Mutant Huntingtin expression in clonal striatal cells: Dissociation of inclusion formation and neuronal survival by caspase inhibition

Journal of Neuroscience

Volumn 19, Issue 3, 1999, Pages 964-973

  Kim, Manho ^a   Lee, H S ^a   LaForet, Genevieve ^b   McIntyre, Charmian ^a   Martin, Eileen J ^a   Chang, Patrick ^a   Kim, Tae Wan ^a   Williams, M ^c   Reddy, P H ^c   Tagle, Dan ^c   Boyce, Frederick M ^a   Won, Lisa ^d   Heller, Alfred ^d   Aronin, Neil ^b   DiFiglia, Marian ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d UNIVERSITY OF CHICAGO   (United States)

Author keywords

Apoptosis; Apoptotic bodies; Cytoplasmic inclusions; Full length huntingtin; Membrane blebbing; NH2 terminal huntingtin fragments; Nuclear inclusions; Striatal hybrid cells; Z DEVD FMK; Z VAD FMK

Indexed keywords

CASPASE;

AMINO TERMINAL SEQUENCE; APOPTOSIS; ARTICLE; CELL INCLUSION; CELL SURVIVAL; DNA SEQUENCE; ENZYME INHIBITION; GENE MUTATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUNTINGTON CHOREA; HYBRID CELL; IMMUNOHISTOCHEMISTRY; MOLECULAR CLONING; PRIORITY JOURNAL;

EID: 0033081766     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.19-03-00964.1999     Document Type: Article

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