-
1
-
-
4644362726
-
P38alpha stress-activated protein kinase phosphorylates neurofilaments and is associated with neurofilament pathology in amyotrophic lateral sclerosis
-
Ackerley S., Grierson A.J., Banner S., Perkinton M.S., Brownlees J., Byers H.L., Ward M., Thornhill P., Hussain K., Waby J.S., Anderton B.H., Cooper J.D., Dingwall C., Leigh P.N., Shaw C.E., Miller C.C. p38alpha stress-activated protein kinase phosphorylates neurofilaments and is associated with neurofilament pathology in amyotrophic lateral sclerosis. Mol. Cell. Neurosci. 2004, 26:354-364.
-
(2004)
Mol. Cell. Neurosci.
, vol.26
, pp. 354-364
-
-
Ackerley, S.1
Grierson, A.J.2
Banner, S.3
Perkinton, M.S.4
Brownlees, J.5
Byers, H.L.6
Ward, M.7
Thornhill, P.8
Hussain, K.9
Waby, J.S.10
Anderton, B.H.11
Cooper, J.D.12
Dingwall, C.13
Leigh, P.N.14
Shaw, C.E.15
Miller, C.C.16
-
3
-
-
14844341251
-
Identification of combinatorial drug regimens for treatment of Huntington's disease using Drosophila
-
Agrawal N., Pallos J., Slepko N., Apostol B.L., Bodai L., Chang L.W., Chiang A.S., Thompson L.M., Marsh J.L. Identification of combinatorial drug regimens for treatment of Huntington's disease using Drosophila. Proc. Natl. Acad. Sci. USA 2005, 102:3777-3781.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 3777-3781
-
-
Agrawal, N.1
Pallos, J.2
Slepko, N.3
Apostol, B.L.4
Bodai, L.5
Chang, L.W.6
Chiang, A.S.7
Thompson, L.M.8
Marsh, J.L.9
-
4
-
-
18544408628
-
A cancer gene therapy approach utilizing an anti-erbB-2-single-chain antibody-encoding adenovirus (AD21): a phase I trial
-
Alvarez R.D., Barnes M.N., Gomez-Navarro J., Wang M., Strong T.V., Arafat W., Arani R.B., Johnson M.R., Roberts B.L., Siegal G.P., Curiel D.T. A cancer gene therapy approach utilizing an anti-erbB-2-single-chain antibody-encoding adenovirus (AD21): a phase I trial. Clin. Cancer Res. 2000, 6:3081-3087.
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 3081-3087
-
-
Alvarez, R.D.1
Barnes, M.N.2
Gomez-Navarro, J.3
Wang, M.4
Strong, T.V.5
Arafat, W.6
Arani, R.B.7
Johnson, M.R.8
Roberts, B.L.9
Siegal, G.P.10
Curiel, D.T.11
-
5
-
-
0025779179
-
Solution structures of beta peptide and its constituent fragments: relation to amyloid deposition
-
Barrow C.J., Zagorski M.G. Solution structures of beta peptide and its constituent fragments: relation to amyloid deposition. Science 1991, 253:179-182.
-
(1991)
Science
, vol.253
, pp. 179-182
-
-
Barrow, C.J.1
Zagorski, M.G.2
-
6
-
-
0038701684
-
Huntington aggregation and toxicity in Huntington's disease
-
Bates G. Huntington aggregation and toxicity in Huntington's disease. Lancet 2003, 361:1642-1644.
-
(2003)
Lancet
, vol.361
, pp. 1642-1644
-
-
Bates, G.1
-
7
-
-
2442585128
-
Seroprotection rate mean fold increase, seroconversion rate: which parameter adequately expresses seroresponse to influenza vaccination?
-
Beyer W.E., Palache A.M., Luchters G., Nauta J., Osterhaus A.D. Seroprotection rate mean fold increase, seroconversion rate: which parameter adequately expresses seroresponse to influenza vaccination?. Virus Res. 2004, 103:125-132.
-
(2004)
Virus Res.
, vol.103
, pp. 125-132
-
-
Beyer, W.E.1
Palache, A.M.2
Luchters, G.3
Nauta, J.4
Osterhaus, A.D.5
-
8
-
-
0024293979
-
Single-chain antigen-binding proteins [erratum appears in Science, 1989 Apr 28;244(4903):409]
-
Bird R.E., Hardman K.D., Jacobson J.W., Johnson S., Kaufman B.M., Lee S.M., Lee T., Pope S.H., Riordan G.S., Whitlow M. Single-chain antigen-binding proteins [erratum appears in Science, 1989 Apr 28;244(4903):409]. Science 1988, 242:423-426.
-
(1988)
Science
, vol.242
, pp. 423-426
-
-
Bird, R.E.1
Hardman, K.D.2
Jacobson, J.W.3
Johnson, S.4
Kaufman, B.M.5
Lee, S.M.6
Lee, T.7
Pope, S.H.8
Riordan, G.S.9
Whitlow, M.10
-
9
-
-
0030994634
-
Yeast surface display for screening combinatorial polypeptide libraries
-
Boder E.T., Wittrup K.D. Yeast surface display for screening combinatorial polypeptide libraries. Nat. Biotechnol. 1997, 15:553-557.
-
(1997)
Nat. Biotechnol.
, vol.15
, pp. 553-557
-
-
Boder, E.T.1
Wittrup, K.D.2
-
10
-
-
0034922671
-
Identification of the region of non-Abeta component (NAC) of Alzheimer's disease amyloid responsible for its aggregation and toxicity
-
Bodles A.M., Guthrie D.J., Greer B., Irvine G.B. Identification of the region of non-Abeta component (NAC) of Alzheimer's disease amyloid responsible for its aggregation and toxicity. J. Neurochem. 2001, 78:384-395.
-
(2001)
J. Neurochem.
, vol.78
, pp. 384-395
-
-
Bodles, A.M.1
Guthrie, D.J.2
Greer, B.3
Irvine, G.B.4
-
11
-
-
0025863618
-
Neuropathological stageing of Alzheimer-related changes
-
Braak H., Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. 1991, 82:239-259.
-
(1991)
Acta Neuropathol.
, vol.82
, pp. 239-259
-
-
Braak, H.1
Braak, E.2
-
12
-
-
1842524044
-
Role of the prion protein in copper turnover in astrocytes
-
Brown D.R. Role of the prion protein in copper turnover in astrocytes. Neurobiol. Dis. 2004, 15:534-543.
-
(2004)
Neurobiol. Dis.
, vol.15
, pp. 534-543
-
-
Brown, D.R.1
-
13
-
-
0031051485
-
ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions
-
Bruijn L.I., Becher M.W., Lee M.K., Anderson K.L., Jenkins N.A., Copeland N.G., Sisodia S.S., Rothstein J.D., Borchelt D.R., Price D.L., Cleveland D.W. ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions. Neuron 1997, 18:327-338.
-
(1997)
Neuron
, vol.18
, pp. 327-338
-
-
Bruijn, L.I.1
Becher, M.W.2
Lee, M.K.3
Anderson, K.L.4
Jenkins, N.A.5
Copeland, N.G.6
Sisodia, S.S.7
Rothstein, J.D.8
Borchelt, D.R.9
Price, D.L.10
Cleveland, D.W.11
-
14
-
-
0032544674
-
Aggregation and motor neuron toxicity of an ALS-linked SOD1 mutant independent from wild-type SOD1
-
Bruijn L.I., Houseweart M.K., Kato S., Anderson K.L., Anderson S.D., Ohama E., Reaume A.G., Scott R.W., Cleveland D.W. Aggregation and motor neuron toxicity of an ALS-linked SOD1 mutant independent from wild-type SOD1. Science 1998, 281:1851-1854.
-
(1998)
Science
, vol.281
, pp. 1851-1854
-
-
Bruijn, L.I.1
Houseweart, M.K.2
Kato, S.3
Anderson, K.L.4
Anderson, S.D.5
Ohama, E.6
Reaume, A.G.7
Scott, R.W.8
Cleveland, D.W.9
-
15
-
-
0027407570
-
Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells
-
Busciglio J., Gabuzda D.H., Matsudaira P., Yankner B.A. Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells. Proc. Natl. Acad. Sci. USA. 1993, 90:2092-2096.
-
(1993)
Proc. Natl. Acad. Sci. USA.
, vol.90
, pp. 2092-2096
-
-
Busciglio, J.1
Gabuzda, D.H.2
Matsudaira, P.3
Yankner, B.A.4
-
17
-
-
2942715242
-
Molecular mechanisms of neurotoxicity of pathological prion protein
-
Castilla J., Hetz C., Soto C. Molecular mechanisms of neurotoxicity of pathological prion protein. Curr. Mol. Med. 2004, 4:397-403.
-
(2004)
Curr. Mol. Med.
, vol.4
, pp. 397-403
-
-
Castilla, J.1
Hetz, C.2
Soto, C.3
-
18
-
-
0025944507
-
Secondary structure analysis of the scrapie-associated protein PrP 27-30 in water by infrared spectroscopy[erratum appears in Biochemistry, 1991 Oct 29; 30(43): 10600]
-
Caughey B.W., Dong A., Bhat K.S., Ernst D., Hayes S.F., Caughey W.S. Secondary structure analysis of the scrapie-associated protein PrP 27-30 in water by infrared spectroscopy[erratum appears in Biochemistry, 1991 Oct 29; 30(43): 10600]. Biochemistry 1991, 30:7672-7680.
-
(1991)
Biochemistry
, vol.30
, pp. 7672-7680
-
-
Caughey, B.W.1
Dong, A.2
Bhat, K.S.3
Ernst, D.4
Hayes, S.F.5
Caughey, W.S.6
-
19
-
-
4344580888
-
Strategies for disease modification in Alzheimer's disease
-
Citron M. Strategies for disease modification in Alzheimer's disease. Nat. Rev. Neurosci. 2004, 5:677-685.
-
(2004)
Nat. Rev. Neurosci.
, vol.5
, pp. 677-685
-
-
Citron, M.1
-
20
-
-
19944395483
-
Potent inhibition of huntingtin aggregation and cytotoxicity by a disulfide bond-free single-domain intracellular antibody
-
Colby D.W., Chu Y., Cassady J.P., Duennwald M., Zazulak H., Webster J.M., Messer A., Lindquist S., Ingram V.M., Wittrup K.D. Potent inhibition of huntingtin aggregation and cytotoxicity by a disulfide bond-free single-domain intracellular antibody. Proc. Natl. Acad. Sci. 2004, 101:17616-17621.
