메뉴 건너뛰기




Volumn 36, Issue 11, 2003, Pages 1004-1010

Neuronal DNA damage correlates with a positive detection of c-Jun, nuclear factor κB, p53 and Par-4 transcription factors in Alzheimer's disease;El daño nuclear neuronal se correlaciona con la detección in situ de los factores de transcripción c-Jun, factor nuclear κb, p53 y Par-4 en la enfermedad de Alzheimer

Author keywords

Alzheimer; c Jun; p53; Par 4; TUNEL

Indexed keywords

ALPHA,BETA PROTEIN[25-65]; AMYLOID BETA PROTEIN; CARRIER PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PAR 4 PROTEIN; PAR-4 PROTEIN; PROTEIN; PROTEIN C JUN; PROTEIN P53; PROTEINASE ACTIVATED RECEPTOR 4; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

EID: 0041304626     PISSN: 02100010     EISSN: None     Source Type: Journal    
DOI: 10.33588/rn.3611.2002533     Document Type: Article
Times cited : (22)

References (47)
  • 1
    • 0042602091 scopus 로고    scopus 로고
    • The biology and molecular neuropathology of b-amyloid protein
    • Dawbarn D, Allen SJ, eds. Oxford: Oxford University Press
    • Howlett DR, Allsop D, Karran EH. The biology and molecular neuropathology of b-amyloid protein. In Dawbarn D, Allen SJ, eds. Neurobiology of Alzheimer's disease. Oxford: Oxford University Press; 2001. p. 75-102.
    • (2001) Neurobiology of Alzheimer's Disease , pp. 75-102
    • Howlett, D.R.1    Allsop, D.2    Karran, E.H.3
  • 2
    • 0042602090 scopus 로고    scopus 로고
    • The molecular basis of tau protein pathology in Alzheimer's disease and related neurodegenerative dementias
    • Dawbarn D, Allen SJ, eds. Oxford: Oxford University Press
    • Wischik CM, Theuring F, Harrington CH-R. The molecular basis of tau protein pathology in Alzheimer's disease and related neurodegenerative dementias. In Dawbarn D, Allen SJ, eds. Neurobiology of Alzheimer's disease. Oxford: Oxford University Press; 2001. p. 103-206.
    • (2001) Neurobiology of Alzheimer's Disease , pp. 103-206
    • Wischik, C.M.1    Theuring, F.2    Harrington, C.H.-R.3
  • 3
    • 0034612175 scopus 로고    scopus 로고
    • Inflammation and Alzheimer's disease
    • Neuroinflammation Working Group. Inflammation and Alzheimer's disease. Neurobiol Aging 2000; 21: 383-421.
    • (2000) Neurobiol Aging , vol.21 , pp. 383-421
  • 4
    • 0003786674 scopus 로고    scopus 로고
    • MRI studies of the hippocampal formation: Contributions to the early diagnosis of Alzheimer's disease
    • DeLeon MJ. New York: The Parthenon Publishing Group
    • DeLeon MJ, Convit A, Tarshish CH, DeSanti S, Bobinski M. MRI studies of the hippocampal formation: contributions to the early diagnosis of Alzheimer's disease. In DeLeon MJ. An atlas of Alzheimer's disease. New York: The Parthenon Publishing Group; 1999. p. 31-55.
    • (1999) An Atlas of Alzheimer's Disease , pp. 31-55
    • DeLeon, M.J.1    Convit, A.2    Tarshish, C.H.3    DeSanti, S.4    Bobinski, M.5
  • 5
    • 17944382037 scopus 로고    scopus 로고
    • Enhanced neurofibrillary degeneration in transgenic mice expressing mutant Tau and APP
    • Lewis J, Dickson DW, Lin W-L, Chisholm L, Corral A, Jones G, et al. Enhanced neurofibrillary degeneration in transgenic mice expressing mutant Tau and APP. Science 2001; 293: 1487-91.
    • (2001) Science , vol.293 , pp. 1487-1491
    • Lewis, J.1    Dickson, D.W.2    Lin, W.-L.3    Chisholm, L.4    Corral, A.5    Jones, G.6
  • 6
    • 0035943436 scopus 로고    scopus 로고
    • Formation of neurofibrillary tangles in P301 L Tau transgenic mice induced by Ab42 fibrils
    • Gotz J, Chen F, Dorpe JV, Nitsch RM. Formation of neurofibrillary tangles in P301 L Tau transgenic mice induced by Ab42 fibrils. Science 2001; 293: 1491-5.
