK1; Rotenone

Indexed keywords

ALPHA SYNUCLEIN; DJ 1 PROTEIN; DOPAMINE; ENZYME; LEUCINE RICH REPEAT KINASE 2; NEUROTOXIN; PARAQUAT; PARKIN; PTEN INDUCED PUTATIVE KINASE 1; SERINE PROTEINASE OMI; UNCLASSIFIED DRUG;

EID: 72949108454     PISSN: 15351084     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12017-009-8098-6     Document Type: Review
Times cited : (65)

References (82)
  • 3
    • 0036468432 scopus 로고    scopus 로고
    • Chaperone suppression of α-synuclein toxicity in a Drosophila model for Parkinson's disease
    • DOI 10.1126/science.1067389
    • PK Auluck HY Chan JQ Trojanowski, et al. 2002 Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease Science 295 865 868 10.1126/science.1067389 11823645 (Pubitemid 34118369)
    • (2002) Science , vol.295 , Issue.5556 , pp. 865-868
    • Auluck, P.K.1    Chan, H.Y.E.2    Trojanowski, J.Q.3    Lee, V.M.-Y.4    Bonini, N.M.5
  • 4
    • 13244267202 scopus 로고    scopus 로고
    • Mechanisms of suppression of α-synuclein neurotoxicity by geldanamycin in Drosophila
    • DOI 10.1074/jbc.M412106200
    • PK Auluck MC Meulener NM Bonini 2005 Mechanisms of suppression of {alpha}-synuclein neurotoxicity by geldanamycin in Drosophila The Journal of Biological Chemistry 280 2873 2878 10.1074/jbc.M412106200 15556931 (Pubitemid 40189396)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.4 , pp. 2873-2878
    • Auluck, P.K.1    Meulener, M.C.2    Bonini, N.M.3
  • 5
    • 0345304849 scopus 로고    scopus 로고
    • Genomic organization and expression of parkin in Drosophila melanogaster
    • 14646593
    • YJ Bae KS Park SJ Kang 2003 Genomic organization and expression of parkin in Drosophila melanogaster Experimental and Molecular Medicine 35 393 402 14646593
    • (2003) Experimental and Molecular Medicine , vol.35 , pp. 393-402
    • Bae, Y.J.1    Park, K.S.2    Kang, S.J.3
  • 6
    • 0036710567 scopus 로고    scopus 로고
    • Glutathione, iron and Parkinson's disease
    • DOI 10.1016/S0006-2952(02)01174-7, PII S0006295202011747
    • S Bharath M Hsu D Kaur, et al. 2002 Glutathione, iron and Parkinson's disease Biochemical Pharmacology 64 1037 1048 10.1016/S0006-2952(02)01174-7 12213603 (Pubitemid 35232279)
    • (2002) Biochemical Pharmacology , vol.64 , Issue.5-6 , pp. 1037-1048
    • Bharath, S.1    Hsu, M.2    Kaur, D.3    Rajagopalan, S.4    Andersen, J.K.5
  • 7
    • 40849130108 scopus 로고    scopus 로고
    • Superoxide dismutase overexpression protects dopaminergic neurons in a Drosophila model of Parkinson's disease
    • 10.1016/j.nbd.2007.11.013
    • JA Botella F Bayersdorfer S Schneuwly 2008 Superoxide dismutase overexpression protects dopaminergic neurons in a Drosophila model of Parkinson's disease Neurobiology of Diseases 30 65 73 10.1016/j.nbd.2007.11.013
    • (2008) Neurobiology of Diseases , vol.30 , pp. 65-73
    • Botella, J.A.1    Bayersdorfer, F.2    Schneuwly, S.3
  • 8
    • 26844505808 scopus 로고    scopus 로고
    • Toxin-induced models of Parkinson's disease
    • DOI 10.1602/neurorx.2.3.484
    • J Bové D Prou C Perier, et al. 2005 Toxin-induced models of Parkinson's disease NeuroRx 2 484 494 10.1602/neurorx.2.3.484 16389312 (Pubitemid 41444882)
    • (2005) NeuroRx , vol.2 , Issue.3 , pp. 484-494
    • Bove, J.1    Prou, D.2    Perier, C.3    Przedborski, S.4
  • 9
    • 0027160708 scopus 로고
    • Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
    • 8223268