-
(2004)
Proc. Natl. Acad. Sci.
, vol.101
, pp. 17616-17621
-
-
Colby, D.W.1
Chu, Y.2
Cassady, J.P.3
Duennwald, M.4
Zazulak, H.5
Webster, J.M.6
Messer, A.7
Lindquist, S.8
Ingram, V.M.9
Wittrup, K.D.10
-
21
-
-
4444239017
-
Development of a human light chain variable domain (V(L)) intracellular antibody specific for the amino terminus of hungtingtin via yeast surface display
-
Colby D.W., Garg P., Holden T., Chao G., Webster J.M., Messer A., Ingram V.M., Wittrup K.D. Development of a human light chain variable domain (V(L)) intracellular antibody specific for the amino terminus of hungtingtin via yeast surface display. J. Mol. Biol. 2004, 342:901-912.
-
(2004)
J. Mol. Biol.
, vol.342
, pp. 901-912
-
-
Colby, D.W.1
Garg, P.2
Holden, T.3
Chao, G.4
Webster, J.M.5
Messer, A.6
Ingram, V.M.7
Wittrup, K.D.8
-
22
-
-
4043170599
-
Engineering antibody affinity by yeast surface display
-
Colby D.W., Kellogg B.A., GraffC.P., Yeung Y.A., Swers J.S., Wittrup K.D. Engineering antibody affinity by yeast surface display. Method. Enzymol. 2004, 388:348-358.
-
(2004)
Method. Enzymol.
, vol.388
, pp. 348-358
-
-
Colby, D.W.1
Kellogg, B.A.2
Graff, C.P.3
Yeung, Y.A.4
Swers, J.S.5
Wittrup, K.D.6
-
23
-
-
0031787871
-
Accelerated in vitro formation by a mutant alpha-synuclein linked to early-onset Parkinson disease
-
Conway K.A., Harper J.D., Lansbury P.T. Accelerated in vitro formation by a mutant alpha-synuclein linked to early-onset Parkinson disease. Nat. Med. 1998, 4:1318-1320.
-
(1998)
Nat. Med.
, vol.4
, pp. 1318-1320
-
-
Conway, K.A.1
Harper, J.D.2
Lansbury, P.T.3
-
24
-
-
0033850080
-
Abnormal tau-containing filaments in neurodegenerative disease
-
Crowther R.A., Goedert M. Abnormal tau-containing filaments in neurodegenerative disease. J. Struct. Biol. 2000, 130:271-279.
-
(2000)
J. Struct. Biol.
, vol.130
, pp. 271-279
-
-
Crowther, R.A.1
Goedert, M.2
-
25
-
-
0242363670
-
Molecular pathways of neurodegeneration in Parkinson's disease
-
Dawson T.M., Dawson V.L. Molecular pathways of neurodegeneration in Parkinson's disease. Science 2003, 302:819-822.
-
(2003)
Science
, vol.302
, pp. 819-822
-
-
Dawson, T.M.1
Dawson, V.L.2
-
26
-
-
5644276383
-
Delivery of bioactive molecules into the cell: the Trojan horse approach
-
Dietz G.P., Bahr M. Delivery of bioactive molecules into the cell: the Trojan horse approach. Mol. Cell. Neurosci. 2004, 27:85-131.
-
(2004)
Mol. Cell. Neurosci.
, vol.27
, pp. 85-131
-
-
Dietz, G.P.1
Bahr, M.2
-
27
-
-
4644360412
-
MARKing tau for tangles and toxicity
-
Drewes G. MARKing tau for tangles and toxicity. Trends Biochem. Sci. 2004, 29:548-555.
-
(2004)
Trends Biochem. Sci.
, vol.29
, pp. 548-555
-
-
Drewes, G.1
-
28
-
-
0033678217
-
Widespread nitration of pathological inclusions in neurodegenerative synucleinopatheis
-
Duda J.E., Giasson B.I., Chen Q., Gur T.L., Hurtig H.L., Stern M.B., Gollomp S.M., Ischiropoulos H., Lee V.M., Trojanowski J.Q. Widespread nitration of pathological inclusions in neurodegenerative synucleinopatheis. Am. J. Pathol. 2000, 157:1439-1445.
-
(2000)
Am. J. Pathol.
, vol.157
, pp. 1439-1445
-
-
Duda, J.E.1
Giasson, B.I.2
Chen, Q.3
Gur, T.L.4
Hurtig, H.L.5
Stern, M.B.6
Gollomp, S.M.7
Ischiropoulos, H.8
Lee, V.M.9
Trojanowski, J.Q.10
-
29
-
-
0032573597
-
Aggregates from mutant and wild-type alpha-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of beta-sheet and amyloid-like filaments
-
El-Agnaf O.M., Jakes R., Curran M.D., Middleton D., Ingenito R., Bianchi E., Pessi A., Neill D., Wallace A. Aggregates from mutant and wild-type alpha-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of beta-sheet and amyloid-like filaments. FEBS Lett. 1998, 440:71-75.
-
(1998)
FEBS Lett.
, vol.440
, pp. 71-75
-
-
El-Agnaf, O.M.1
Jakes, R.2
Curran, M.D.3
Middleton, D.4
Ingenito, R.5
Bianchi, E.6
Pessi, A.7
Neill, D.8
Wallace, A.9
-
30
-
-
9444229299
-
A strategy for designing inhibitors of alpha-synuclein aggregation and toxicity as a novel treatment for Parkinson's disease and related disorders
-
El-Agnaf O.M., Paleologou K.E., Greer B., Abogrein A.M., King J.E., Salem S.A., Fullwood N.J., Benson F.E., Hewitt R., Ford K.J., Martin F.L., Harriott P., Cookson M.R., Allsop D. A strategy for designing inhibitors of alpha-synuclein aggregation and toxicity as a novel treatment for Parkinson's disease and related disorders. FASEB J 2004, 18:1315-1317.
-
(2004)
FASEB J
, vol.18
, pp. 1315-1317
-
-
El-Agnaf, O.M.1
Paleologou, K.E.2
Greer, B.3
Abogrein, A.M.4
King, J.E.5
Salem, S.A.6
Fullwood, N.J.7
Benson, F.E.8
Hewitt, R.9
Ford, K.J.10
Martin, F.L.11
Harriott, P.12
Cookson, M.R.13
Allsop, D.14
-
31
-
-
0038442784
-
Amyloid-like filaments and water-filled nanotubes formed by SOD1 mutant proteins linked to familial ALS
-
Elam J.S., Taylor A.B., Strange R., Antonyuk S., Doucette P.A., Rodriguez J.A., Hasnain S.S., Hayward L.J., Valentine J.S., Yeates T.O., Hart P.J. Amyloid-like filaments and water-filled nanotubes formed by SOD1 mutant proteins linked to familial ALS. Nat. Struct Biol. 2003, 10:461-467.
-
(2003)
Nat. Struct Biol.
, vol.10
, pp. 461-467
-
-
Elam, J.S.1
Taylor, A.B.2
Strange, R.3
Antonyuk, S.4
Doucette, P.A.5
Rodriguez, J.A.6
Hasnain, S.S.7
Hayward, L.J.8
Valentine, J.S.9
Yeates, T.O.10
Hart, P.J.11
-
32
-
-
1542357652
-
Inhibiting aggregation of alpha-synuclein with human single chain antibody fragments
-
Emadi S., Liu R., Yuan B., Schulz P., McAllister C., Lyubchenko Y., Messer A., Sierks M.R. Inhibiting aggregation of alpha-synuclein with human single chain antibody fragments. Biochemistry 2004, 43:2871-2878.
-
(2004)
Biochemistry
, vol.43
, pp. 2871-2878
-
-
Emadi, S.1
Liu, R.2
Yuan, B.3
Schulz, P.4
McAllister, C.5
Lyubchenko, Y.6
Messer, A.7
Sierks, M.R.8
-
33
-
-
0037846441
-
Serine 776 of ataxin-1 is critical for polyglutamine-induced disease in SCA1 transgenic mice
-
Emamian E.S., Kaytor M.D., Duvick L.A., Zu T., Tousey S.K., Zoghbi H.Y., Clark H.B., Orr H.T. Serine 776 of ataxin-1 is critical for polyglutamine-induced disease in SCA1 transgenic mice. Neuron 2003, 38:375-387.
-
(2003)
Neuron
, vol.38
, pp. 375-387
-
-
Emamian, E.S.1
Kaytor, M.D.2
Duvick, L.A.3
Zu, T.4
Tousey, S.K.5
Zoghbi, H.Y.6
Clark, H.B.7
Orr, H.T.8
-
34
-
-
4143110187
-
Stability improvement of antibodies for extracellular and intracellular applications: CDR grafting to stable frameworks and structure-based framework engineering
-
Ewert S., Honegger A., Pluckthun A. Stability improvement of antibodies for extracellular and intracellular applications: CDR grafting to stable frameworks and structure-based framework engineering. Methods 2004, 34:184-199.
-
(2004)
Methods
, vol.34
, pp. 184-199
-
-
Ewert, S.1
Honegger, A.2
Pluckthun, A.3
-
36
-
-
0036174010
-
Alpha-Synuclein is phosphorylated in synucleinopathy lesions
-
Fujiwara H., Hasegawa M., Dohmae N., Kawashima A., Masliah E., Goldberg M.S., Shen J., Takio K., Iwatsubo T. Alpha-Synuclein is phosphorylated in synucleinopathy lesions. Nat. Cell Biol. 2002, 4:160-164.
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 160-164
-
-
Fujiwara, H.1
Hasegawa, M.2
Dohmae, N.3
Kawashima, A.4
Masliah, E.5
Goldberg, M.S.6
Shen, J.7
Takio, K.8
Iwatsubo, T.9
-
37
-
-
0345549465
-
Direct phage to intrabody screening (DPIS): demonstration by isolation of cytosolic intrabodies against the TES1 site of Epstein Barr virus latent membrane protein 1 (LMP1) that block NF-kappaB transactivation
-
Gennari F., Mehta S., Wang Y., St Clair Tallarico A., Palu G., Marasco W.A. Direct phage to intrabody screening (DPIS): demonstration by isolation of cytosolic intrabodies against the TES1 site of Epstein Barr virus latent membrane protein 1 (LMP1) that block NF-kappaB transactivation. J. Mol. Biol. 2004, 335:193-207.
-
(2004)
J. Mol. Biol.
, vol.335
, pp. 193-207
-
-
Gennari, F.1
Mehta, S.2
Wang, Y.3
St Clair Tallarico, A.4
Palu, G.5
Marasco, W.A.6
-
38
-
-
0344688272
-
Tau phosphorylation, tangles, and neurodegeneration: the chicken or the egg?