    • (2001) Science , vol.293 , pp. 1491-1495
    • Gotz, J.1    Chen, F.2    Dorpe, J.V.3    Nitsch, R.M.4
  • 7
    • 0036592636 scopus 로고    scopus 로고
    • Amyloid b-peptide and amyloid pathology are central to oxidative stress and inflammatory cascades under which Alzheimer's disease brain exists
    • Butterfield DA, Griffin S, Munch G, Pasinetti GM. Amyloid b-peptide and amyloid pathology are central to oxidative stress and inflammatory cascades under which Alzheimer's disease brain exists. J Alzheimer's disease 2002; 4: 193-201.
    • (2002) J Alzheimer's Disease , vol.4 , pp. 193-201
    • Butterfield, D.A.1    Griffin, S.2    Munch, G.3    Pasinetti, G.M.4
  • 8
    • 0000617396 scopus 로고    scopus 로고
    • Molecular and cellular aspects of oxidative damage in Alzheimer's disease
    • Poli G, Cadenas C, Packer L, eds. New York: Marcel Dekker
    • Smith M, Perry G. Molecular and cellular aspects of oxidative damage in Alzheimer's disease. In Poli G, Cadenas C, Packer L, eds. Free radicals in brain pathophysiology. New York: Marcel Dekker; 2000. p. 313-21.
    • (2000) Free Radicals in Brain Pathophysiology , pp. 313-321
    • Smith, M.1    Perry, G.2
  • 10
    • 0035081475 scopus 로고    scopus 로고
    • Alzheimer's disease results from the cerebral accumulation and cytotoxicity of amyloid b-protein
    • Selkoe DJ. Alzheimer's disease results from the cerebral accumulation and cytotoxicity of amyloid b-protein. J Alzheimer's disease 2001; 3: 75-81.
    • (2001) J Alzheimer's Disease , vol.3 , pp. 75-81
    • Selkoe, D.J.1
  • 11
    • 0042100996 scopus 로고    scopus 로고
    • B-amyloid toxicity: Diverse biological activities drive multiple cellular mechanisms
    • Iqbal K, Sisodia SS, Winblad B, eds. New York: John Wiley & Sons, Ltd
    • Cotman CW, Tong L, Anderson A, Cribss D, Su J. b-amyloid toxicity: diverse biological activities drive multiple cellular mechanisms. In Iqbal K, Sisodia SS, Winblad B, eds. Alzheimer's disease: Advances in etiology, pathogenesis, and therapeutics. New York: John Wiley & Sons, Ltd; 2001. p. 407-20.
    • (2001) Alzheimer's Disease: Adavances in Etiology, Pathogenesis, and Therapeutics , pp. 407-420
    • Cotman, C.W.1    Tong, L.2    Anderson, A.3    Cribss, D.4    Su, J.5
  • 12
    • 0034672942 scopus 로고    scopus 로고
    • The role of oxidative stress in the toxicity induced by amyloid b-peptide in Alzheimer's disease
    • Miranda S, Opazo C, Larrondo LF, Muñoz FJ, Ruiz F, Leighton F. The role of oxidative stress in the toxicity induced by amyloid b-peptide in Alzheimer's disease. Prog Neurobiol 2000; 62: 633-48.
    • (2000) Prog Neurobiol , vol.62 , pp. 633-648
    • Miranda, S.1    Opazo, C.2    Larrondo, L.F.3    Muñoz, F.J.4    Ruiz, F.5    Leighton, F.6
  • 14
    • 0033970158 scopus 로고    scopus 로고
    • JNK and p38 stress kinases-degenerative effectors of signal transduction-cascades in the nervous system
    • Mielke K, Herdegen T. JNK and p38 stress kinases-degenerative effectors of signal transduction-cascades in the nervous system. Prog Neurobiol 2000; 61: 45-60.
    • (2000) Prog Neurobiol , vol.61 , pp. 45-60
    • Mielke, K.1    Herdegen, T.2
  • 16
    • 0030983079 scopus 로고    scopus 로고
    • Transcription factor NF-ℏB is activated in primary neurons by amyloid b peptides and in neurons surrounding early plaques from patients with Alzheimer disease
    • Kaltschmidt B, Uherek M, Volk B, Baeuerle PA, Kaltschmidt C. Transcription factor NF-ℏB is activated in primary neurons by amyloid b peptides and in neurons surrounding early plaques from patients with Alzheimer disease. Proc Natl Acad Sci 1997; 94: 2642-7.