    • AH Brand N Perrimon 1993 Targeted gene expression as a means of altering cell fates and generating dominant phenotypes Development 118 401 415 8223268
    • (1993) Development , vol.118 , pp. 401-415
    • Brand, A.H.1    Perrimon, N.2
  • 10
    • 34347242465 scopus 로고    scopus 로고
    • Mitochondria are a major source of paraquat-induced reactive oxygen species production in the brain
    • DOI 10.1074/jbc.M700827200
    • PR Castello DA Drechsel M Patel 2007 Mitochondria are a major source of paraquat-induced reactive oxygen species production in the brain The Journal of Biological Chemistry 282 14186 14193 10.1074/jbc.M700827200 17389593 (Pubitemid 47100444)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.19 , pp. 14186-14193
    • Castello, P.R.1    Drechsel, D.A.2    Patel, M.3
  • 13
    • 17844406856 scopus 로고    scopus 로고
    • α-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease
    • DOI 10.1038/nn1443
    • L Chen MB Feany 2005 Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease Nature Neuroscience 8 657 663 10.1038/nn1443 15834418 (Pubitemid 40594208)
    • (2005) Nature Neuroscience , vol.8 , Issue.5 , pp. 657-663
    • Chen, L.1    Feany, M.B.2
  • 14
    • 33745589773 scopus 로고    scopus 로고
    • Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
    • DOI 10.1038/nature04779, PII N04779
    • IE Clark MW Dodson C Jiang, et al. 2006 Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin Nature 441 1162 1166 10.1038/nature04779 16672981 (Pubitemid 43990738)
    • (2006) Nature , vol.441 , Issue.7097 , pp. 1162-1166
    • Clark, I.E.1    Dodson, M.W.2    Jiang, C.3    Cao, J.H.4    Huh, J.R.5    Seol, J.H.6    Yoo, S.J.7    Hay, B.A.8    Guo, M.9
  • 16
    • 10044292870 scopus 로고    scopus 로고
    • Chronic exposure to rotenone models sporadic Parkinson's disease in Drosophila melanogaster
    • DOI 10.1523/JNEUROSCI.2993-04.2004
    • H Coulom S Birman 2004 Chronic exposure to rotenone models sporadic Parkinson's disease in Drosophila melanogaster Journal of Neuroscience 24 10993 10998 10.1523/JNEUROSCI.2993-04.2004 15574749 (Pubitemid 39602410)
    • (2004) Journal of Neuroscience , vol.24 , Issue.48 , pp. 10993-10998
    • Coulom, H.1    Birman, S.2
  • 18
    • 55749090654 scopus 로고    scopus 로고
    • The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila
    • 10.1073/pnas.0803998105 18799731
    • H Deng MW Dodson H Huang, et al. 2008 The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila Proceedings of the National Academy of Sciences of the United States of America 105 14503 14508 10.1073/pnas.0803998105 18799731
    • (2008) Proceedings of the National Academy of Sciences of the United States of America , vol.105 , pp. 14503-14508
    • Deng, H.1    Dodson, M.W.2    Huang, H.3
  • 19
    • 20444372698 scopus 로고    scopus 로고
    • α-synuclein targets the plasma membrane via the secretory pathway and induces toxicity in yeast
    • DOI 10.1534/genetics.104.035493
    • C Dixon N Mathias RM Zweig, et al. 2005 Alpha-synuclein targets the plasma membrane via the secretory pathway and induces toxicity in yeast Genetics 170 47 59 10.1534/genetics.104.035493 15744056 (Pubitemid 40799970)
    • (2005) Genetics , vol.170 , Issue.1 , pp. 47-59
    • Dixon, C.1    Mathias, N.2    Zweig, R.M.3    Davis, D.A.4    Gross, D.S.5
  • 20
    • 0037413452 scopus 로고    scopus 로고
    • Apoptosis-inducing neurotoxicity of dopamine and its metabolites via reactive quinone generation in neuroblastoma cells
    • 12495814