-
Geschwind D.H. Tau phosphorylation, tangles, and neurodegeneration: the chicken or the egg?. Neuron 2003, 40:457-460.
-
(2003)
Neuron
, vol.40
, pp. 457-460
-
-
Geschwind, D.H.1
-
39
-
-
0034602442
-
Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions.[see comment].
-
Giasson B.I., Duda J.E., Murray I.V., Chen Q., Souza J.M., Hurtig H.I., Ischiropoulos H., Trojanowski J.Q., Lee V.M. Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions.[see comment]. Science 2000, 290:985-989.
-
(2000)
Science
, vol.290
, pp. 985-989
-
-
Giasson, B.I.1
Duda, J.E.2
Murray, I.V.3
Chen, Q.4
Souza, J.M.5
Hurtig, H.I.6
Ischiropoulos, H.7
Trojanowski, J.Q.8
Lee, V.M.9
-
40
-
-
0038784529
-
Are ubiquitination pathways central to Parkinson's disease?
-
Giasson B.I., Lee V.M. Are ubiquitination pathways central to Parkinson's disease?. Cell 2003, 114:1-8.
-
(2003)
Cell
, vol.114
, pp. 1-8
-
-
Giasson, B.I.1
Lee, V.M.2
-
41
-
-
4644293577
-
Conformation-dependent antibodies target diseases of protein misfolding
-
Glabe C.G. Conformation-dependent antibodies target diseases of protein misfolding. Trends Biochem. Sci. 2004, 29:542-547.
-
(2004)
Trends Biochem. Sci.
, vol.29
, pp. 542-547
-
-
Glabe, C.G.1
-
42
-
-
0021256895
-
Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein
-
Glenner G.G., Wong C.W. Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem. Biophys. Res. Commun. 1984, 120:885-890.
-
(1984)
Biochem. Biophys. Res. Commun.
, vol.120
, pp. 885-890
-
-
Glenner, G.G.1
Wong, C.W.2
-
43
-
-
0023506466
-
Isolation, characterization, and chromosomal localization of human brain cDNA clones coding for the precursor of the amyloid of brain in Alzheimer's disease, Down's syndrome and aging
-
Goldgaber D., Lerman M.I., McBride W.O., Saffiotti U., Gajdusek D.C. Isolation, characterization, and chromosomal localization of human brain cDNA clones coding for the precursor of the amyloid of brain in Alzheimer's disease, Down's syndrome and aging. J. Neural Transm. Suppl. 1987, 24:23-28.
-
(1987)
J. Neural Transm. Suppl.
, vol.24
, pp. 23-28
-
-
Goldgaber, D.1
Lerman, M.I.2
McBride, W.O.3
Saffiotti, U.4
Gajdusek, D.C.5
-
44
-
-
0027374493
-
Normal cellular processing of the beta-amyloid precursor protein results in the secretion of the amyloid beta peptide and related molecules
-
Haass C., Hung A.Y., Schlossmacher M.G., Oltersdorf T., Teplow D.B., Selkoe D.J. Normal cellular processing of the beta-amyloid precursor protein results in the secretion of the amyloid beta peptide and related molecules. Ann. NY Acad. Sci. 1993, 695:109-116.
-
(1993)
Ann. NY Acad. Sci.
, vol.695
, pp. 109-116
-
-
Haass, C.1
Hung, A.Y.2
Schlossmacher, M.G.3
Oltersdorf, T.4
Teplow, D.B.5
Selkoe, D.J.6
-
45
-
-
0029257497
-
The core Alzheimer's peptide NAC forms amyloid fibrils which seed and are seeded by beta-amyloid: is NAC a common trigger or target in neurodegenerative disease?
-
Han H., Weinreb P.H., Lansbury P.T. The core Alzheimer's peptide NAC forms amyloid fibrils which seed and are seeded by beta-amyloid: is NAC a common trigger or target in neurodegenerative disease?. Chem. Biol. 1995, 2:163-169.
-
(1995)
Chem. Biol.
, vol.2
, pp. 163-169
-
-
Han, H.1
Weinreb, P.H.2
Lansbury, P.T.3
-
46
-
-
0028301455
-
Altered microtubule organization in small-calibre axons of mice lacking tau protein
-
Harada A., Oguchi K., Okabe S., Kuno J., Terada S., Ohshima T., Sato-Yoshitake R., Takei Y., Noda T., Hirokawa N. Altered microtubule organization in small-calibre axons of mice lacking tau protein. Nature 1994, 369:488-491.
-
(1994)
Nature
, vol.369
, pp. 488-491
-
-
Harada, A.1
Oguchi, K.2
Okabe, S.3
Kuno, J.4
Terada, S.5
Ohshima, T.6
Sato-Yoshitake, R.7
Takei, Y.8
Noda, T.9
Hirokawa, N.10
-
47
-
-
20244378556
-
From the cover: RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model
-
Harper S.Q., Staber P.D., He X., Eliason S.L., Martins I.H., Mao Q., Yang L., Kotin R.M., Paulson H.L., Davidson B.L. From the cover: RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model. Proc. Natl. Acad. Sci. USA 2005, 102:5820-5825.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 5820-5825
-
-
Harper, S.Q.1
Staber, P.D.2
He, X.3
Eliason, S.L.4
Martins, I.H.5
Mao, Q.6
Yang, L.7
Kotin, R.M.8
Paulson, H.L.9
Davidson, B.L.10
-
48
-
-
2242472974
-
Phosphorylated alpha-synuclein is ubiquitinated in alphasynucleinopathy lesions
-
Hasegawa M., Fujiwara H., Nonaka T., Wakabayashi K., Takahashi H., Lee V.M., Trojanowski J.Q., Mann D., Iwatsubo T. Phosphorylated alpha-synuclein is ubiquitinated in alphasynucleinopathy lesions. J. Biol. Chem. 2002, 277:49071-49076.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 49071-49076
-
-
Hasegawa, M.1
Fujiwara, H.2
Nonaka, T.3
Wakabayashi, K.4
Takahashi, H.5
Lee, V.M.6
Trojanowski, J.Q.7
Mann, D.8
Iwatsubo, T.9
-
49
-
-
0035812752
-
Prevention of scrapie pathogenesis by transgenic expression of anti-prion protein antibodies
-
Heppner F.L., Musahl C., Arrighi I., Klein M.A., Rulicke T., Oesch B., Zinkernagel R.M., Kalinke U., Aguzzi A. Prevention of scrapie pathogenesis by transgenic expression of anti-prion protein antibodies. Science 2001, 294:178-182.
-
(2001)
Science
, vol.294
, pp. 178-182
-
-
Heppner, F.L.1
Musahl, C.2
Arrighi, I.3
Klein, M.A.4
Rulicke, T.5
Oesch, B.6
Zinkernagel, R.M.7
Kalinke, U.8
Aguzzi, A.9
-
50
-
-
18844447024
-
Translating therapies for Huntington's disease from genetic animal models to clinical trials
-
Hersch S.M., Ferrante R.J. Translating therapies for Huntington's disease from genetic animal models to clinical trials. Neurorx 2004, 1:298-306.
-
(2004)
Neurorx
, vol.1
, pp. 298-306
-
-
Hersch, S.M.1
Ferrante, R.J.2
-
51
-
-
0036311587
-
USP7, a ubiquitin-specific protease, interacts with ataxin-1, the SCA1 gene product
-
Hong S., Kim S.J., Ka S., Choi I., Kang S. USP7, a ubiquitin-specific protease, interacts with ataxin-1, the SCA1 gene product. Mol. Cell. Neurosci. 2002, 20:298-306.
-
(2002)
Mol. Cell. Neurosci.
, vol.20
, pp. 298-306
-
-
Hong, S.1
Kim, S.J.2
Ka, S.3
Choi, I.4
Kang, S.5
-
52
-
-
0042926482
-
Nitration of tau protein is linked to neurodegeneration in tauopathies [erratum appears in Am J Pathol, 2003 Dec; 163(6): 2645]
-
Horiguchi T., Uryu K., Giasson B.I., Ischiropoulos H., LightFoot R., Bellmann C., Richter-Landsberg C., Lee V.M., Trojanowski J.Q. Nitration of tau protein is linked to neurodegeneration in tauopathies [erratum appears in Am J Pathol, 2003 Dec; 163(6): 2645]. Am. J. Pathol. 2003, 163:1021-1031.
-
(2003)
Am. J. Pathol.
, vol.163
, pp. 1021-1031
-
-
Horiguchi, T.1
Uryu, K.2
Giasson, B.I.3
Ischiropoulos, H.4
LightFoot, R.5
Bellmann, C.6
Richter-Landsberg, C.7
Lee, V.M.8
Trojanowski, J.Q.9
-
53
-
-
0004198722
-
Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli
-
Huston J.S., Levinson D., Mudgett-Hunter M., Tai M.S., Novotny J., Margolies M.N., Ridge R.J., Bruccoleri R.E., Haber E., Crea R. Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli. Proc. Natl. Acad. Sci. USA 1988, 85:5879-5883.
-
(1988)
Proc. Natl. Acad. Sci. USA
, vol.85
, pp. 5879-5883
-
-
Huston, J.S.1
Levinson, D.2
Mudgett-Hunter, M.3
Tai, M.S.4
Novotny, J.5
Margolies, M.N.6
Ridge, R.J.7
Bruccoleri, R.E.8
Haber, E.9
Crea, R.10
-
54
-
-
0038389681
-
Oxidative modifications of alpha-synuclein
-
Ischiropoulos H. Oxidative modifications of alpha-synuclein. Ann. NY Acad. Sci. 2003, 991:93-100.
-
(2003)
Ann. NY Acad. Sci.
, vol.991
, pp. 93-100
-
-
Ischiropoulos, H.1
-
55
-
-
2542638001
-
Scrapie-specific neuronal lesions are independent of neuronal PrP expression
-
Jeffrey M., Goodsir C.M., Race R.E., Chesebro B. Scrapie-specific neuronal lesions are independent of neuronal PrP expression. Ann. Neurol. 2004, 55:781-792.
-
(2004)
Ann. Neurol.