    • (1997) Proc Natl Acad Sci , vol.94 , pp. 2642-2647
    • Kaltschmidt, B.1    Uherek, M.2    Volk, B.3    Baeuerle, P.A.4    Kaltschmidt, C.5
  • 17
    • 0031596151 scopus 로고    scopus 로고
    • NF-κB immunoreactivity is observed in association with beta A4 diffuse plaques in patients with Alzheimer's disease
    • Ferrer I, Martí E, López E, Tortosa A. NF-κB immunoreactivity is observed in association with beta A4 diffuse plaques in patients with Alzheimer's disease. Neuropathol Appl Neurobiol 1998; 24: 271-7.
    • (1998) Neuropathol Appl Neurobiol , vol.24 , pp. 271-277
    • Ferrer, I.1    Martí, E.2    López, E.3    Tortosa, A.4
  • 18
    • 0031826073 scopus 로고    scopus 로고
    • Strong nuclear factor-kappaB-DNA binding parallels cyclooxygenase-2 gene transcription in aging and in sporadic Alzheimer's disease superior temporal lobe neocortex
    • Lukiw WJ, Bazan NG. Strong nuclear factor-kappaB-DNA binding parallels cyclooxygenase-2 gene transcription in aging and in sporadic Alzheimer's disease superior temporal lobe neocortex. J Neurosci Res 1998; 53: 583-92.
    • (1998) J Neurosci Res , vol.53 , pp. 583-592
    • Lukiw, W.J.1    Bazan, N.G.2
  • 19
    • 0030638139 scopus 로고    scopus 로고
    • Bax protein expression is increased in Alzheimer's brain: Correlations with DNA damage, Bcl-2 expression, and brain pathology
    • Su JH, Deng G, Cotman CW. Bax protein expression is increased in Alzheimer's brain: correlations with DNA damage, Bcl-2 expression, and brain pathology. J Neuropathol Exp Neurol 1997; 56: 86-93.
    • (1997) J Neuropathol Exp Neurol , vol.56 , pp. 86-93
    • Su, J.H.1    Deng, G.2    Cotman, C.W.3
  • 21
    • 0035077448 scopus 로고    scopus 로고
    • Problems of cell death in neurodegeneration and Alzheimer's disease
    • Jellinger KA, Stadelmann CH. Problems of cell death in neurodegeneration and Alzheimer's disease. J Alzheimer's Disease 2001; 3: 31-40.
    • (2001) J Alzheimer's Disease , vol.3 , pp. 31-40
    • Jellinger, K.A.1    Stadelmann, C.H.2
  • 22
    • 0031927628 scopus 로고    scopus 로고
    • Par-4 is a mediator of neuronal degeneration associate with the pathogenesis of Alzheimer's Disease
    • Guo Q, Fu W, Xie J, Luo H, Sells SF, Geddes JW, et al. Par-4 is a mediator of neuronal degeneration associate with the pathogenesis of Alzheimer's Disease. Nat Med 1998; 4: 957-62.
    • (1998) Nat Med , vol.4 , pp. 957-962
    • Guo, Q.1    Fu, W.2    Xie, J.3    Luo, H.4    Sells, S.F.5    Geddes, J.W.6
  • 23
    • 0034120657 scopus 로고    scopus 로고
    • DNA damage does not correlate with beta-plaques and neurofibrillary tangles in Familial Alzheimer's disease Presenilin-1 [E280A] mutation
    • Vélez-Pardo C, Lopera F, Jiménez Del Río M. DNA damage does not correlate with beta-plaques and neurofibrillary tangles in Familial Alzheimer's disease Presenilin-1 [E280A] mutation. J Alzheimer's Disease 2000; 2: 47-57.
    • (2000) J Alzheimer's Disease , vol.2 , pp. 47-57
    • Vélez-Pardo, C.1    Lopera, F.2    Jiménez Del Río, M.3
  • 24
    • 0031255112 scopus 로고    scopus 로고
    • Editorial on consensus recommendations for the post-mortem diagnosis of Alzheimer disease from the National Institute on Aging and the Reagan Institute working group on diagnostic criteria for the neuropathological assessment of Alzheimer disease
    • Hyman BD, Trojanowski JQ. Editorial on consensus recommendations for the post-mortem diagnosis of Alzheimer disease from the National Institute on Aging and the Reagan Institute working group on diagnostic criteria for the neuropathological assessment of Alzheimer disease. J Neuropathol Exp Neurol 1997; 56: 1095-7.
    • (1997) J Neuropathol Exp Neurol , vol.56 , pp. 1095-1097
    • Hyman, B.D.1    Trojanowski, J.Q.2
  • 25
    • 0025908356 scopus 로고
    • The Consortium to Establish a Registry for Alzheimer's Disease (CERAD), part II: Standardization of the neurophatologic assessment of Alzheimer's disease
    • Mirra SS, Heyman A, McKeel D, Sumi SM, Crain BJ, Brownlee LM, et al. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD), part II: standardization of the neurophatologic assessment of Alzheimer's disease. Neurology 1991; 41: 479-86.