    • M Emdadul-Haque M Asanuma Y Higashi, et al. 2003 Apoptosis-inducing neurotoxicity of dopamine and its metabolites via reactive quinone generation in neuroblastoma cells Biochimica et Biophysica Acta 1619 39 52 12495814
    • (2003) Biochimica et Biophysica Acta , vol.1619 , pp. 39-52
    • Emdadul-Haque, M.1    Asanuma, M.2    Higashi, Y.3
  • 21
    • 0034704752 scopus 로고    scopus 로고
    • A Drosophila model of Parkinson's disease
    • DOI 10.1038/35006074
    • MB Feany WW Bender 2000 A Drosophila model of Parkinson's disease Nature 404 394 398 10.1038/35006074 10746727 (Pubitemid 30164341)
    • (2000) Nature , vol.404 , Issue.6776 , pp. 394-398
    • Feany, M.B.1    Bender, W.W.2
  • 23
    • 0037370716 scopus 로고    scopus 로고
    • Targeted gene expression in Drosophila dopaminergic cells using regulatory sequences from tyrosine hydroxylase
    • DOI 10.1002/neu.10185
    • F Friggi-Grelin H Coulom M Meller D Gomez J Hirsh S Birman 2003 Targeted gene expression in Drosophila dopaminergic cells using regulatory sequences from tyrosine hydroxylase Journal of Neurobiology 54 618 627 10.1002/neu.10185 12555273 (Pubitemid 36232667)
    • (2003) Journal of Neurobiology , vol.54 , Issue.4 , pp. 618-627
    • Friggi-Grelin, F.1    Coulom, H.2    Meller, M.3    Gomez, D.4    Hirsh, J.5    Birman, S.6
  • 24
    • 0036713779 scopus 로고    scopus 로고
    • Microscopic analysis of polymerization dynamics with individual actin filaments
    • DOI 10.1038/ncb841
    • H Fujiwara M Hasegawa N Dohmae, et al. 2002 alpha-Synuclein is phosphorylated in synucleinopathy lesions Nature Cell Biology 4 160 164 10.1038/ncb841 11813001 (Pubitemid 34993702)
    • (2002) Nature Cell Biology , vol.4 , Issue.9 , pp. 666-673
    • Fujiwara, I.1    Takahashi, S.2    Tadakuma, H.3    Funatsu, T.4    Ishiwata, S.5
  • 25
    • 15544380902 scopus 로고    scopus 로고
    • Genetic and genomic studies of Drosophila parkin mutants implicate oxidative stress and innate immune responses in pathogenesis
    • DOI 10.1093/hmg/ddi074
    • JC Greene AJ Whitworth LA Andrews, et al. 2005 Genetic and genomic studies of Drosophila parkin mutants implicate oxidative stress and innate immune responses in pathogenesis Human Molecular Genetics 14 799 811 10.1093/hmg/ddi074 15689351 (Pubitemid 40403276)
    • (2005) Human Molecular Genetics , vol.14 , Issue.6 , pp. 799-811
    • Greene, J.C.1    Whitworth, A.J.2    Andrews, L.A.3    Parker, T.J.4    Pallanck, L.J.5
  • 27
    • 67349185546 scopus 로고    scopus 로고
    • Hyperoxia-induced neurodegeneration as a tool to identify neuroprotective genes in Drosophila melanogaster
    • 10.1016/j.freeradbiomed.2009.03.025 19345730
    • C Gruenewald JA Botella F Bayersdorfer, et al. 2009 Hyperoxia-induced neurodegeneration as a tool to identify neuroprotective genes in Drosophila melanogaster Free Radical Biology and Medicine 46 1668 1676 10.1016/j. freeradbiomed.2009.03.025 19345730
    • (2009) Free Radical Biology and Medicine , vol.46 , pp. 1668-1676
    • Gruenewald, C.1    Botella, J.A.2    Bayersdorfer, F.3
  • 28
    • 0035132962 scopus 로고    scopus 로고
    • Immunodetection of Parkin protein in vertebrate and invertebrate brains: A comparative study using specific antibodies
    • DOI 10.1016/S0891-0618(00)00111-3, PII S0891061800001113
    • JM Horowitz VA Vernace JJ Myers, et al. 2001 Immunodetection of Parkin protein in vertebrate and invertebrate brains: A comparative study using specific antibodies Journal of Chemical Neuroanatomy 21 75 93 10.1016/S0891-0618(00)00111-3 11173222 (Pubitemid 32155393)