, vol.55
, pp. 781-792
-
-
Jeffrey, M.1
Goodsir, C.M.2
Race, R.E.3
Chesebro, B.4
-
56
-
-
0036304315
-
Hyperphosphorylation and insolubility of alpha-synuclein, in transgenic mouse oligodendrocytes
-
Kahle P.J., Neumann M., Ozmen L., Muller V., Jacobsen H., Spooren W., Fuss B., Mallon B., Macklin W.B., Fujiwara H., Hasegawa M., Iwatsubo T., Kretzschmar H.A., Haass C. Hyperphosphorylation and insolubility of alpha-synuclein, in transgenic mouse oligodendrocytes. EMBO Rep. 2002, 3:583-588.
-
(2002)
EMBO Rep.
, vol.3
, pp. 583-588
-
-
Kahle, P.J.1
Neumann, M.2
Ozmen, L.3
Muller, V.4
Jacobsen, H.5
Spooren, W.6
Fuss, B.7
Mallon, B.8
Macklin, W.B.9
Fujiwara, H.10
Hasegawa, M.11
Iwatsubo, T.12
Kretzschmar, H.A.13
Haass, C.14
-
57
-
-
0023105114
-
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
-
Kang J., Lemaire H.G., Unterbeck A., Salbaum J.M., Masters C.L., Grzeschik K.H., Multhaup G., Beyreuther K., Muller-Hill B. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 1987, 325:733-736.
-
(1987)
Nature
, vol.325
, pp. 733-736
-
-
Kang, J.1
Lemaire, H.G.2
Unterbeck, A.3
Salbaum, J.M.4
Masters, C.L.5
Grzeschik, K.H.6
Multhaup, G.7
Beyreuther, K.8
Muller-Hill, B.9
-
58
-
-
0242668337
-
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
-
Kayed R., Head E., Thompson J.L., McIntire T.M., Milton S.C., Cotman C.W., Glabe C.G. Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science 2003, 300:486-489.
-
(2003)
Science
, vol.300
, pp. 486-489
-
-
Kayed, R.1
Head, E.2
Thompson, J.L.3
McIntire, T.M.4
Milton, S.C.5
Cotman, C.W.6
Glabe, C.G.7
-
59
-
-
18544379477
-
A bivalent Huntingtin binding peptide, suppresses polyglutamine aggregation and pathogenesis in Drosophila
-
Kazantsev A., Walker H.A., Slepko N., Bear J.E., Preisinger E., Steffan J.S., Zhu Y.Z., Gertler F.B., Housman D.E., Marsh J.L., Thompson L.M. A bivalent Huntingtin binding peptide, suppresses polyglutamine aggregation and pathogenesis in Drosophila. Nat. Genet. 2002, 30:367-376.
-
(2002)
Nat. Genet.
, vol.30
, pp. 367-376
-
-
Kazantsev, A.1
Walker, H.A.2
Slepko, N.3
Bear, J.E.4
Preisinger, E.5
Steffan, J.S.6
Zhu, Y.Z.7
Gertler, F.B.8
Housman, D.E.9
Marsh, J.L.10
Thompson, L.M.11
-
60
-
-
0037154165
-
Effects of intracellular expression of anti-huntingtin, antibodies of various specificities on mutant huntingtin aggregation and toxicity
-
Khoshnan A., Ko J., Patterson P.H. Effects of intracellular expression of anti-huntingtin, antibodies of various specificities on mutant huntingtin aggregation and toxicity. Proc. Natl. Acad. Sci. USA. 2002, 99:1002-1007.
-
(2002)
Proc. Natl. Acad. Sci. USA.
, vol.99
, pp. 1002-1007
-
-
Khoshnan, A.1
Ko, J.2
Patterson, P.H.3
-
61
-
-
0031424522
-
Isolation of anti-T cell receptor scFv mutants by yeast surface display
-
Kieke M.C., Cho B.K., Boder E.T., Kranz D.M., Wittrup K.D. Isolation of anti-T cell receptor scFv mutants by yeast surface display. Protein Eng. 1997, 10:1303-1310.
-
(1997)
Protein Eng.
, vol.10
, pp. 1303-1310
-
-
Kieke, M.C.1
Cho, B.K.2
Boder, E.T.3
Kranz, D.M.4
Wittrup, K.D.5
-
62
-
-
0033081766
-
Mutant huntingtin expression in clonal striatal cells: dissociation of inclusion formation and neuronal survival by caspase inhibition
-
Kim M., Lee H.S., LaForet G., McIntyre C., Martin E.J., Chang P., Kim T.W., Williams M., Reddy P.H., Tagle D., Boyce F.M., Won L., Heller A., Aronin N., DiFiglia M. Mutant huntingtin expression in clonal striatal cells: dissociation of inclusion formation and neuronal survival by caspase inhibition. J. Neurosci. 1999, 19:964-973.
-
(1999)
J. Neurosci.
, vol.19
, pp. 964-973
-
-
Kim, M.1
Lee, H.S.2
LaForet, G.3
McIntyre, C.4
Martin, E.J.5
Chang, P.6
Kim, T.W.7
Williams, M.8
Reddy, P.H.9
Tagle, D.10
Boyce, F.M.11
Won, L.12
Heller, A.13
Aronin, N.14
DiFiglia, M.15
-
63
-
-
0035940412
-
Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis
-
Kim Y.J., Yi Y., Sapp E., Wang Y., Cuiffo B., Kegel K.B., Qin Z.H., Aronin N., DiFiglia M. Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis. Proc. Natl. Acad. Sci. USA 2001, 98:12784-12789.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 12784-12789
-
-
Kim, Y.J.1
Yi, Y.2
Sapp, E.3
Wang, Y.4
Cuiffo, B.5
Kegel, K.B.6
Qin, Z.H.7
Aronin, N.8
DiFiglia, M.9
-
64
-
-
0025983158
-
Abnormal isoform of prion protein accumulates in follicular dendritic cells in mice with Creutzfeldt-Jakob disease
-
Kitamoto J., Muramoto T., Mohri S., Doh-Ura K., Tateishi J. Abnormal isoform of prion protein accumulates in follicular dendritic cells in mice with Creutzfeldt-Jakob disease. J. Virol. 1991, 65:6292-6295.
-
(1991)
J. Virol.
, vol.65
, pp. 6292-6295
-
-
Kitamoto, J.1
Muramoto, T.2
Mohri, S.3
Doh-Ura, K.4
Tateishi, J.5
-
65
-
-
0026670809
-
Identification and diffential expression of a novel alternative splice isoform of the beta A4 amyloid precursor protein (APP) mRNA in leukocytes and brain microglial cells
-
Konig G., Monning U., Czech C., Prior R., Banati R., Schreiter-Gasser U., Bauer J., Masters C.L., Beyreuther K. Identification and diffential expression of a novel alternative splice isoform of the beta A4 amyloid precursor protein (APP) mRNA in leukocytes and brain microglial cells. J. Biol. Chem. 1992, 267:10804-10809.
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 10804-10809
-
-
Konig, G.1
Monning, U.2
Czech, C.3
Prior, R.4
Banati, R.5
Schreiter-Gasser, U.6
Bauer, J.7
Masters, C.L.8
Beyreuther, K.9
-
66
-
-
1842830810
-
Single-chain antibodies: a therapeutic modality for cancer gene therapy (review)
-
Leath C.A., Douglas J.T., Curiel D.T., Alvarez R.D. Single-chain antibodies: a therapeutic modality for cancer gene therapy (review). Int. J. Oncol 2004, 24:765-771.
-
(2004)
Int. J. Oncol
, vol.24
, pp. 765-771
-
-
Leath, C.A.1
Douglas, J.T.2
Curiel, D.T.3
Alvarez, R.D.4
-
67
-
-
0035836675
-
Human single-chain Fv intrabodies counteract in situ huntingtin aggregation in cellular models of Huntington's disease
-
Lecerf J.M., Shirley T.L., Zhu Q., Kazantsev A., Amersdorfer P., Housman D.E., Messer A., Huston J.S. Human single-chain Fv intrabodies counteract in situ huntingtin aggregation in cellular models of Huntington's disease. Proc. Natl. Acad. Sci. USA 2001, 98:4764-4769.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 4764-4769
-
-
Lecerf, J.M.1
Shirley, T.L.2
Zhu, Q.3
Kazantsev, A.4
Amersdorfer, P.5
Housman, D.E.6
Messer, A.7
Huston, J.S.8
-
68
-
-
0034458844
-
Selection and characterization of single chain Fv fragments against murine recombinant prion protein from a synthetic human antibody phage display library
-
Leclerc E., Liemann S., Wildegger G., Vetter S.W., Nilsson F. Selection and characterization of single chain Fv fragments against murine recombinant prion protein from a synthetic human antibody phage display library. Hum. Antibodies 2000, 9:207-214.
-
(2000)
Hum. Antibodies
, vol.9
, pp. 207-214
-
-
Leclerc, E.1
Liemann, S.2
Wildegger, G.3
Vetter, S.W.4
Nilsson, F.5
-
69
-
-
0037173006
-
Human alpha-synuclein-harboring familial Parkinson's disease with alpha-synuclein aggregation in transgenic mice
-
Lee M.K., Stirling W., Xu Y., Xu X., Qui D., Mandir A.S., Dawson T.M., Copeland N.G., Jenkins N.A., Price D.L. Human alpha-synuclein-harboring familial Parkinson's disease with alpha-synuclein aggregation in transgenic mice. Proc. Natl. Acad. Sci. USA 2002, 99:896-897.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 896-897
-
-
Lee, M.K.1
Stirling, W.2
Xu, Y.3
Xu, X.4
Qui, D.5
Mandir, A.S.6
Dawson, T.M.7
Copeland, N.G.8
Jenkins, N.A.9
Price, D.L.10
-
70
-
-
1342321775
-
More than just two peas in a pod: common amyloidogenic properties of tau and alpha-synuclein in neurodegenerative diseases
-
Lee V.M., Giasson B.I., Trojanowski J.Q. More than just two peas in a pod: common amyloidogenic properties of tau and alpha-synuclein in neurodegenerative diseases. Trends neurosci 2004, 27:129-134.
-
(2004)
Trends neurosci
, vol.27
, pp. 129-134
-
-
Lee, V.M.1
Giasson, B.I.2
Trojanowski, J.Q.3
-
72
-
-
0034426011
-
Neurofibrillary tangles amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein
-
Lewis J., McGowan E., Rockwood J., Melrose H., Nacharaju P., Van Slegtenhorst M., Gwinn-Hardy K., Paul Murphy M., Baker M., Yu X., DuffK., Hardy J., Corral A., Lin W.L., Yen S.H., Dickson D.W., Davies P., Hutton M. Neurofibrillary tangles amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein. Nat. Genet. 2000, 25:402-405.
-
(2000)
Nat. Genet.