    • (1991) Neurology , vol.41 , pp. 479-486
    • Mirra, S.S.1    Heyman, A.2    McKeel, D.3    Sumi, S.M.4    Crain, B.J.5    Brownlee, L.M.6
  • 27
    • 0037013327 scopus 로고    scopus 로고
    • Intracellular amyloid b-1-42, but not extracellular soluble amyloid-b peptides, induces neuronal apoptosis
    • Kienlen-Campard P, Miolet S, Tasiaux B, Octave J-N. Intracellular amyloid b-1-42, but not extracellular soluble amyloid-b peptides, induces neuronal apoptosis. J Biol Chem 2002; 277: 15666-70.
    • (2002) J Biol Chem , vol.277 , pp. 15666-15670
    • Kienlen-Campard, P.1    Miolet, S.2    Tasiaux, B.3    Octave, J.-N.4
  • 29
    • 0032728505 scopus 로고    scopus 로고
    • C-Jun contributes to amyloid b-induced neuronal apoptosis but is not necessary for amyloid b-induced c-jun induction
    • Kihiko M, Tucker HM, Rydel RE, Estus S. c-Jun contributes to amyloid b-induced neuronal apoptosis but is not necessary for amyloid b-induced c-jun induction. J Neurochem 1999; 73: 2609-12.
    • (1999) J Neurochem , vol.73 , pp. 2609-2612
    • Kihiko, M.1    Tucker, H.M.2    Rydel, R.E.3    Estus, S.4
  • 30
    • 0041389838 scopus 로고    scopus 로고
    • La apoptosis en las enfermedades neurodegenerativas: Evidencias y controversias
    • Jiménez Del Rio M, Vélez-Pardo C. La apoptosis en las enfermedades neurodegenerativas: evidencias y controversias. Rev Neurol 2001; 32: 851-60.
    • (2001) Rev Neurol , vol.32 , pp. 851-860
    • Jiménez Del Rio, M.1    Vélez-Pardo, C.2
  • 31
    • 0030806869 scopus 로고    scopus 로고
    • DNA damage distribution in the human brain as shown by in situ end labeling: Area-specific differences in aging and Alzheimer's disease in the absence of apoptotic morphology
    • Lucassen PJ, Chung WCJ, Kamphorst W, Swaab DF. DNA damage distribution in the human brain as shown by in situ end labeling: Area-specific differences in aging and Alzheimer's disease in the absence of apoptotic morphology. J Neuropathol Exp Neurol 1997; 56: 887-900.
    • (1997) J Neuropathol Exp Neurol , vol.56 , pp. 887-900
    • Lucassen, P.J.1    Chung, W.C.J.2    Kamphorst, W.3    Swaab, D.F.4
  • 33
    • 0036019165 scopus 로고    scopus 로고
    • Mechanisms of cell death in Neurodegenerative diseases: Fashion, fiction, and facts
    • Graeber MB, Moran LB. Mechanisms of cell death in Neurodegenerative diseases: fashion, fiction, and facts. Brain Pathol 2002; 12: 385-90.
    • (2002) Brain Pathol , vol.12 , pp. 385-390
    • Graeber, M.B.1    Moran, L.B.2
  • 34
    • 0042100999 scopus 로고    scopus 로고
    • Apoptosis. Detection of apoptotic cells
    • Gopa M. Apoptosis. Detection of Apoptotic Cells. Promega Notes 1996; 57: 10-5.
    • (1996) Promega Notes , vol.57 , pp. 10-15
    • Gopa, M.1
  • 35
    • 0031880094 scopus 로고    scopus 로고
    • A suicide note from Alzheimer's disease neurons?
    • Perry G, Nunomura A, Smith MA. A suicide note from Alzheimer's disease neurons? Nat Med 1998; 4: 897-8.
    • (1998) Nat Med , vol.4 , pp. 897-898
    • Perry, G.1    Nunomura, A.2    Smith, M.A.3
  • 37
    • 0035433420 scopus 로고    scopus 로고
    • Four deaths and a funeral: From caspases to alternative mechanism
    • Leist M, Jaattela M. Four deaths and a funeral: From caspases to alternative mechanism. Nat Rev Mol Cell Biol 2001; 2: 1-10.