    • (2001) Journal of Chemical Neuroanatomy , vol.21 , Issue.1 , pp. 75-93
    • Horowitz, J.M.1    Vernace, V.A.2    Myers, J.3    Stachowiak, M.K.4    Hanlon, D.W.5    Fraley, G.S.6    Torres, G.7
  • 29
    • 51949090816 scopus 로고    scopus 로고
    • Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila
    • 10.1038/emboj.2008.163 18701920
    • Y Imai S Gehrke HQ Wang, et al. 2008 Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila EMBO Journal 27 2432 2443 10.1038/emboj.2008.163 18701920
    • (2008) EMBO Journal , vol.27 , pp. 2432-2443
    • Imai, Y.1    Gehrke, S.2    Wang, H.Q.3
  • 31
    • 56049091236 scopus 로고    scopus 로고
    • PINK1 controls mitochondrial localization of Parkin through direct phosphorylation
    • 10.1016/j.bbrc.2008.10.104 18957282
    • Y Kim J Park S Kim, et al. 2008 PINK1 controls mitochondrial localization of Parkin through direct phosphorylation Biochemical and Biophysical Research Communications 377 975 980 10.1016/j.bbrc.2008.10.104 18957282
    • (2008) Biochemical and Biophysical Research Communications , vol.377 , pp. 975-980
    • Kim, Y.1    Park, J.2    Kim, S.3
  • 33
    • 2942620074 scopus 로고    scopus 로고
    • Hsp70 reduces α-synuclein aggregation and toxicity
    • DOI 10.1074/jbc.M400255200
    • J Klucken Y Shin E Masliah, et al. 2004 Hsp70 reduces alpha-synuclein aggregation and toxicity The Journal of Biological Chemistry 279 25497 25502 10.1074/jbc.M400255200 15044495 (Pubitemid 38756808)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.24 , pp. 25497-25502
    • Klucken, J.1    Shin, Y.2    Masliah, E.3    Hyman, B.T.4    McLean, P.J.5
  • 34
    • 0031990490 scopus 로고    scopus 로고
    • Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease
    • 10.1038/ng0298-106 9462735
    • R Kruger W Kuhn T Muller, et al. 1998 Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease Nature Genetics 18 106 108 10.1038/ng0298-106 9462735
    • (1998) Nature Genetics , vol.18 , pp. 106-108
    • Kruger, R.1    Kuhn, W.2    Muller, T.3
  • 35
    • 34548021452 scopus 로고    scopus 로고
    • Drosophila DJ-1 mutants are sensitive to oxidative stress and show reduced lifespan and motor deficits
    • DOI 10.1016/j.gene.2007.06.013, PII S0378111907003241
    • E Lavara-Culebras N Paricio 2007 Drosophila DJ-1 mutants are sensitive to oxidative stress and show reduced lifespan and motor deficits Gene 400 158 165 10.1016/j.gene.2007.06.013 17651920 (Pubitemid 47284741)
    • (2007) Gene , vol.400 , Issue.1-2 , pp. 158-165
    • Lavara-Culebras, E.1    Paricio, N.2
  • 36
    • 34248574535 scopus 로고    scopus 로고
    • Loss of LRRK2/PARK8 induces degeneration of dopaminergic neurons in Drosophila
    • DOI 10.1016/j.bbrc.2007.04.156, PII S0006291X07008972
    • SB Lee W Kim S Lee, et al. 2007 Loss of LRRK2/PARK8 induces degeneration of dopaminergic neurons in Drosophila Biochemical and Biophysical Research Communications 358 534 539 10.1016/j.bbrc.2007.04.156 17498648 (Pubitemid 46755736)
    • (2007) Biochemical and Biophysical Research Communications , vol.358 , Issue.2 , pp. 534-539
    • Lee, S.B.1    Kim, W.2    Lee, S.3    Chung, J.4
  • 37
    • 51349166968 scopus 로고    scopus 로고
    • Wild-type LRRK2 but not its mutant attenuates stress-induced cell death via ERK pathway
    • 10.1016/j.nbd.2008.06.016
