A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 3, 2005, Pages 892-897

  Zhang, Xiaoqian ^a   Smith, Donna L ^b   Meriin, Anatoli B ^a   Engemann, Sabine ^c   Russel, Deborah E ^d   Roark, Margo ^e   Washington, Shetia L ^e   Maxwell, Michele M ^d   Lawrence Marsh, J ^e   Thompson, Leslie Michels ^e,f   Wanker, Erich E ^c   Young, Anne B ^d   Housman, David E ^g   Bates, Gillian P ^b   Sherman, Michael Y ^a   Kazantsev, Aleksey G ^d  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b GUY S HOSPITAL   (United Kingdom)

^c MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Drosophila; Genetic disease; High throughput screen; R6 2 brain slices; Small molecule therapeutics

Indexed keywords

BENZAMIDE DERIVATIVE; MUTANT PROTEIN; N (4 BROMOPHENYL) 3 [[(4 BROMOPHENYL)AMINO]SULFONYL]BENZAMIDE; NEW DRUG; POLYGLUTAMINE; SULFONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DROSOPHILA; DRUG MECHANISM; DRUG POTENCY; HIGH THROUGHPUT SCREENING; HUNTINGTON CHOREA; IC 50; MOUSE; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; RAT;

ANIMALS; BRAIN; DIMERIZATION; DISEASE MODELS, ANIMAL; DROSOPHILA; HUNTINGTON DISEASE; INHIBITORY CONCENTRATION 50; MICE; MICE, TRANSGENIC; NEURODEGENERATIVE DISEASES; NEURONS; PEPTIDES; POLYCYCLIC HYDROCARBONS, AROMATIC; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; MAMMALIA; MUS MUSCULUS;

EID: 20044390015     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0408936102     Document Type: Article

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