, vol.25
, pp. 402-405
-
-
Lewis, J.1
McGowan, E.2
Rockwood, J.3
Melrose, H.4
Nacharaju, P.5
Van Slegtenhorst, M.6
Gwinn-Hardy, K.7
Paul Murphy, M.8
Baker, M.9
Yu, X.10
Duff, K.11
Hardy, J.12
Corral, A.13
Lin, W.L.14
Yen, S.H.15
Dickson, D.W.16
Davies, P.17
Hutton, M.18
-
73
-
-
13844320376
-
Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations
-
Li W., West N., Colla E., Pletnikova O., Troncoso J.C., Marsh L., Dawson T.M., Jakala P., Hartmann T., Price D.L., Lee M.K. Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations. Proc. Natl. Acad. Sci. 2005, 102:2162-2167.
-
(2005)
Proc. Natl. Acad. Sci.
, vol.102
, pp. 2162-2167
-
-
Li, W.1
West, N.2
Colla, E.3
Pletnikova, O.4
Troncoso, J.C.5
Marsh, L.6
Dawson, T.M.7
Jakala, P.8
Hartmann, T.9
Price, D.L.10
Lee, M.K.11
-
74
-
-
20744442130
-
A precipitating role for truncated alphasynuclein and the proteasome in alpha-synuclein aggregation: implications for pathogenesis of Parkinson's disease
-
Liu C.W., Giasson B.I., Lewis K.A., Lee V.M., Demartino G.N., Thomas P.J. A precipitating role for truncated alphasynuclein and the proteasome in alpha-synuclein aggregation: implications for pathogenesis of Parkinson's disease. J. Biol. Chem. 2005, 280:22670-22678.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 22670-22678
-
-
Liu, C.W.1
Giasson, B.I.2
Lewis, K.A.3
Lee, V.M.4
Demartino, G.N.5
Thomas, P.J.6
-
75
-
-
3543054598
-
Proteolytic antibody light chains alter beta-amyloid aggregation and prevent cytotoxicity
-
Liu R., McAllister C., Lyubchenko Y., Sierks M.R. Proteolytic antibody light chains alter beta-amyloid aggregation and prevent cytotoxicity. Biochemistry 2004, 43:9999-10007.
-
(2004)
Biochemistry
, vol.43
, pp. 9999-10007
-
-
Liu, R.1
McAllister, C.2
Lyubchenko, Y.3
Sierks, M.R.4
-
76
-
-
2642578354
-
Single chain variable fragments against beta-amyloid (Abeta) can inhibit Abeta aggregation and prevent abeta-induced neurotoxicity
-
Liu R., Yuan B., Emadi S., Zameer A., Schulz P., McAllister C., Lyubchenko Y., Goud G., Sierks M.R. Single chain variable fragments against beta-amyloid (Abeta) can inhibit Abeta aggregation and prevent abeta-induced neurotoxicity. Biochemistry 2004, 43:6959-6967.
-
(2004)
Biochemistry
, vol.43
, pp. 6959-6967
-
-
Liu, R.1
Yuan, B.2
Emadi, S.3
Zameer, A.4
Schulz, P.5
McAllister, C.6
Lyubchenko, Y.7
Goud, G.8
Sierks, M.R.9
-
77
-
-
0028172886
-
Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red
-
Lorenzo A., Yankner B.A. Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red. Proc. Natl. Acad. Sci. USA 1994, 91:12243-12247.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 12243-12247
-
-
Lorenzo, A.1
Yankner, B.A.2
-
78
-
-
3242772435
-
Scrapie protein degradation by cysteine proteases in CD11c+ dendritic cells and GT1-1 neuronal cells
-
Luhr K.M., Nordstrom E.K., Low P., Ljunggren H.G., Taraboulos A., Kristensson K. Scrapie protein degradation by cysteine proteases in CD11c+ dendritic cells and GT1-1 neuronal cells. J. Virol. 2004, 78:4776-4782.
-
(2004)
J. Virol.
, vol.78
, pp. 4776-4782
-
-
Luhr, K.M.1
Nordstrom, E.K.2
Low, P.3
Ljunggren, H.G.4
Taraboulos, A.5
Kristensson, K.6
-
79
-
-
0037195617
-
sc-like conformation in the cytosol. [see comment]
-
sc-like conformation in the cytosol. [see comment]. Science 2002, 298:1785-1788.
-
(2002)
Science
, vol.298
, pp. 1785-1788
-
-
Ma, J.1
Lindquist, S.2
-
80
-
-
0037195647
-
Neurotoxicity and neurodegeneration when PrP accumulates in the cytosol. [see comment]
-
Ma J., Wollmann R., Lindquist S. Neurotoxicity and neurodegeneration when PrP accumulates in the cytosol. [see comment]. Science 2002, 298:1781-1785.
-
(2002)
Science
, vol.298
, pp. 1781-1785
-
-
Ma, J.1
Wollmann, R.2
Lindquist, S.3
-
81
-
-
0037713491
-
Convergent pathobiologic model of Parkinson's disease
-
Maguire-Zeiss K.A., FederoffH.J. Convergent pathobiologic model of Parkinson's disease. Ann. NY Acad. Sci. 2003, 991:152-166.
-
(2003)
Ann. NY Acad. Sci.
, vol.991
, pp. 152-166
-
-
Maguire-Zeiss, K.A.1
Federoff, H.J.2
-
82
-
-
33645247555
-
HSV amplicon expression of single-chain antibodies directed against alpha-synuclein conformers
-
Maguire-Zeiss K.A., Yehling E., Giuliano R., Sullivan M., FederoffH.J. HSV amplicon expression of single-chain antibodies directed against alpha-synuclein conformers. Mol. Ther. 2004, 9:S86.
-
(2004)
Mol. Ther.
, vol.9
-
-
Maguire-Zeiss, K.A.1
Yehling, E.2
Giuliano, R.3
Sullivan, M.4
Federoff, H.J.5
-
83
-
-
4444270135
-
Human single chain Fv antibodies and a complementarity determining region-derived peptide binding to amyloid-beta 1-42
-
Manoutcharian K., Acero G., Munguia M.E., Becerril B., Massieu L., Govezensky T., Ortiz E., Marks J.D., Cao C., Ugen K., Gevorkian G. Human single chain Fv antibodies and a complementarity determining region-derived peptide binding to amyloid-beta 1-42. Neurobiol. Dis. 2004, 17:114-121.
-
(2004)
Neurobiol. Dis.
, vol.17
, pp. 114-121
-
-
Manoutcharian, K.1
Acero, G.2
Munguia, M.E.3
Becerril, B.4
Massieu, L.5
Govezensky, T.6
Ortiz, E.7
Marks, J.D.8
Cao, C.9
Ugen, K.10
Gevorkian, G.11
-
84
-
-
0033499430
-
Human anti-HIV-1 tat sFv intrabodies for gene therapy of advanced HIV-1-infection and AIDS
-
Marasco W.A., LaVecchio J., Winkler A. Human anti-HIV-1 tat sFv intrabodies for gene therapy of advanced HIV-1-infection and AIDS. J. Immunol. Methods 1999, 231:223-238.
-
(1999)
J. Immunol. Methods
, vol.231
, pp. 223-238
-
-
Marasco, W.A.1
LaVecchio, J.2
Winkler, A.3
-
85
-
-
0026317443
-
By-passing immunization: human antibodies from V-gene libraries displayed on phage
-
Marks J.D., Hoogenboom H.R., Bonnert T.P., McCafferty J., Griffiths A.D., Winter G. By-passing immunization: human antibodies from V-gene libraries displayed on phage. J. Mol. Biol. 1991, 222:581-597.
-
(1991)
J. Mol. Biol.
, vol.222
, pp. 581-597
-
-
Marks, J.D.1
Hoogenboom, H.R.2
Bonnert, T.P.3
McCafferty, J.4
Griffiths, A.D.5
Winter, G.6
-
86
-
-
2542468586
-
Can flies help humans treat neurodegenerative diseases?
-
Marsh J.L., Thompson L.M. Can flies help humans treat neurodegenerative diseases?. Bioessays 2004, 26:485-496.
-
(2004)
Bioessays
, vol.26
, pp. 485-496
-
-
Marsh, J.L.1
Thompson, L.M.2
-
87
-
-
0035889973
-
Proteasomal-dependent aggregate reversal and absence of cell death in a conditional mouse model of Huntington's disease
-
Martin-Aparicio E., Yamamoto A., Hernandez F., Hen R., Avila J., Lucas J.J. Proteasomal-dependent aggregate reversal and absence of cell death in a conditional mouse model of Huntington's disease. J. Neurosci. 2001, 21:8772-8781.
-
(2001)
J. Neurosci.
, vol.21
, pp. 8772-8781
-
-
Martin-Aparicio, E.1
Yamamoto, A.2
Hernandez, F.3
Hen, R.4
Avila, J.5
Lucas, J.J.6
-
88
-
-
0036098113
-
Targeting functional subtypes of spinal motoneurons and skeletal muscle fibers in vivo by intramuscular injection of adenoviral and adeno-associated viral vectors
-
Martinov V.N., Sefland I., Walaas S.I., Lomo T., Nja A., Hoover F. Targeting functional subtypes of spinal motoneurons and skeletal muscle fibers in vivo by intramuscular injection of adenoviral and adeno-associated viral vectors. Anat. Embryol. (Berl.) 2002, 205:215-221.
-
(2002)
Anat. Embryol. (Berl.)
, vol.205
, pp. 215-221
-
-
Martinov, V.N.1
Sefland, I.2
Walaas, S.I.3
Lomo, T.4
Nja, A.5
Hoover, F.6
-
89
-
-
0012510759
-
Amyloid plaque core protein in Alzheimer disease and Down syndrome
-
Masters C.L., Simms G., Weinman N.A., Multhaup G., McDonald B.L., Beyreuther K. Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc. Natl. Acad. Sci. 1985, 82:4245-4249.
-
(1985)
Proc. Natl. Acad. Sci.
, vol.82
, pp. 4245-4249
-
-
Masters, C.L.1
Simms, G.2
Weinman, N.A.3
Multhaup, G.4
McDonald, B.L.5
Beyreuther, K.6
-
90
-
-
0034781791
-
Rabies virus glycoprotein pseudotyping of lentiviral vectors enables retrograde axonal transport and access to the nervous system after peripheral delivery
-
Mazarakis N.D., Azzouz M., Rohll J.B., Ellard F.M., Wilkes F.J., Olsen A.L., Carter E.E., Barber R.D., Baban D.F., Kingsman S.M., Kingsman A.J., O'Malley K., Mitrophanous K.A. Rabies virus glycoprotein pseudotyping of lentiviral vectors enables retrograde axonal transport and access to the nervous system after peripheral delivery. Hum. Mol. Genet. 2001, 10:2109-2121.