    • AK Liou RK Leak L Li, et al. 2008 Wild-type LRRK2 but not its mutant attenuates stress-induced cell death via ERK pathway Neurobiology of Diseases 32 116 124 10.1016/j.nbd.2008.06.016
    • (2008) Neurobiology of Diseases , vol.32 , pp. 116-124
    • Liou, A.K.1    Leak, R.K.2    Li, L.3
  • 39
    • 0036797552 scopus 로고    scopus 로고
    • Impaired dopamine storage resulting from alpha-synuclein mutations may contribute to the pathogenesis of Parkinson's disease
    • 10.1093/hmg/11.20.2395 12351575
    • J Lotharius P Brundin 2002 Impaired dopamine storage resulting from alpha-synuclein mutations may contribute to the pathogenesis of Parkinson's disease Human Molecular Genetics 11 2395 2407 10.1093/hmg/11.20.2395 12351575
    • (2002) Human Molecular Genetics , vol.11 , pp. 2395-2407
    • Lotharius, J.1    Brundin, P.2
  • 41
    • 24044506249 scopus 로고    scopus 로고
    • Roles of Drosophila DJ-1 in survival of dopaminergic neurons and oxidative stress
    • DOI 10.1016/j.cub.2005.07.036, PII S0960982205007918
    • FM Menzies SC Yenisetti KT Min 2005 Roles of Drosophila DJ-1 in survival of dopaminergic neurons and oxidative stress Current Biology 15 1578 1582 10.1016/j.cub.2005.07.036 16139214 (Pubitemid 41219598)
    • (2005) Current Biology , vol.15 , Issue.17 , pp. 1578-1582
    • Menzies, F.M.1    Yenisetti, S.C.2    Min, K.-T.3
  • 42
    • 24044472010 scopus 로고    scopus 로고
    • Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease
    • DOI 10.1016/j.cub.2005.07.064, PII S0960982205008481
    • M Meulener AJ Whitworth CE Armstrong-Gold, et al. 2005 Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease Current Biology 15 1572 1577 10.1016/j.cub.2005.07.064 16139213 (Pubitemid 41219597)
    • (2005) Current Biology , vol.15 , Issue.17 , pp. 1572-1577
    • Meulener, M.1    Whitworth, A.J.2    Armstrong-Gold, C.E.3    Rizzu, P.4    Heutink, P.5    Wes, P.D.6    Pallanck, L.J.7    Bonini, N.M.8
  • 45
    • 58149314211 scopus 로고    scopus 로고
    • Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
    • 10.1083/jcb.200809125 19029340
    • D Narendra A Tanaka DF Suen, et al. 2008 Parkin is recruited selectively to impaired mitochondria and promotes their autophagy Journal of Cell Biology 183 795 803 10.1083/jcb.200809125 19029340
    • (2008) Journal of Cell Biology , vol.183 , pp. 795-803
    • Narendra, D.1    Tanaka, A.2    Suen, D.F.3
  • 46
    • 67650243261 scopus 로고    scopus 로고
    • Parkin-induced mitophagy in the pathogenesis of Parkinson disease
    • 19377297
    • D Narendra A Tanaka DF Suen, et al. 2009 Parkin-induced mitophagy in the pathogenesis of Parkinson disease Autophagy 5 706 708 19377297
    • (2009) Autophagy , vol.5 , pp. 706-708
    • Narendra, D.1    Tanaka, A.2    Suen, D.F.3
  • 47
    • 0026790115 scopus 로고
    • Aminergic neurons in the brain of blowflies and Drosophila: Dopamine- and tyrosine hydroxylase-immunoreactive neurons and their relationship with putative histaminergic neurons
    • 10.1007/BF00318701 1346506
    • DR Nässel K Elekes 1992 Aminergic neurons in the brain of blowflies and Drosophila: Dopamine- and tyrosine hydroxylase-immunoreactive neurons and their relationship with putative histaminergic neurons Cell and Tissue Research 267 147 167 10.1007/BF00318701 1346506
    • (1992) Cell and Tissue Research , vol.267 , pp. 147-167
    • Nässel, D.R.1    Elekes, K.2
  • 49
    • 27144519984 scopus 로고    scopus 로고
    • Drosophila DJ-1 mutants show oxidative stress-sensitive locomotive dysfunction
    • DOI 10.1016/j.gene.2005.06.040, PII S0378111905004336
