Mutations in amyloid precursor protein and presenilin-1 genes increase the basal oxidative stress in murine neuronal cells and lead to increased sensitivity to oxidative stress mediated by amyloid β-peptide (1-42), H2O2 and kainic acid: Implications for Alzheimer's disease

Journal of Neurochemistry

Volumn 96, Issue 5, 2006, Pages 1322-1335

  Mohmmad Abdul, Hafiz ^a   Sultana, Rukhsana ^a   Keller, Jeffrey N ^b   St Clair, Daret K ^a   Markesbery, William R ^b   Butterfield, D Allan ^a,b  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

amyloid peptide (1 42); Alzheimer's disease; Amyloid precursor protein; Oxidative stress; Presenilin 1

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; HYDROGEN PEROXIDE; KAINIC ACID; PRESENILIN 1;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; FAMILIAL DISEASE; GENE MUTATION; LIPID PEROXIDATION; MOUSE; NERVE CELL CULTURE; NEUROLOGIC DISEASE; NONHUMAN; ONSET AGE; OXIDATIVE STRESS; PRIORITY JOURNAL; WESTERN BLOTTING;

ALDEHYDES; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANALYSIS OF VARIANCE; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL SURVIVAL; CELLS, CULTURED; CYTOCHROMES C; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION; HYDROGEN PEROXIDE; KAINIC ACID; LIPID PEROXIDATION; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; MUTATION; NEURONS; OXIDATION-REDUCTION; OXIDATIVE STRESS; PEPTIDE FRAGMENTS; PRESENILIN-1;

ANIMALIA; MURINAE;

EID: 33645106304     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2005.03647.x     Document Type: Article

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