-
(2001)
Hum. Mol. Genet.
, vol.10
, pp. 2109-2121
-
-
Mazarakis, N.D.1
Azzouz, M.2
Rohll, J.B.3
Ellard, F.M.4
Wilkes, F.J.5
Olsen, A.L.6
Carter, E.E.7
Barber, R.D.8
Baban, D.F.9
Kingsman, S.M.10
Kingsman, A.J.11
O'Malley, K.12
Mitrophanous, K.A.13
-
91
-
-
3042794162
-
Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease
-
McNaught K.S., Perl D.P., Brownell A.L., Olanow C.W. Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease. Ann. Neurol. 2004, 56:149-162.
-
(2004)
Ann. Neurol.
, vol.56
, pp. 149-162
-
-
McNaught, K.S.1
Perl, D.P.2
Brownell, A.L.3
Olanow, C.W.4
-
92
-
-
0141891215
-
Pathogenesis of polyglutamine disorders: aggregation revisited
-
Michalik A., Van Broeckhoven C. Pathogenesis of polyglutamine disorders: aggregation revisited. Hum. Mol. Genet. 2003, 12(Spec No 2):R173-R186.
-
(2003)
Hum. Mol. Genet.
, vol.12
, Issue.SPEC NO 2
-
-
Michalik, A.1
Van Broeckhoven, C.2
-
93
-
-
23844450357
-
Intrabody applications in neurological disorders: progress and future prospects
-
Miller T.W., Messer A. Intrabody applications in neurological disorders: progress and future prospects. Mol. Ther. 2005, 12:394-401.
-
(2005)
Mol. Ther.
, vol.12
, pp. 394-401
-
-
Miller, T.W.1
Messer, A.2
-
94
-
-
17544377783
-
A human single-chain Fv intrabody selectively targets amino-terminal huntingtin fragments in striatal models of Huntington's disease
-
Miller T.W., Zhou C., Gines S., MacDonald M.E., Mazarakis N.D., Bates G.P., Messer A. A human single-chain Fv intrabody selectively targets amino-terminal huntingtin fragments in striatal models of Huntington's disease. Neurobiol. Dis. 2005, 19:47-56.
-
(2005)
Neurobiol. Dis.
, vol.19
, pp. 47-56
-
-
Miller, T.W.1
Zhou, C.2
Gines, S.3
MacDonald, M.E.4
Mazarakis, N.D.5
Bates, G.P.6
Messer, A.7
-
95
-
-
0043233011
-
Distinct cleavage patterns of normal and pathologic forms of alpha-synuclein by calpain I in vitro
-
Mishizen-Eberz A.J., Guttmann R.P., Giasson B.I., Day G.A., Hodara R., Ischiropoulos H., Lee V.M., Trojanowski J.Q., Lynch D.R. Distinct cleavage patterns of normal and pathologic forms of alpha-synuclein by calpain I in vitro. J. Neurochem. 2003, 86:836-847.
-
(2003)
J. Neurochem.
, vol.86
, pp. 836-847
-
-
Mishizen-Eberz, A.J.1
Guttmann, R.P.2
Giasson, B.I.3
Day, G.A.4
Hodara, R.5
Ischiropoulos, H.6
Lee, V.M.7
Trojanowski, J.Q.8
Lynch, D.R.9
-
96
-
-
0032757387
-
Stable gene transfer to the nervous system using a non-primate lentiviral vector
-
Mitrophanous K., Yoon S., Rohll J., Patil D., Wilkes F., Kim V., Kingsman S., Kingsman A., Mazarakis N. Stable gene transfer to the nervous system using a non-primate lentiviral vector. Gene Ther. 1999, 6:1808-1818.
-
(1999)
Gene Ther.
, vol.6
, pp. 1808-1818
-
-
Mitrophanous, K.1
Yoon, S.2
Rohll, J.3
Patil, D.4
Wilkes, F.5
Kim, V.6
Kingsman, S.7
Kingsman, A.8
Mazarakis, N.9
-
97
-
-
0035957521
-
Fast selection of antibodies without antigen purification: adaptation of the protein fragment complementation assay to select antigen-antibody pairs
-
Mossner E., Koch H., Pluckthun A. Fast selection of antibodies without antigen purification: adaptation of the protein fragment complementation assay to select antigen-antibody pairs. J. Mol. Biol. 2001, 308:115-122.
-
(2001)
J. Mol. Biol.
, vol.308
, pp. 115-122
-
-
Mossner, E.1
Koch, H.2
Pluckthun, A.3
-
98
-
-
1242351323
-
A single-chain Fv intrabody provides functional protection against the effects of mutant protein in an organotypic slice culture model of Huntington's disease
-
Murphy R.C., Messer A. A single-chain Fv intrabody provides functional protection against the effects of mutant protein in an organotypic slice culture model of Huntington's disease. Brain Res. Mol. Brain Res. 2004, 121:141-145.
-
(2004)
Brain Res. Mol. Brain Res.
, vol.121
, pp. 141-145
-
-
Murphy, R.C.1
Messer, A.2
-
99
-
-
0034615932
-
Inhibition of polyglutamine protein aggregation and cell death by novel peptides identified by phage display screening
-
Nagai Y., Tucker T., Ren H., Kenan D.J., Henderson B.S., Keene J.D., Strittmatter W.J., Burke J.R. Inhibition of polyglutamine protein aggregation and cell death by novel peptides identified by phage display screening. J. Biol. Chem. 2000, 275:10437-10442.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 10437-10442
-
-
Nagai, Y.1
Tucker, T.2
Ren, H.3
Kenan, D.J.4
Henderson, B.S.5
Keene, J.D.6
Strittmatter, W.J.7
Burke, J.R.8
-
100
-
-
0022614193
-
Down's syndrome and Alzheimer's disease: a review
-
Oliver C., Holland A.J. Down's syndrome and Alzheimer's disease: a review. Psychol. Med. 1986, 16:307-322.
-
(1986)
Psychol. Med.
, vol.16
, pp. 307-322
-
-
Oliver, C.1
Holland, A.J.2
-
101
-
-
0031577584
-
Oligomerization of expanded-polyglutamine domain fluorescent fusion proteins in cultured mammalian cells
-
Onodera O., Burke J.R., Miller S.E., Hester S., Tsuji S., Roses A.D., Strittmatter W.J. Oligomerization of expanded-polyglutamine domain fluorescent fusion proteins in cultured mammalian cells. Biochem. Biophys. Res. Commun. 1997, 238:599-605.
-
(1997)
Biochem. Biophys. Res. Commun.
, vol.238
, pp. 599-605
-
-
Onodera, O.1
Burke, J.R.2
Miller, S.E.3
Hester, S.4
Tsuji, S.5
Roses, A.D.6
Strittmatter, W.J.7
-
102
-
-
0037022297
-
Conformational Abs recognizing a generic amyloid fibril epitope
-
O'Nuallain B., Wetzel R. Conformational Abs recognizing a generic amyloid fibril epitope. Proc. Natl. Acad. Sci. USA 2002, 99:1485-1490.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 1485-1490
-
-
O'Nuallain, B.1
Wetzel, R.2
-
103
-
-
1542698957
-
Cloning immunoglobulin variable domains for expression by the polymerase chain reaction
-
Orlandi R., Gussow D.H., Jones P.T., Winter G. Cloning immunoglobulin variable domains for expression by the polymerase chain reaction. Proc. Natl. Acad. Sci. USA 1989, 86:3833-3837.
-
(1989)
Proc. Natl. Acad. Sci. USA
, vol.86
, pp. 3833-3837
-
-
Orlandi, R.1
Gussow, D.H.2
Jones, P.T.3
Winter, G.4
-
104
-
-
0030250722
-
Generation of a panel of related human scFv antibodies with high affinities for human CEA
-
Osbourn J.K., Field A., Wilton J., Derbyshire E., Earnshaw J.C., Jones P.T., Allen D., McCafferty J. Generation of a panel of related human scFv antibodies with high affinities for human CEA. Immunotechnology 1996, 2:181-196.
-
(1996)
Immunotechnology
, vol.2
, pp. 181-196
-
-
Osbourn, J.K.1
Field, A.2
Wilton, J.3
Derbyshire, E.4
Earnshaw, J.C.5
Jones, P.T.6
Allen, D.7
McCafferty, J.8
-
105
-
-
15444374558
-
β-site specific intrabodies to decrease and prevent generation of Alzheimer's Aβ peptide
-
Paganetti P., Calanca V., Galli C., Stefani M., Molinari M. β-site specific intrabodies to decrease and prevent generation of Alzheimer's Aβ peptide. J. Cell Biol. 2005, 168:863-868.
-
(2005)
J. Cell Biol.
, vol.168
, pp. 863-868
-
-
Paganetti, P.1
Calanca, V.2
Galli, C.3
Stefani, M.4
Molinari, M.5
-
106
-
-
0027332116
-
Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins
-
Pan K.M., Baldwin M., Nguyen J., Gasset M., Serban A., Groth D., Mehlhorn I., Huang Z., Fletterick R.J., Cohen F.E. Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins. Proc. Natl. Acad. Sci. USA 1993, 90:10962-10966.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 10962-10966
-
-
Pan, K.M.1
Baldwin, M.2
Nguyen, J.3
Gasset, M.4
Serban, A.5
Groth, D.6
Mehlhorn, I.7
Huang, Z.8
Fletterick, R.J.9
Cohen, F.E.10
-
107
-
-
18644371727
-
Mice expressing the alpha(1B)-adrenergic receptor induces a synucleinopathy with excessive tyrosine nitration but decreased phosphorylation
-
Papay R., Zuscik M.J., Ross S.A., Yun J., McCune D.F., Gonzalez-Cabrera P., Gaivin R., Drazba J., Perez D.M. Mice expressing the alpha(1B)-adrenergic receptor induces a synucleinopathy with excessive tyrosine nitration but decreased phosphorylation. J. Neurochem. 2002, 83:623-634.