    • J Park SY Kim GH Cha, et al. 2005 Drosophila DJ-1 mutants show oxidative stress-sensitive locomotive dysfunction Gene 361 133 139 10.1016/j.gene.2005.06. 040 16203113 (Pubitemid 41506941)
    • (2005) Gene , vol.361 , Issue.1-2 , pp. 133-139
    • Park, J.1    Sung, Y.K.2    Cha, G.-H.3    Sung, B.L.4    Kim, S.5    Chung, J.6
  • 50
    • 57749194390 scopus 로고    scopus 로고
    • The PINK1-Parkin pathway is involved in the regulation of mitochondrial remodeling process
    • 10.1016/j.bbrc.2008.11.086 19056353
    • J Park G Lee J Chung 2009 The PINK1-Parkin pathway is involved in the regulation of mitochondrial remodeling process Biochemical and Biophysical Research Communications 378 518 523 10.1016/j.bbrc.2008.11.086 19056353
    • (2009) Biochemical and Biophysical Research Communications , vol.378 , pp. 518-523
    • Park, J.1    Lee, G.2    Chung, J.3
  • 52
    • 36248929304 scopus 로고    scopus 로고
    • Disruption of dopamine homeostasis underlies selective neurodegeneration mediated by α-synuclein
    • DOI 10.1111/j.1460-9568.2007.05929.x
    • SS Park EM Schulz D Lee 2007 Disruption of dopamine homeostasis underlies selective neurodegeneration mediated by alpha-synuclein European Journal of Neuroscience 26 3104 3112 10.1111/j.1460-9568.2007.05929.x 18005066 (Pubitemid 350135175)
    • (2007) European Journal of Neuroscience , vol.26 , Issue.11 , pp. 3104-3112
    • Park, S.S.1    Schulz, E.M.2    Lee, D.3
  • 53
    • 0036137083 scopus 로고    scopus 로고
    • Effects of pharmacological agents upon a transgenic model of Parkinson's disease in Drosophila melanogaster
    • DOI 10.1124/jpet.300.1.91
    • RG Pendleton F Parvez M Sayed, et al. 2002 Effects of pharmacological agents upon a transgenic model of Parkinson's disease in Drosophila melanogaster Journal of Pharmacology and Experimental Therapeutics 300 91 96 10.1124/jpet.300.1.91 11752102 (Pubitemid 34028513)
    • (2002) Journal of Pharmacology and Experimental Therapeutics , vol.300 , Issue.1 , pp. 91-96
    • Pendleton, R.G.1    Parvez, F.2    Sayed, M.3    Hillman, R.4
  • 54
    • 18544362489 scopus 로고    scopus 로고
    • Whole-mount analysis reveals normal numbers of dopaminergic neurons following misexpression of α-Synuclein in Drosophila
    • DOI 10.1002/gene.20106
    • Y Pesah H Burgess B Middlebrooks, et al. 2005 Whole-mount analysis reveals normal numbers of dopaminergic neurons following misexpression of alpha-Synuclein in Drosophila Genesis 41 154 159 10.1002/gene.20106 15789427 (Pubitemid 40656685)
    • (2005) Genesis , vol.41 , Issue.4 , pp. 154-159
    • Pesah, Y.1    Burgess, H.2    Middlebrooks, B.3    Ronningen, K.4    Prosser, J.5    Tirunagaru, V.6    Zysk, J.7    Mardon, G.8
  • 57
    • 33846898753 scopus 로고    scopus 로고
    • The Drosophila parkin homologue is required for normal mitochondrial dynamics during spermiogenesis
    • DOI 10.1016/j.ydbio.2006.10.038, PII S0012160606013339
    • MG Riparbelli G Callaini 2007 The Drosophila parkin homologue is required for normal mitochondrial dynamics during spermiogenesis Developmental Biology 303 108 120 10.1016/j.ydbio.2006.10.038 17123504 (Pubitemid 46241091)
    • (2007) Developmental Biology , vol.303 , Issue.1 , pp. 108-120
    • Riparbelli, M.G.1    Callaini, G.2
  • 58
    • 53749093969 scopus 로고    scopus 로고
    • Genetic variation of Omi/HtrA2 and Parkinson's disease
    • 10.1016/j.parkreldis.2008.08.003 18790661
