Extended half-life and elevated steady-state level of a single-chain Fv intrabody are critical for specific intracellular retargeting of its antigen, caspase-7

Journal of Immunological Methods

Volumn 231, Issue 1-2, 1999, Pages 207-222

  Zhu, Quan ^a   Zeng, Congmei ^a   Huhalov, Alexandra ^a,e   Yao, Jin ^a   Turi, Thomas G ^b   Danley, Dennis ^b   Hynes, Thomas ^b   Cong, Yang ^b   DiMattia, Debra ^b   Kennedy, Scott ^b   Daumy, Gaston ^b   Schaeffer, Eric ^b   Marasco, Wayne A ^c,d   Huston, James S ^a  

^a IntraImmune Therapies Inc   (United States)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Apoptosis; Caspase 7; Intracellular targeting; Protein turnover; sFv intrabody

Indexed keywords

ANTIBODY; ANTIGEN; CASPASE 7;

ANTIBODY SPECIFICITY; ANTIGEN BINDING; APOPTOSIS; ARTICLE; GENE DOSAGE; HALF LIFE TIME; IMMUNOFLUORESCENCE MICROSCOPY; LEUKEMIA CELL LINE; MAMMAL CELL; PRIORITY JOURNAL; PROTEIN METABOLISM; PROTEIN TARGETING; STEADY STATE; WESTERN BLOTTING;

MAMMALIA;

EID: 0033499632     PISSN: 00221759     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-1759(99)00158-1     Document Type: Article

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