-
(2002)
J. Neurochem.
, vol.83
, pp. 623-634
-
-
Papay, R.1
Zuscik, M.J.2
Ross, S.A.3
Yun, J.4
McCune, D.F.5
Gonzalez-Cabrera, P.6
Gaivin, R.7
Drazba, J.8
Perez, D.M.9
-
108
-
-
0025992417
-
In vitro aging of beta-amyloid protein causes peptide aggregation and neurotoxicity
-
Pike C.J., Walencewicz A.J., Glabe C.G., Cotman C.W. In vitro aging of beta-amyloid protein causes peptide aggregation and neurotoxicity. Brain Res. 1991, 563:311-314.
-
(1991)
Brain Res.
, vol.563
, pp. 311-314
-
-
Pike, C.J.1
Walencewicz, A.J.2
Glabe, C.G.3
Cotman, C.W.4
-
109
-
-
0020321767
-
Novel proteinaceous infectious particles cause scrapie
-
Prusiner S.B. Novel proteinaceous infectious particles cause scrapie. Science 1982, 216:136-144.
-
(1982)
Science
, vol.216
, pp. 136-144
-
-
Prusiner, S.B.1
-
110
-
-
0025910229
-
Molecular biology of prion diseases
-
Prusiner S.B. Molecular biology of prion diseases. Science 1991, 252:1515-1522.
-
(1991)
Science
, vol.252
, pp. 1515-1522
-
-
Prusiner, S.B.1
-
112
-
-
2442624720
-
Monomeric Cu, Zn-superoxide dismutase is a common misfolding intermediate in the oxidation models of sporadic and familial amyotrophic lateral sclerosis
-
Rakhit R., Crow J.P., Lepock J.R., Kondejewski L.H., Cashman N.R., Chakrabartty A. Monomeric Cu, Zn-superoxide dismutase is a common misfolding intermediate in the oxidation models of sporadic and familial amyotrophic lateral sclerosis. J. Biol. Chem. 2004, 279:15499-15504.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 15499-15504
-
-
Rakhit, R.1
Crow, J.P.2
Lepock, J.R.3
Kondejewski, L.H.4
Cashman, N.R.5
Chakrabartty, A.6
-
113
-
-
0345060484
-
Degradation of beta-amyloid by proteolytic antibody light chains
-
Rangan S.K., Liu R., Brune D., Planque S., Paul S., Sierks M.R. Degradation of beta-amyloid by proteolytic antibody light chains. Biochemistry 2003, 42:14328-14334.
-
(2003)
Biochemistry
, vol.42
, pp. 14328-14334
-
-
Rangan, S.K.1
Liu, R.2
Brune, D.3
Planque, S.4
Paul, S.5
Sierks, M.R.6
-
114
-
-
3142514201
-
Protein aggregation and neurodegenerative disease
-
Ross C.A., Poirier M.A. Protein aggregation and neurodegenerative disease. Nat. Med. 2004, 10(Suppl):S10-S17.
-
(2004)
Nat. Med.
, vol.10
, Issue.SUPPL
-
-
Ross, C.A.1
Poirier, M.A.2
-
115
-
-
0037422616
-
Polyglutamine fibrillogenesis: the pathway unfolds
-
Ross C.A., Poirier M.A., Wanker E.E., Amzel M. Polyglutamine fibrillogenesis: the pathway unfolds. Proc. Natl. Acad. Sci. USA 2003, 100:1-3.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 1-3
-
-
Ross, C.A.1
Poirier, M.A.2
Wanker, E.E.3
Amzel, M.4
-
116
-
-
18544400323
-
Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo
-
Scherzinger E., Lurz R., Turmaine M., Mangiarini L., Hollenbach B., Hasenbank R., Bates G.P., Davies S.W., Lehrach H., Wanker E.E. Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo. Cell 1997, 90:549-558.
-
(1997)
Cell
, vol.90
, pp. 549-558
-
-
Scherzinger, E.1
Lurz, R.2
Turmaine, M.3
Mangiarini, L.4
Hollenbach, B.5
Hasenbank, R.6
Bates, G.P.7
Davies, S.W.8
Lehrach, H.9
Wanker, E.E.10
-
117
-
-
0030485173
-
Efficient in vitro affinity maturation of phage antibodies using BIAcore guided selections
-
Schier R., Marks J.D. Efficient in vitro affinity maturation of phage antibodies using BIAcore guided selections. Hum. Antibodies Hybridomas 1993, 7:97-105.
-
(1993)
Hum. Antibodies Hybridomas
, vol.7
, pp. 97-105
-
-
Schier, R.1
Marks, J.D.2
-
118
-
-
0026760261
-
Production of the Alzheimer amyloid beta protein by normal proteolytic processing
-
Shoji M., Golde T.E., Ghiso J., Cheung T.T., Estus S., Shaffer L.M., Cai X.D., McKay D.M., Tintner R., Frangione B. Production of the Alzheimer amyloid beta protein by normal proteolytic processing. Science 1992, 258:126-129.
-
(1992)
Science
, vol.258
, pp. 126-129
-
-
Shoji, M.1
Golde, T.E.2
Ghiso, J.3
Cheung, T.T.4
Estus, S.5
Shaffer, L.M.6
Cai, X.D.7
McKay, D.M.8
Tintner, R.9
Frangione, B.10
-
119
-
-
0034674652
-
Dityrosine cross-linking promotes formation of stable alphasynuclein polymers; implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies
-
Souza J.M., Giasson B.I., Chen Q., Lee V.M., Ischiropoulos H. Dityrosine cross-linking promotes formation of stable alphasynuclein polymers; implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies. J. Biol. Chem. 2000, 275:18344-18349.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 18344-18349
-
-
Souza, J.M.1
Giasson, B.I.2
Chen, Q.3
Lee, V.M.4
Ischiropoulos, H.5
-
120
-
-
0028110130
-
DNA shuffling by random fragmentation and reassembly: in vitro recombination for molecular evolution
-
Stemmer W.P. DNA shuffling by random fragmentation and reassembly: in vitro recombination for molecular evolution. Proc. Natl. Acad. Sci. USA 1994, 91:10747-10751.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 10747-10751
-
-
Stemmer, W.P.1
-
121
-
-
7944230671
-
Intrabodies: production and promise
-
Stocks M.R. Intrabodies: production and promise. Drug Discov. Today 2004, 9:960-966.
-
(2004)
Drug Discov. Today
, vol.9
, pp. 960-966
-
-
Stocks, M.R.1
-
122
-
-
0028004290
-
Amyloid fibrils in Gerstmann-Straussler-Scheinker disease (Indiana and Swedish kindreds) express only PrP peptides encoded by the mutant allele
-
Tagliavini F., Prelli F., Porro M., Rossi G., Giaccone G., Farlow M.R., Dlouhy S.R., Ghetti B., Bugiani O., Frangione B. Amyloid fibrils in Gerstmann-Straussler-Scheinker disease (Indiana and Swedish kindreds) express only PrP peptides encoded by the mutant allele. Cell 1994, 79:695-703.
-
(1994)
Cell
, vol.79
, pp. 695-703
-
-
Tagliavini, F.1
Prelli, F.2
Porro, M.3
Rossi, G.4
Giaccone, G.5
Farlow, M.R.6
Dlouhy, S.R.7
Ghetti, B.8
Bugiani, O.9
Frangione, B.10
-
123
-
-
0037205095
-
Tyrosine 125 of alpha-synuclein plays a critical role for dimerization following nitrative stress
-
Takahashi T., Yamashita H., Nakamura T., Nagano Y., Nakamura S. Tyrosine 125 of alpha-synuclein plays a critical role for dimerization following nitrative stress. Brain Res. 2002, 938:73-80.
-
(2002)
Brain Res.
, vol.938
, pp. 73-80
-
-
Takahashi, T.1
Yamashita, H.2
Nakamura, T.3
Nagano, Y.4
Nakamura, S.5
-
124
-
-
0037362559
-
De novo production of diverse intracellular antibody libraries
-
Tanaka T., Chung G.T., Forster A., Lobato M.N., Rabbitts T.H. De novo production of diverse intracellular antibody libraries. Nucleic Acids Res. 2003, 31:E23.
-
(2003)
Nucleic Acids Res.
, vol.31
-
-
Tanaka, T.1
Chung, G.T.2
Forster, A.3
Lobato, M.N.4
Rabbitts, T.H.5
-
125
-
-
0242361780
-
Role of proteolysis in polyglutamine disorders
-
Tarlac V., Storey E. Role of proteolysis in polyglutamine disorders. J. Neurosci. Res. 2003, 74:406-416.
-
(2003)
J. Neurosci. Res.
, vol.74
, pp. 406-416
-
-
Tarlac, V.1
Storey, E.2
-
126
-
-
0037936926
-
Inhibition of HIV-1 replication in primary human T cells transduced with an intracellular anti-HIV-1 p17 antibody gene
-
Tewari D., Notkins A.L., Zhou P. Inhibition of HIV-1 replication in primary human T cells transduced with an intracellular anti-HIV-1 p17 antibody gene. J. Gene Med. 2003, 5:182-189.
-
(2003)
J. Gene Med.
, vol.5
, pp. 182-189
-
-
Tewari, D.1
Notkins, A.L.2
Zhou, P.3
-
127
-
-
0036299007
-
Intracellular antibody capture technology: application to selection of intracellular antibodies recognising the BCR-ABL oncogenic protein
-
Tse E., Lobato M.N., Forster A., Tanaka T., Chung G.T., Rabbitts T.H. Intracellular antibody capture technology: application to selection of intracellular antibodies recognising the BCR-ABL oncogenic protein. J. Mol. Biol. 2002, 317:85-94.
-
(2002)
J. Mol. Biol.
, vol.317
, pp. 85-94
-
-
Tse, E.1
Lobato, M.N.2
Forster, A.3
Tanaka, T.4
Chung, G.T.5
Rabbitts, T.H.6
-
128
-
-
0027489773
-
Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease
-
Ueda K., Fukushima H., Masliah E., Xia Y., Iwai A., Yoshimoto M., Otero D.A., Kondo J., Ihara Y., Saitoh T. Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. Proc. Natl. Acad. Sci. USA 1993, 90:11282-11286.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 11282-11286
-
-
Ueda, K.1
Fukushima, H.2
Masliah, E.3
Xia, Y.4
Iwai, A.5
Yoshimoto, M.6
Otero, D.A.7
Kondo, J.8
Ihara, Y.9
Saitoh, T.10
-
129
-
-
0037014618
-
Amino acid determinants of alpha-synuclein aggregation: putting together pieces of the puzzle
-
Uversky V.N., Fink A.L. Amino acid determinants of alpha-synuclein aggregation: putting together pieces of the puzzle. FEBS Lett. 2002, 522:9-13.
-
(2002)
FEBS Lett.