    • OA Ross AI Soto C Vilariño-Güell, et al. 2008 Genetic variation of Omi/HtrA2 and Parkinson's disease Parkinsonism and Related Disorders 14 539 543 10.1016/j.parkreldis.2008.08.003 18790661
    • (2008) Parkinsonism and Related Disorders , vol.14 , pp. 539-543
    • Ross, O.A.1    Soto, A.I.2    Vilariño-Güell, C.3
  • 60
    • 0037229425 scopus 로고    scopus 로고
    • Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and α-synuclein aggregation
    • DOI 10.1006/exnr.2002.8072
    • TB Sherer JH Kim R Betarbet, et al. 2003 Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation Experimental Neurology 179 9 16 10.1006/exnr.2002.8072 12504863 (Pubitemid 36062614)
    • (2003) Experimental Neurology , vol.179 , Issue.1 , pp. 9-16
    • Sherer, T.B.1    Kim, J.-H.2    Betarbet, R.3    Greenamyre, J.T.4
  • 61
    • 45749135862 scopus 로고    scopus 로고
    • Sequencing analysis of OMI/HTRA2 shows previously reported pathogenic mutations in neurologically normal controls
    • DOI 10.1093/hmg/ddn096
    • J Simón-Sánchez AB Singleton 2008 Sequencing analysis of OMI/HTRA2 shows previously reported pathogenic mutations in neurologically normal controls Human Molecular Genetics 17 1988 1993 10.1093/hmg/ddn096 18364387 (Pubitemid 351865847)
    • (2008) Human Molecular Genetics , vol.17 , Issue.13 , pp. 1988-1993
    • Simon-Sanchez, J.1    Singleton, A.B.2
  • 64
    • 57149110259 scopus 로고    scopus 로고
    • Pink1 suppresses alpha-synuclein-induced phenotypes in a Drosophila model of Parkinson's disease
    • 10.1139/G08-085 19088817
    • AM Todd BE Staveley 2008 Pink1 suppresses alpha-synuclein-induced phenotypes in a Drosophila model of Parkinson's disease Genome 51 1040 1046 10.1139/G08-085 19088817
    • (2008) Genome , vol.51 , pp. 1040-1046
    • Todd, A.M.1    Staveley, B.E.2
  • 65
    • 38349014710 scopus 로고    scopus 로고
    • Induction of the phase II detoxification pathway suppresses neuron loss in Drosophila models of Parkinson's disease
    • 10.1523/JNEUROSCI.4778-07.2008 18184789
    • K Trinh K Moore PD Wes, et al. 2008 Induction of the phase II detoxification pathway suppresses neuron loss in Drosophila models of Parkinson's disease Journal of Neuroscience 28 465 472 10.1523/JNEUROSCI.4778- 07.2008 18184789
    • (2008) Journal of Neuroscience , vol.28 , pp. 465-472
    • Trinh, K.1    Moore, K.2    Wes, P.D.3
  • 67
    • 34547885021 scopus 로고    scopus 로고
    • Drosophila overexpressing parkin R275W mutant exhibits dopaminergic neuron degeneration and mitochondrial abnormalities
    • DOI 10.1523/JNEUROSCI.0218-07.2007
    • C Wang R Lu X Ouyang, et al. 2007 Drosophila overexpressing parkin R275W mutant exhibits dopaminergic neuron degeneration and mitochondrial abnormalities Journal of Neuroscience 27 8563 8570 10.1523/JNEUROSCI.0218-07.2007 17687034 (Pubitemid 47254271)
    • (2007) Journal of Neuroscience , vol.27 , Issue.32 , pp. 8563-8570
    • Wang, C.1    Lu, R.2    Ouyang, X.3    Ho, M.W.L.4    Chia, W.5    Yu, F.6    Lim, K.-L.7
  • 69
    • 41549124987 scopus 로고    scopus 로고
    • Dispensable role of Drosophila ortholog of LRRK2 kinase activity in survival of dopaminergic neurons
    • 10.1186/1750-1326-3-3 18257932
    • D Wang B Tang G Zhao, et al. 2008 Dispensable role of Drosophila ortholog of LRRK2 kinase activity in survival of dopaminergic neurons Molecular Neurodegeneration 3 3 10.1186/1750-1326-3-3 18257932
    • (2008) Molecular Neurodegeneration , vol.3 , pp. 3
    • Wang, D.1    Tang, B.2    Zhao, G.3