    • (2001) Nat Rev Mol Cell Biol , vol.2 , pp. 1-10
    • Leist, M.1    Jaattela, M.2
  • 38
    • 0035409448 scopus 로고    scopus 로고
    • Programmed cell death and apoptosis: Origins of the theory
    • Lockshin RA, Zakeri Z. Programmed cell death and apoptosis: origins of the theory. Nat Rev Mol Cell Biol 2001; 2: 545-50.
    • (2001) Nat Rev Mol Cell Biol , vol.2 , pp. 545-550
    • Lockshin, R.A.1    Zakeri, Z.2
  • 39
    • 0036162719 scopus 로고    scopus 로고
    • Apoptosis: A guide for the perplexed
    • Sloviter RS. Apoptosis: a guide for the perplexed. Trends Pharmacol Sci 2002; 23: 19-24.
    • (2002) Trends Pharmacol Sci , vol.23 , pp. 19-24
    • Sloviter, R.S.1
  • 40
    • 0029823454 scopus 로고    scopus 로고
    • Extracellular deposition of b-amyloid upon p53-dependent neuronal cell death in transgenic Mice
    • LaFerla F, Hall CK, Ngo L, Jay G. Extracellular deposition of b-amyloid upon p53-dependent neuronal cell death in transgenic Mice. J Clin Invest 1996; 98: 1626-32.
    • (1996) J Clin Invest , vol.98 , pp. 1626-1632
    • LaFerla, F.1    Hall, C.K.2    Ngo, L.3    Jay, G.4
  • 41
    • 0030831489 scopus 로고    scopus 로고
    • Correlates of p53 and Fas (CD95) mediate apoptosis in Alzheimer's disease
    • De la Monte SM, Sohn YK, Wands JR. Correlates of p53 and Fas (CD95) mediate apoptosis in Alzheimer's disease. J Neurol Sci 1997; 152: 73-83.
    • (1997) J Neurol Sci , vol.152 , pp. 73-83
    • De la Monte, S.M.1    Sohn, Y.K.2    Wands, J.R.3
  • 42
    • 0035812914 scopus 로고    scopus 로고
    • Aberrant induction of Par-4 is involved in apoptosis of hippocampal neurons in presenilin-1 M146V mutant knock-in mice
    • Xie J, Chang X, Guo Q. Aberrant induction of Par-4 is involved in apoptosis of hippocampal neurons in presenilin-1 M146V mutant knock-in mice. Brain Res 2001; 915: 1-10.
    • (2001) Brain Res , vol.915 , pp. 1-10
    • Xie, J.1    Chang, X.2    Guo, Q.3
  • 43
    • 0037086078 scopus 로고    scopus 로고
    • In lymphatic cells par-4 sensitizes to apoptosis by down-regulating bcl-2 and promoting disruption of mitochondrial membrane potential and caspase activation
    • Boehrer S, Chow KU, Beske F, Kukoc-Zivojnov N, Puccetti E, Ruthardt M, et al. In lymphatic cells par-4 sensitizes to apoptosis by down-regulating bcl-2 and promoting disruption of mitochondrial membrane potential and caspase activation. Cancer Res 2002; 62: 1768-75.
    • (2002) Cancer Res , vol.62 , pp. 1768-1775
    • Boehrer, S.1    Chow, K.U.2    Beske, F.3    Kukoc-Zivojnov, N.4    Puccetti, E.5    Ruthardt, M.6
  • 44
    • 0029133850 scopus 로고
    • Differential induction of immediate early gene proteins in cultured neurons by b-amyloid (Ab): Association of c-Jun with Ab-induced apoptosis
    • Anderson AJ, Pike CJ, Colman C. Differential induction of immediate early gene proteins in cultured neurons by b-amyloid (Ab): association of c-Jun with Ab-induced apoptosis. J Neurochem 1995; 65: 1487-98.
    • (1995) J Neurochem , vol.65 , pp. 1487-1498
    • Anderson, A.J.1    Pike, C.J.2    Colman, C.3
  • 45
    • 0027946686 scopus 로고
    • Altered gene expression in neurons during programmed cell death: Identification of c-jun as necessary for neuronal apoptosis
    • Estus S, Zaks W, Freeman R, Gruda M, Bravo R, Johnson E. Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis. J Cell Biol 1994; 127: 1717-27.
    • (1994) J Cell Biol , vol.127 , pp. 1717-1727
    • Estus, S.1    Zaks, W.2    Freeman, R.3    Gruda, M.4    Bravo, R.5    Johnson, E.6
  • 46
    • 0028883179 scopus 로고
    • Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
    • Miyashita T, Reed JC. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 1995; 80: 293-9.
    • (1995) Cell , vol.80 , pp. 293-299
    • Miyashita, T.1    Reed, J.C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.