, vol.522
, pp. 9-13
-
-
Uversky, V.N.1
Fink, A.L.2
-
130
-
-
3142523288
-
Genetic clues to the pathogenesis of Parkinson's disease
-
Vila M., Przedborski S. Genetic clues to the pathogenesis of Parkinson's disease. Nat. Med. 2004, 10(Suppl):S58-S62.
-
(2004)
Nat. Med.
, vol.10
, Issue.SUPPL
-
-
Vila, M.1
Przedborski, S.2
-
131
-
-
0036299049
-
The intracellular antibody capture technology (IACT): towards a consensus sequence for intracellular antibodies
-
Visintin M., Settanni G., Maritan A., Graziosi S., Marks J.D., Cattaneo A. The intracellular antibody capture technology (IACT): towards a consensus sequence for intracellular antibodies. J. Mol. Biol. 2002, 317:73-83.
-
(2002)
J. Mol. Biol.
, vol.317
, pp. 73-83
-
-
Visintin, M.1
Settanni, G.2
Maritan, A.3
Graziosi, S.4
Marks, J.D.5
Cattaneo, A.6
-
132
-
-
0038386274
-
Zeroing in on the pathogenic form of alpha-synuclein and its mechanism of neurotoxicity in Parkinson's disease
-
Volles M.J., Lansbury P.T. Zeroing in on the pathogenic form of alpha-synuclein and its mechanism of neurotoxicity in Parkinson's disease. Biochemistry 2003, 42:7871-7878.
-
(2003)
Biochemistry
, vol.42
, pp. 7871-7878
-
-
Volles, M.J.1
Lansbury, P.T.2
-
133
-
-
0141738255
-
PrP knock-out and PrP transgenic mice in prion research
-
Weissmann C., Flechsig E. PrP knock-out and PrP transgenic mice in prion research. Brit. Med. Bull. 2003, 66:43-60.
-
(2003)
Brit. Med. Bull.
, vol.66
, pp. 43-60
-
-
Weissmann, C.1
Flechsig, E.2
-
134
-
-
0034733607
-
Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells
-
Wellington C.L., Singaraja R., Ellerby L., Savill J., Roy S., Leavitt B., Cattaneo E., Hackam A., Sharp A., Thornberry N., Nicholson D.W., Bredesen D.E., Hayden M.R. Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells. J. Biol. Chem. 2000, 275:19831-19838.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 19831-19838
-
-
Wellington, C.L.1
Singaraja, R.2
Ellerby, L.3
Savill, J.4
Roy, S.5
Leavitt, B.6
Cattaneo, E.7
Hackam, A.8
Sharp, A.9
Thornberry, N.10
Nicholson, D.W.11
Bredesen, D.E.12
Hayden, M.R.13
-
135
-
-
0141521636
-
Intrabody and intrakine strategies for molecular therapy
-
Wheeler Y.Y., Chen S.Y., Sane D.C. Intrabody and intrakine strategies for molecular therapy. Mol. Ther. 2003, 8:355-366.
-
(2003)
Mol. Ther.
, vol.8
, pp. 355-366
-
-
Wheeler, Y.Y.1
Chen, S.Y.2
Sane, D.C.3
-
136
-
-
0141483468
-
Intrabody-based strategies for inhibition of vascular endothelial growth factor receptor-2: effects on apoptosis, cell growth, and angiogenesis
-
Wheeler Y.Y., Kute T.E., Willingham M.C., Chen S.Y., Sane D.C. Intrabody-based strategies for inhibition of vascular endothelial growth factor receptor-2: effects on apoptosis, cell growth, and angiogenesis. FASEB J. 2003, 17:1733-1735.
-
(2003)
FASEB J.
, vol.17
, pp. 1733-1735
-
-
Wheeler, Y.Y.1
Kute, T.E.2
Willingham, M.C.3
Chen, S.Y.4
Sane, D.C.5
-
137
-
-
0021956826
-
Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome
-
Wisniewski K.E., Wisniewski H.M., Wen G.Y. Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome. Ann. Neurol. 1985, 17:278-282.
-
(1985)
Ann. Neurol.
, vol.17
, pp. 278-282
-
-
Wisniewski, K.E.1
Wisniewski, H.M.2
Wen, G.Y.3
-
138
-
-
0038423087
-
Correlation between in vitro stability and in vivo performance of anti-GCN4 intrabodies as cytoplasmic inhibitors
-
Worn A., Auf der Maur A., Escher D., Honegger A., Barberis A., Pluckthun A. Correlation between in vitro stability and in vivo performance of anti-GCN4 intrabodies as cytoplasmic inhibitors. J. Biol. Chem. 2000, 275:2795-2803.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 2795-2803
-
-
Worn, A.1
Auf der Maur, A.2
Escher, D.3
Honegger, A.4
Barberis, A.5
Pluckthun, A.6
-
139
-
-
33645260787
-
Single-chain antibodies for viral-based passive immuno-therapy for prion disease: linear epitope mapping and clearance from thalamic injection
-
Wuertzer C.A., Sullivan M., FederoffH.J. Single-chain antibodies for viral-based passive immuno-therapy for prion disease: linear epitope mapping and clearance from thalamic injection. Mol. Ther. 2004, 9:S208.
-
(2004)
Mol. Ther.
, vol.9
-
-
Wuertzer, C.A.1
Sullivan, M.2
Federoff, H.J.3
-
140
-
-
4043057946
-
RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia
-
Xia H., Mao Q., Eliason S.L., Harper S.Q., Martins I.H., Orr H.T., Paulson H.L., Yang L., Kotin R.M., Davidson B.L. RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia. Nat. Med. 2004, 10:816-820.
-
(2004)
Nat. Med.
, vol.10
, pp. 816-820
-
-
Xia, H.1
Mao, Q.2
Eliason, S.L.3
Harper, S.Q.4
Martins, I.H.5
Orr, H.T.6
Paulson, H.L.7
Yang, L.8
Kotin, R.M.9
Davidson, B.L.10
-
141
-
-
0034737299
-
Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease.[see comment]
-
Yamamoto A., Lucas J.J., Hen R. Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease.[see comment]. Cell 2000, 101:57-66.
-
(2000)
Cell
, vol.101
, pp. 57-66
-
-
Yamamoto, A.1
Lucas, J.J.2
Hen, R.3
-
142
-
-
0029056115
-
NACP, the precursor protein of the non-amyloid beta/A4 protein (Abeta) component of Alzheimer disease amyloid, binds Abeta and stimulates Abeta aggregation
-
Yoshimoto M., Iwai A., Kang D., Otero D.A., Xia Y., Saitoh T. NACP, the precursor protein of the non-amyloid beta/A4 protein (Abeta) component of Alzheimer disease amyloid, binds Abeta and stimulates Abeta aggregation. Proc. Natl. Acad. Sci. USA 1995, 92:9141-9145.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 9141-9145
-
-
Yoshimoto, M.1
Iwai, A.2
Kang, D.3
Otero, D.A.4
Xia, Y.5
Saitoh, T.6
-
143
-
-
17644416738
-
Microtubule-associated protein tau is a substrate of ATP/Mg(2+)-dependent proteasome protease system
-
Zhang J.Y., Liu S.J., Li H.L., Wang J.Z. Microtubule-associated protein tau is a substrate of ATP/Mg(2+)-dependent proteasome protease system. J. Neural Transm. 2004, 112:547-555.
-
(2004)
J. Neural Transm.
, vol.112
, pp. 547-555
-
-
Zhang, J.Y.1
Liu, S.J.2
Li, H.L.3
Wang, J.Z.4
-
144
-
-
20044390015
-
A pontent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo
-
Zhang X., Smith D.L., Meriin A.B., Engemann S., Russel D.E., Roark M., Washington S.L., Maxwell M.M., Marsh J.L., Thompson L.M., Wanker E.E., Young A.B., Housman D.E., Bates G.P., Sherman M.Y., Kazantsev A.G. A pontent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo. Proc. Natl. Acad. Sci. USA 2005, 102:892-897.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 892-897
-
-
Zhang, X.1
Smith, D.L.2
Meriin, A.B.3
Engemann, S.4
Russel, D.E.5
Roark, M.6
Washington, S.L.7
Maxwell, M.M.8
Marsh, J.L.9
Thompson, L.M.10
Wanker, E.E.11
Young, A.B.12
Housman, D.E.13
Bates, G.P.14
Sherman, M.Y.15
Kazantsev, A.G.16
-
145
-
-
10344257196
-
A human single-chain Fv intrabody blocks aberrant cellular effects of overexpressed a-synuclein
-
Zhou C., Emadi S., Sierks M.R., Messer A. A human single-chain Fv intrabody blocks aberrant cellular effects of overexpressed a-synuclein. Mol. Ther. 2004, 10:1023-1031.
-
(2004)
Mol. Ther.
, vol.10
, pp. 1023-1031
-
-
Zhou, C.1
Emadi, S.2
Sierks, M.R.3
Messer, A.4
-
146
-
-
4444225471
-
Proteasomal inhibition induced by manganese ethylene-bisdithiocarbamate: relevance to Parkinson's disease
-
Zhou Y., Shie F.S., Piccardo P., Montine T.J., Zhang J. Proteasomal inhibition induced by manganese ethylene-bisdithiocarbamate: relevance to Parkinson's disease. Neuroscience 2004, 128:281-291.
-
(2004)
Neuroscience
, vol.128
, pp. 281-291
-
-
Zhou, Y.1
Shie, F.S.2
Piccardo, P.3
Montine, T.J.4
Zhang, J.5
-
147
-
-
0033499632
-
Extended half-life and elevated steady-state level of a single-chain Fv intrabody are critical for specific intracellular retargeting of its antigen, caspase-7
-
Zhu Q., Zeng C., Huhalov A., Yao J., Turi T.G., Danley D., Hynes T., Cong Y., DiMattia D., Kennedy S., Daumy G., Schaeffer E., Marasco W.A., Huston J.S. Extended half-life and elevated steady-state level of a single-chain Fv intrabody are critical for specific intracellular retargeting of its antigen, caspase-7. J. Immunol. Methods 1999, 231:207-222.
-
(1999)
J. Immunol. Methods
, vol.231
, pp. 207-222
-
-
Zhu, Q.1
Zeng, C.2
Huhalov, A.3
Yao, J.4
Turi, T.G.5
Danley, D.6
Hynes, T.7
Cong, Y.8
DiMattia, D.9
Kennedy, S.10
Daumy, G.11
Schaeffer, E.12
Marasco, W.A.13
Huston, J.S.14
|