  • 70
    • 0032727617 scopus 로고    scopus 로고
    • Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70
    • 10.1038/70532 10581028
    • JM Warrick HY Chan GL Gray-Board, et al. 1999 Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70 Nature Genetics 23 425 428 10.1038/70532 10581028
    • (1999) Nature Genetics , vol.23 , pp. 425-428
    • Warrick, J.M.1    Chan, H.Y.2    Gray-Board, G.L.3
  • 71
    • 36349025347 scopus 로고    scopus 로고
    • Methionine sulfoxide reductase A and a dietary supplement S-methyl-L-cysteine prevent Parkinson's-like symptoms
    • DOI 10.1523/JNEUROSCI.0322-07.2007
    • R Wassef R Haenold A Hansel, et al. 2007 Methionine sulfoxide reductase A and a dietary supplement S-methyl-l-cysteine prevent Parkinson's-like symptoms Journal of Neuroscience 27 12808 12816 10.1523/JNEUROSCI.0322-07.2007 18032652 (Pubitemid 350159591)
    • (2007) Journal of Neuroscience , vol.27 , Issue.47 , pp. 12808-12816
    • Wassef, R.1    Haenold, R.2    Hansel, A.3    Brot, N.4    Heinemann, S.H.5    Hoshi, T.6
  • 72
    • 58149397651 scopus 로고    scopus 로고
    • Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin
    • 10.1242/dmm.000109 19048081
    • AJ Whitworth JR Lee VM Ho, et al. 2008 Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin Disease Models and Mechanisms 1 168 174 10.1242/dmm.000109 19048081
    • (2008) Disease Models and Mechanisms , vol.1 , pp. 168-174
    • Whitworth, A.J.1    Lee, J.R.2    Ho, V.M.3
  • 74
    • 33644862373 scopus 로고    scopus 로고
    • Drosophila models pioneer a new approach to drug discovery for Parkinson's disease
    • DOI 10.1016/S1359-6446(05)03693-7, PII S1359644605036937
    • AJ Whitworth PD Wes LJ Pallanck 2006 Drosophila models pioneer a new approach to drug discovery for Parkinson's disease Drug Discovery Today 11 119 126 10.1016/S1359-6446(05)03693-7 16533709 (Pubitemid 43375962)
    • (2006) Drug Discovery Today , vol.11 , Issue.3-4 , pp. 119-126
    • Whitworth, A.J.1    Wes, P.D.2    Pallanck, L.J.3
  • 77
    • 0037468831 scopus 로고    scopus 로고
    • Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila
    • DOI 10.1016/S0896-6273(03)00143-0
    • Y Yang I Nishimura Y Imai, et al. 2003 Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila Neuron 37 911 924 10.1016/S0896-6273(03)00143-0 12670421 (Pubitemid 36398298)
    • (2003) Neuron , vol.37 , Issue.6 , pp. 911-924
    • Yang, Y.1    Nishimura, I.2    Imai, Y.3    Takahashi, R.4    Lu, B.5
  • 79
    • 24644507043 scopus 로고    scopus 로고
    • α-synuclein and dopamine metabolism
    • DOI 10.1385/MN:31:1-3:243
    • S Yu K Ueda P Chan 2005 Alpha-synuclein and dopamine metabolism Molecular Neurobiology 31 243 254 10.1385/MN:31:1-3:243 15953825 (Pubitemid 41271207)
    • (2005) Molecular Neurobiology , vol.31 , Issue.1-3 , pp. 243-254
    • Yu, S.1    Ueda, K.2    Chan, P.3
  • 80
    • 58149375389 scopus 로고    scopus 로고
    • Loss-of-function analysis suggests that Omi/HtrA2 is not an essential component of the PINK1/PARKIN pathway in vivo
    • 10.1523/JNEUROSCI.5141-08.2008 19118185
    • J Yun JH Cao MW Dodson, et al. 2008 Loss-of-function analysis suggests that Omi/HtrA2 is not an essential component of the PINK1/PARKIN pathway in vivo Journal of Neuroscience 28 14500 14510 10.1523/JNEUROSCI.5141-08.2008 19118185
    • (2008) Journal of Neuroscience , vol.28 , pp. 14500-14510
    • Yun, J.1    Cao, J.H.2    Dodson, M.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.